Physiological accumulation of lipid droplets in the newborn liver during breastfeeding is driven by TLR4 ligands by Wanderson Ferreira da Silva Júnior, Karen Marques de Oliveira Costa, Hortência Maciel Castro Oliveira, Maísa Mota Antunes, Kassiana Mafra, Brenda Naemi Nakagaki, Pedro Sérgio Corradi da Silva, Júlia Duarte Megale, Sarah Campos de Sales, Douglas Carvalho Caixeta, Mário Machado Martins, Robinson Sabino-Silva, Cristina Maria Pinto de Paula, Luiz Ricardo Goulart, Rafael Machado Rezende, Gustavo Batista Menezes

“…Here we investigated a transient surge in hepatic lipid droplets observed in newborn mice immediately after birth. …”
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AlphaFold-based AI docking reveals AMPK/SIRT1-TFEB pathway modulation by traditional Chinese medicine in metabolic-associated fatty liver disease by Lulu Zhang, Yi Zheng, Mingyan Shao, Aiping Chen, Meiyi Liu, Wenlong Sun, Tianxing Li, Yini Fang, Yang Dong, Shipeng Zhao, Hui Luo, Juan Feng, Qi Wang, Lingru Li, Yanfei Zheng

“…Metabolic-associated fatty liver disease (MAFLD) is a chronic, progressive disorder characterized by hepatic steatosis and excessive lipid accumulation. …”
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Anterograde Colonic Stent Placement via a Cecostomy Tube Site by Lawrence M Gillman, Steven Latosinsky

“…A unique case is presented where the colonic stent was passed in an anterograde fashion through a recently created cecostomy tube site as a method of palliation to relieve an obstructing hepatic flexure tumour.…”
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A Population-Based Cross-Sectional Study of the Association between Liver Enzymes and Lipid Levels by Subrata Deb, Prasanth Puthanveetil, Prashant Sakharkar

“…Conclusions. Underlying hepatic pathophysiology from dyslipidemia deserves further exploration due to its potential effects on hepatic drug metabolism/detoxification.…”
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Enhanced Hepatocarcinogenicity Due to Agonists of Peroxisome Proliferator-Activated Receptors in Senescent Rats: Role of Peroxisome Proliferation, Cell Proliferation, and Apoptosis by Jihan Youssef, Mostafa Badr

“…Treatment with these chemicals produced a five- to sevenfold higher yield of grossly visible hepatic tumors in old rats compared to young animals. …”
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New Oral Anaticoagulant Prescribing Decisions amongst General Practitioners: Handle with Care by Ann Kirby, Aileen Murphy, Colin Bradley

“…This measures the joint decision making process of prescribing a NOAC based on four risk factors - renal impairment, hepatic impairment, other comorbidities and drug interactions. …”
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Liver Fibrosis and Altered Matrix Synthesis by Katrin Neubauer, Bernhard Saile, Giuliano Ramadori

“…A number of substances are currently being tested that either neutralize fibrogenic stimuli and prevent the activation of hepatic stellate cells, or directly modulate the matrix metabolism. …”
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Unfavorable Tumor Responses to Immunotherapy in the Liver: Lessons Learned from Clinical and Preclinical Studies by Li-Chun Lu, Gen-Sheng Feng, Chih-Hung Hsu

“…Mechanistically, modulation of hepatic innate immune cells was associated with the improved response of anti-PD-L1 antibody in the liver. …”
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Extracellular matrix turnover in severe COVID-19 is reduced by corticosteroids by Janesh Pillay, Antine W. Flikweert, Matijs van Meurs, Marco J. Grootenboers, Simone van der Sar-van der Brugge, Peter H. J. van der Voort, Morten A. Karsdal, Jannie M. B. Sand, Diana J. Leeming, Janette K. Burgess, Jill Moser

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The Pull-Through Technique for Recanalization of Transjugular Intrahepatic Portosystemic Shunt Dysfunction by Si-liang Chen, Cheng-jiang Xiao, Shuai Wang, Si-yi Jin, Jian-bo Zhao

“…During the follow-up, three patients developed hepatic encephalopathy, and one patient developed TIPS dysfunction again and experienced variceal bleeding. …”
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Nuclear Imaging to Detect Diaphragmatic Perforation as a Rare Complication of Microwave Ablation by Stephanie Cull, Gebran Khneizer, Abhishek Krishna, Razi Muzaffar, Sameer Gadani, Zafar Jamkhana

“…Acquired diaphragmatic perforation leading to massive hepatic hydrothorax and respiratory failure is a rare complication of microwave ablation (MWA) of hepatocellular carcinoma (HCC). …”
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Chronic Ethanol Feeding Modulates Inflammatory Mediators, Activation of Nuclear Factor-κB, and Responsiveness to Endotoxin in Murine Kupffer Cells and Circulating Leukocytes by Miriam Maraslioglu, Elsie Oppermann, Carolin Blattner, Roxane Weber, Dirk Henrich, Christian Jobin, Elke Schleucher, Ingo Marzi, Mark Lehnert

