Can the Spinal Cord Learn and Remember? by Pierre A. Guertin

“…Learning and memory traditionally have been associated with cellular processes occurring in a specialized region of the brain called the hippocampus. However, recent data have provided strong evidence to suggest that comparable processes are also expressed in the spinal cord. …”
Get full text

Effect of fecal microbiota transplantation on ulcerative colitis model in rats: The gut–brain axis by Mahdis Morshedbak, Kaveh Rahimi, Mohammad Reza Tabandeh

“…FMT reduced anxiety in open field and plus maze tests, and resulted in decreased levels of IL-6 and TNF-a in the hippocampus.…”
Get full text

Transplantation of Stem Cells from Human Exfoliated Deciduous Teeth Decreases Cognitive Impairment from Chronic Cerebral Ischemia by Reducing Neuronal Apoptosis in Rats by Shu Zhu, Dongyu Min, Jianhong Zeng, Yetao Ju, Yao Liu, Xu Chen

“…In this study, we showed that either systemic transplantation of SHED or SHED infusion into the hippocampus ameliorated cognitive impairment of CCI rats in four weeks after SHED treatment by rescuing the number of neurons in the hippocampus area. …”
Get full text

Cilostazol Combats Lipopolysaccharide-Induced Hippocampal Injury in Rats: Role of AKT/GSK3β/CREB Curbing Neuroinflammation by Doaa Abou El-ezz, Waleed Aldahmash, Tuba Esatbeyoglu, Sherif M. Afifi, Marawan Abd Elbaset

“…This study looked at the potential neuroprotective benefits of cilostazol, a phosphodiesterase inhibitor, against LPS-induced hippocampus damage in rodents and the principal molecular involvement of AKT/GSK3β/CREB signaling pathways. …”
Get full text

The expression profile of genes associated with behavior, stress, and adult neurogenesis along the hippocampal dorsoventral axis in tame and aggressive foxes by Yu. V. Alexandrovich, E. V. Antonov, S. G. Shikhevich, A. V. Kharlamova, L. V. Meister, Y. V. Makovka, D. V. Shepeleva, R. G. Gulevich, Yu. E. Herbeck

“…The hippocampus plays the key role in stress response regulation, and stress response appears to be weakened in domesticated animals compared to their wild relatives. …”
Get full text

Involvement of Adult Hippocampal Neurogenesis in Learning and Forgetting by Suk-yu Yau, Ang Li, Kwok-Fai So

“…Adult hippocampal neurogenesis is a process involving the continuous generation of newborn neurons in the hippocampus of adult animals. Mounting evidence has suggested that hippocampal neurogenesis contributes to some forms of hippocampus-dependent learning and memory; however, the detailed mechanism concerning how this small number of newborn neurons could affect learning and memory remains unclear. …”
Get full text

A Novel Rat Infant Model of Medial Temporal Lobe Epilepsy Reveals New Insight into the Molecular Biology and Epileptogenesis in the Developing Brain by Carola Wormuth, Anna Papazoglou, Christina Henseler, Dan Ehninger, Karl Broich, Britta Haenisch, Jürgen Hescheler, Rüdiger Köhling, Marco Weiergräber

“…The model had a survival rate of >80% and exhibited characteristic spontaneous recurrent electrographic seizures (SRES) in both the hippocampus and cortex that persisted into adulthood. …”
Get full text

Brain mapping, biomarker identification and using machine learning method for diagnosis of anxiety during emotional face in preschool children by Samira Jafari, Hamid Sharini, Aliakbar Foroughi, Afshin Almasi

“…Result: The results of the brain mapping comparisons between anxiety and the non-anxiety showed that there was an increased FC between medial prefrontal cortex (MPFC) and right lateral amygdala (RLA) and a decreased FC between left anterior hippocampus (LAH) and left posterior hippocampus (LPH) in the angry condition. …”
Get full text

Proteomic Analysis Reveals the Vital Role of Synaptic Plasticity in the Pathogenesis of Temporal Lobe Epilepsy by Xu Qian, Ji-Qiang Ding, Xin Zhao, Xin-Wen Sheng, Zhao-Rui Wang, Qi-xing Yang, Jing-Jun Zheng, Jia-Gui Zhong, Teng-Yue Zhang, Shu-Qiao He, Wei-Dong Ji, Wei Li, Mei Zhang

“…In the present study, a lithium-pilocarpine-induced TLE model was employed to reveal the pathological changes of hippocampus in rats. Hippocampal samples were taken for proteomic analysis at 2 weeks after the onset of spontaneous seizure (a chronic stage of epileptogenesis). …”
Get full text

