Combination drug therapy prevents CIAKI by suppressing ER stress-induced apoptosis by Xuan Wang, Shan Han, Lili Zhao, Hongliang Cong

“…Compared with those in the atorvastatin group, the rate of increase in creatinine and protein expression in the combined treatment groups were decreased to some extent, and the histological morphology was also improved. This was especially evident in Group AA + CC. …”
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Gene therapy by hepatocyte growth factor results in regression of experimental liver fibrosis by N. A. Dzhoyashvili, N. I. Kalinina, I. B. Beloglazova, Z. I. Tsokolayeva, P. I. Makarevich, Yu. L. Perov, Ye. V. Parfenova, V. A. Tkachuk

“…After obtaining liver tissue samples, histological study was carried out, and by real time polymerase chain reaction (RT-PCR) contents of mPNA of liver fibrosis-associated genes were analyzed: transforming growth factor β1 (TGF-β1), collagen 1α1 (Coll1α1), matrix metalloproteinase-13 (ММР-13), tissue inhibitor of matrix metalloproteinase (TIMP-1) and smooth-muscle actin α (α-SMA). …”
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Melasma management: Unveiling recent breakthroughs through literature analysis by Darshan Kumar R, Richa Sood, Prashant Tiwari

“…Research leveraging histological analyses, genetic profiling, and biochemical assays has elucidated novel therapeutic targets, including oxidative stress pathways and inflammatory mediators. …”
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Enzyme-linked immunosorbent assay for post-slaughter diagnosis of bovine leukosis by A. R. Mustafayev, M. O. Baratov

“…Postmortem diagnosis of enzootic bovine leukosis is made on the basis of the results of tests of biological materials from emergently slaughtered or fallen animals using pathomorphological, histological and molecular genetic methods that have some disadvantages. …”
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Pengaruh Pemberian Mesenchymal Stem Cells Wharton’s Jelly terhadap Ekspresi Gen PPAR-γ pada Tikus Alzheimer by Nabila Priscilla Putri, Hirowati Ali, Tofrizal Tofrizal, Eryati Darwin, Restu Susanti, Hasmiwati Hasmiwati

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Prognostic Factors and a Predictive Nomogram of Cancer-Specific Survival of Epithelial Ovarian Cancer Patients with Pelvic Exenteration Treatment by Ting Wang, Xin Fu, Lei Zhang, Shuna Liu, Ziqi Tao, Fang Wang

“…In the training cohort, age, histological type, Federation of Gynecology and Obstetrics (FIGO) stage, number of examined lymph nodes, and number of positive lymph nodes were found to be independent prognostic factors of postoperative CSS. …”
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Evaluation of the Acute Hepatoprotective Potential of Hydroethanolic Extract of Duranta erecta L. Parts by Shadrack Donkor, Christopher Larbie, Gustav Komlaga, Benjamin Obukowho Emikpe

“…Hepatoprotective efficacy was assessed by assaying serum biochemical markers such as alanine aminotransferase (ALT), aspartate aminotransferase (AST), alkaline phosphatase (ALP), gamma-glutamyl transferase (γGT), bilirubin (Bil), antioxidative biomarkers including reduced glutathione (GSH), glutathione peroxidase (GPx), glutathione transferase (GST), superoxide dismutase (SOD), malondialdehyde (MDA), hydrogen peroxidase (H202), and nitric oxide (NO), as well as histological observations. Results. Exposure of the animals to CCl4 and acetaminophen resulted in liver injury as evidenced by elevated ALT, AST, ALP, γGT, Bil, MDA, H2O2, and NO levels with resultant derangement in liver microarchitecture. …”
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Pulmonary cavernous hemangioma: a case report by Wei Li, Xingxing Zheng, Hongzhe Tian, Yu Xi, Yuhao Liu

“…In summary, the thoracic surgeon could not rule out the possibility of lung malignant tumors and chose to proceed with surgical excision to secure a conclusive diagnosis. Post-operative histological examination showed that the lesion consisted of dilated nodular hyperplasia rich in red blood cells, leading to a diagnosis of PCH. …”
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High protein diet increases the risk of allergic sensitization but not asthma in mice through modulation of the cytokine milieu toward Th2 bias by Waleed Al-Herz, MD, Fawaz Azizieh, PhD, Raj Raghupathy, PhD

“…Airway inflammation was tested by measuring total and differential cell counts in bronchoalveolar lavage fluid and by measuring bronchial mucus production, goblet cell hyperplasia and perivascular and peribronchial inflammation severity scores by histologic examination. Results: Mice fed HP diet had a significant increase in weight and higher levels of OVA-specific IgE and IgG1 antibodies compared to the ND group (P-values 0.002, 0.007 and <0.001, respectively). …”
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Activation of the Peroxisome Proliferator-Activated Receptors (PPAR-α/γ) and the Fatty Acid Metabolizing Enzyme Protein CPT1A by Camel Milk Treatment Counteracts the High-Fat Diet-... by Haifa M. AlNafea, Aida A. Korish

