How does chronic pain lead to memory loss? by Suelen Pereira, Ivan Tomsic, Robson da Costa, Mychael V Lourenco

“…A dysfunctional signaling pathway in the hippocampus has been linked to chronic pain-related memory impairment in mice.…”
Get full text

Evaluation of cannabinoid type 2 receptor expression and pyridine-based radiotracers in brains from a mouse model of Alzheimer’s disease by Vasil Kecheliev, Francesco Spinelli, Adrienne Herde, Achi Haider, Linjing Mu, Linjing Mu, Jan Klohs, Simon M. Ametamey, Ruiqing Ni, Ruiqing Ni

“…Specific increased CB2R immunofluorescence intensities on the increased number of GFAP-positive astrocytes and Iba1-positive microglia were detected in the hippocampus and cortex of 17-month-old arcAß mice compared to NTL mice. …”
Get full text

Functional Connectivity Alterations Associated with COVID-19-Related Sleep Problems: A Longitudinal Resting-State fMRI Study by Chen HB, Li L, Sun YK, Liu Y, Chen W, Liu P, Liao YH, Xie A

“…Higher FC between left hippocampus and right SFG correlated with PSQI scores. …”
Get full text

Corticosterone-induced postpartum depression induces depression-like behavior and impairs hippocampal neurogenesis in adolescent offspring via HPA axis and BDNF-mTOR pathway by Hongxiao Xie, Yanning Jiang, Xiumeng Zhang, Xinran Min, Jiuseng Zeng, Li Chen, Nan Zeng, Rong Liu

“…These offspring also showed diminished levels of DCX+, decreased levels of synaptic proteins, and reduced dendritic spine density and length in hippocampus. Additionally, we detected increased serum stressed hormones and decreased hippocampal glucocorticoid receptor (GR) protein level in the offspring. …”
Get full text

Awake brain MRSI reveals anesthetic sensitivity and regional aging effects on [13C]bicarbonate metabolism in mice by Maiko Ono, Rena Kono, Kosei Hirata, Kosei Hirata, Keita Saito, Motonao Nakao, Yoichi Takakusagi, Rikita Araki, Akira Sumiyoshi, Yuhei Takado

“…Moreover, a comparison of hyperpolarized [1-13C]pyruvate metabolism in young and aged mouse brains using awake MRSI detected age-related decreases in oxidative phosphorylation flux in brain regions that include the hippocampus with variations in the extent of these changes across different brain regions. …”
Get full text

Interleukin 10 Plays an Important Role in Neonatal Rats with Hypoxic-Ischemia Associated with B-Cell Lymphoma 2 and Endoplasmic Reticulum Protein 29 by Xue Bai, Liu-Lin Xiong, Chang-Le Fang, Hao-Li Zhou, Lu-Lu Xue, Yue Hu, Qing-Jie Xia, Jia Liu, Jun-Yan Zhang, Ting-Hua Wang, Si-Jin Yang

“…The expression of IL-10 in the cortex, hippocampus, and lung tissues was measured with immunohistochemistry, real-time quantitative polymerase chain reaction (RT-qPCR), and western blot (WB). …”
Get full text

Individualized gray matter morphological abnormalities unveil two neuroanatomical obsessive-compulsive disorder subtypes by Baohong Wen, Keke Fang, Qiuying Tao, Ya Tian, Lianjie Niu, Wenqing Shi, Zijun Liu, Jin Sun, Liang Liu, Xiaopan Zhang, Ruiping Zheng, Hui-Rong Guo, Yarui Wei, Yong Zhang, Jingliang Cheng, Shaoqiang Han

“…Specifically, subtype 1 showed disease epicenters in the middle frontal gyrus, while subtype 2 displayed disease epicenters in the striatum, thalamus and hippocampus. Furthermore, structural brain abnormalities in these subtypes displayed distinct associations with neurotransmitter receptors/transporters. …”
Get full text

P2Y Receptors in Synaptic Transmission and Plasticity: Therapeutic Potential in Cognitive Dysfunction by Segundo J. Guzman, Zoltan Gerevich

“…We show that P2Y receptors inhibit the release of neurotransmitters, modulate voltage- and ligand-gated ion channels, and differentially influence the induction of synaptic plasticity in the prefrontal cortex, hippocampus, and cerebellum. The findings discussed here may explain how P2Y1 receptor activation during brain injury, hypoxia, inflammation, schizophrenia, or Alzheimer’s disease leads to an impairment of cognitive processes. …”
Get full text

Emerging Roles of Immune Cells in Postoperative Cognitive Dysfunction by Yue Liu, Yiqing Yin

“…After surgery, alarmins are leaked from the injury sites and proinflammatory cytokines are increased in the peripheral circulation. Neurons in the hippocampus, which is responsible for learning and memory, can be damaged by cytokines transmitted to the brain parenchyma. …”
Get full text

Peripheral Cytokines as a Chemical Mediator for Postconcussion Like Sickness Behaviour in Trauma and Perioperative Patients: Literature Review by Yasir Rehman, Nadia Rehman, Riaz Rehman

“…The neuroinflammatory response triggers glial activation and consequently the release of proinflammatory cytokines within the hippocampus. We review clinical studies that have investigated neurocognitive and psychosomatic symptoms related to muscular trauma and in perioperative conditions. …”
Get full text

