The cellular distribution of P2X7, P2Y6, and P2Y12 during or after pilocarpine-induced status epilepticus and literature review by Yue Li, Fengru Tang, Yumin Luo

“…Therefore, we studied the protein expression patterns of the purinergic receptors P2X7, P2Y6, and P2Y12 in the normal mice hippocampus, as well as during or after pilocarpine-induced status epilepticus (DPISE or APISE). …”
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The glucocorticoid hypothesis of depression: history and perspectives by G. T. Shishkina, N. N. Dygalo

“…The purpose of this review was to analyze available literature data on the effects of stress and glucocorticoids on the expression of GR in the hippocampus, which is traditionally considered as the most sensitive to stress brain structure. …”
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Impairments in Brain Perfusion, Metabolites, Functional Connectivity, and Cognition in Severe Asymptomatic Carotid Stenosis Patients: An Integrated MRI Study by Tao Wang, Feng Xiao, Guangyao Wu, Jian Fang, Zhenmeng Sun, Hongliang Feng, Junjian Zhang, Haibo Xu

“…By utilizing an integrated MRI including pulsed arterial spin labeling (pASL) MRI, Proton MR Spectroscopy (MRS), and resting-state functional MRI (R-fMRI), we also found that aCAS patients suffered decreased cerebral blood flow (CBF) mainly in the Left Frontal Gyrus and had decreased NAA/Cr ratio in the left hippocampus and decreased connectivity to the posterior cingulate cortex (PCC) in the anterior part of default mode network (DMN).…”
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Trimethyltin-Induced Microglial Activation via NADPH Oxidase and MAPKs Pathway in BV-2 Microglial Cells by Da Jung Kim, Yong Sik Kim

“…Trimethyltin (TMT) is known as a potent neurotoxicant that causes neuronal cell death and neuroinflammation, particularly in the hippocampus. Microglial activation is one of the prominent pathological features of TMT neurotoxicity. …”
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Effectiveness of the tetrapeptide HAEE: an innovative approach to Alzheimer's treatment in experimentation by Evgenii A. Patrakhanov

“…Results and Discussion: Histological analysis indicated the efficacy of the tetrapeptide HAEE at a dosage of 50 mg per kg of mouse weight, showing a significant reduction in amyloid plaques in the cerebral cortex and hippocampus of the mice. Conclusion: The study supports the proposed hypotheses and suggests further investigation into additional drug groups recommended for Alzheimer’s treatment for comparative studies.…”
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Perspectives in Molecular Imaging Using Staging Biomarkers and Immunotherapies in Alzheimer’s Disease by Benoît Leclerc, Abedelnasser Abulrob

“…The most promising diagnostic strategies in today’s world would consist in performing high diagnostic accuracy of combined modality imaging technologies using beta-amyloid 42 peptide-cerebrospinal fluid (CSF) positron emission tomography (PET), Pittsburgh compound B-PET, fluorodeoxyglucose-PET, total and phosphorylated tau-CSF, and volumetric magnetic resonance imaging hippocampus biomarkers for criteria evaluation and validation. …”
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Microfluidic Cultures of Basal Forebrain Cholinergic Neurons for Assessing Retrograde Cell Death by Live Imaging by Srestha Dasgupta, Mansi Pandya, Wilma Friedman

“…In the brain, basal forebrain cholinergic neurons (BFCNs) possess extensive axons that project to several target regions such as the cortex, hippocampus, and amygdala, and may be exposed to a specific microenvironment in their axon targets that may have retrograde effects on neuronal health. …”
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Statistical Evaluations of the Reproducibility and Reliability of 3-Tesla High Resolution Magnetization Transfer Brain Images: A Pilot Study on Healthy Subjects by Kelly H. Zou, Hongyan Du, Shawn Sidharthan, Lisa M. DeTora, Yunmei Chen, Ann B. Ragin, Robert R. Edelman, Ying Wu

“…Repeated measures were taken for 12 brain regions of interest (ROIs): genu, splenium, and the left and right hemispheres of the hippocampus, caudate, putamen, thalamus, and cerebral white matter. …”
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The compound (E)-2-(3,4-dihydroxystyryl)-3-hydroxy-4H-pyran-4-one alleviates neuroinflammation and cognitive impairment in a mouse model of Alzheimer’s disease by Xueyan Liu, Wei Wu, Xuejuan Li, Chengyan Wang, Ke Chai, Fanru Yuan, Huijuan Zheng, Yuxing Yao, Chenlu Li, Zu-Cheng Ye, Daijun Zha

“…Our results showed that D30 alleviated fibrillar amyloid-β–induced cognitive impairment, promoted fibrillar amyloid-β clearance from the hippocampus and cortex, suppressed oxidative stress, and inhibited activation of microglia and astrocytes. …”
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A Case of Anorexia Nervosa with Focal Cortical Dysplasia by Hiroki Nemoto, Kazuo Imagawa, Takashi Enokizono, Yosuke Masuda, Masayuki Ide, Takuma Deguchi, Monami Hara, Atsushi Morita, Takahiro Kido, Mai Tanaka, Tatsuyuki Ohto, Hidetoshi Takada

