Ionotropic Glutamate Receptors and Voltage-Gated Ca2+ Channels in Long-Term Potentiation of Spinal Dorsal Horn Synapses and Pain Hypersensitivity by Dong-ho Youn, Gábor Gerber, William A. Sather

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Renal Clear Cell Carcinoma and Tonsil Metastasis by Dario Marcotullio, Giannicola Iannella, Gian Franco Macri, Caterina Marinelli, Melissa Zelli, Giuseppe Magliulo

“…Clear cell carcinoma represents 85% of all histological subtypes. In February 2012 a 72-year-old woman came to our department due to the appearance of massive hemoptysis and pharyngodinia. …”
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The Activity of Plant Crude Extracts against Schistosoma mansoni by Hirut Basha, Hassen Mamo

“…Nearly all of the plants significantly reduced schistosome egg output, killed adult worms, and improved liver histology and function. Further studies are required to assess the therapeutic potential of more promising plant species.…”
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Promising Remission with Reduced Bevacizumab and Pembrolizumab Dosage in a Patient with AT-rich Interaction Domain 1A Mutated Ovarian Clear-cell Carcinoma Refractory to Chemotherap... by Cheng-Wei Huang, Ruo-Han Tseng

“…The phase II KEYNOTE-100 trial revealed that pembrolizumab monotherapy demonstrated a 15.8% objective response in patients with ovarian clear-cell carcinoma in the subgroup analysis, which is much higher than that of other histology subtypes of ovarian cancer. Immune checkpoint inhibitors may play a new role in the treatment of these malignancies. …”
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Acute Warfarin Toxicity as Initial Manifestation of Metastatic Liver Disease by Varalaxmi Bhavani Nannaka, Nihar Jani, Masooma Niazi, Dmitry Lvovsky

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Superparamagnetic Iron Oxide–Enhanced Magnetic Resonance Imaging of Neuroinflammation in a Rat Model of Radicular Pain by Daniel L.J. Thorek, Christine L. Weisshaar, Julie C. Czupryna, Beth A. Winkelstein, Andrew Tsourkas

“…SPIO did not generate any significant postcontrast enhancement in the nerve roots of the sham group. Histology confirmed colocalization of SPIO with macrophage at the injury site. …”
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A case of extraskeletal chondroma in the left inguinal region by Alexey Shabunin, Ivan Lebedinsky, David Dolidze, Zurab Bagatelia, Ekaterina Solomonova, Anna Bumbu, Serghei Covantsev

“…The mass was resected with surrounding tissues (a surgical margin of 1 cm) under combined endotracheal anesthesia and the histology confirmed the tumor to be a chondroma.…”
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Understanding the role of nerves in head and neck cancers - a review by Krzysztof Rutkowski, Michał Gola, Michał Gola, Janusz Godlewski, Janusz Godlewski, Anna Starzyńska, Anna Starzyńska, Giulia Marvaso, Giulia Marvaso, Federico Mastroleo, Federico Mastroleo, Maria Giulia Vincini, Maria Giulia Vincini, Alice Porazzi, Mattia Zaffaroni, Barbara Alicja Jereczek-Fossa, Barbara Alicja Jereczek-Fossa

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Medullary thyroid cancer in MEN2 pediatric/adolescent carriers of RET mutation: genotype/phenotype correlation and outcome in a retrospective series of 23 patients by Guenda Di Benedetto, Ignazio Barca, Laura De Gregorio, Claudia Scollo, Fiorenza Gianì, Federica Martorana, Marco Russo, Francesco Frasca, Gabriella Pellegriti, Gabriella Pellegriti, Giulia Sapuppo

“…All patients underwent surgery: at histology, MTC was found in 19/23 (82.6%) patients, C-cell hyperplasia in 2/23 (8.7%), and benign histology in 2/23 (8.7%). …”
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Intradiscal Injection of Induced Pluripotent Stem Cell-Derived Nucleus Pulposus-Like Cell-Seeded Polymeric Microspheres Promotes Rat Disc Regeneration by Kaishun Xia, Jian Zhu, Jianming Hua, Zhe Gong, Chao Yu, Xiaopeng Zhou, Jingkai Wang, Xianpeng Huang, Wei Yu, Liming Li, Jianqing Gao, Qixin Chen, Fangcai Li, Chengzhen Liang

