Olfm4 Is Highly Expressed in HCC Patients and as a Biomarker and Therapeutic Target for HCC by Yulong Wei, Qingzhu Song, Fenglan Zhang, Tian Yuan

“…Hepatocellular carcinoma (HCC) is one of the primary types of cancer that claims many lives worldwide, and its incidence continues to increase. …”
Get full text

Increased Porphyrins in Primary Liver Cancer Mainly Reflect a Parallel Liver Disease by Jerzy Kaczynski, Göran Hansson, Sven Wallerstedt

“…To evaluate the role of an underlying liver disorder we analyzed porphyrins in patients with hepatocellular carcinoma (HCC) (n=65), cholangiocellular carcinoma (n=3), or suspected PLC, which turned out to be metastases (n=18) or a benign disorder (n=11). …”
Get full text

Fibrolamellar Carcinoma: 2012 Update by Michael Torbenson

“…Fibrolamellar carcinomas are not indolent tumors, but have an overall better prognosis than typical hepatocellular carcinomas, in part because of the younger age at presentation and the lack of cirrhosis. …”
Get full text

Recent Advances in Antiviral Therapy for Chronic Hepatitis C by Akihiro Tamori, Masaru Enomoto, Norifumi Kawada

“…Chronic infection induces continuous inflammation in the liver, progression of hepatic fibrosis, eventual cirrhosis, and possible hepatocellular carcinoma. Eradication of the virus is one of the most important treatment aims. …”
Get full text

Autoimmune hepatitis with abnormally high level of serum alpha-fetoprotein (Clinical case) by A. O. Bueverov, Ye. S. Dolmagambetova

“…Manifestations of AIH, at first glance were typical, accompanied by over 200-fold elevation of serum concentration of AFP that required differential diagnostics with hepatocellular carcinoma. Achievement of immunosuppressor-induced remission resulted in normalization of AFP level.Conclusion. …”
Get full text

Oxidative stress in viral hepatitis by Huseyin Erdal, Hacer Ozlem Kalayci

“…This damage manifests as lipid peroxidation, DNA damage, and protein oxidation, which in turn promote hepatic inflammation, fibrosis, and hepatocellular carcinoma. Furthermore, OS has been implicated in the resistance to antiviral therapy observed in some patients. …”
Get full text

Reenvisioning Traditional to Regenerative Therapeutic Advances in Managing Nonalcoholic Fatty Liver Disease in Diabetes Mellitus by Lung-Wen Tsai, Yi-Hsiang Lu, Rajni Dubey, Jeng-Fong Chiou

“…Clinically, it has also been revealed that the existence of nonalcoholic fatty liver disease (NAFLD) enhances the incidence of type 2 diabetes mellitus (T2DM), while T2DM exacerbates NAFLD to extremely severe forms of steatohepatitis, cirrhosis, and hepatocellular carcinoma. This implies the coexistence and bidirectional nature of NAFLD and T2DM, which function synergistically to drive adverse consequences in clinical practice. …”
Get full text

Sorafenib-Induced Liver Failure: A Case Report and Review of the Literature by Anneleen Van Hootegem, Chris Verslype, Werner Van Steenbergen

“…In patients with hepatocellular carcinoma characterized by vascular invasion and/or extrahepatic disease, Sorafenib is considered treatment of choice. …”
Get full text

Motion – The Available Treatments for Hepatitis C Are Cost Effective: Arguments against the Motion by W Ray Kim

“…Available cohortbased studies suggest that only a relative minority of patients develop significant liver disease, such as cirrhosis and/or hepatocellular carcinoma. Other studies, mostly conducted based on referral patients with established disease, portray much more serious consequences of HCV infection. …”
Get full text

Transitioning to Highly Effective Therapies for the Treatment of Chronic Hepatitis C Virus Infection: A Policy Statement and Implementation Guideline by Daniel J Smyth, Duncan Webster, Lisa Barrett, Mark MacMillan, Lisa McKnight, Frank Schweiger

“…Chronic hepatitis C virus (HCV) infection increases all-cause mortality, rates of cirrhosis, hepatocellular carcinoma, liver transplantation and overall health care utilization. …”
Get full text

Cabozantinib Cutaneous Toxicity—Comprehensive Review by Cristina Violeta Tutunaru, Dragos Ovidiu Alexandru, Sanda Amelia Dracea, Loredana Ungureanu, Liliana Gabriela Popa, Cristina Beiu