“…We found that chronic ethanol upregulated NF-κB activation and increased hepatic and systemic proinflammatory cytokine levels. …”
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Circulatory Support with Venoarterial ECMO Unsuccessful in Aiding Endogenous Diltiazem Clearance after Overdose by Erin N. Frazee, Sarah J. Lee, Ejaaz A. Kalimullah, Heather A. Personett, Darlene R. Nelson

“…In cardiovascular collapse from diltiazem poisoning, extracorporeal membrane oxygenation (ECMO) may offer circulatory support sufficient to preserve endogenous hepatic drug clearance. Little is known about patient outcomes and diltiazem toxicokinetics in this setting. …”
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The Pathogenesis of Nonalcoholic Fatty Liver Disease: Interplay between Diet, Gut Microbiota, and Genetic Background by Jinsheng Yu, Sharon Marsh, Junbo Hu, Wenke Feng, Chaodong Wu

“…Nonalcoholic fatty liver disease (NAFLD) is the most common chronic liver disease in the world, and it comprises a spectrum of hepatic abnormalities from simple hepatic steatosis to steatohepatitis, fibrosis, cirrhosis, and liver cancer. …”
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Anti-Glycemic and Anti-Hepatotoxic Effects of Mangosteen Vinegar Rind from Garcinia mangostana Against HFD/STZ-Induced Type II Diabetes in Mice by Karim Naymul, Jeenduang Nutjaree, Tangpong Jitbanjong

“…MVR and glibenclamide treatment to HFD/STZ-induced diabetic mice significantly reduced their plasma glucose, plasma lipid profile, and hepatic lipid profile (P<0.05). Increased hepatic glycogen content indicates improvement of insulin sensitivity. …”
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Reversal of acetaminophen-generated oxidative stress and concomitant hepatotoxicity by a phytopharmaceutical product by Afolabi C. Akinmoladun, Kehinde O. Oguntunde, Lawrence O. Owolabi, Omotayo B. Ilesanmi, Joan O. Ogundele, M.Tolulope Olaleye, Afolabi A. Akindahunsi

“…In this study, Trévo™, a nutraceutical and phytopharmaceutical product, was evaluated for beneficial effects in acetaminophen-induced hepatic toxicity in Wistar rats. Animals received Trévo™ (1.5 mL/kg, 3.0 mL/kg or 4.5 mL/kg) orally for 14 days. …”
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Effects of Aminoglycoside Antibiotics on Human Embryonic Stem Cell Viability during Differentiation In Vitro by Divya S. Varghese, Shama Parween, Mustafa T. Ardah, Bright Starling Emerald, Suraiya A. Ansari

“…However, during directed differentiation towards neural and hepatic fate, significant cell death was noted through the activation of caspase cascade. …”
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Fucosterol Protects against Concanavalin A-Induced Acute Liver Injury: Focus on P38 MAPK/NF-κB Pathway Activity by Wenhui Mo, Chengfen Wang, Jingjing Li, Kan Chen, Yujing Xia, Sainan Li, Ling Xu, Xiya Lu, Wenwen Wang, Chuanyong Guo

“…Fucosterol attenuated serum liver enzyme levels and hepatic necrosis and apoptosis induced by TNF-α, IL-6, and IL-1β. …”
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Primary Diffuse Large B-Cell Lymphoma of the Liver in a Patient with Sjogren Syndrome by Vadim Gorodetskiy, Wolfram Klapper, Natalya Probatova, Vladimir Vasilyev

“…After 8 cycles of R-CHOP chemotherapy (rituximab, cyclophosphamide, doxorubicin, vincristine, and prednisone), the complete remission was achieved, which persists after 45 months of follow-up. Primary hepatic lymphomas are extremely rare, and previously only low-grade hepatic lymphomas have been described in SS. …”
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Beneficial Effects of Capybara Oil Supplementation on Steatosis and Liver Apoptosis in Obese Mice by Luciana Lontro Alves, Priscila Gomes Pereira, Bianca Torres Ciambarella, Miguel Porto Campos, Kíssila Rabelo, Ana Lúcia Rosa Nascimento, Raíssa Leal de Carvalho dos Santos Cunha, Cherley Borba Vieira Andrade, Alan Cesar Nunes Moraes, Andressa Bernardi, Fernanda Verdini Guimarães, Jemima Fuentes Ribeiro da Silva, Jorge José de Carvalho

“…So, we intend to evaluate the hepatic pathophysiological alterations in C57Bl/6 mice with NAFLD, caused by obesity, and the possible beneficial effects of OC in the treatment of this disease. …”
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