Regional hippocampal thinning and gyrification abnormalities and associated cognition in children with prenatal alcohol exposure by Blake A. Gimbel, Jeffrey R. Wozniak, Bryon A. Mueller, Kent A. Tuominen, Abigail M. Ernst, Mary E. Anthony, Erik de Water, the CIFASD, Donovan J. Roediger

“…Also in the PAE group, lower episodic memory performance was associated with thinness in the right hippocampus, especially in the subiculum region. There were no significant regional hippocampal patterns that were associated with cognitive functioning for individuals in the unexposed comparison group. …”
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Neural correlates of olfactory working memory in the human brain by Zhuofeng Li, Shu-bin Li, Shaozhen Tan, Lu-lu Liu, Chao Yan, Lai-quan Zou

“…Previous research has revealed that the insula, pallidum, thalamus, hippocampus, middle frontal gyrus, and supplementary motor area are activated during odor memory and that the performance of olfactory working memory is affected by the verbalization of odors. …”
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Platelets tune fear memory in mice by Stefano Garofalo, Alessandro Mormino, Letizia Mazzarella, Germana Cocozza, Arianna Rinaldi, Erika Di Pietro, Maria Amalia Di Castro, Eleonora De Felice, Laura Maggi, Giuseppina Chece, Diego Andolina, Rossella Ventura, Donald Ielpo, Roberto Piacentini, Myriam Catalano, Lucia Stefanini, Cristina Limatola

“…Here, we identify platelets as key actors in the modulation of fear behaviors in mice through the control of inhibitory neurotransmission and plasticity in the hippocampus. Interfering with platelet number or activation reduces hippocampal serotonin (5-HT) and modulates fear learning and memory in mice, and this effect is reversed by serotonin replacement by serotonin precursor (5-HTP)/benserazide. …”
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SDF-1/CXCR4 Signaling Maintains Stemness Signature in Mouse Neural Stem/Progenitor Cells by Shih-Yin Ho, Thai-Yen Ling, Hsing-Yu Lin, Jeffrey Tsai-Jui Liou, Fei-Chih Liu, I-Chun Chen, Sue-Wei Lee, Yu Hsu, Dar-Ming Lai, Horng-Huei Liou

“…Loss of SDF-1/CXCR4 signaling causes abnormal development of neural stem/progenitor cells (NSCs/NPCs) in the cerebellum, hippocampus, and cortex. However, the mechanism of SDF-1/CXCR4 axis in NSCs/NPCs regulation remains unknown. …”
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Betaine Inhibits NLRP3 Inflammasome Hyperactivation and Regulates Microglial M1/M2 Phenotypic Differentiation, Thereby Attenuating Lipopolysaccharide-Induced Depression-Like Behavi... by Man Zhang, Xiao-Long Wang, Hui Shi, Lan-Qing Meng, Hong-Feng Quan, Lin Yan, Hui-Fang Yang, Xiao-Dong Peng

“…After the behavioral study, the mouse brain, hippocampus, and serum were taken for detection. The expressions of cytokines and inflammatory mediators were detected by ELISA, HE staining, immunofluorescence, immunohistochemistry, and western blotting. …”
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Neuroprotective effects of quercetin on hippocampal CA1 neurons following middle cerebral artery ischemia‒reperfusion in male rats: a behavioral, biochemical, and histological stud... by Mehran Mahyar, Erfan Ghadirzadeh, Pedram Nezhadnaderi, Zahrasadat Moayedi, Parniyan Maboud, Arvin Ebrahimi, Ali Siahposht-Khachaki, Narges Karimi

“…One of the regions most affected by middle cerebral artery occlusion (MCAO) is the hippocampus, specifically the CA1 area, which is highly susceptible to ischemia. …”
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Radix Scutellariae Ameliorates Stress-Induced Depressive-Like Behaviors via Protecting Neurons through the TGFβ3-Smad2/3-Nedd9 Signaling Pathway by Fan Zhao, Chenyiyu Zhang, Dong Xiao, Weihua Zhang, Liping Zhou, Simeng Gu, Rong Qu

