Outcomes following immunosuppressive therapy withdrawal after complete renal response in proliferative lupus nephritis by Javier Narváez, Francesca Mitjavila, Joan M Nolla, Paola Vidal-Montal, Montserrat Gomà, Xavier Fulladosa, Olga Capdevila, Joan Torras

“…Renal rebiopsy was performed in 25 of these patients (86.2%), with 80% retaining the same histological class.Discontinuation of IST at ≤34 years of age significantly increased the risk of RR (adjusted HR: 3.5). …”
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Features of the Parameters of 24-Hours pH-Impedance and High-Resolution Esophageal Manometry in Patients with Barrett's Esophagus on Proton Pump Inhibitors by I. V. Maev, D. S. Bordin, E. V. Barkalova, M. A. Ovsepyan, E. R. Valitova, N. G. Kalashnikova, D. N. Andreev

“…Аim: to identify predictors of insufficient effectiveness of proton pump inhibitors based on the evaluation of the results of 24-hour pH-impedance and high-resolution esophageal manometry in patients with Barrett's esophagus.Materials and methods. 52 patients with histologically confirmed Barrett's esophagus who are on therapy with proton pump inhibitors were examined. …”
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Phase II, single-arm trial of preoperative short-course radiotherapy followed by chemotherapy and camrelizumab in locally advanced rectal cancer by Jun Fan, Jing Wang, Tao Zhang, Xin Li, Lan Zhang, Zheng Wang, Tao Liu, Gang Li, Peng Zhang, Chi Ma, Ming Cai, Gang Wu, Zhenyu Lin, Kailin Cai, Xiu Nie, Junli Liu, Hongli Liu, Weikang Zhang, Jingbo Gao, Chuanqing Wu, Linfang Wang, Zhiguo Hou, Kunyu Yang, Kaixiong Tao

“…Treatment-naïve patients with histologically confirmed T3-4N0M0 or T1-4N+M0 rectal adenocarcinoma received 5×5 Gy SCRT with two subsequent 21-day cycles of CAPOX plus camrelizumab after 1 week, followed by radical surgery after 1 week. …”
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Multimodal Imaging of Patients With Gliomas Confirms C-MET PET as a Complementary Marker to MRI for Noninvasive Tumor Grading and Intraindividual Follow-Up After Therapy by Kai R. Laukamp MD, Florian Lindemann PhD, Matthias Weckesser MD, Volker Hesselmann MD, Sandra Ligges PhD, Johannes Wölfer MD, Astrid Jeibmann MD, Bastian Zinnhardt PhD, Thomas Viel PhD, Michael Schäfers MD, Werner Paulus MD, Walter Stummer MD, Otmar Schober PhD, MD, Andreas H. Jacobs MD

“…In n = 65 patients with histologically verified brain lesions n = 70 MET-PET and MRI (T1-weighted gadolinium-enhanced [T1w-Gd] and fluid-attenuated inversion recovery or T2-weighted [FLAIR/T2w]) examinations were performed. …”
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Ficus deltoidea standardized methanolic extract improves kidney structure and function against streptozotocin-induced diabetic nephropathy in rats by Nurdiana Samsulrizal, Noor Syaffinaz Noor Mohamad Zin, Nur Syimal`ain Azmi, Mohd Daud Bakar, Hafandi Ahmad, Yong-Meng Goh

“…The biochemical and histological examinations consistently showed that F. deltoidea extract improved kidney structure and function by reducing oxidative stress and apoptosis. …”
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The Global RAdical Cystectomy Evaluation and Management (GRACEM) pathway: single‐centre prospective observational cohort study protocol by Bruno Bernardini, Federico Piccioni, Manuele Pastore, Paolo Casale, NicolòMaria Buffi, Giovanni Lughezzani, Massimo Lazzeri, Alberto Saita, Maria Vittoria Fantacci, Stefano Mancon, Filipo Dagnino, Roberto Contieri, Pietro Brin, Stefano Mancin, Andrea Gobbo, Maria Rosaria Martucci, Giovanna Cerina, Sara Ghirmai, Ezio Lanza, Giulia Goretti, Giorgio Ferruccio Guazzoni, Rodolfoi Hurle

“…Patients and methods The GRACEM study includes patients with non‐metastatic, histologically confirmed, muscle‐infiltrating bladder cancer who underwent RC surgery with curative intent. …”
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A multicenter, randomized, double-blind, placebo-controlled phase 3 study of Socazolimab or placebo combined with carboplatin and etoposide in the first-line treatment of extensive... by Zhiwei Chen, Jianhua Chen, Dingzhi Huang, Wei Zhang, Lin Wu, Tienan Yi, Qiming Wang, Liang Han, Liping Tan, Yinyin Li, Zhihong Zhang, Na Li, Jie li, Tongmei Zhang, Ying Hu, Hongmei Sun, Youhua Wu, Zhiyong He, Runxiang Yang, Peng Cheng, Xingya Li, Jianhua Shi, Guohua Yu, Daiyuan Ma, Benjamin Xiaoyi Li, Xiangrong Dai, Michael Wong, Yujie Li, Xiaohui Yu, Shun Lu, for the Socazolimab Study Group