“…The protective effects of CM against the histological and biochemical features of NAFLD are at least in part related to the activation of the hepatic and extrahepatic PPARs (α, γ) with consequent activation of the downstream enzymes involved in fat metabolism. …”
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Molecular Hydrogen Modulates T Cell Differentiation and Enhances Neuro-Regeneration in a Vascular Dementia Mouse Model by Dain Lee, Hyunjun Jo, Jong-Il Choi

“…Behavioral assessments using open field and novel object recognition tests revealed that VaD mice exhibited anxiety-deficient behavior and memory impairment, both of which were reversed by H₂ treatment. Histological examinations showed pyknotic neuronal morphologies and elevated reactive oxygen species (ROS) in the VaD hippocampus, whereas H₂ administration mitigated these alterations. …”
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Primary Signet Ring Cell/Histiocytoid Carcinoma of the Eyelid: Clinicopathologic Analysis with Evaluation of the E-Cadherin/β-Catenin Complex and Associated Genetic Alterations by Maria Del Valle Estopinal, Lavinia P. Middleton, Bita Esmaeli, Keyur P. Patel, Sara Nowroozizadeh, Michelle D. Williams

“…Signet Ring Cell (SRC)/Histiocytoid carcinoma of the eyelid is a rare neoplasm that shares histological and immunohistochemical similarities with diffuse gastric cancer and breast lobular carcinoma. …”
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MORPHOFUNCTIONAL EVALUATION OF THYMUS IN PEKIN DUCK DURING DIETARY INCORPORATION OF ORGANIC SELENIUM FEED ADDITIVE DAFS-25k by V. V. Pronin, Ye. O. Anisimova, M. S. Dyumin, S. P. Fisenko

“…The histological study results of the thymus structure of Pekin ducks during administration of DAFS-25k feed additive are presented. …”
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Ruellia tuberosa L. Extract Improves Histopathology and Lowers Malondialdehyde Levels and TNF Alpha Expression in the Kidney of Streptozotocin-Induced Diabetic Rats by Anna Roosdiana, Fajar Shodiq Permata, Riera Indah Fitriani, Khairul Umam, Anna Safitri

“…Furthermore, severe histological alterations of kidney tissues occurred in the diabetic rats group. …”
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Nonalcoholic Fatty Liver Disease in Patients Investigated for Elevated Liver Enzymes by Krikor Kichian, Ross Mclean, Leah M Gramlich, Robert J Bailey, Vincent G Bain

“…The gold standard, however, is a liver biopsy to show the typical histological features of NAFLD, which are almost identical to those of alcohol-induced liver damage and can range from mild steatosis to cirrhosis. …”
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Application of ursodeoxycholic acid at non-alcoholic and alcohol-induced steatohepatitis by Ye. A. Fedos’ina, M. V. Mayevskaya

“…Corticosteroids are drugs of choice at treatment of severe decompensated forms of alcoholic liver disease, that reduce level of circulating proinflammatory cytokines and promote histological improvement with a short period. UDCA has antiapoptotic, cytoprotective, immunomodulating, anti-oxidative effect, so it can be used as pathogenic therapy at alcohol-induced and non-alcoholic steatohepatitis. …”
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Neural induction in Xenopus: requirement for ectodermal and endomesodermal signals via Chordin, Noggin, beta-Catenin, and Cerberus. by Hiroki Kuroda, Oliver Wessely, E M De Robertis

“…We found that explanted blastula dorsal animal cap cells that have not yet contacted a mesodermal substratum can, when cultured in saline solution, express definitive neural markers and differentiate histologically into CNS tissue. Transplantation experiments showed that the BCNE region was required for brain formation, even though it lacked CNS-inducing activity when transplanted ventrally. …”
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Successful Treatment of Linear Psoriasis With the IL-17a-Antagonist Ixekizumab: A Case Report by Christov S, Ohm F, Augustin M, Wagner JN

“…This case report shows the importance of histological confirmation in differentiating LP from clinically similar appearing diseases like ILVEN and highlights the potential therapeutic benefit of IL-17 blockade in LP. …”
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The Role of Antioxidant Activity of Chitosan-Pinus merkusii Extract Nanoparticle in against Lead Acetate-Induced Toxicity in Rat Pancreas by G. Wardani, Ernawati, K. Eraiko, S. A. Sudjarwo

“…The pancreas tissues were also collected to evaluate the malondialdehyde (MDA), superoxide dismutase (SOD), glutathione peroxidase (GPx), and histological evaluations of cell damage. The PSA showed that the size of Chitosan-Pinus merkusii nanoparticle was 530.2 ± 38.27 nm. …”
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Neutrophil gelatinase-associated lipocalin (NGAL) in lupus nephritis and beyond by Elisabet Svenungsson, Iva Gunnarsson, Andreas Jönsen, Ting Wang, Anders A Bengtsson, Christian Lood, Marina Barguil Macedo

“…NGAL levels were measured in supernatant from IC-stimulated neutrophils in the presence or absence of a toll-like receptor 8 inhibitor (TLR8i).Results In the exploratory cohort, serum levels of NGAL were increased in patients with SLE as compared with healthy controls (p=0.021), and associated with histological-proven membranoproliferative lupus nephritis (LN) (p=0.018). …”
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