The glucocorticoid hypothesis of depression: history and perspectives by G. T. Shishkina, N. N. Dygalo

“…The purpose of this review was to analyze available literature data on the effects of stress and glucocorticoids on the expression of GR in the hippocampus, which is traditionally considered as the most sensitive to stress brain structure. …”
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Trimethyltin-Induced Microglial Activation via NADPH Oxidase and MAPKs Pathway in BV-2 Microglial Cells by Da Jung Kim, Yong Sik Kim

“…Trimethyltin (TMT) is known as a potent neurotoxicant that causes neuronal cell death and neuroinflammation, particularly in the hippocampus. Microglial activation is one of the prominent pathological features of TMT neurotoxicity. …”
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Perspectives in Molecular Imaging Using Staging Biomarkers and Immunotherapies in Alzheimer’s Disease by Benoît Leclerc, Abedelnasser Abulrob

“…The most promising diagnostic strategies in today’s world would consist in performing high diagnostic accuracy of combined modality imaging technologies using beta-amyloid 42 peptide-cerebrospinal fluid (CSF) positron emission tomography (PET), Pittsburgh compound B-PET, fluorodeoxyglucose-PET, total and phosphorylated tau-CSF, and volumetric magnetic resonance imaging hippocampus biomarkers for criteria evaluation and validation. …”
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Microfluidic Cultures of Basal Forebrain Cholinergic Neurons for Assessing Retrograde Cell Death by Live Imaging by Srestha Dasgupta, Mansi Pandya, Wilma Friedman

“…In the brain, basal forebrain cholinergic neurons (BFCNs) possess extensive axons that project to several target regions such as the cortex, hippocampus, and amygdala, and may be exposed to a specific microenvironment in their axon targets that may have retrograde effects on neuronal health. …”
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Statistical Evaluations of the Reproducibility and Reliability of 3-Tesla High Resolution Magnetization Transfer Brain Images: A Pilot Study on Healthy Subjects by Kelly H. Zou, Hongyan Du, Shawn Sidharthan, Lisa M. DeTora, Yunmei Chen, Ann B. Ragin, Robert R. Edelman, Ying Wu

“…Repeated measures were taken for 12 brain regions of interest (ROIs): genu, splenium, and the left and right hemispheres of the hippocampus, caudate, putamen, thalamus, and cerebral white matter. …”
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A Case of Anorexia Nervosa with Focal Cortical Dysplasia by Hiroki Nemoto, Kazuo Imagawa, Takashi Enokizono, Yosuke Masuda, Masayuki Ide, Takuma Deguchi, Monami Hara, Atsushi Morita, Takahiro Kido, Mai Tanaka, Tatsuyuki Ohto, Hidetoshi Takada

“…Head MRI showed a localized high-signal area from the cortex to the white matter of the fusiform gyrus near the left hippocampus, with no associated decreased blood flow or electroencephalography (EEG) abnormalities. …”
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Effects of subclinical hypothyroidism during pregnancy on mtDNA methylation in the brain of rat offspring by Liangzhuo Xie, Yangling Huang, Xiande Ma, Xiaoqiu Ma, Jian Wang, Tianshu Gao, Wei Chen

“…The mitochondrial structure in the hippocampus of the SCH group was less intact compared to the CON group. …”
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The Coexpression of Reelin and Neuronal Nitric Oxide Synthase in a Subpopulation of Dentate Gyrus Neurons Is Downregulated in Heterozygous Reeler Mice by Raquel Romay-Tallón, Iria G. Dopeso-Reyes, April L. Lussier, Lisa E. Kalynchuk, Hector J. Caruncho

“…Reelin is an extracellular matrix protein expressed in several interneuron subtypes in the hippocampus and dentate gyrus. Neuronal nitric oxide synthase (nNOS) is also expressed by interneurons in these areas. …”
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Repeated Three-Hour Maternal Separation Induces Depression-Like Behavior and Affects the Expression of Hippocampal Plasticity-Related Proteins in C57BL/6N Mice by Yaoyao Bian, Lili Yang, Zhongli Wang, Qing Wang, Li Zeng, Guihua Xu

“…To determine whether adverse early life experiences induce changes in plasticity in the brain hippocampus, we established an MS paradigm. In this research, the mice were treated with mild (15 min, MS15) or prolonged (180 min, MS180) maternal separation from postnatal day 2 to postnatal day 21. …”
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Stress and Memory: Behavioral Effects and Neurobiological Mechanisms by Carmen Sandi, M. Teresa Pinelo-Nava

“…Among the brain regions implicated, the hippocampus, amygdala, and prefrontal cortex were highlighted as critical for the mediation of stress effects.…”
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Overexpression of SFPQ Improves Cognition and Memory in AD Mice by Jinshan Tie, Hongxiang Wu, Wei Liu, Yuying Li, Lu Li, Suju Zhao, Zhijiao Yuan, Khan Mahmood, Shaochun Chen, Huidong Wu