“…Head MRI showed a localized high-signal area from the cortex to the white matter of the fusiform gyrus near the left hippocampus, with no associated decreased blood flow or electroencephalography (EEG) abnormalities. …”
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Effects of Diet on Brain Plasticity in Animal and Human Studies: Mind the Gap by Tytus Murphy, Gisele Pereira Dias, Sandrine Thuret

“…In particular, we evaluate the gap in mechanistic understanding between recent findings from animal studies and those human studies reporting that these dietary factors can benefit cognition, mood, and anxiety, aging, and Alzheimer’s disease—with focus on the enhancement of structural and functional plasticity markers in the hippocampus, such as increased expression of neurotrophic factors, synaptic function and adult neurogenesis. …”
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Effects of subclinical hypothyroidism during pregnancy on mtDNA methylation in the brain of rat offspring by Liangzhuo Xie, Yangling Huang, Xiande Ma, Xiaoqiu Ma, Jian Wang, Tianshu Gao, Wei Chen

“…The mitochondrial structure in the hippocampus of the SCH group was less intact compared to the CON group. …”
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Topological Analysis of Brain Glucose Metabolic Connectivity Networks of Patients with Type 2 Diabetes Mellitus Combined with Mild Cognitive Impairment by LIANG Shengxiang, YANG Junchao, ZHANG Yusi, YIN Xiaolong, HUANG Li, LI Zuanfang

“…The nodal local efficiencies of the left straight gyrus (<italic>P</italic>=0.028), left parahippocampal gyrus (<italic>P</italic>=0.044), left hippocampus (<italic>P</italic>=0.026), left subparietal angular gyrus (<italic>P</italic>=0.031), left angular gyrus (<italic>P</italic>=0.024), right angular gyrus (<italic>P</italic>=0.004), right subparietal angular gyrus (<italic>P</italic>=0.039) decreased significantly. …”
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Depressive symptoms in older adults are associated with changes in stress-related markers, functional connectivity and brain volume by Edelweiss Touron, Robin de Flores, Laurent Coulbault, Cassandre Palix, Anne Chocat, Elizabeth Kuhn, Brigitte Landeau, Florence Mézenge, Daniel Roquet, Léa Chauveau, Sacha Haudry, Denis Vivien, Vincent de La Sayette, Natalie L. Marchant, Gaël Chételat, Géraldine Poisnel, for the Medit-Ageing Research Group

“…The neurobiological mechanisms underlying this link may involve stress system dysfunction, notably related to the hippocampus which is particularly sensitive to AD. We aimed to investigate the links between blood stress markers and changes in brain regions involved in the stress response in older adults with or without subclinical depressive symptoms. …”
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Effect of Electroacupuncture at Shuigou Acupoint on L-type Voltage-gated Calcium Channels in hippocampal CA1 region of MCAO rats by Da LONG, Ling CHEN, Yu YAO, Mingan ZENG

“…Then vertebral neurons in the hippocampus CA1 area of the MCAO model mice were obtained by acute enzyme isolation technology. …”
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The Coexpression of Reelin and Neuronal Nitric Oxide Synthase in a Subpopulation of Dentate Gyrus Neurons Is Downregulated in Heterozygous Reeler Mice by Raquel Romay-Tallón, Iria G. Dopeso-Reyes, April L. Lussier, Lisa E. Kalynchuk, Hector J. Caruncho

“…Reelin is an extracellular matrix protein expressed in several interneuron subtypes in the hippocampus and dentate gyrus. Neuronal nitric oxide synthase (nNOS) is also expressed by interneurons in these areas. …”
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Repeated Three-Hour Maternal Separation Induces Depression-Like Behavior and Affects the Expression of Hippocampal Plasticity-Related Proteins in C57BL/6N Mice by Yaoyao Bian, Lili Yang, Zhongli Wang, Qing Wang, Li Zeng, Guihua Xu

“…To determine whether adverse early life experiences induce changes in plasticity in the brain hippocampus, we established an MS paradigm. In this research, the mice were treated with mild (15 min, MS15) or prolonged (180 min, MS180) maternal separation from postnatal day 2 to postnatal day 21. …”
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Age-Related Decrease in the Schaffer Collateral-Evoked EPSP in Awake, Freely, Behaving Rats by C. A. Barnes, G. Rao, G. Orr

“…Synaptic response size in the CA1 region of the hippocampus in aged rats is reduced for a given stimulus intensity, compared with that elicited in young rats. …”
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Stress and Memory: Behavioral Effects and Neurobiological Mechanisms by Carmen Sandi, M. Teresa Pinelo-Nava

“…Among the brain regions implicated, the hippocampus, amygdala, and prefrontal cortex were highlighted as critical for the mediation of stress effects.…”
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Overexpression of SFPQ Improves Cognition and Memory in AD Mice by Jinshan Tie, Hongxiang Wu, Wei Liu, Yuying Li, Lu Li, Suju Zhao, Zhijiao Yuan, Khan Mahmood, Shaochun Chen, Huidong Wu

“…Subsequently, adeno-associated virus was administered to overexpress SFPQ in the hippocampus of AD mice. The results demonstrate that SFPQ overexpression improves recognition and memory in AD mice, while reducing AD-related marker proteins such as amyloid precursor protein (APP) and Tau. …”
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