Hepatocyte Growth Factor in Synaptic Plasticity and Alzheimer's Disease by Shiv K. Sharma

“…The hepatocyte growth factor (HGF) was initially identified as a protein that promoted growth of hepatocytes. …”
Get full text

The influence of hepatocyte growth factor on the proliferation and differentiation of stem cells by Rafał Bieś, Agnieszka Mikosińska, Jakub Parys, Mateusz Litwin, Patrycja Kałuziak, Marta Jajczak, Maciej Mossakowski, Aleksandra Witek, Martyna Kaźmierczak, Stanisław Jesionek

Subjects: “…hepatocyte growth factor…”
Get full text

Hepatocyte growth factor stimulates neutrophil degranulation but not respiratory burst by I. C. Kowanko, A. Ferrante, T. Nakamura

“…Neutrophil function is regulated in part by cytokines with growth factor activities for different cell types. Hepatocyte growth factor (HGF) is a cytokine produced during injury to the liver and other organs. …”
Get full text

RETRACTED: Development of a lyophilized preparation enriched with hepatocyte growth factor by Inozemcev P.O., Grigoriev G.E., Lepekhova S.A.

Get full text

Gene therapy by hepatocyte growth factor results in regression of experimental liver fibrosis by N. A. Dzhoyashvili, N. I. Kalinina, I. B. Beloglazova, Z. I. Tsokolayeva, P. I. Makarevich, Yu. L. Perov, Ye. V. Parfenova, V. A. Tkachuk

Subjects: Get full text

Radioimmunoscintigraphy of Tumors Autocrine for Human Met and Hepatocyte Growth Factor/Scatter Factor by Rick V. Hay, Brian Cao, R. Scot Skinner, Ling-Mei Wang, Yanli Su, James H. Resau, George F. Vande Woude, Milton D. Gross

“…Inappropriate expression of the c-met-protooncogene product (Met) and/or of its ligand, hepatocyte growth factor/scatter factor (HGF/SF), has been correlated with poor prognosis in a variety of human solid tumors. …”
Get full text

Sequential Treatment with Activin and Hepatocyte Growth Factor Induces FOXM1 to Promote Colorectal Cancer Liver Metastasis by Hong Peng, Ting Ye, Lei Deng, Xiaofang Yang, Zheng Jiang, Jinjun Guo

“…Activin and hepatocyte growth factor (HGF) are important regulators of stem cell properties. …”
Get full text

mTORC2 Activation Mediated by Mesenchymal Stem Cell-Secreted Hepatocyte Growth Factors for the Recovery of Lipopolysaccharide-Induced Vascular Endothelial Barrier by Shan-Shan Meng, Feng-Mei Guo, Li-Li Huang, Ying-Zi Huang, Jian-Feng Xie, Cong-Shan Yang, Hai-Bo Qiu, Yi Yang

“…Mesenchymal stem cell-secreted hepatocyte growth factor (HGF) has positive effects of lipopolysaccharide- (LPS-) induced pulmonary endothelial barrier. …”
Get full text

Hepatocyte Growth Factor in Patients with Three Different Stages of Chronic Liver Disease including Hepatocellular Carcinoma, Cirrhosis and Chronic Hepatitis: An Immunohistochemical Study by Banu Bilezikçi, Asuman Nihan Haberal, Beyhan Demirhan

“…BACKGROUND AND AIMS: The specific role of hepatocyte growth factor in liver disease is unknown. The presence and density of this factor in patients with three different stages of liver disease were investigated, with the aim of assessing its prognostic significance.…”
Get full text

Hepatocyte Growth Factor Effects on Mesenchymal Stem Cells Derived from Human Arteries: A Novel Strategy to Accelerate Vascular Ulcer Wound Healing by Sabrina Valente, Carmen Ciavarella, Emanuela Pasanisi, Francesca Ricci, Andrea Stella, Gianandrea Pasquinelli

“…Several approaches to treat the wounds are proposed but they show poor outcomes and require long healing times. Hepatocyte Growth Factor/Scatter Factor (HGF/SF) is a pleiotropic cytokine exerting many biological activities through the c-Met receptor. …”
Get full text

High serum level of endostatin in multiple myeloma at diagnosis but not in the plateau phase after treatment by Halina Urbanska-Rys, Tadeusz Robak

“…We failed to find positive or negative correlations between the level of endostatin and vascular endothelial growth factor, hepatocyte growth factor, fibroblast growth factor and transforming growth factor-β. …”
Get full text

Zebularine Promotes Hepatic Differentiation of Rabbit Bone Marrow Mesenchymal Stem Cells by Interfering with p38 MAPK Signaling by Yong-Heng Luo, Juan Chen, En-Hua Xiao, Qiu-Yun Li, Yong-Mei Luo

“…BMMSCs were treated with zebularine at concentrations of 10, 20, 50, and 100 μM in the presence of hepatocyte growth factor; changes in the levels of hepatic-specific alpha-fetoprotein and albumin were detected and determined by RT-PCR, WB, and immunofluorescence staining. …”
Get full text

