Variation in human gut microbiota impacts tamoxifen pharmacokinetics by Yasmine Alam, Sheron Hakopian, Lizett Ortiz de Ora, Ian Tamburini, Julio Avelar-Barragan, Sunhee Jung, Zane Long, Alina Chao, Katrine Whiteson, Cholsoon Jang, Elizabeth Bess

“…Tamoxifen is orally delivered and must be activated by metabolizing enzymes in the liver; however, clinical studies show that neither genotype nor hepatic metabolic enzymes are sufficient to predict why some patients have sub-therapeutic levels of the drug. …”
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PBMCs gene expression predicts liver fibrosis regression after successful HCV therapy in HIV/HCV-coinfected patients by Ana Virseda-Berdices, Ana Virseda-Berdices, Óscar Brochado-Kith, Óscar Brochado-Kith, Juan Berenguer, Juan Berenguer, Juan Berenguer, Juan González-García, Juan González-García, Juan González-García, Leire Pérez-Latorre, Leire Pérez-Latorre, Leire Pérez-Latorre, Carmen Busca, Carmen Busca, Carmen Busca, Cristina Díez, Cristina Díez, Cristina Díez, Rafael Micán, Rafael Micán, Rafael Micán, Amanda Fernández-Rodríguez, Amanda Fernández-Rodríguez, María Ángeles Jiménez-Sousa, María Ángeles Jiménez-Sousa, Salvador Resino, Salvador Resino

“…BackgroundHCV eradication with antiviral treatment reduces hepatic disease, but some patients remain at risk of progression to cirrhosis despite HCV clearance. …”
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Assessing the neuroprotective potential of Eucalyptus globulus essential oil in a 6-hydroxydopamine rat model of Parkinson's disease by Aracely Janneth Naranjo-Viteri, Matías Jávega Cometto, Matías Caverzan, Leandro Gabriel Champarini, María Paula Zunino, Rogelio E. Abburra, Claudia B. Hereñú, Rosana Crespo

“…We evaluated tyrosine hydroxylase (TH) and dopamine transporter (DAT) expression in the brain caudate-putamen unit; inflammatory cytokine (TNF-α, IL-6) expression in the hippocampus; liver, kidney, and gut histology; serum parameters; and hepatic lipid content. Results: Our findings indicate that EuEO is mainly composed of 1,8-cineole (81.8 %) and that, in the parkinsonian rats, it improved impairments in spatial memory, motor performance, and strength; increased TH and DAT protein content; decreased TNF-α expression; diminished liver lipid content and body weight gain without changes in the rats’ food/water consumption or their serum lipid levels; diminished transaminase and alkaline phosphatase activity, and the albumin/globulin ratio. …”
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Effects of replacing fishmeal with soybean meal on growth performance, liver antioxidant capacity and intestinal health in juvenile Asian red-tailed catfish (Hemibagrus wyckioides) by Weijia Cai, Xinping Li, Minglang Cai, Zhe Tang, Bo Zhu, Mengxi Yang, Yi Hu, Jihong Dai

“…Concurrently, there were decreases in triglyceride (TG) and total cholesterol (TC) levels (P < 0.05). Besides, hepatic antioxidant enzyme activities and nrf2 gene expression levels were markedly upregulated in the SBM45 and SBM60 groups (P < 0.05). …”
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FLI and FIB-4 in diagnosing metabolic dysfunction-associated steatotic liver disease in primary care: High prevalence and risk of significant disease by Mário Reis Álvares-da-Silva, Márcia da Silva Vargas, Soheyla Mohd Souza Rabie, Gabriella Jonko, Patricia Gabriela Riedel, Larisse Longo, Marcelo Rodrigues Gonçalves, Vivian Cristine Luft, Dvora Joveleviths

“…In RETR, metabolic and hepatic profiles of 12,054 patients, including FIB-4, were evaluated. …”
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Substituting Fish Meal with Tubiechong (Eupolyphaga sinensis) By-Product in the Diets of Largemouth Bass (Micropterus salmoides): Effects on Growth, Meat Quality, and Liver Health by Yuhua Yue, Binbin Tong, Mingshi Chen, Xiaoxue Bao, Yanming Qiu, Ying Yang, Hui Yu, Yingying Yu