“…Abstract This is a randomized, double-blind, placebo-controlled phase 3 clinical trial (ClinicalTrials.gov, NCT04878016) conducted in 54 hospitals in China. Adults who were histologically diagnosed and never treated for extensive-stage small cell lung cancer (ES-SCLC) were enrolled. …”
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Total neoadjuvant chemotherapy according to the FOLFIRINOX regimen for locally advanced adenocarcinoma of the stomach and cardioesophageal junction: interim results by M. V. Sedova, M. A. Batov, A. A. Kolomeytseva, V. M. Khomyakov, N. N. Volchenko, A. A. Fedenko

“…To study the efficacy and safety of total neoadjuvant chemotherapy (NACT) with the FOLFIRINOX regimen for locally advanced gastric (GC) and cardioesophageal junction (CEJ) cancer.Patients and methods. Patients with histologically confirmed locally advanced gastric adenocarcinoma and CEJ, clinical stage cT3 or higher and/or regional lymph node involvement (cN+), without evidence of distant metastasis were included in our open-label, single-centre, non-randomised study. …”
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Apallic syndrome of toxic origin: the diagnostic criteria by N.V. Kurdil, A.O. Volosovets, O.V. Ivashchenko, V.S. Lisovska, H.M. Balan, O.M. Rozhkova, V.V. Andriushchenko

“…The visualization zones of the pathological process in the brain in case of toxic damage are mainly basal ganglia and/or thalamus and dentate nucleus, cortical zone of grey matter, periventricular zone of white matter, corticospinal tract and corpus callosum; asymmetric white matter damage as a sign of demyelination; parietal-occipital subcortical vasogenic edema and lesions of the central pons are characteristic. Forensic and histological studies of the cerebral cortex revealed diffuse loss of neurons, neuronophagia, satellitosis, deformed pyramidal neurons with apical dendrites and manifestations of homogenising necrosis, angiomatosis microfoci and neuropil vacuolation, mineralization of the tissue and a moderate glial reaction around the petrifications. …”
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A pelvis MR transformer-based deep learning model for predicting lung metastases risk in patients with rectal cancer by Yin Li, Yin Li, Yin Li, Shuang Li, Shuang Li, Ruolin Xiao, Ruolin Xiao, Xi Li, Yongju Yi, Yongju Yi, Liangyou Zhang, Liangyou Zhang, You Zhou, You Zhou, Yun Wan, Chenhua Wei, Liming Zhong, Liming Zhong, Wei Yang, Wei Yang, Lin Yao, Lin Yao, Lin Yao

“…This study aims to develop and validate a transformer-based deep learning (DL) model based on pelvic MR images, integrated with clinical features, to predict RCLM.MethodsA total of 819 patients with histologically confirmed rectal cancer who underwent preoperative pelvis MRI and carcinoembryonic antigen (CEA) tests were enrolled. …”
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Study of the neuroprotective properties of metformin in rats with type 2 diabetes mellitus and brain injury induced by intracerebral hemorrhage by V.L. Holubiev, M.H. Oberemok, V.A. Tkachenko, Yu.V. Kharchenko, O.O. Bondarenko, A.E. Lievykh, V.I. Zhyliuk

“…Histopathological examination was performed using general histological staining techniques and immunohistochemical methods for assessment of expression of endothelial NO-synthase (eNOS), Growth Associated Protein 43 (GAP43), Hypoxia-inducible factor 1-alpha (HIF-1α), neural cadherine (N-cadherine) and vascular endothelial cadherine (VE-cadherine). …”
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Improved diagnosis of small cervical lymph node metastasis using postvascular phase perfluorobutane CEUS in cancer patients by Naxiang Liu, Zhaoming Zhong, Wenrong Lin, Zhongshi Du, Zhougui Wu, Songsong Wu, Lina Tang

“…The reference standard was histological assessment of the LNs through biopsy. The US and CEUS features were analyzed to assess the diagnostic performance of the US, vascular phase-CEUS, and postvascular phase-CEUS features, as well as their association with LN size. …”
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Hydrogen Sulfide Promotes Functional Endometrium Recovery via Regulating Pyroptosis in Severe Endometrial Injury: A Prospective Laboratory Based Randomized Control Trial by Haiyan Shan, Mingyuan Xu, Jie Ni, Ling Zhou, Mengchun Xue, Jun Xue, Xiaohuan Yuan, Luyang Tao, Mingyang Zhang, Hong Zhang