“…Results showed that RS could ameliorate depressive-like behaviors, increase the expression of the antiapoptotic protein B-cell lymphoma 2 (BCL-2), reduce the expression of the proapoptotic protein BCL-2-associated X (BAX), and increase the number of doublecortin- (DCX-), microtubule-associated protein 2- (MAP2-), and neuronal nucleus- (NeuN-) positive cells in the hippocampus. Moreover, RS could reverse the CUMS-induced decrease of TGFβ3 protein, promote the phosphorylation of SMAD2/3, and increase the expression of downstream NEDD9 protein. …”
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Effect of metformin on the neuronal morphology of frontal cortex and hippocampal regions in lipopolysaccharide induced neuroinflammation in male Wistar rats by Vandana Blossom, Sheetal D. Ullal, Rajalakshmi Rai, Amit Massand, Chettiar Ganesh Kumar, Teresa Joy, Melisha Michael D souza, B.V. Murlimanju

“…Background: Neuroinflammation in the frontal cortex and hippocampus is the key contributor in the pathogenesis of neurodegenerative diseases. …”
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A Novel Mouse Model of Alzheimer's Disease with Chronic Estrogen Deficiency Leads to Glial Cell Activation and Hypertrophy by Annik Prat, Maik Behrendt, Edwige Marcinkiewicz, Sebastien Boridy, Ram M. Sairam, Nabil G. Seidah, Dusica Maysinger

“…The most prominent changes in the cerebral cortex and hippocampus of these hypoestrogenic mice were marked hypertrophy of both cortical neurons and astrocytes and an increased number of activated microglia. …”
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Anti-apoptosis Effect of Gualou Guizhi Granule on Neurons in Ischemic Stroke Rats and Primary Hippocampal Neurons by Yu LIN, Wei XU, Yuqin ZHANG, Huang LI, Wen XU

“…At the same time, Western Blot and Real-time PCR were used to detect the effect of GLGZG on gene expressions of Caspase-3, Bcl-2 and Bax mRNA in primary hippocampal neurons as well as the protein expressions in hippocampus tissues of rats.Results:The hippocampal neuron cells were treated with different concentrations of GLGZG(100 μg/mL, 200 μg/mL, 300 μg/mL)for 24 hours, the cell viability increased(<italic>P</italic>&lt;0.05, <italic>P</italic>&lt;0.01)and the LDH activity significantly reduced (<italic>P</italic>&lt;0.05, <italic>P</italic>&lt;0.01) in the above three GLGZG groups in comparison with that in the glutamate group. …”
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Differential gray matter correlates and machine learning prediction of abuse and internalizing psychopathology in adolescent females by Sara A. Heyn, Taylor J. Keding, Josh Cisler, Katie McLaughlin, Ryan J. Herringa

“…At a group-level, VBM analyses identified widespread decreases in GMV across the prefrontal cortex, insula, and hippocampus in youth with IP, while abuse experience was specifically associated with increased GMV in the cingulate cortex and supramarginal gyrus. …”
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Citrus aurantium L. extract alleviate depression by inhibiting gut microbiota-mediated inflammation in mice by Tao Li, Guirong Zeng, Lingfeng Zhu, Yanyang Wu, Qun Zhang, Fuhua Fu, Donglin Su, Gaoyang Li, Qili Li, Yang Shan

“…In addition, FEMC could increase CUMS-induced reduction in the levels of BDNF, PSD95, and SYN in the hippocampus. Moreover, FEMC intervention slightly decreased the ratio of Firmicutes to Bacteroidota. …”
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Electroacupuncture Treatment Alleviates Central Poststroke Pain by Inhibiting Brain Neuronal Apoptosis and Aberrant Astrocyte Activation by Gui-Hua Tian, Shan-Shan Tao, Man-Tang Chen, Yu-Sang Li, You-Ping Li, Hong-Cai Shang, Xiao-Yi Tang, Jian-Xin Chen, He-Bin Tang

“…Together, these findings suggest that CPSP is closely related to pathological changes of the neocortex and hippocampus. EA treatments at different frequencies may exert abirritative effects by inhibiting brain neuronal apoptosis and aberrant astrocyte activation in the brain.…”
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Glucose Metabolic Brain Network Differences between Chinese Patients with Lewy Body Dementia and Healthy Control by Danyan Chen, Jiaying Lu, Hucheng Zhou, Jiehui Jiang, Ping Wu, Qihao Guo, Jingjie Ge, Huiwei Zhang, Kuangyu Shi, Chuantao Zuo