Effect of the Entorhinal Cortex on Ictal Discharges in Low-Mg2+-Induced Epileptic Hippocampal Slice Models by Ye-Jun Shi, Xin-Wei Gong, Hai-Qing Gong, Pei-Ji Liang, Pu-Ming Zhang, Qin-Chi Lu

“…The hippocampus plays an important role in the genesis of mesial temporal lobe epilepsy, and the entorhinal cortex (EC) may affect the hippocampal network activity because of the heavy interconnection between them. …”
Get full text

Identification of Protein Kinase C Isoforms Involved in Type 1 Diabetic Encephalopathy in Mice by Jiayin Zheng, Yue Wang, Song Han, Yanlin Luo, Xiuli Sun, Ning Zhu, Li Zhao, Junfa Li

“…Meanwhile, the expression of cPKCβII, nPKCε, and cPKCγ did not change in the hippocampus, cortex, and striatum at 2 and 8 weeks after STZ injection. …”
Get full text

Ripples Make Waves: Binding Structured Activity and Plasticity in Hippocampal Networks by Josef H. L. P. Sadowski, Matthew W. Jones, Jack R. Mellor

“…In this paper, we explore the ways in which SWRs and other network events can bridge the gap between spatiomnemonic processing at cellular/synaptic and network levels in the hippocampus.…”
Get full text

Enhanced detection of mild cognitive impairment in Alzheimer’s disease: a hybrid model integrating dual biomarkers and advanced machine learning by John Sahaya Rani Alex, R. Roshini, G. Maneesha, Jeetashree Aparajeeta, B. Priyadarshini, Chih-Yang Lin, Chi-Wen Lung

“…A 3D-CNN architecture is employed to segment the hippocampus from the structural brain 3D-MR images and quantify the hippocampus volume. …”
Get full text

Prediction models for cognitive impairment in middle-aged patients with cerebral small vessel disease by Wei Zheng, Xiaoyan Qin, Ronghua Mu, Peng Yang, Bingqin Huang, Bingqin Huang, Zhixuan Song, Xiqi Zhu, Xiqi Zhu

“…An Unet-based deep learning neural network model was developed to automate the segmentation of the hippocampus. Features were extracted for each subject, and the least absolute shrinkage and selection operator (LASSO) method was used to select radiomic features. …”
Get full text

Suspension of Mitotic Activity in Dentate Gyrus of the Hibernating Ground Squirrel by Victor I. Popov, Igor V. Kraev, Dmitri A. Ignat'ev, Michael G. Stewart

“…Neurogenesis occurs in the adult mammalian hippocampus, a region of the brain important for learning and memory. …”
Get full text

Electroacupuncture Stimulation Suppresses Postoperative Inflammatory Response and Hippocampal Neuronal Injury by Xiang-feng Wang, Qin Lin, Guan-hui Wang, Gen-ming Zhan, Wei Liu, Zhi-wei Lin

“…The peripheral inflammation response and the neuron impairment and inflammation response in the hippocampus was significantly reduced by the electroacupuncture stimulation. …”
Get full text

Clocking In Time to Gate Memory Processes: The Circadian Clock Is Part of the Ins and Outs of Memory by Oliver Rawashdeh, Rex Parsons, Erik Maronde

“…These memory-essential signaling components cycle rhythmically in the hippocampus across the day and night and are clearly molded by an intricate interplay between the circadian system and memory. …”
Get full text

RNA helicase MOV10 suppresses fear memory and dendritic arborization and regulates microtubule dynamics in hippocampal neurons by Temirlan Shilikbay, Aatiqa Nawaz, Megan Doon, Stephanie Ceman

“…Numa1 mRNA is a MOV10 CLIP target and is among the genes significantly decreased in Mov10 Deletion hippocampus. Restoration of NUMA1 expression and knockdown of HAUS rescued phenotypes of the Mov10 Deletion hippocampal neurons. …”
Get full text

A human single-neuron dataset for object recognition by Runnan Cao, Peter Brunner, Nicholas J. Brandmeir, Jon T. Willie, Shuo Wang

“…The human amygdala and hippocampus play a key role in object recognition, contributing to both the encoding and retrieval of visual information. …”
Get full text

Acute Toxicity and Neuroprotective Effect of “RJ6601”, a Newly Formulated Instant Soup, in Geriatric Rats by Rujikarn Chaisanam, Jintanaporn Wattanathorn

“…Given its antioxidant effects and central nervous system benefits, we hypothesized that RJ6601 should improve neurodegeneration in the hippocampus, a region critical for cognition and the maintenance of quality of life (QoL). …”
Get full text