Metabolic syndrome and pancreatic lesions by O. S. Shifrin, I. A. Sokolina, A. E. Leonovich, M. A. Ashitko, T. L. Lemina, A. V. Korolyov

“…The issue of application of new phospholipid drug Resalut in patients with SP, associated to hepatic steatosis and lipidemia is discussed. Conclusion. …”
Get full text

Glycyrrhizinate Monoammonium Cysteine-Loaded Lipid Nanoparticles Allow for Improved Acute Liver Injury Therapy by Yunjie Xu, Pinghui Li, Shiran Sun, Yulin Chen, Lixia Feng, Dawei Jiang, Chidan Wan, Jianbo Li, Xiong Cai

“…However, challenges such as rapid drug excretion and insufficient concentration at hepatic lesions often impede the treatment’s effectiveness. …”
Get full text

Effect of different feeding regimes in amur common carp fingerlings: compensatory growth, physio-metabolic responses, and expression of IGF-1 gene by Chowdhury Arka, Ghosh Tapas Kumar, Khatua Sanjib, Hore Sayani, Kumari Palak, Kajal Kumari, Jana Prasanta

“…In the current study, elevated (P < 0.05) level of hepatic superoxide dismutase, catalase, glutathione peroxidase activity and Insulin like growth factor 1 and reduced (P < 0.05) blood glucose level, parallel to the degree of starvation was also evidenced. …”
Get full text

High fructose rewires gut glucose sensing via glucagon-like peptide 2 to impair metabolic regulation in mice by Eya Sellami, Paulo Henrique Evangelista-Silva, Caio Jordão Teixeira, Khoudia Diop, Patricia Mitchell, Fernando Forato Anhê

“…Results: High fructose feeding led to impairment of blood glucose disposal, ectopic fat accumulation in the liver, and hepatic (but not muscle or adipose tissue) insulin resistance independent of changes in fat mass. …”
Get full text

Fatty Liver and Insulin Resistance in the Liver-Specific Knockout Mice of Mitogen Inducible Gene-6 by Byung Kil Park, Eun-Ah Lee, Hee-Youn Kim, Jun Choul Lee, Koon Soon Kim, Won Hoon Jeong, Ki Young Kim, Bon Jeong Ku, Sang Dal Rhee

“…But the Mig-6d/d mice had the improved glucose intolerance and insulin resistance without increased amount of phosphoinsulin receptor after insulin infusion in the liver. The hepatic concentration of phosphoenolpyruvate carboxykinase was increased in fasting Mig-6d/d mice. …”
Get full text

Liver Transplantation for Acute Liver Failure due to Mushroom Poisoning by Hayri Canbaz, Attila Bestemir, Sami Akbulut, Sezai Yilmaz, Yusuf Yavuz

“…Materials and Methods: In this descriptive and observational study, the demographic and clinical data of 26 patients who presented to emergency units due to clinical features of acute hepatic failure secondary to mushroom poisoning between October 2008 and November 2023 and who underwent emergent liver transplantation were retrospectively reviewed. …”
Get full text

Purulent Pericarditis after Liver Abscess: A Case Report by María Fidalgo García, Juan Carlos Rodríguez Sanjuán, María Riaño Molleda, Marta González Andaluz, Hector Real Noval, Manuel Gómez Fleitas

“…We present the case of a 49-year-old woman, with previous clinical antecedents of recent hepatic metastasis, who was admitted to the ICU due to respiratory failure and hemodynamic instability. …”
Get full text

Transcatheter Embolization for Giant Splenic Artery Aneurisms: Still an Open Question by Marianna Mastroroberto, Sonia Berardi, Matteo Renzulli, Caterina Maggioli, Paolo Pianta, Antonio Daniele Pinna, Rita Golfieri, Claudia Sama

“…The procedure was complicated by bacterial infection of the coils within the aneurismatic sac, leading to the development of hepatic failure. A liver transplant was then successfully performed despite the presence of a nonresponsive infection.…”
Get full text

CPEO and Mitochondrial Myopathy in a Patient with DGUOK Compound Heterozygous Pathogenetic Variant and mtDNA Multiple Deletions by V. Montano, C. Simoncini, Cassi L. Calì, A. Legati, G. Siciliano, M. Mancuso

“…The classic features of deoxyguanosine kinase (DGUOK) deficiency are infantile onset hepatic failure with nystagmus and hypotonia; mitochondrial DNA studies on affected tissue reveal mitochondrial DNA depletion. …”
Get full text

Embryonal Sarcoma of the Liver in an Adult Patient by Nicole Lightfoot, Mehrdad Nikfarjam

“…An UES should be considered in the differential of large cystic hepatic lesions, with aggressive surgical resection considered when possible.…”
Get full text

Physiological and pathological roles of PGAM5: An update and future trend by Weibin He, Wenlong He, Zhongchan Sun, Pengcheng He

“…Finally, we discuss PGAM5’s contribution to the pathological state of cardiovascular, hepatic, neurological, and neoplastic diseases, offering potential perspectives for future research.…”
Get full text

