Correlation Between Learning and Memory Impairment and Changes in Cerebral White Matter Nerve Fibers and Pericytes in Rats with Chronic Cerebral Ischemia by HUANG Jia, WANG Mengxue, NI Jinglei, LIANG Shengxiang, LIN Bingbing

“…The grade of myelin disorder in the 28 days after operation group and the 56 days after operation group was significantly higher (<italic>P</italic>&lt;0.05). (5) Expression of MBP and PDGFR-β protein in corpus callosum and hippocampus: compared with the sham operation group, the expression of myelin basic protein in the corpus callosum and hippocampus decreased significantly in the 28 days after operation group and the 56 days after operation group (<italic>P</italic>&lt;0.05). …”
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Structural Alteration of Medial Temporal Lobe Subfield in the Amnestic Mild Cognitive Impairment Stage of Alzheimer’s Disease by Pan He, Hang Qu, Ming Cai, Weijie Liu, Xinyi Gu, Qiang Ma

“…FreeSurfer was utilized to automatically segment the hippocampus into 21 subregions and the amygdala into 9 subregions. …”
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Effects of Neural Stem Cells combine with Nerve Growth Factor Nanoparticles Transplantation in Alzheimer's Disease Transgenic Mice by Qing ZHU, Shuai SHAO, Nan HU, Yan CHEN

“…NSC derived from fetal brain of transgenic mice expressing enhanced green fluorescent protein(EGFP)was isolated and cultured in vitro.5 μL phosphate buffer(PBS)were injected in bilateral hippocampus of the WT control group and the AD control group, 5 μL NSC suspension and NSC combined with NGF nanoparticle suspension were injected in the bilateral hippocampus of the NSC transplant group and the combined group respectively. …”
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Mechanisms of oral ciprofloxacin-induced depressive-like behavior and the potential benefit of lactulose: A correlation analysis by Havizur Rahman, Kusnandar Anggadiredja, Lucy Sasongko

“…They were then sacrificed for biochemical assessment in the hippocampus and prefrontal cortex. The mechanism studies revealed significant correlation between SPT vs. serotonin in the hippocampus, and SPT vs. serotonin, cortisol, NF-κB in the prefrontal cortex. …”
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Involvement of Thalamus in Initiation of Epileptic Seizures Induced by Pilocarpine in Mice by Yong-Hua Li, Jia-Jia Li, Qin-Chi Lu, Hai-Qing Gong, Pei-Ji Liang, Pu-Ming Zhang

“…Two measures, redundancy and directionality index, were used to analyze the electrophysiological characters of neuronal activities and the information flow between thalamus and hippocampus. We found that LFPs became more regular during the seizure in both hippocampus and thalamus, and in some cases LFPs showed a transient disorder at seizure onset. …”
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Mechanism of Electroacupuncture Quchi (LI 11) -Yanglingquan (GB 34) in Rats with Spasticity of Cerebral Apoplexy by Bin GUO, Penghan WANG, Linxing HUANG, Zhiqiang XIE, Lina XIE, Weiai LIU, Lizhen YI, Xin LIU, Zenghui YUE

“…The ultrastructural changes of synapses in hippocampus were observed by electron microscopy. The expressions of BDNF and TrkB related genes in hippocampus were detected by RT-PCR. …”
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Effects of Treadmill Exercise on Hippocampal Synaptic Plasticity and Expression of Related Proteins in Aging Mice by WANG Sinuo, CAO Yajun, XIANG Qing, YAN Jiamin, LIN Yanting, ZHUANG Yueyang, GUO Xiaoqin, LIU Weilin

“…Nissl staining was used to detect the morphology of hippocampal neurons, Golgi staining was used to detect the number of dendritic spines in the hippocampus. RT-PCR was used to detect the changes of cognitive function-related factors in the hippocampus of aged mice, and Western blot was used to detect the changes of BDNF/TrkB/PI3K signaling pathway related proteins in the hippocampus.ResultsThe escape latency time of Barnes maze in the aged group was significantly longer than that in the adult group (<italic>P</italic>&lt;0.05), and the spontaneous alternation rate of T maze and the recognition rate of new objects significantly decreased (<italic>P</italic>&lt;0.05). …”
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Forebrain Ischemia-Reperfusion Simulating Cardiac Arrest in Mice Induces Edema and DNA Fragmentation in the Brain by Christina H. Liu, Shuning Huang, Young R. Kim, Bruce R. Rosen, Philip K. Liu

“…This model is known to induce neuronal death in the hippocampus, striatum, and cortex. We report the appearance of edema after transient BCAO of 60 minutes and 1 day of reperfusion. …”
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Association of Alzheimer’s and Lewy body disease pathology with basal forebrain volume and cognitive impairment by Julia Schumacher, Stefan Teipel, Alexander Storch

“…Abstract Background Degeneration of the basal forebrain cholinergic system is a hallmark feature shared by Alzheimer’s disease (AD) and Lewy body disease (LBD) whereas hippocampus atrophy is more specifically related to AD. …”
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Effects of Electroacupuncture at Baihui and Shenting Acupoints on Learning and Memory and Synaptic Plasticity in Rats with Cerebral Ischemia-reperfusion Injury by Xiaomin LIN, Jia HUANG, Xiaofang YOU, Bingbing LIN, Lidian CHEN