“…This review offers an overview of the skin-related toxicities associated with Cabozantinib, a multikinase inhibitor (MKI) that is approved for treating advanced kidney cancer, hepatocellular carcinoma, and medullary thyroid cancer. It covers the most common dermatological side effects, such as palmar–plantar erythrodysesthesia, stomatitis, hair alterations, xerosis, scrotal erythema, and subungual splinter hemorrhages. …”
Get full text

Hepatitis C Virus–Pediatric and Adult Perspectives in the Current Decade by Nanda Kerkar, Kayla Hartjes

“…Despite this, HCV continues to remain a global health burden, leading to cirrhosis as well as hepatocellular carcinoma, and is a reason for liver transplantation in the adult population. …”
Get full text

A Review on the Antimutagenic and Anticancer Effects of Cysteamine by Chun-Man Lee

“…The efficacy of cysteamine has been shown in vitro and in vivo for the treatment of different types of cancer, such as gastrointestinal cancer, pancreatic cancer, sarcomas, hepatocellular carcinoma, and melanoma, leading to the significant reduction of lesions and/or the increase of survival time. …”
Get full text

HCV and Lymphoproliferation by Anna Linda Zignego, Carlo Giannini, Laura Gragnani

“…It is not only a hepatotropic but also a lymphotropic agent and is responsible not only for liver injury—potentially evolving to cirrhosis and hepatocellular carcinoma—but also for a series of sometimes severely disabling extrahepatic diseases and, in particular, B-cell lymphoproliferative disorders. …”
Get full text

Hepatitis C Virus and Nonliver Solid Cancers: Is There an Association between HCV and Cancers of the Pancreas, Thyroid, Kidney, Oral Cavity, Breast, Lung, and Gastrointestinal Trac... by Saad Qadwai, Tayyaba Rehman, Jonathan Barsa, Zeeshan Solangi, Edward Lebovics

“…Hepatitis C virus (HCV) is known for its oncogenic potential and has been found to be associated with hepatocellular carcinoma (HCC) and non-Hodgkin lymphoma. It has also been postulated that HCV may play a role in the development of other extrahepatic solid tumors of other organs of the body since it has been isolated from the vessel wall, kidney, and oral mucosa. …”
Get full text

Surveillance Following Hepatitis B Surface Antigen Loss: An Issue Requiring Attention by Shuai-Wen Huang, Hong Long, Jia-Quan Huang

“…However, even after HBsAg loss, hepatitis B virus can persist, with a risk of recurrence, reactivation, cirrhosis, and hepatocellular carcinoma. Therefore, follow-up and surveillance are still necessary. …”
Get full text

Clinicopathological analysis of sclerosing angiomatoid nodular transformation in the spleen by Shufei Wei, Yongliang Han, Yingyong Hou, Liangliang Wang

“…One case was complicated with renal clear cell carcinoma, and one was complicated with hepatocellular carcinoma. The gross neoplasm is multinodular and well defined. …”
Get full text

Detection of Total Aflatoxins in Groundnut and Soybean Samples in Yemen Using Enzyme-Linked Immunosorbent Assay by Safwan Ahmed Abdullah Murshed, Nafees Bacha, Talal Alharazi

“…Aflatoxins are fungal toxins that have mutagenic and carcinogenic effects, especially hepatocellular carcinoma effect. This work aimed to investigate the presence of aflatoxins in groundnuts and soybeans that are consumed in Yemen. …”
Get full text

The Role of mTOR Inhibitors in Liver Transplantation: Reviewing the Evidence by Goran B. Klintmalm, Björn Nashan

“…Despite the success of liver transplantation, long-term complications remain, including de novo malignancies, metabolic syndrome, and the recurrence of hepatitis C virus (HCV) and hepatocellular carcinoma (HCC). The current mainstay of treatment, calcineurin inhibitors (CNIs), can also worsen posttransplant renal dysfunction, neurotoxicity, and diabetes. …”
Get full text

Clinical Relevance of HLA Gene Variants in HBV Infection by Li Wang, Zhi-Qiang Zou, Kai Wang

“…Genome-wide association studies (GWASs) have shown that single nucleotide polymorphisms (SNPs) near certain HLA gene loci are strongly associated with not only persistent HBV infection but also spontaneous HBV clearance and seroconversion, disease progression, and the development of liver cirrhosis and HBV-related hepatocellular carcinoma (HCC) in chronic hepatitis B (CHB). …”
Get full text