Transdermal patches: Design and current approaches to painless drug delivery by Al Hanbali Othman A., Khan Haji Muhammad Shoaib, Sarfraz Muhammad, Arafat Mosab, Ijaz Shakeel, Hameed Abdul

“…Use of transdermal patches can evade many issues associated with oral drug delivery, such as first-pass hepatic metabolism, enzymatic digestion attack, drug hydrolysis and degradation in acidic media, drug fluctuations, and gastrointestinal irritation. …”
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Role of Toll-Like Receptors and Their Downstream Molecules in the Development of Nonalcoholic Fatty Liver Disease by Kouichi Miura, Ekihiro Seki, Hirohide Ohnishi, David A. Brenner

“…Upon stimulation by these TLR ligands, hepatic immune cells produce various mediators that are involved in host defense. …”
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Atypical Presentation of Cat-Scratch Disease in an Immunocompetent Child with Serological and Pathological Evidence by Serkan Atıcı, Eda Kepenekli Kadayıfcı, Ayşe Karaaslan, Muhammed Hasan Toper, Cigdem Ataizi Celikel, Ahmet Soysal, Mustafa Bakır

“…Herein we present a case of systemic CSD presenting with hepatic mass in an immunocompetent child. The differential diagnosis is made by serological and pathological evidence. …”
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Peritoneal dialysis in an end-stage renal disease patient with massive ascites and primary liver cancer by Lulu Sun, Chunmei Liang, Yuqin Wang, Hui Li, Lijun Yao, Huajun Jiang

“…We present a case of a 68-year-old male patient with ESRD who experienced various decompensated complications of liver cirrhosis, particularly massive ascites and hepatic space-occupying lesions. Peritoneal dialysis (PD) catheter insertion and continuous ambulatory peritoneal dialysis (CAPD) treatment were successfully performed. …”
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Case Report of Probable DRESS Syndrome Associated with Ribociclib by Florian Carneiro, Marine Bove, Frédérique Beau-Salinas, Tevy San, Pierre Combe

“…Here, we present the case of an 83-year-old patient who developed a probable DRESS syndrome induced by ribociclib, presenting with fever, eosinophilia, rash, and hepatic cytolysis. The RegiSCAR score was 4. The symptomatology evolved favorably with topical and systemic corticosteroids, without any sequel. …”
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Primary Synovial Sarcoma of the Scrotum by Nourah Al-Oudah, Sara Alanazi, Sarah Saad Alotaibi, Nayef Alzahrani

“…Treatment failed to improve the hepatic lesion that was then resected, while the spine and lung lesions were followed by radiotherapy. …”
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The Utility of Xenon-133 Liver Scan in the Diagnosis and Management of Nonalcoholic Fatty Liver Disease by Said A Al-Busafi, Peter Ghali, Philip Wong, Javier A Novales-Diaz, Marc Deschênes

“…Liver biopsy remains the gold standard diagnostic method; however, its invasive nature, among other factors, has prompted the need to develop less invasive, alternative methods to quantify hepatic fat and determine disease severity. Xenon-133 liver scanning is one such method that has been in use for more than 10 years in the evaluation of patients with suspected NAFLD. …”
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Update on Ppar𝜸 and Nonalcoholic Fatty Liver Disease by Gene P. Ables

“…Uninterrupted progression of hepatic lipid accumulation often leads to fatty liver disease and eventually cirrhosis. …”
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Pharmacological and Pharmacodynamic Implications of Nonsteroidal Anti-Inflammatory Drug Therapy in Elderly Arthritic Patients by W Watson Buchanan

“…Physiological changes, which include reduced muscle mass, total body water and albumin levels, as well as effects on renal and hepatic function, affect pharmacokinetic factors, including absorption, distribution, biotransformation and renal clearance. …”
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Bacterial Infections in Cirrhosis by Guadalupe Garcia-Tsao

“…Cirrhotic patients who develop abdominal pain, tenderness, fever, renal failure or hepatic encephalopathy should undergo diagnostic paracentesis, and those who meet the criterion for SBP (eg, an ascites neutrophil count greater than 250/mm3) should receive antibiotics, preferably a third-generation cephalosporin. …”
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Salvia deserti Decne., an endemic and rare subshrub from Arabian desert: antidiabetic and antihyperlipidemic effects of leaf hydroethanolic extracts by Arbi Guetat, Slimen Selmi, Abdelrhman T. Abdelwahab, Marwa A. Abdelfattah, Abd Ealrhman M. Elhaj, Roaa T. Mogharbel, M. J. A. Abualreish, Abdullah F. Alanazi, Karim Hosni, Naceur Mejri, Abdennacer Boulila