“…The imaging examination indicated that disc height recovered and water content increased. Histology and immunohistochemistry results indicated that the NP cells as well as their extracellular matrix were partially restored. …”
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Exploring the CD3/CD56/TNF-α/Caspase3 pathway in pyrethroid-induced immune dysregulation: curcumin-loaded chitosan nanoparticle intervention by Nawal Alsubaie, Yasmina M. Abd-Elhakim, Amany Abdel-Rahman Mohamed, Tarek Khamis, Tarek Khamis, Mohamed M. M. Metwally, Mohamed M. M. Metwally, Nawal Helmi, Afnan M. Alnajeebi, Badriyah S. Alotaibi, Amirah Albaqami, Wedad Mawkili, Mai A. Samak, Mai A. Samak, Samar A. Eissa

“…Moreover, their splenic tissues displayed a substantial increase in the ROS, MDA, IL-6, and IL-1β content, altered splenic histology, and reduced GPX, GSH, and GSH/GSSG. Furthermore, a substantial upregulation of mRNA expression of splenic CD20, CD56, CD8, CD4, CD3, IL-6, and TNF-α, but downregulation of CD8 was detected in FTN-exposed rats. …”
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Multicentric Giant Cell Tumor of Bone: Synchronous and Metachronous Presentation by Reiner Wirbel, Frank Blümler, Dirk Lommel, Guido Syré, Veit Krenn

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Multimodality Imaging Evaluation of an Uncommon Entity: Esophageal Heterotopic Pancreas by Takman Mack, Debra Lowry, Peter Carbone, Brian Barbick, Joshua Kindelan, Robert Marks

“…Surgical findings and histology confirmed the diagnosis of esophageal heterotopic pancreas.…”
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Comparative Evaluation of Enalapril and Losartan in Pharmacological Correction of Experimental Osteoporosis and Fractures of Its Background by D. S. R. Rajkumar, A. V. Faitelson, O. S. Gudyrev, G. M. Dubrovin, M. V. Pokrovski, A. V. Ivanov

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Confocal Endomicroscopy of Colorectal Polyps by Vivian M. Ussui, Michael B. Wallace

“…CLE and related technologies are often termed “virtual biopsy” as they simulate the images seen in traditional histology. However, the imaging of living tissue allows more than just pragmatic convenience; it also allows imaging of living tissue such as active capillary circulation, cellular death, and vascular and endothelial translocation, thus extending beyond what is capable in traditional biopsy. …”
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State of competition: conceptual shoehorning behind priority on calcitonin precursor biosynthesis by Enrique Wulff

“…However, it was José Fernández Nonídez from the Spanish School of Histology, died in Augusta (Georgia, USA) in 1947, whose expertise in the parafollicular cells of the mammalian thyroid had led him to an advanced understanding of this separate endocrine organ, which secretes calcitonin. …”
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Mesonephric-like adenocarcinoma of the uterine corpus with focal sarcomatous differentiation: A case report by Serika Kanao, Makoto Urano, Kazuhisa Fujita, Fumi Utsumi, Kazuhiro Sugihara, Kiyosumi Shibata

“…It accounts for approximately 1% of patients with uterine corpus cancer, being rare. The histology of this carcinoma varies, making pathological diagnosis difficult. …”
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Case Report of Kikuchi-Fujimoto Disease from Sub-Saharan Africa: An Important Mimic of Tuberculous Lymphadenitis by Karishma Sharma, Fredrick Otieno, Reena Shah

“…She was found to have aseptic meningitis, eventually attributed to TB based on cervical node biopsy, although further histology suggested KFD. Blood tests for systemic lupus erythematosus (SLE) were negative; she had already been commenced on anti-TB treatment and had responded well and so was continued with this therapy. …”
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Angiosarcoma Arising in a Patient with a 10-Year-Old Hemangioma by Michael J. Nathenson, Diana Molavi, Albert Aboulafia

“…We describe the case of a 40-year-old woman with a preceding history of a suspected hemangioma for ten years, who upon resection was found on histology to have evidence of a hemangioma with an associated area of epithelioid hemangioendothelioma as well as areas of overt high grade epithelioid angiosarcoma. …”
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Spontaneous Regression of a Carcinoid Tumor following Pregnancy by A. Sewpaul, D. Bargiela, A. James, S. J. Johnson, J. J. French

“…The diagnosis of a nonsecretory carcinoid tumor was confirmed using CT imaging, octreotide scan, and histology. Furthermore, serial imaging has demonstrated spontaneous regression of the carcinoid suggesting that pregnancy did not worsen the course of the disease but instead may have contributed to tumour regression. …”
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