PI3Kδ inhibitor linperlisib combined with gemcitabine and oxaliplatin for relapsed or refractory diffuse large B-cell lymphoma: a multicenter, single-arm phase Ib/II trial by Peng Sun, Hong Cen, Haiyan Yang, Rui Huang, Zhen Cai, Xuekui Gu, Hanying Bao, Zusheng Xu, Zuhong Xu, Zhi-Ming Li

“…Methods This was a multicenter, phase Ib/II clinical study conducted across six sites in China, enrolling 39 individuals with histologically confirmed R/R DLBCL. The treatment protocol included oral linperlisib alongside GEMOX administered intravenously every three weeks for up to six cycles. …”
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Predicting Axillary Metastasis of Breast Cancer Patients with MRI Relaxometry by Roxana Pintican, Radu Fechete, Delia Ioana Radutiu, Manuela Lenghel, Ioana Bene, Carolina Solomon, Cristiana Ciortea, Anca Ciurea

“…All axillary metastases were histologically confirmed using core-needle biopsy or surgical specimens. …”
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Effects of repeated intragastric administrations with heat-inactivated Mycobacterium aurum DSM 33539 on the stress-induced aggravation of dextran sulfate sodium (DSS) colitis in C5... by Dominik Langgartner, Anna-Lena J. Weiss, Mattia Amoroso, John D. Sterrett, Christopher A. Lowry, Christopher A. Lowry, Christopher A. Lowry, Christopher A. Lowry, Christopher A. Lowry, Stefan O. Reber, Stefan O. Reber

“…Indeed, the relative abundance of Deferribacterota on day 19 was strongly correlated with histological damage to the colon. In line with the latter, M. aurum DSM 33539 was further protective against the aggravating effects of stress on subsequent DSS colitis. …”
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Platelet-rich fibrin and silver nano-particles loaded chitosan treatment for post- laminectomy epidural scar adhesions: in vivo rats study model by Samah Fouad, Awad Rizk, Esam Mosbah, Mostafa M. Nabeeh, Walaa Awadin, Ayman S. Elmezayyen, Ekramy Elmorsy, Adel Zaghloul

“…After a 30-days follow-up, macroscopic examination, histological studies, and mRNA evaluation for TGFβ-1and IL-6, were conducted. …”
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Injectable Hierarchical Bioactive Hydrogels with Fibroblast Growth Factor 21/Edaravone/Caffeic Acid Asynchronous Delivery for Treating Parkinson's Disease by Junpeng Xu, Peng Dai, Chen Zhang, Na Dong, Caiyan Li, Chonghui Tang, Zhihao Jin, Shih‐Ho Lin, Luyang Ye, Tianmiao Sun, Yukai Jin, Fenzan Wu, Lihua Luo, Ping Wu, Shengcun Li, Xiaokun Li, Shan‐hui Hsu, Dawei Jiang, Zhouguang Wang

“…The triple‐loaded hydrogel is injected into the brains of PD rats, showing behavioral improvement. Histological analysis revealed that the triple‐loaded OACDP hydrogels are effective in achieving immediate neuroprotection, i.e., reduction the loss of tyrosine hydroxylase in substantia nigra compacta and striatum (retained ≈10‐fold versus control), decreasing oxidative stress, reducing astrocyte and microglia activation, and stimulating the AMPK/PGC‐1α axis to regulate the mitochondrial function, providing a multi‐dimensional PD therapy. …”
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Effect of partial and total replacement of fishmeal by soybean meal in feed on growth and gut performance of Penaeus vannamei by Chanadda Kasamechotchung, Natthinee Munkongwongsiri, Pichet Plaipetch, Kanokwan Lertsiri, Siripong Thitamadee, Rapeepun Vanichviriyakit, Siriwan Khidprasert, Kallaya Sritunyalucksana, Felipe Nobre Façanha, Thanapong Kruangkum