“…Subsequently, adeno-associated virus was administered to overexpress SFPQ in the hippocampus of AD mice. The results demonstrate that SFPQ overexpression improves recognition and memory in AD mice, while reducing AD-related marker proteins such as amyloid precursor protein (APP) and Tau. …”
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A hypothesis about interrelations of epigenetic factors and transposable elements in memory formation by R. N. Mustafin

“…These changes occur in the hippocampus dentate gyrus, where a pronounced activity of transposons and their insertion near neuron-specific genes have been detected. …”
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Glycogen Synthase Kinase 3β Promotes Postoperative Cognitive Dysfunction by Inducing the M1 Polarization and Migration of Microglia by Jingjin Li, Chonglong Shi, Zhengnian Ding, Wenjie Jin

“…Prophylactic administration of lithium chloride (2 mM/kg) can inhibit the expression of proinflammatory mediators in the hippocampus, reduce the hippocampal expression of NF-κB, and increase both the downregulation of M1 microglial-related genes (inducible nitric oxide synthase and CD86) and upregulation of M2 microglial-related genes (IL-10 and CD206), to alleviate the cognitive impairment caused by orthopedic surgery. …”
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Neuroprotective Potentials Of Extracts From Moringa Oleifera And Musa Sapientum Against Cadmium Chloride-Induced Neurotoxicity In Rats Cerebri by Adelaja Akinlolu

“…In rats, Cd-exposure resulted in increases of nitric oxide and lipid peroxidation levels in the hippocampus. This study evaluated the neuroprotective potential of active drug compounds extracted from Moringa oleifera leaves (MO11) and Musa sapientum suckers (MS06) in cadmium chloride (CdCl2)-induced neurotoxicity in rats. …”
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Functional Role of Adult Hippocampal Neurogenesis as a Therapeutic Strategy for Mental Disorders by Heechul Jun, Syed Mohammed Qasim Hussaini, Michael J. Rigby, Mi-Hyeon Jang

“…In the mammalian brain, it continues to occur well into adulthood in discrete regions, namely, the hippocampus and olfactory bulb. During the past decade, significant progress has been made in understanding the mechanisms regulating adult hippocampal neurogenesis and its role in the etiology of mental disorders. …”
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Development and Structural Variety of the Chondroitin Sulfate Proteoglycans-Contained Extracellular Matrix in the Mouse Brain by Noriko Horii-Hayashi, Takayo Sasagawa, Wataru Matsunaga, Mayumi Nishi

“…In the limbic system, PNN formation in the hippocampus started earlier than that of the amygdala. …”
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An enriched environment promotes cognitive recovery and cerebral blood flow in aged mice under sevoflurane anaesthesia by Wenfeng Gao, Wenji Xie, Wenqin Xie, Changcheng Jiang, Zhenming Kang, Naizhen Liu

“…The proangiogenic factors (CD31, angiopoietin-1, vascular endothelial growth factor, and N-cadherin) and neurotrophic (brain-derived neurotrophic factor, post-synaptic density protein 95) expression in hippocampus of aged mice were evaluated by Western blotting and RT-PCR analysis. …”
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Neural mechanisms of self-processing in autism: An ALE-based meta-analysis by Yue Yuan, Mingda Tao, Aibao Zhou, Xiangli Guan, Jiaomei Zhang

“…As shown by the fact that TD primarily activated the right frontal lobe when it came to self-processing, whereas ASD activated the limbic lobe, temporal lobe, hippocampus, amygdala, pontine gyrus, and a portion of the left frontal lobe. …”
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THE LIMBIC SYSTEM IN ADULT HUMAN BRAINS – COMPARATIVE MORPHOMETRIC ANATOMO-IMAGISTIC STUDY by Alin Horatiu Nedelcu, David-Constantin Bulgaru, Simona Alice Partene Vicoleanu, Razvan Tudor Tepordei, Cosmin Gabriel Popa, Roxana-Andreea Popa, Marius Constantin Moraru, Manuela Ursaru

“…The limbic system is made up of a vast network of components such as the cingulate gyrus, the hippocampus and the parahippocampus or ismic formation. …”
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Miglustat Reverts the Impairment of Synaptic Plasticity in a Mouse Model of NPC Disease by G. D’Arcangelo, D. Grossi, M. Racaniello, A. Cardinale, A. Zaratti, S. Rufini, A. Cutarelli, V. Tancredi, D. Merlo, C. Frank

“…Here, we studied synaptic plasticity phenomena and evaluated ERKs activation in the hippocampus of BALB/c NPC1−/− mice, a well described animal model of the disease. …”
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