“…The identity of phenolic compounds of the hydroethanolic extract of S. deserti was conducted through HPLC-Electrospray Ionization-Mass Spectrometry (LC-ESI-MS) analyses.ResultsOral administration of hydroethanolic extract of S. deserti at 200 and 400 mg/kg for 14 days significantly decreased blood glucose and restored the hepatic and renal function by reducing the levels of ALT, AST, ALP, GGT, LDH, urea and creatinine. …”
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Safety and efficacy of oral edible bird’s nest supplementation: Anti-inflammatory and immunomodulatory benefits for Arabian race stallions during exercise by Khalid Obaid AL-Khaldi, Khalid Hamed Al-Ruzaiqi, Abdul Salam Babji, Seng Joe Lim, Mohammed Babatunde Sadiq, Nurhusien Yimer

“…Key objectives included assessing EBN’s impact on hepatic and renal function, hematological profiles, and sialic acid (SA) levels. …”
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A Comprehensive Analysis of <i>Echinococcus granulosus</i> Infections in Children and Adolescents: Results of a 7-Year Retrospective Study and Literature Review by Cristina Maria Mihai, Ancuta Lupu, Tatiana Chisnoiu, Adriana Luminita Balasa, Ginel Baciu, Vasile Valeriu Lupu, Violeta Popovici, Felicia Suciu, Florin-Daniel Enache, Simona Claudia Cambrea, Ramona Mihaela Stoicescu

“…Moderate IgE values were recorded in cases of urban residences, pig and sheep contact, and hepatic involvement. The IgG concentration considerably increased with sheep contact and moderately increased in cases of rural zones, hepatic involvement, complications, and surgical treatment. …”
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Effects of Anthocyanin and Flavanol Compounds on Lipid Metabolism and Adipose Tissue Associated Systemic Inflammation in Diet-Induced Obesity by Roel A. van der Heijden, Martine C. Morrison, Fareeba Sheedfar, Petra Mulder, Marijke Schreurs, Pascal P. H. Hommelberg, Marten H. Hofker, Casper Schalkwijk, Robert Kleemann, Uwe J. F. Tietge, Debby P. Y. Koonen, Peter Heeringa

“…Adipose tissue (AT) histopathology and inflammatory gene expression as well as hepatic lipid content were analyzed after sacrifice. …”
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EGCG improve meat quality, restore lipid metabolism disorder and regulate intestinal flora in high-fat fed broilers by Lujia Gao, Chen Liu, Jiaqi Wu, Ying Cui, Man Zhang, Chongpeng Bi, Anshan Shan, Xiujing Dou

“…Compared to high-fat diet-induced obese chickens, supplementation of EGCG significantly lowered hepatic fatty acid synthase (FAS) expression and lipid synthesis metabolites, while fatty acid decomposition enzymes showed no significant changes. …”
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The serum hepcidin and the hepcidin/ferritin ratio in NAFLD: a systematic review and meta-analysis by Jingmin Song, Heqing Wang, Xiaolian Gao, Fen Yang, Xinhong Zhu, Guiyuan Qiao, Ting Gan, Junxiu Tao

“…Abstract Background Non-alcoholic fatty liver disease (NAFLD) is a spectrum of chronic liver diseases characterized by hepatic steatosis exceeding 5% in the absence of alcohol and other liver-damaging factors. …”
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A Case of Sevoflurane Use during Pregnancy in the Management of Persistent Status Asthmaticus by Jessica Parrott, Mitch Tener, Katie Dennis, Matthew Sharpe, Cecily Clark-Ganheart

“…Histologic features suggested drug induced hepatic injury. Liver function subsequently normalized. …”
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Urosepsis Causing Gastric Ischemia: A Rare but Deadly Complication by Vijay Jarodiya, Chirag Kher, Sangeetha Nanthabalan, Gunjan Shah

“…He was found to have sepsis secondary to a urinary tract infection with imaging showing hepatic portal venous gas and gastric pneumatosis. …”
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Clinical Outcome with Oral Linezolid and Rifampin Following Recurrent Methicillin-Resistant Staphylococcus aureus Bacteremia Despite Prolonged Vancomycin Treatment by Jon-David Schwalm, Philippe El-Helou, Christine H Lee

“…More than two years since the initiation of linezolid and rifampin, the study patient has been clinically well with no evidence of adverse drug reactions including cytopenia and hepatic toxicities. Physicians must be aware of the novel developments in antibiotic therapy to treat drug-resistant bacterial infections.…”
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Hydropneumothorax Revealing a Pneumoblastoma in Children by Karima El Fakiri, Ghizlane Draiss, Noureddine Rada, Mohammed Bouskraoui, Abderrachid Hamdaoui, Mohamed Oulad Saiad

“…Pathological study specimen showed a high-grade type II pneumoblastoma The extension assessment identified a secondary hepatic location. Chemotherapy has been indicated. …”
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