“…F1-fed shrimp showed a high gut passage rate (GPR), whereas F3-fed shrimp had a low GPR until day 21, with differences becoming negligible by day 28. Histological examination of the hepatopancreas revealed an increased R-cell population in shrimp fed F3. …”
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Regulation of Paneth cell-specific genes in COVID-19 patients and SARS-CoV-2-infected mice by quantification of mRNA from exfoliated cells in stool samples by Gill Diamond, Erika L. Figgins, Denny Gao, Tanya O. Robinson, Kenneth Wilson, Jon D. Gabbard, Charles D. Anderson, Lalit Batra, Chithra Sreenivasan, Jian Zheng, Uyen Do, Braden Mulcahy, Lisa K. Ryan, Nathaniel McLaughlin, Anna H. Owings, Neha Dhaliwal, Haley B. Williams, T. Grant Wichman, Michelle Galeas-Pena, Sarah C. Glover

“…We observed a similar time-dependent reduction in Paneth cell-specific transcripts, which correlates with histological changes in the gut. This is the first demonstration of quantification of Paneth cell-specific transcripts without invasive sampling. …”
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Additional Evidence for DDB2 T338M as a Genetic Risk Factor for Ocular Squamous Cell Carcinoma in Horses by Moriel H. Singer-Berk, Kelly E. Knickelbein, Zachary T. Lounsberry, Margo Crausaz, Savanna Vig, Nikhil Joshi, Monica Britton, Matthew L. Settles, Christopher M. Reilly, Ellison Bentley, Catherine Nunnery, Ann Dwyer, Mary E. Lassaline, Rebecca R. Bellone

“…To determine if this same variant in DDB2 contributes to risk for ocular SCC in the Arabian, Appaloosa, and Percheron breeds and to determine if the variant contributes to risk for oral or urogenital SCC, histologically confirmed SCC cases were genotyped for the DDB2 variant and associations were investigated. …”
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Metallothioneins 1 and 2 Modulate Inflammation and Support Remodeling in Ischemic Cardiomyopathy in Mice by Georg D. Duerr, Daniela Dewald, Eva J. Schmitz, Luise Verfuerth, Katharina Keppel, Christine Peigney, Alexander Ghanem, Armin Welz, Oliver Dewald

“…Hearts were examined with M-mode echocardiography and processed for histological and mRNA studies. Results. Expression of MT1/2 mRNA was transiently induced during repetitive I/R in WT-mice, accompanied by a transient inflammation, leading to interstitial fibrosis with left ventricular dysfunction without infarction. …”
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Prospects of betulin application in broiler farming by M. V. Novikova, I. A. Lebedeva, L. I. Drozdova, A. V. Byuler

“…It was established that the phytobiotic consumption resulted in reduced deposition of subcutaneous and abdominal fat, higher biological value of meat by increasing the ash content, improved technological properties of meat due to increasing water-holding capacity of muscle fiber and intensity of formation and maturation of muscle fiber. Histological studies of pancreatic tissue samples from broiler chickens showed increase in the mass of islets of Langerhans and insulin-producing cell complexes. …”
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The effect of Miya on skeletal muscle changes by regulating gut microbiota in rats with osteoarthritis through AMPK pathway by Sen Wang, Zhengwei Duan, Zihua Li, Dong Yang, Hengli Lu, Yiwei Zhang, Yuesong Fu, Yonghao Guan, Guodong Li, Feng Qian, Tianyang Xu

“…Hematoxylin eosin (HE) staining was used to observe the histological morphology of the knee joint. The levels of succinate dehydrogenase (SDH) and muscle glycogen (MG) in the tibia muscle of rats were detected by the corresponding kits, as well as the expression of related genes/proteins were assessed by real-time quantitative PCR (RT-qPCR) and western blot. …”
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IL-33 Protects Mice against DSS-Induced Chronic Colitis by Increasing Both Regulatory B Cell and Regulatory T Cell Responses as Well as Decreasing Th17 Cell Response by Jun-feng Zhu, Ying Xu, Jian Zhao, Xue Li, Xinrui Meng, Tian-qi Wang, Ben-yao Zou, Peng-yan Zhao, Qi Liu, Chang-long Lu, Fang-liang Zheng, Hong-sheng Liu

“…Clinical symptoms, colon length, and histological changes were determined. The production of cytokines was measured by ELISA. …”
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Downregulation of the immunoproteasome subunit PSMB8 attenuates sepsis-associated acute kidney injury through the NF-κB pathway by Min Li, Wenjia Tong, Chao Dai, Guoping Lu, Danqun Jin, Fang Deng