“…Conclusively, the present study indicated that the partial dietary replacement of fish meal using the Tubiechong by-product (for up to 40% replacement level) in the diet of largemouth bass not only caused no adverse effects on fish health but also improved the growth performance, meat quality, antioxidant capacity, and hepatic health and is conducive to supplying nutritious, high-quality, and healthy aquatic products.…”
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Evaluation of the effects of Keratinase-treated feather meal as a replacement for fishmeal on growth performance, liver function, and intestinal health in juvenile largemouth bass... by Yi-Huan Xu, Li-Han Zhang, Min Liu, Mei-Yan Li, Xue-Dan Fang, Hui Xia, Ran Guo, Fazhan Hanafiah, Waiho Khor, Guang Chen, Xin Hao

“…Besides, the expression of fatty acid synthetase (fas) gene presented a linearly increased difference with the increasing KFM concentrations (P = 0.001), whereas the expression of adipose triglyceride lipase (atgl) gene was linearly decreased (P = 0.000), resulting in hepatic lipid accumulation in largemouth bass. Furthermore, there was a significant enhancement of antioxidant capacity along with oxidative stress in liver of largemouth bass with the increasing KFM concentration (P < 0.05). …”
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Isoxazole-based molecules restore NK cell immune surveillance in hepatocarcinogenesis by targeting TM4SF5 and SLAMF7 linkage by Ji Eon Kim, Hyun Su Kim, Wonsik Kim, Eun Hae Lee, Soyeon Kim, Taewoo Kim, Eun-Ae Shin, Kyung-hee Pyo, Haesong Lee, Seo Hee Jin, Jae-Ho Lee, Soo-Min Byeon, Dong Joo Kim, Jinwook Jeong, Jeongwon Lee, Minjae Ohn, Hyojung Lee, Su Jong Yu, Dongyun Shin, Semi Kim, Jun Yeob Yoo, Seung-Chul Lee, Young-Ger Suh, Jung Weon Lee

“…We investigated how TM4SF5-mediated hepatic tumorigenesis avoids surveillance by natural killer (NK) cells, which are prevalent in the liver, and whether the avoidance can be blocked by anti-TM4SF5 agents. …”
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Glucose‐induced LINC01419 reprograms the glycolytic pathway by recruiting YBX1 to enhance PDK1 mRNA stability in hepatocellular carcinoma by Yanfang Liu, Junjiao Song, Qili Shi, Bing Chen, Wenying Qiu, Yizhe Liu, Shenglin Huang, Xianghuo He

“…The newly identified LINC01419/YBX1‐PDK1 axis constitutes a valuable target. Hepatic‐specific delivery of GalNAc‐siLINC01419 presents a promising therapeutic strategy for HCC.…”
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Rationale and design of a randomised, double-blind, placebo-controlled, parallel-group, investigator-initiated phase 2a study to investigate the efficacy and safety of elobixibat i... by Atsushi Nakajima, Takeharu Yamanaka, Koji Yamamoto, Yasushi Honda, Kento Imajo, Masato Yoneda, Yuji Ogawa, Takaomi Kessoku, Takashi Kobayashi, Anna Ozaki, Satoru Saito, Michihiro Iwaki, Yusuke Saigusa, Haruki Usuda, Koichiro Wada

“…Introduction Non-alcoholic fatty liver disease (NAFLD) pathogenesis involves abnormal metabolism of cholesterol and hepatic accumulation of toxic free-cholesterol. Elobixibat (EXB) inhibits the ileal bile acid (BA) transporter. …”
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Visualization of Right Adrenal Vein in Non‐Contrast‐Enhanced MDCT and Its Guiding Role for Right Adrenal Venous Sampling by Hong‐liang Xiong, Li Du, Jiao Yang, Wei‐Tong Hu, Jia‐Bing Huang, Yun‐De Li, Xi Chen, Yi‐Fei Dong