“…The changes of synaptic ultrastructure in the hippocampus were observed by transmission electron microscope. …”
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The Effects of GABAergic System under Cerebral Ischemia: Spotlight on Cognitive Function by Juan Li, Luting Chen, Feng Guo, Xiaohua Han

“…In this review, we present evidence about the changes of the GABAergic system on the hippocampus under the ischemic environment, which may be an underlying mechanism to the ischemia-induced cognitive deficit. …”
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Memory consolidation from a reinforcement learning perspective by Jong Won Lee, Min Whan Jung, Min Whan Jung

“…Additionally, a growing body of evidence indicates the involvement of the hippocampus, especially the CA1 region, in valuation processes. …”
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Alterations of gray matter volume and functional connectivity in patients with cognitive impairment induced by occupational aluminum exposure: a case-control study by Huaxing Meng, Bo Liu, Xiaoting Lu, Yan Tan, Shanshan Wang, Baolong Pan, Hui Zhang, Qiao Niu

“…Furthermore, plasma Al concentration was negatively correlated with the Montreal Cognitive Assessment score, bilateral hippocampal GM volume, and FC coefficient between the left hippocampus and left cerebellar vermis. Mediation analysis showed GM alteration of left caudate and bilateral hippocampus and FC alteration of left hippocampus to left cerebellar vermis could explained 19.80–32.07% of the effect of MoCA scores change related to Al exposure, besides the GM alteration of right hippocampus acted as indirect mediator (68.75%) of the association between Al and AVLT delayed recall scores.ConclusionOur data indicates that alterations in the structure and function of special brain domain, especially the hippocampus, are associated with Al-induced CI. …”
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Cerebellar and Hippocampal Activation During Eyeblink Conditioning Depends on the Experimental Paradigm: A MEG Study by Peter Kirsch, Caroline Achenbach, Martina Kirsch, Matthias Heinzmann, Anne Schienle, Dieter Vaitl

“…The cerebellum and the hippocampus are key structures for the acquisition of conditioned eyeblink responses. …”
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Effect of Electroacupuncture at Baihui and Shenting on Learning and Memory of Cerebral Ischemia-reperfusion Injuried Rats Via Magnetic Resonance Spectroscopy by Congkuai ZHAO, Weilin LIU, Ruhui LIN, Jing TAO

“…Objective:To observe the nerve cell metabolism of hippocampus in focal cerebral ischemia/reperfusion (FCIR) rats, and explore the mechanism of electroacupuncture (EA) improving the learning and memory ability of FCIR rats.Methods:Sprague-dawley (SD) rats were randomly divided into sham operated group, model group and EA group. …”
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Growth Hormone Increases BDNF and mTOR Expression in Specific Brain Regions after Photothrombotic Stroke in Mice by Sonia Sanchez-Bezanilla, Daniel J. Beard, Rebecca J. Hood, N. David Åberg, Patricia Crock, Frederick R. Walker, Michael Nilsson, Jörgen Isgaard, Lin Kooi Ong

“…We have shown that growth hormone (GH) treatment poststroke increases neuroplasticity in peri-infarct areas and the hippocampus, improving motor and cognitive outcomes. …”
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Recovery of Chronic Stress-Triggered Changes of Hippocampal Glutamatergic Transmission by Min Lin, Gonglin Hou, Ying Zhao, Ti-Fei Yuan

“…Both acute and chronic stress stimuli lead to dynamic changes in excitatory transmission in the hippocampus. The present study examined the potential effects of spontaneous recovery after chronic stress on spatial memory function and glutamatergic transmission in the hippocampus. …”
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Magnetic resonance spectroscopy of hippocampal and striatal neurometabolites in experimental PTSD rat modeling by V. E. Tseilikman, O. B. Shevelev, N. V. Khotskin, A. S. Dotsenko, G. V. Kontsevaya, M. S. Lapshin, M. P. Moshkin, M. V. Komelkova, I. V. Feklicheva, O. B. Tseilikman, E. Dremencov, E. L. Zavjalov

“…The spectrum of the metabolites in the dorsal region of the hippocampus and striatum was studied using the method of 1H magnetic resonance spectroscopy at experimental modeling of the posttraumatic stress disorder syndrome (PTSD) in rats. …”
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Modulatory Role of Simvastatin against Aluminium Chloride-Induced Behavioural and Biochemical Changes in Rats by Madhavan Nampoothiri, Jessy John, Nitesh Kumar, Jayesh Mudgal, Gopalan Kutty Nampurath, Mallikarjuna Rao Chamallamudi

“…To conclude, the present study suggests that simvastatin per se protects the neurons in hippocampus and frontal cortex from AlCl3, an environmental toxin.…”
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Neuroprotective Effect of Wharton’s Jelly-Derived Mesenchymal Stem Cell-Conditioned Medium (WJMSC-CM) on Diabetes-Associated Cognitive Impairment by Improving Oxidative Stress, Neu... by Zohre Aghaei, Narges Karbalaei, Mohammad Reza Namavar, Masoud Haghani, Mahboobeh Razmkhah, Mahdi Khorsand Ghaffari, Marzieh Nemati

“…Colorimetric assays were used to determine hippocampus glutathione (GSH), malondialdehyde (MDA) levels, and antioxidant enzyme activity. …”
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