“…Moreover, four significantly altered regions were observed in the DLB group: Inferior frontal gyrus, opercular part (IFG.R), olfactory cortex (OLF.R), hippocampus (HIP.R), and fusiform gyrus (FFG.L). Amongst them, in the DLB group, betweenness centrality became strong in OLF.R, HIP.R, and FFG.L, whereas betweenness centrality became weaker in IFG.R. …”
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S100A8-CAMKK2-AMPK axis confers the protective effects of mild hypothermia against cerebral ischemia-reperfusion injury in rats by Dandan Zhang, Yuting Dai, Xiaoyan Xu, Fuguo Ma, Mingshan Wang, Weiwei Qin

“…To investigate the role of S100A8 in MH treatment of cerebral IR injury, hippocampus-specific S100A8 loss or gain of function was achieved using an adeno-associated virus system. …”
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Effects of Quetiapine on Novelty‐Related Object Recognition Memory and Hippocampal BDNF Level in Sleep‐Deprived Rats by Öznur Özge Özcan, Burcu Çevreli, Emel Serdaroğlu Kaşıkçı, Mesut Karahan, Muhsin Konuk

“…Results Long‐term QET administration in healthy rats decreased NOR and BDNF protein expression in the hippocampus, as did 72 h SD. Long‐ and short‐term QET administration reversed SD effects, but only short‐term QET administration increased hippo BDNF. …”
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Effects of Mating and Social Exposure on Cell Proliferation in the Adult Male Prairie Vole (Microtus ochrogaster) by A. E. Castro, L. J. Young, F. J. Camacho, R. G. Paredes, N. F. Diaz, W. Portillo

“…Here, we determine whether mating-induced pair bonding increases cell proliferation in the subventricular zone (SVZ), rostral migratory stream (RMS), and dentate gyrus (DG) of the hippocampus in male voles. Males were assigned to one of the four groups: (1) control: males were placed alone in a clean cage; (2) social exposure to a female (SE m/f): males that could see, hear, and smell a sexually receptive female but where physical contact was not possible, because the animals were separated by an acrylic screen with small holes; (3) social exposure to a male (SE m/m): same as group 2 but males were exposed to another male without physical contact; and (4) social cohabitation with mating (SCM): males that mated freely with a receptive female for 6 h. …”
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Identification of Critical Signature in Post‐Traumatic Stress Disorder Using Bioinformatics Analysis and in Vitro Analyses by Lifen Liu, Yang Liu, Rui Li, Yue Teng, Shuyang Zhao, Jinhong Chen, Changjiang Li, Xinyu Hu, Lin Sun

“…Results A total of 157 common upregulated DEGs and 53 common downregulated DEGs were identified in the amygdala (AMY) and the hippocampus (HIP). Notably enriched pathways included neuroactive ligand‐receptor interaction, mechanistic target of rapamycin (mTOR) signaling pathway, nicotine addiction, and dopaminergic synapse. …”
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Your brain on art, nature, and meditation: a pilot neuroimaging study by Beatrix Krause-Sorio, Sergio Becerra, Prabha Siddarth, Stacey Simmons, Taylor Kuhn, Helen Lavretsky

“…Brain oxygen-level dependent (BOLD) images were processed using FSL Version 6.0 and a general linear model (GLM) tested the contrasts between art, nature, and meditation blocks, using a cluster-corrected p-value of 0.05.ResultsCompared to rest, meditation led to BOLD increases in bilateral lateral occipital and fusiform gyri, as well as right postcentral gyrus and hippocampus. Compared to viewing AI-generated digital art, increased BOLD responses during meditation were observed in left parietal and central operculum, and right pre- and postcentral gyri, and compared to nature, in the left parietal operculum, bilateral postcentral and supramarginal gyri, and bilateral lateral occipital cortices.ConclusionMeditation compared to rest showed brain activation in regions associated with object, sensory, and memory processing. …”
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Sugemule-7 alleviates oxidative stress, neuroinflammation, and cell death, promoting synaptic plasticity recovery in mice with postpartum depression by Qiang Fu, Rui Qiu, Jiaquan Liang, Shuai Wu, Dezhi Huang, Yuxiang Qin, Qiaosheng Li, Xiaojie Shi, Xiyue Xiong, Zhongyong Jiang, Yuewen Chen, Yong Cheng

“…Furthermore, Sugemule-7 significantly improved oxidative stress levels in the serum, prefrontal cortex, and hippocampus of PPD-induced mice while also suppressing inflammatory responses and abnormal neuronal death in these brain regions. …”
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