Two Patients with Extremely Elevated Tumor Markers: Where Is the Malignancy? by Patrick P. J. van der Veek, Wouter H. de Vos tot Nederveen Cappel, Alexandra M. J. Langers, Bart van Hoek

“…An 18-year-old patient suffering from autoimmune hepatitis had markedly increased alpha-fetoprotein (aFP) levels (2,002 μg/L; normal <10 ug/L). …”
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The Pivotal Role of TBK1 in Inflammatory Responses Mediated by Macrophages by Tao Yu, Young-Su Yi, Yanyan Yang, Jueun Oh, Deok Jeong, Jae Youl Cho

“…Inflammation is considered to be a major cause of most chronic diseases, especially in more than 100 types of inflammatory diseases which include Alzheimer's disease, rheumatoid arthritis, asthma, atherosclerosis, Crohn's disease, colitis, dermatitis, hepatitis, and Parkinson's disease. Recently, an increasing number of studies have focused on inflammatory diseases. …”
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Necrotic stomatitis and haemorrhagic enteritis in an indian rock python by Balasundara Kavitha Rani, Shekhya Ganga Naik, Konanur Javaregowda Ananda, Basavanal Eswarappa Shambulingappa, Suresh Revanna Patel, Mosarukunte Devaraj

“…Histological investigation of the stomach and intestine indicated epithelial sloughing, congestion, catarrh and bacillary population embedded in the crypts. Liver had focal hepatitis, haemosiderosis and portal fibrosis with biliary proliferation. …”
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Downregulated Copper Homeostasis-Related Gene FOXO1 as a Novel Indicator for the Prognosis and Immune Response of Breast Cancer by Rong Zeng, Bi Peng, Emin Peng

“…Moreover, FOXO1 expression was positively associated with multiple immune checkpoints, such as sialic acid-binding immunoglobulin-like lectin 15 (SIGLEC15), indoleamine 2,3-dioxygenase 1 (IDO1), programmed cell death 1 ligand 1 (PD-L1/CD274), hepatitis A virus cellular receptor 2 (HAVCR2), programmed cell death 1 (PDCD1), cytotoxic T lymphocyte antigen 4 (CTLA4), and programmed cell death 1 ligand 2 (PDCD1LG2). …”
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Multiple Comorbid Conditions among Middle-Aged and Elderly Hemophilia Patients: Prevalence Estimates and Implications for Future Care by Aroub A. Khleif, Nidra Rodriguez, Deborah Brown, Miguel A. Escobar

“…The most common conditions identified were chronic hepatitis C, hypertension, HIV, chronic arthropathy, and overweight/obesity. …”
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Laboratory diagnostics of alcohol intoxication in patients with alcohol-induced liver disease by A. I. Pavlov, A. I. Khazanov

“…Results of these investigations demonstrated, that at testing only for asialotransferrin positive result was obtained only in 3 (5,4%) patients admitted to the hospital with severe manifestations of acute alcoholic hepatitis. At assessment of integral deficiency of transferrin, changes have been found in 36 (76,6%) patients. …”
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3-(5-Hydroxyphenyl)-5-Phenyl-2-Pyrazolines as Toll-Like Receptor 7 Agonists by Ji Hwan Kim, Seunghyun Ahn, Dongsoo Koh, Young Han Lee, Yoongho Lim, Soon Young Shin

“…Toll-like receptor 7 (TLR7) is an attractive target for developing immune modulators to enhance innate immunity against ssRNA virus infections, including hepatitis C and COVID-19. Ten 3-(5-hydroxyphenyl)-5-phenyl-2-pyrazolines were tested using TLR7 reporter cells, overexpressing TLR7 and the NF-κB-inducible SEAP reporter gene to discover a novel TLR7 agonist enhancing innate immunity. …”
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Liver Transplantation in the Treatment of Unresectable Hepatocellular Carcinoma in the Absence of Liver Cirrhosis by O. D. Olisov, M. S. Novruzbekov, I. E. Galankina, L. N. Zimina, V. A. Gulyaev, L. V. Donova, M. Sh. Khubutiya

“…Hepatocellular carcinoma is one of the most common types of cancer, which occurs mainly in patients with liver cirrhosis and chronic viral hepatitis. Only about 10 % of HCC develops in non-cirrhotic liver among young and somatically healthy patients. 1-, 3-, 5-year recurrence-free and overall survival in LT group was significantly better than in the control group.Conclusion.  …”
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Concomitant Nephrotic Syndrome and Cryoglobulinemia in a Case of Malignant Mesothelioma by Kei Nagai, Hiroaki Tachi, Kohei Inoue, Atsushi Ueda

“…Cryoglobulinemia is found in various pathological statuses, such as hepatitis C virus infection but rarely in malignant neoplasms. …”
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Microbiome interplays in the gut-liver axis: implications for liver cancer pathogenesis and therapeutic insights by Xuran Wang, Bin Zhang, Runqiu Jiang

“…With the advancement of modern medical research and care system, the main etiology of PLC more and more switches from hepatitis viruses such as HAV, HBV, HCV, HEV to other causes like metabolism-associated steatohepatitis (MASH) and metabolic-associated fatty liver disease (MAFLD). …”
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Successful case of using suture-mediated system Perclose ProGlide in TAVI by B. M. Todurov, M. B. Todurov, A. V. Khokhlov, M. V. Stan, K. L. Berestova, O. V. Zelenchuk, A. V. Besaga, S. R. Maruniak