“…Western blot analysis was conducted to assess changes in the expression of endogenous H2S metabolism and pyroptosis-related markers and histological analysis (Hematoxylin & Eosin and Masson staining) was employed to examine alterations in endometrial morphology. …”
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Morphological features of compensatory and reparative processes of the cecum in the long term of the experiment using polycaprolactone thread modified with L-arginine by O.M. Pronina, S.M. Bilash, I.V. Ksyonz, M.M. Kobeniak, A.V. Pirog-Zakaznikova, Ya.O. Oliinichenko, M.M. Koptev, S.V. Donchenko, B.S. Kononov, V.V. Oleksiienko

“…The following research methods were used: histological, method of semi-thin serial sections, morphometric, and statistical methods. …”
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Identification of progressive pulmonary fibrosis: consensus findings from a modified Delphi study by Athol U. Wells, Simon L. F. Walsh, Ayodeji Adegunsoye, Vincent Cottin, Sonye K. Danoff, Anand Devaraj, Kevin R. Flaherty, Peter M. George, Kerri A. Johannson, Martin Kolb, Yasuhiro Kondoh, Andrew G. Nicholson, Sara Tomassetti, Elizabeth R. Volkmann, Kevin K. Brown

“…Consensus was reached that a histological pattern of usual interstitial pneumonia (UIP) is a risk factor for progression of ILD, but that a biopsy to look for a UIP pattern should not be performed solely for prognostic reasons. …”
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The Correlation of Serum Adropin with Cardiovascular Risk Factors in the Experimental Rat Model of Chronic Kidney Disease and Its Implication in the Ameliorative Effect of Angioten... by Samaa Salah Abd-El-Fatah, Maha A. Fathy, Mohamed Ali Alabiad, Raja Aljafil, Mai Ahmed Gobran, Enssaf A. Ahmad, Ashwag S. Alsharidah, Mohammed Alorini, Sulaiman Mohammed Alnasser, Sara A. Awadh, Enas N. Morgan

“…Renal, cardiac, and aortic tissues were examined histologically and immunohistochemically to detect the expression of vascular endothelial growth factor receptor-2 (VEGFR-2). …”
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Ozone Therapy on Rats Submitted to Subtotal Nephrectomy: Role of Antioxidant System by José Luis Calunga, Zullyt B. Zamora, Aluet Borrego, Sarahí del Río, Ernesto Barber, Silvia Menéndez, Frank Hernández, Teresita Montero, Dunia Taboada

“…Serum creatinine values and protein excretion in 24 hours in the ozone group were decreased compared with nephrectomized rats, but were still higher than normal values. Histological study demonstrated that animals treated with ozone showed less number of lesions in comparison with nephrectomized rats. …”
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Caspase-1 activation, IL-1/IL-6 signature and IFNγ-induced chemokines in lungs of COVID-19 patients by Audrey Cambon, Christophe Guervilly, Christophe Guervilly, Clémence Delteil, Nicola Potere, Richard Bachelier, Edwige Tellier, Evelyne Abdili, Evelyne Abdili, Marine Leprince, Marco Giani, Ildo Polidoro, Valentina Albanese, Paolo Ferrante, Laurence Coffin, Michael Schiffrin, Laurent Arnaud, Romaric Lacroix, Romaric Lacroix, Sandrine Roque, Jean-Marie Forel, Jean-Marie Forel, Sami Hraiech, Sami Hraiech, Laurent Daniel, Laurent Papazian, Françoise Dignat-George, Françoise Dignat-George, Gilles Kaplanski, Gilles Kaplanski

“…However, cytokine profile in the lung compartment of C-ARDS patients has not been widely studied, nor compared to non-COVID related ARDS (NC-ARDS).ObjectivesTo evaluate caspase-1 activation, IL-1 signature, and other inflammatory cytokine pathways associated with tissue damage using post-mortem lung tissues, bronchoalveolar lavage fluids (BALF), and serum across the spectrum of COVID-19 severity.MethodsHistological features were described and activated-caspase-1 labeling was performed in 40 post-mortem biopsies. …”
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Early Myocardial Strain Reduction and miR-122-5p Elevation Associated with Interstitial Fibrosis in Anthracycline-Induced Cardiotoxicity by María de Regla Caballero-Valderrama, Elisa Bevilacqua, Miriam Echevarría, Francisco Javier Salvador-Bofill, Antonio Ordóñez, José Eduardo López-Haldón, Tarik Smani, Eva M. Calderón-Sánchez

“…In the animal model, epirubicin-induced circumferential strain (CS) decrease correlates with myocardial fibrosis assessed histologically and by a significant increase in <i>COL1</i> and <i>TGFB2</i> expression. …”
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Coincidental or Connected: Synchronous Giant Gastric GIST and Malignant Colonic Polyp: A Case Report by Terukumar Chandrasekaran, Lim Li Yi, JJ Mah, RK Sriram, Nik Amin Sahid

“…In a case of GIST, the surgeon should recognize the possibility of another tumor with a different histological origin. High clinical analysis needed during laparotomy for GIST to detect a synchronous tumor. …”
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