A Potential Protective Effect of Alcohol Consumption in Male Genital Lichen Sclerosus: A Case-Control Study by Joey El Khoury, Jessica Andraos, Anthony Kanbar, Rami Halabi, Serge Assaf, Anthony Mina, Sabine El Breidi, Charbel Dabal, Charbel El Hachem, Rodrigue Saad, Antoine Kassis, Maher Abdessater, Raghid El Khoury

“…Lichen sclerosus (LSc) is a chronic inflammatory process of the skin characterized by its unique histological features. It affects men and women of all ages, mainly in the anogenital area. …”
Get full text

First Experiences with Fusion of PET-CT and MRI Datasets for Navigation-Assisted Percutaneous Biopsies for Primary and Metastatic Bone Tumors by Hagen Fritzsche, Alexander Pape, Klaus-Dieter Schaser, Franziska Beyer, Verena Plodeck, Ralf-Thorsten Hoffmann, Patricia Hahlbohm, Elisabeth Mehnert, Anne Weidlich

“…<b>Conclusions:</b> Navigation-assisted percutaneous tumor biopsy resulted in correct, histologically useable diagnoses in all patients and reached a higher accuracy and first-time success rate (diagnostic yield: 100%) in comparison to CT-guided biopsies. …”
Get full text

Effects of Renal Denervation via Renal Artery Adventitial Cryoablation on Atrial Fibrillation and Cardiac Neural Remodeling by Wei Wang, Zhaolei Jiang, Rongxin Lu, Hao Liu, Nan Ma, Jie Cai, Min Tang, Ju Mei

“…After 2 months of postoperative recovery, AF vulnerability, AF duration, and histological examination were performed in both groups. …”
Get full text

Therapeutic Efficacy of <i>Lavandula dentata</i>’s Oil and Ethanol Extract in Regulation of the Neuroinflammation, Histopathological Alterations, Oxidative Stress, and Restoring Ba... by Aziza Antar, Eman S. Abdel-Rehiem, Areej A. Al-Khalaf, Abdelaziz S. A. Abuelsaad, Mohamed Abdel-Gabbar, Gaber M. G. Shehab, Ayman M. Abdel-Aziz

“…Numerous electrolyte levels, monoamine levels, neurotransmitter levels, and the mRNA expression of specific gate channel subtypes were evaluated in homogenate brain tissue. Additionally, histological changes in various brain regions were investigated. …”
Get full text

Analysis of mutations in CDC27, CTBP2, HYDIN and KMT5A genes in carotid paragangliomas by E. N. Lukyanova, A. V. Snezhkina, D. V. Kalinin, A. V. Pokrovsky, A. L. Golovyuk, O. A. Stepanov, E. A. Pudova, G. S. Razmakhaev, M. V. Orlova, A. P. Polyakov, M. V. Kiseleva, A. D. Kaprin, A. V. Kudryavtseva

“…Previously, we performed the exome sequencing of 52 CPGLs and estimated mutational load (ML). Paired histologically normal tissues or blood were unavailable, so potentially germline mutations were excluded from the analysis with strong filtering conditions using 1000 Genomes Project and ExAC databases. …”
Get full text

Ablation of IGFBP5 expression alleviates neurogenic erectile dysfunction by inducing neurovascular regeneration by Jiyeon Ock, Guo Nan Yin, Fang-Yuan Liu, Yan Huang, Fitri Rahma Fridayana, Minh Nhat Vo, Ji-Kan Ryu

“…One week after CNI, erectile function was evaluated and the penile tissue was then harvested for histological examination and western blot analysis. Additionally, the major pelvic ganglia (MPG) and dorsal root ganglia (DRG) were cultured for ex vivo neurite outgrowth assays. …”
Get full text

The ABC transporter A7 modulates neuroinflammation via NLRP3 inflammasome in Alzheimer’s disease mice by Irene Santos-García, Pablo Bascuñana, Mirjam Brackhan, María Villa, Ivan Eiriz, Thomas Brüning, Jens Pahnke