“…This clinical case describes the performance of TAVI in a patient with liver cirrhosis, autoimmune hepatitis, coagulopathy, and secondary anemia. Particular attention was paid to complications in the postoperative period. …”
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Profile and complexity of travel medicine consultations in Chile: unicentric cross-sectional study by Thomas Weitzel

“…The indicated vaccine indications comprised hepatitis A (84%), yellow fever (58%), typhoid fever (51%), rabies (29%), polio (8%), Japanese encephalitis (6%) and meningococcal meningitis (5%). …”
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A call for aflatoxin control in Asia by Abeera Umar, Hamzah Shahbaz Bhatti, Sabyan Faris Honey

“…This not only exposes to health issues like growth impairment, immunosuppression, hepatic disorders etc. but also result in heavy economic losses due to trade restrictions. …”
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Hepatocellular Carcinoma to the Right Ventricle by George R. Marzouka, Apurva Badheka, Alexis P. Rodriguez, Sandra V. Chaparro

“…We present a case of a 63-year-old man with history of hepatitis C and cirrhosis, which had progressed to HCC. …”
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Liver Fibrosis and Mechanisms of the Protective Action of Medicinal Plants Targeting Inflammation and the Immune Response by Florent Duval, Jorge E. Moreno-Cuevas, María Teresa González-Garza, Carmen Maldonado-Bernal, Delia Elva Cruz-Vega

“…Inflammation is a central feature of liver fibrosis as suggested by its role in the activation of hepatic stellate cells leading to extracellular matrix deposition. …”
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Liver damage in patients living with HIV on antiretroviral treatment with normal baseline liver function and without HBV/HCV infection: an 11-year retrospective cohort study in Gua... by Jun Yu, Hao Liang, Fengxiang Qin, Junjun Jiang, Chunwei Qin, Yunxuan Huang, Bingyu Liang, Yuexiang Xu, Jiegang Huang, Zhiliang Xu, Chuanyi Ning, Yanyan Liao, Ning Zang, Jingzhen Lai, Wudi Wei, Li Ye, Xionglin Qin

“…Objective To characterise the association between duration of exposure to antiretroviral treatment (ART) and liver damage in HIV patients with an initially normal baseline liver function and without hepatitis B virus (HBV)/hepatitis C virus (HCV) infection.Methods A retrospective cohort study was conducted in HIV-infected individuals with normal liver function parameters at ART initiation and without HBV/HCV infection, from 14 April 2004 to 13 April 2015 in Guigang city, Guangxi, China. …”
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Metabolic Alteration in Hepatocellular Carcinoma: Mechanism of Lipid Accumulation in Well-Differentiated Hepatocellular Carcinoma by Hideo Suzuki, Motoyuki Kohjima, Masatake Tanaka, Takeshi Goya, Shinji Itoh, Tomoharu Yoshizumi, Masaki Mori, Mariko Tsuda, Motoi Takahashi, Miho Kurokawa, Koji Imoto, Shigeki Tashiro, Akifumi Kuwano, Masaki Kato, Seiji Okada, Makoto Nakamuta, Yoshihiro Ogawa

“…Tissue samples were obtained from 103 HCC patients who had undergone hepatic resection and 12 living donors of liver transplantation. …”
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Autoimmune Conditions in 235 Hemochromatosis Probands with HFE C282Y Homozygosity and Their First-Degree Relatives by James C. Barton, J. Clayborn Barton

“…We performed a retrospective study of autoimmune conditions (ACs) in 235 hemochromatosis probands at diagnosis by analyzing age, sex, ACs, history of first-degree family members with ACs (FH), diabetes, heavy ethanol consumption, elevated serum ALT/AST, nonalcoholic fatty liver disease, viral hepatitis, cirrhosis, iron removed to achieve iron depletion (QFe), and positivity for human leukocyte antigen (HLA) haplotypes A∗01, B∗08; A∗02, B∗44; A∗03, B∗07; A∗03, B∗14; and A∗29, B∗44. …”
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Recurrence of Herpetic Keratitis after COVID-19 Vaccination: A Report of Two Cases by Ali Mahdavi Fard, Jeffrey Desilets, Sangita Patel

“…Recurrence of herpetic keratitis following vaccination has been documented following vaccination with the Zostavax, trivalent flu, hepatitis A, and rabies vaccines. The USFDA and WHO have acknowledged that the novel COVID-19 vaccines similarly have a risk of reactive immunologic-based inflammation, namely, myositis, pericarditis, and Guillain-Barré syndrome. …”
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The Dietary Use of Pigeon Pea for Human and Animal Diets by Belete Kuraz Abebe

“…PP’s green leaves, roots, seeds, and pods are high in phenolic compounds, which have anti-inflammation, antibacterial, antioxidant, anticarcinogenic, and antidiabetic properties, as well as the ability to cure diseases like measles, smallpox, chicken pox, sickle cell anemia, fever, dysentery, hepatitis, and antimalarial medications for the body. …”
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