“…In 6.2% (n = 12) of patients who can display RAV, RAV formed a common trunk with the accessory hepatic vein and then merged into the inferior vena cava. …”
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Rapid Determination of Water-Soluble Vitamins in Human Serum by Ultrahigh-Performance Liquid Chromatography-Tandem Mass Spectrometry by Mengyu Zhang, Chao Zhang, Haidong Cai, Yuan Xie, Li Chai, Ming Sun, Jin Liu, Jisong Liu, Chong Yi, Hengwei Fan, Wanwan Yi, Zhongwei Lv

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Efficacy and safety of currently approved and lower starting doses of inotuzumab ozogamicin in adult patients with relapsed or refractory acute lymphoblastic leukemia: a phase IV s... by Muhit Özcan, Ryan D. Cassaday, Ewa Zarzycka, Erik Vandendries, Fan Zhang, Ying Chen, Alejandra Nieto, Fatih Demirkan, Pau Montesinos, Fevzi Altuntas

“…Previous studies reported higher rates of post– hematopoietic stem cell transplant (HSCT) hepatic sinusoidal obstruction syndrome (SOS) in patients receiving InO versus chemotherapy prior to HSCT. …”
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A Review of the Therapeutic Potential of Ginseng and Its Bioactive Components in Nonalcoholic Fatty Liver Disease by Hao L, Li S, Li C, Zhang Z, Hu X, Yan H

“…In NAFLD, studies have demonstrated that ginseng can improve hepatic lipid metabolism, reduce inflammatory responses, and inhibit oxidative stress and fibrosis, thereby attenuating the progression of NAFLD. …”
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The RNA M5C methyltransferase NSUN2 promotes progression of hepatocellular carcinoma by enhancing PKM2-mediated glycolysis by Qin Qi, Rui Zhong, Yan Huang, Yong Tang, Xiao-wen Zhang, Chang Liu, Chun-fang Gao, Lin Zhou, Jian Yu, Lu-yi Wu

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Bone cell differentiation and mineralization in wild-type and osteogenesis imperfecta zebrafish are compromised by per- and poly-fluoroalkyl substances (PFAS) by Francesca Tonelli, Cecilia Masiero, Carla Aresi, Camilla Torriani, Simona Villani, Guido Premoli, Antonio Rossi, Antonella Forlino

“…In conclusion, our data demonstrate that PFAS impair operculum development mainly compromising cell differentiation in mutant fish whereas alter lipid hepatic distribution in both genotypes with a more severe effect on Chi/+ preosteoblast survival. …”
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Fully Covered Stent-TIPS for Advanced HCC Patients with Portal Vein Tumor Thrombus-Related Severe Symptomatic Portal Hypertension by Liu Z, Lyu T, Yang J, Xie Y, Fan S, Song L, Zou Y, Wang J

“…One patient (4.0%) experienced overt hepatic encephalopathy (OHE) and three (12.0%) patients developed shunt dysfunction during the follow-up period. …”
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Multidetector CT Enterography versus Double-Balloon Enteroscopy: Comparison of the Diagnostic Value for Patients with Suspected Small Bowel Diseases by Jingjing Wang, Qiaozhen Guo, Jianping Zhao, Mei Liu, Guangquan Liao, Nianjun Chen, Dean Tian, Xiaoli Wu

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Was It an Adrenocortical Adenoma or an Adrenocortical Carcinoma? Limitation of the Weiss Scoring System in Determining the Malignant Potential of Adrenocortical Tumor: Report on Tw... by Cheuk-Lik Wong, Chun-Kit Fok, Yuk-Kit Chan, Vicki Ho-Kee Tam, Lai-Ming Fung

“…Five years later, she presented with recurrent hypercortisolism due to hepatic and peritoneal metastases. The patient had progressive disease despite mitotane therapy and succumbed 7 years after initial presentation. …”
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Pharmacogenetics: Influence of CYP2C9*2 and *3 alleles polymorphisms on Iraqi type 2 diabetic patients by Ghada S. Rasool, Asmaa A. Hussien, Suhad R. Al-Tayie, Salwa J. Al-Awadi, Hussein OM Al-Dahmoshi

“…The enzyme responsible for metabolizing of SUs is hepatic cytochrome P4502C9 (CYP2C9). The CYP2C9 gene has numerous allelic variations; among those, the CYP2C9*2 and CYP2C9*3 are the most common and clinically significant allelic variations. …”
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