Hypothalamus-pituitary-adrenal and gut-brain axes in biological interaction pathway of the depression by Amanda Gollo Bertollo, Camila Ferreira Santos, Margarete Dulce Bagatini, Zuleide Maria Ignácio

“…The HPA axis regulates the body's stress response, and chronic stress can lead to overactivation of the HPA axis, resulting in elevated cortisol levels that contribute to neuronal damage, particularly in regions such as the hippocampus and prefrontal cortex, both of which are involved in mood regulation and mental disorders. …”
Get full text

Revealing complexity: segmentation of hippocampal subfields in adolescents with major depressive disorder reveals specific links to cognitive dysfunctions by Yixin Zhang, Xuan Liu, Ying Yang, Yihao Zhang, Qiang He, Feiyu Xu, Xinjuan Jin, Junqi Gao, Yuan Yao, Dexin Yu, Bernhard Hommel, Xingxing Zhu, Kangcheng Wang, Wenxin Zhang

“…Given heterogeneous outcomes of whole-hippocampus analyses, we investigated subregional abnormalities in depressed adolescents and their associations with symptom severity and cognitive dysfunctions. …”
Get full text

Effect of High Frequency Repetitive Transcranial Magnetic Stimulation on Postoperative Cognitive Dysfunction in Elderly Mice Based on BDNF/TrkB Signaling Pathway by LI Min, YANG Xiao, REN Lulu, WU Tingmei, ZHANG Hong

“…Compared with the operation group，the protein expression levels of BDNF，TrkB and NGF in the hippocampus of rTMS group were significantly increased，and the differences were statistically significant （<italic>P</italic>&lt;0. 05）.ConclusionHigh frequency rTMS can improve POCD in aged mice，and its mechanism may be related to rTMS activating BDNF/TrkB signaling pathway and increasing NGF expression.…”
Get full text

A simple model for Behavioral Time Scale Synaptic Plasticity (BTSP) provides content addressable memory with binary synapses and one-shot learning by Yujie Wu, Wolfgang Maass

“…Altogether, our results create a link between synaptic plasticity in area CA1 of the hippocampus and its network function. They also provide a promising approach for implementing content-addressable memory with on-chip learning capability in highly energy-efficient crossbar arrays of memristors.…”
Get full text

Prophylactic Subacute Administration of Zinc Increases CCL2, CCR2, FGF2, and IGF-1 Expression and Prevents the Long-Term Memory Loss in a Rat Model of Cerebral Hypoxia-Ischemia by Victor Manuel Blanco-Alvarez, Guadalupe Soto-Rodriguez, Juan Antonio Gonzalez-Barrios, Daniel Martinez-Fong, Eduardo Brambila, Maricela Torres-Soto, Ana Karina Aguilar-Peralta, Alejandro Gonzalez-Vazquez, Constantino Tomás-Sanchez, I. Daniel Limón, Jose R. Eguibar, Araceli Ugarte, Jeanett Hernandez-Castillo, Bertha Alicia Leon-Chavez

“…The cerebral cortex-hippocampus was dissected at different times before and after CCAO. …”
Get full text

Connectome-based prediction of functional impairment in experimental stroke models. by Oliver Schmitt, Peter Eipert, Yonggang Wang, Atsushi Kanoke, Gratianne Rabiller, Jialing Liu

“…Dynamic modeling with the weighted bilateral connectome detected changes in signal propagation in the remote hippocampus in all 3 stroke types, predicting the extent of hippocampal hypoactivation and impairment in spatial learning and memory function. …”
Get full text

Hippocampal Neurogenesis and the Brain Repair Response to Brief Stereotaxic Insertion of a Microneedle by Shijie Song, Shuojing Song, Chuanhai Cao, Xiaoyang Lin, Kunyu Li, Vasyl Sava, Juan Sanchez-Ramos

“…Brief stereotaxic insertion and removal of a microneedle into the right hippocampus resulted in (a) significantly increased expression of granulocyte-colony stimulating factor (G-CSF), the chemokine MIP-1a, and the proinflammatory cytokine IL12p40; (b) pronounced activation of microglia and astrocytes; and (c) increase in hippocampal neurogenesis. …”
Get full text

Memory Effects of Benzodiazepines: Memory Stages and Types Versus Binding-Site Subtypes by Miroslav M. Savic, Dragan I. Obradovic, Nenad D. Ugrešic, Dubravko R. Bokonjic

“…On the other hand, the role of α5 subunits, mainly expressed in the hippocampus, in modulating distinct forms of memory gives promise of selective pharmacological coping with certain memory deficit states.…”
Get full text

Methamphetamine Use: A Narrative Review of Adverse Effects and Related Toxicities by Amber N. Edinoff, Sarah E. Kaufman, Keionne M. Green, Daniel A. Provenzano, Jesse Lawson, Elyse M. Cornett, Kevin S. Murnane, Adam M. Kaye, Alan D. Kaye

“…Methamphetamine-induced neurotoxicity in serotonergic systems is more diffuse, involving the striatum, hippocampus, septum, amygdala, and hypothalamus leading to mood changes, psychosis, and memory impairment. …”
Get full text

TREM1—Microglia crosstalk: Neurocognitive disorders by Huashan Li, Wanqiu Yu, Xue Zheng, Zhaoqiong Zhu

“…Emerging evidence suggests that microglial inflammatory activation within the hippocampus underlies the pathogenesis of cognitive impairment. …”
Get full text