“…The role of ABCA7 was analyzed using histological, biochemical, molecular and mass spectrometry methods. …”
Get full text

Mortality Prognostic Factors in Patients with Cutaneous Malignant Melanoma by Víctor Ernesto González Velázquez, Lázaro Roque Pérez, Elys María Pedraza Rodríguez, Lissi Lisbet Rodríguez Rodríguez, Mabel González Escudero

“…The variables analyzed were: age, sex, skin color, histological subtype, Breslow index, Clark level, mitotic index, lymph node involvement, distant metastasis, ulceration, topographic location, clinical stage, type of treatment, and lactate dehydrogenase levels blood at diagnosis. …”
Get full text

Quzhou Aurantii Fructus Flavonoids Ameliorate Inflammatory Responses, Intestinal Barrier Dysfunction in DSS-Induced Colitis by Modulating PI3K/AKT Signaling Pathway and Gut Microbi... by Wang H, Huang W, Pan X, Tian M, Chen J, Liu X, Li Q, Qi J, Ye Y, Gao L

“…The therapeutic impacts of QAFF were assessed in dextran sulfate sodium (DSS)-induced UC mice, focusing on the changes in body weight, disease activity index (DAI), colon length, histological assessment of colonic tissues, levels of pro-inflammatory cytokines, and expression of tight junction proteins. …”
Get full text

Clinicopathological Features of 166 Cases of Invasive Ductal Breast Carcinoma and Effect of Primary Tumor Location on Prognosis after Modified Radical Mastectomy by Shiman Chen, Liang Yang, Yaqiong Li

“…There were no significant differences in age, menopause, histological grading, molecular typing, lymph node metastasis, vascular invasion, radiation therapy, and chemotherapy among different groups (P>0.05). …”
Get full text

In-Situ Electrospinning Dressings Loaded with Kaempferol for Reducing MMP9 to Promote Diabetic Ulcer Healing by Li J, Meng H, Guo W, Zhou L, Wu S, Gao G, Liu Q, You D, Qu W

“…The in vivo wound healing efficacy of the dressings was analyzed in the diabetic wound model rats. Histological and immunofluorescence staining were performed to determine the status of epithelization, collagen deposition, MMP9 expression, macrophage polarization, inflammation response and angiogenesis.Results: Material science experiments have shown that the dressing has optimal fiber micromorphology and good water vapor transport properties (WVTR: 4.88 kg m− 2 24h− 1); in vivo, diabetic wound experiments have shown that the high porosity and pharmacological effects of PED4 can mutually promote the rapid healing of diabetic wounds (healed 95.9% on day 15), facilitate the transformation of macrophages from M1-type to M2-type and regulate the expression of MMP9.Conclusion: Portable electrospinning dressings equipped with kaempferol not only better fit irregular wounds, but also promote wound healing through MMP9 and macrophage polarization. …”
Get full text

Starvation Affects the Muscular Morphology, Antioxidant Enzyme Activity, Expression of Lipid Metabolism-Related Genes, and Transcriptomic Profile of Javelin Goby (Synechogobius has... by Xiangning Chen, Yili Xu, Xiangyu Cui, Siying Zhang, Xiangqi Zhong, Juntao Ke, Yuze Wu, Zhiyu Liu, Chaoqing Wei, Zhujin Ding, Jianhe Xu, Hanliang Cheng

“…This study investigated the effects of starvation on the muscular function, morphology, and regulatory signaling in javelin goby (Synechogobius hasta) by evaluating the biochemical, histological, antioxidant, and transcriptional changes in the musculature of S. hasta subjected to 3, 7, and 14 days fasting. …”
Get full text

Use of intraoperative luminescent methods for detecting affected lymph nodes in patients with complicated forms of colon cancer by M. A. Kubrak, S. M. Zavhorodnii, M. B. Danyliuk, A. I. Rylov