“…The model of S-AKI induced by LPS (10 mg/kg) was assessed by histological examination. ELISA and Real-time PCR were used to detect the levels of inflammatory cytokines in the renal cortex. …”
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Liposarcoma in the Inguinal Canal: Challenges in Preoperative Diagnosis and Importance of Routine Pathological Examination of “Hernia Sacs” by Christopher A. Febres-Aldana, Jin Min, Marc Rafols, Irvin Willis, John Alexis

“…Liposarcoma is the most common histologic subtype of soft tissue sarcoma in the retroperitoneum. …”
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Examine the Availability and Safety of Mucosal Cutting Biopsy Technique for Diagnosis of Gastric Submucosal Tumor by Kazuhiro Mizukami, Osamu Matsunari, Ryo Ogawa, Yuka Hirashita, Kazuhisa Okamoto, Kensuke Fukuda, Akira Sonoda, Hidetoshi Akiyama, Sotaro Ozaka, Yoshinari Kawahara, Tadayoshi Okimoto, Masaaki Kodama, Kazunari Murakami

“…The tissue-acquiring rate was 93.3%. A histological diagnosis could not be made in two patients. …”
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Dexamethasone Provides Effective Immunosuppression for Improved Survival of Retinal Organoids after Epiretinal Transplantation by Bikun Xian, Ziming Luo, Kaijing Li, Kang Li, Mingjun Tang, Runcai Yang, Shoutao Lu, Haijun Zhang, Jian Ge

“…Retinal organoids were then seeded onto poly(lactic-co-glycolic) acid (PLGA) scaffolds and implanted into rhesus monkey eyes (including a healthy individual and three monkeys with chronic ocular hypertension (OHT) induction) and subjected to different post-operative immunosuppressant treatments; 8 weeks after the experiment, histological examinations were carried out to assess the success of the different treatments. …”
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Diabetes Mellitus, Extreme Insulin Resistance, and Hypothalamic-Pituitary Langerhans Cells Histiocytosis by Mathilde Sollier, Marine Halbron, Jean Donadieu, Ahmed Idbaih, Fleur Cohen Aubart, Corinne Vigouroux, Martine Auclair, Olivier Bourron, Marie Bastin, Géraldine Béra, Philippe Touraine, Jacques Young, Héléna Mosbah, Agnès Hartemann, Fabrizio Andreelli, Chloé Amouyal

“…The diagnosis of hypothalamopituitary histiocytosis was based on histological features after biopsy of a large suprachiasmatic lesion identified on magnetic resonance imaging (MRI). …”
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Excretory Function of Intestinal Tract Enhanced in Kidney Impaired Rats Caused by Adenine by Yu Yun, Tao Gao, Yue Li, Zhiyi Gao, Jinlian Duan, Hua Yin, Weigang Duan

“…Kidneys were harvested and histologically examined with hematoxylin-eosin staining kits. …”
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Cementum attachment protein‐derived peptide induces cementum formation by Lía Hoz Rodríguez, Maricela Santana Vázquez, Luis Fernando Ramírez González, Gonzalo Montoya Ayala, Sonia López Letayf, A. Sampath Narayanan, Higinio Arzate

“…Demineralized dentin blocks coated with CAP‐p5 implanted subcutaneously in BALB/cAnNCrl were analyzed histologically; the results disclosed that CAP‐p5 could induce the deposition of a cementum layer intimately integrated with the subjacent dentin with cementocytes embedded into the cementum matrix. …”
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Anticancer effect of the antirheumatic drug leflunomide on oral squamous cell carcinoma by the inhibition of tumor angiogenesis by Chieko Niwata, Takayuki Nakagawa, Takako Naruse, Miyuki Sakuma, Nao Yamakado, Misaki Akagi, Shigehiro Ono, Kei Tobiume, Jing Gao, Eijiro Jimi, Kouji Ohta, Tomonao Aikawa

“…In the animal study, LEF significantly suppressed tumor growth in both immunodeficient and syngeneic mice. Histologically, LEF decreased DHODH expression and tumor vascularization. …”
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