Functional interaction between receptor tyrosine kinase MET and ETS transcription factors promotes prostate cancer progression by Elisa Carouge, Clémence Burnichon, Martin Figeac, Shéhérazade Sebda, Nathalie Vanpouille, Audrey Vinchent, Marie‐José Truong, Martine Duterque‐Coquillaud, David Tulasne, Anne Chotteau‐Lelièvre

“…Moreover, bone metastases are incurable and very painful. Hepatocyte growth factor receptor (MET) and fusion of genes encoding E26 transformation‐specific (ETS) transcription factors are both involved in the progression of the disease. …”
Get full text

Orthogonal validation of PROTAC mediated degradation of the integral membrane proteins EGFR and c-MET by Camilla Ruffilli, Sascha Röth, Noam Zelcer, Kevin Moreau

“…Here we compare orthogonal antibody based approaches, i.e. immunoblotting, flow cytometry and immunofluorescence, to measure PROTAC mediated degradation of two established, endogenous targets, epidermal growth factor receptor (EGFR) and hepatocyte growth-factor receptor (c-MET). We discuss advantages and limitations of each methodology for the assessment of PROTAC efficacy on IMPs. …”
Get full text

In Vivo Detection of c-MET Expression in a Rat Hepatocarcinogenesis Model Using Molecularly Targeted Magnetic Resonance Imaging by Rheal A. Towner, Nataliya Smith, Yasvir A. Tesiram, Andrew Abbott, Debbie Saunders, Rebecca Blindauer, Oana Herlea, Robert Silasi-Mansat, Florea Lupu

“…The multifunctional growth factor scatter factor/hepatocyte growth factor and its tyrosine kinase receptor, c-MET, have been implicated in the genesis and malignant progression of numerous human malignancies, including hepatocellular carcinomas. …”
Get full text

Expression of HGF and c-Met Proteins in Human Keratoconus Corneas by Jingjing You, Li Wen, Athena Roufas, Chris Hodge, Gerard Sutton, Michele C. Madigan

“…Recent genetic studies indicate that gene variants of an inflammation-related molecule, hepatocyte growth factor (HGF), are associated with an increased susceptibility for developing KC. …”
Get full text

The continually evolving landscape of novel therapies in oncogene-driven advanced non-small-cell lung cancer by Barbara Melosky, Rosalyn A. Juergens, Shantanu Banerji, Adrian Sacher, Paul Wheatley-Price, Stephanie Snow, Ming-Sound Tsao, Natasha B. Leighl, Ilidio Martins, Parneet Cheema, Geoffrey Liu, Quincy S. C. Chu

“…Ongoing research focuses on the expansion of new agents targeting both previously identified targets (particularly hepatocyte growth factor receptor (MET), human epidermal growth factor receptor 2 (HER2), and Kirsten rat sarcoma viral oncogene homolog (KRAS)) as well as novel, potentially actionable targets (such as neuregulin-1 (NRG1) and phosphatidylinositol 3-kinase (PI3K)). …”
Get full text

Therapeutic Benefit in Rheumatoid Cachexia Illustrated Using a Novel Primary Human Triple Cell Coculture Model by Tracey Ollewagen, Gareth S. Tarr, Kathryn H. Myburgh, Helmuth Reuter, Carine Smith

“…Coculture exposure to serum from RATNR patients demonstrated increased cellular growth (p<0.001), while both hepatocyte growth factor (p<0.01) and follistatin (p<0.001) were reduced when compared to NC. …”
Get full text

Erythromycin and clarithromycin modulation of growth factor-induced expression of heparanase mRNA on human lung cancer cells in vitro by Masahiro Sasaki, Takefumi Ito, Masayuki Kashima, Shin Fukui, Noriko Izumiyama, Akiko Watanabe, Masaaki Sano, Yosimasa Fujiwara, Mamoru Miura

“…We investigated the effect of three growth factors, plateletderived growth factor (PDGF), hepatocyte growth factor (HGF) and basic fibroblast growth factor (bFGF), on heparanase mRNA induction in lung cancer cells in vitro. …”
Get full text

Imaging the Met Receptor Tyrosine Kinase (Met) and Assessing Tumor Responses to a Met Tyrosine Kinase Inhibitor in Human Xenograft Mouse Models with a [Tc] (AH-113018) or CY 5** (A... by Elaine M. Jagoda, Sibaprasad Bhattacharyya, Joseph Kalen, Lisa Riffle, Avrum Leeder, Stephanie Histed, Mark Williams, Karen J. Wong, Biying Xu, Lawrence P. Szajek, Osama Elbuluk, Fabiola Cecchi, Kristen Raffensperger, Meghana Golla, Donald P. Bottaro, Peter Choyke

“…Developing an imaging agent targeting the hepatocyte growth factor receptor protein (Met) status of cancerous lesions would aid in the diagnosis and monitoring of Met-targeted tyrosine kinase inhibitors (TKIS). …”
Get full text