Ascites in the Puerperium in the Context of a Woman with Turner Syndrome Who Conceived through Assisted Reproductive Technology by Nikolaos Tsagkas, George Valasoulis, Konstantinos Zikopoulos, Calliope Zerzi, Ioannis Mitselos, Ioannis Koutoulakis, Nikolaos Tzampouras, Theodor Stefos

“…It is important to exhibit high suspicion for clot formation in the hepatic vasculature during the puerperium, especially in the case of history of chronic hormone treatment. …”
Get full text

Successful Erlotinib Treatment for a Patient with Gefitinib-Related Hepatotoxicity and Lung Adenocarcinoma Refractory to Intermittently Administered Gefitinib by Tatsuya Nagano, Yoshikazu Kotani, Kazuyuki Kobayashi, Masahiro Katsurada, Yukihisa Hatakeyama, Suya Hori, Daisuke Tamura, Daisuke Kasai, Yasuhiro Funada, Yoshihiro Nishimura

“…The patient was treated with gefitinib for 6 weeks until he developed substantially elevated hepatic enzyme levels that resulted in the discontinuation of gefitinib. …”
Get full text

Comment on “Resection Postradioembolization in Patients With Single Large Hepatocellular Carcinoma” by Xu Wang, MD, Li-Heng Liu, MD, Jin-Kai Feng, MD, Shu-Qun Cheng, MD, PhD

Get full text

Rare Case of Adult Undifferentiated (Embryonal) Sarcoma of the Liver Treated with Liver Transplantation: Excellent Long-Term Survival by Renumathy Dhanasekaran, Alan Hemming, Elaine Salazar, Roniel Cabrera

“…We present the case of a 54-year-old gentleman who presented with abdominal distension and a CT scan of his abdomen revealed a large (25 cm) left hepatic lobe tumor. He received chemotherapy for over 1.5 years. …”
Get full text

Animal models of hemorrhage, parameters, and development of hemostatic methods by Gholamhossien Darya, Hamid Mohammadi, Zeinab Dehghan, Alireza Nakhaei, Amin Derakhshanfar

“…The findings indicate that femoral artery hemorrhage and hepatic parenchymal hemorrhage are the predominant modeling techniques for compressible and non-compressible bleeding, respectively. …”
Get full text

Probiotics for Alleviating Alcoholic Liver Injury by Zelin Gu, Yanlong Liu, Shumeng Hu, Ying You, Jiaqi Wen, Wancong Li, Yuhua Wang

“…Probiotics also increase fatty acid β-oxidation and reduce lipogenesis, combating alcohol-induced hepatic steatosis. In this review, we summarize the current knowledge regarding the mechanism of action of probiotics for reducing the effects of alcoholic liver disease.…”
Get full text

Glucagon like peptide-1 (GLP-1) agonists and cardiometabolic protection: historical development and future challenges by Francisco Westermeier, Enrique Z. Fisman

“…This editorial synthesizes key milestones, from the discovery of GLP-1 to recent clinical trials highlighting the pleiotropic effects of GLP-1RAs in addressing the interconnected spectrum of cardiometabolic conditions, with a focus on cardiovascular, renal, and hepatic benefits. In addition, as GLP-1RAs continue to reshape the management of cardiometabolic disease and global public health, we discuss future challenges to better elucidate their mechanisms of cardiometabolic protection and maximize their therapeutic potential. …”
Get full text

Effects of Dietary Vitamin C on the Growth Performance, Biochemical Parameters, and Antioxidant Activity of Coho Salmon Oncorhynchus kisutch (Walbaum, 1792) Postsmolts by Cong-mei Xu, Hai-rui Yu, Ling-yao Li, Min Li, Xiang-yi Qiu, Xiao-qian Fan, Yan-lin Fan, Ling-ling Shan

“…Results showed that VC markedly improved the growth performance indexes and liver VC concentration, enhanced the hepatic and serum antioxidant activities, and increased the contents of serum alkaline phosphatase (AKP) activity, low-density lipoprotein cholesterol (LDL-C), high-density lipoprotein cholesterol (HDL-C), and total cholesterol (TC) whereas decreased the serum aspartate aminotransferase (AST), alanine aminotransferase (ALT) activities, and triglyceride (TG) level. …”
Get full text

The effects of Bifidobacterium animalis QC08 on reducing uric acid level and providing renal protection in mice with hyperuricemia by Huijia Mao, Yang Fan, Fang Tan, Xingyao Long

“…Pathological changes in renal tissue were examined through hematoxylin–eosin (HE) staining.ResultsIn vivo experimental results indicated that compared with the normal group, the serum UA, Cr, and BUN levels, as well as the levels of inflammatory factors (TNF-α and IL-1β), and the activities of hepatic xanthine oxidase (XOD) and adenosine deaminase (ADA) were significantly elevated in the control group (p &lt; 0.05). …”
Get full text