“…These nodes were marked and sent for histological examination separately from the main preparation. …”
Get full text

Examination of non-conventional dysplasias adjacent to colorectal adenocarcinoma in patients with IBD by Szintia Almási, Zsófia Balajthy, Bence Baráth, Zsófia Krisztina Török, Panna Szaszák, Tamás Lantos, Bence Kővári, Anita Sejben

“…The patient’s sex, age (at the diagnosis of IBD and neoplasia), type of IBD, type of specimen [biopsy (n = 8)/surgical specimen (n = 20)], histological type, grade, localisation, stage, disease-free (DFS) and overall survival (OS) were obtained. …”
Get full text

Abord laparoscopique d’un volumineux kyste hépatique simple : à propos d’un cas [A laparoscopic approach to a large simple hepatic cyst : a case report] by Meriem Bouzida, Mustapha Zeggane, Noura Zahi, Benyahia Boukhatem, Noureddine Ait Benamer

“…The treatment consisted of a wide fenestration by laparoscopy after careful puncture of the cyst in order to eliminate a parasitic pathology and an aspiration of around 1.8 liter of a brownish liquid, a cholecystectomy and the exteriorization of the cyst wall in an endobag. The histological study was in favor of a simple liver cyst. …”
Get full text

Application of organoids in drug screening of gynecological malignant tumors by JIANG Yuanyuan, WEI Wenfei, WU Jingya, LI Huawen

“…Organoids are tissue-like structures with a specific spatial arrangement formed in vitro through three-dimensional cell culture, capable of highly simulating the structure and function of tissues in vivo and displaying histological and genotypic characteristics very similar to human organs. …”
Get full text

Transcriptional Profiling Underscores the Role of Preprocurement Allograft Metabolism and Innate Immune Status on Outcomes in Human Liver Transplantation by Joohyun Kim, MD, PhD, Michael T. Zimmermann, PhD, Angela J. Mathison, PhD, Gwen Lomberk, PhD, Raul Urrutia, MD, Johnny C. Hong, MD

“…We conducted clinical data analyses, histologic evaluation, and RNA sequencing of 17 consecutive human primary OLT. …”
Get full text

Correlation between METTL3 overexpression and 18F-FDG uptake in patients with soft tissue sarcoma by Tong Wu, Jinghui Xie, Hongbo Feng, Hua Zhang, Juan Tao, Bo Chen

“…METTL3 expression was associated with histological differentiation (Z=-2.026, p = 0.043), but no significant difference was observed according to age, sex, tumor size, tumor location, or metastasis (all p values > 0.05). …”
Get full text

Surgery lengthens survival for collecting duct carcinoma: analysis of hospital-based cancer registry data in Japan by Shuya Kandori, Shuhei Suzuki, Kosuke Kojo, Bunpei Isoda, Takazo Tanaka, Satoshi Nitta, Masanobu Shiga, Yoshiyuki Nagumo, Atsushi Ikeda, Takashi Kawahara, Akio Hoshi, Hiromitsu Negoro, Bryan J. Mathis, Ayako Okuyama, Hiroyuki Nishiyama

“…Methods We used a hospital-based cancer registry data in Japan to extract CDC cases that were diagnosed in 2013, histologically confirmed, and determined the first course of treatment. …”
Get full text

Aminoguanidine hemisulfate improves mitochondrial autophagy, oxidative stress, and muscle force in Duchenne muscular dystrophy via the AKT/FOXO1 pathway in mdx mice by Shiyue Sun, Tongtong Yu, Joo Young Huh, Yujie Cai, Somy Yoon, Hafiz Muhammad Ahmad Javaid

“…Additionally, AGH reduced apoptosis, shown by fewer TUNEL-positive cells and lower caspase-3 expression. Histological analysis revealed decreased muscle damage and fewer embryonic and neonatal myosin-expressing fibers. …”
Get full text