Prevalence and association of non-alcoholic fatty liver disease and insulin resistance among non-diabetic obese, overweight, and metabolically obese normal-weight adult patients at... by Samik Pramanik, Jimmy Barua, Lokanathan V, Sharmistha Roy

“…All subjects underwent detailed history, complete physical examination, laboratory test, and grading of hepatic fat by ultrasonography. Results: The mean age (mean± standard deviation) of the patients was 36.91±11.01 years with a range of 18–67 years. 53 (38.7%) and 84 (61.3%) of the patients were male and female, respectively. …”
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Effects of Particulate Matter Exhaust on Functional Parameters of Organ Systems and Reactive Oxygen Species: A Cross-Sectional Study by Manjula Shivanagappa, SS Malini, Thanmayi Mahadeshwara Prasad, D. R. Mahadeshwara Prasad

“…We aimed to study the variation in inflammatory cellular components and oxidative stress markers among exposures along with the variation in functional parameters of the organs involved in detoxifying these nanoparticles, the renal and hepatic system.Methods: After the ethical clearance from Institutional Ethical Committee, IHEC-UOM No. 123PhD/2016-17, a cross-sectional study was undertaken in Molecular Reproductive and Human Genetics Lab, Manasa Gangothri, University of Mysore, Mysore, Karnataka, India during 2015-2019, among 500 male garage workers of age group 18-60years with history of exposure for 6-8 hours a day without using any protective aids during work, for past 6-12 years and 300 controls, who live in areas where they were sparsely exposed. …”
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A Comparative Study of the Metabolic and Skeletal Response of C57BL/6J and C57BL/6N Mice in a Diet-Induced Model of Type 2 Diabetes by Elizabeth Rendina-Ruedy, Kelsey D. Hembree, Angela Sasaki, McKale R. Davis, Stan A. Lightfoot, Stephen L. Clarke, Edralin A. Lucas, Brenda J. Smith

“…The C57BL/6N mice exhibited more severe hepatic steatosis and inflammation. Only the C57BL/6N mice lost significant trabecular bone in response to the high fat diet. …”
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Senescent cell depletion alleviates obesity-related metabolic and cardiac disorders by Tábatha de Oliveira Silva, Guilherme Lunardon, Caroline A. Lino, Amanda de Almeida Silva, Shiju Zhang, Maria Cláudia Costa Irigoyen, Yao Wei Lu, John D. Mably, Maria Luiza M. Barreto-Chaves, Da-Zhi Wang, Gabriela P. Diniz

“…Methods and Results: We found that the increase in body weight and adiposity, glucose intolerance, insulin resistance, dyslipidemia, hyperleptinemia, and hepatic disorders which were induced by an obesogenic diet were alleviated by senolytic cocktail treatment in mice. …”
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Identification of a Novel lincRNA-p21-miR-181b-PTEN Signaling Cascade in Liver Fibrosis by Fujun Yu, Zhongqiu Lu, Bicheng Chen, Peihong Dong, Jianjian Zheng

“…Previously, we found that long intergenic noncoding RNA-p21 (lincRNA-p21) inhibits hepatic stellate cell (HSC) activation and liver fibrosis via p21. …”
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Application of Laparoscopic Radical Resection for Type III and IV Hilar Cholangiocarcinoma Treatment by Sulai Liu, Xinyu Liu, Xuepeng Li, Ou Li, Weimin Yi, Junaid Khan, Pingzhou Yang, Chao Guo, Chuang Peng, Bo Jiang

“…All patients underwent total laparoscopic surgery, including basic surgery (laparoscopic gallbladder, hilar bile duct, and common bile duct resection and hepatoduodenal ligament lymph node dissection) combined with left hepatic and caudate lobe resection/portal resection. …”
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Oxygenation and function of endocrine bioartificial pancreatic tissue constructs under flow for preclinical optimization by Brenden N Moeun, Florent Lemaire, Alexandra M Smink, Hamid Ebrahimi Orimi, Richard L Leask, Paul de Vos, Corinne A Hoesli

“…These results were achieved through intraportal infusion which leads to early graft losses and limits the capacity to contain and retrieve implanted cells in case of adverse events. Extra-hepatic sites and encapsulation devices have been developed to address these challenges and potentially create an immunoprotective or immune-privileged environment. …”
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High-grade liver injury: outcomes with a trauma surgery–liver surgery collaborative approach by J Wallis Marsh, Abhinav Humar, Jason L Sperry, David A Geller, Deepika Mohan, Timothy R Billiar, Juan Carlos Puyana, Brian Zuckerbraun, Joshua B Brown, Matthew D Neal, Matthew R Rosengart, David Newhouse, Christine Leeper, Andrew B Peitzman, Raquel Forsythe, Rafael G Ramos-Jimenez, Andrew-Paul Deeb, Evelyn I Truong, Sowmya Narayanan, Louis Alarcon, Graciela M Bauza, Vaishali Dixit Schuchert, Gregory Watson, Amit D Tevar

“…Procedures at the initial operation included hepatorrhaphy±packing (66.4%), nonanatomic resection (5.6%), segmentectomy (9.3%), and hepatic lobectomy (7.5%). Thirty-day mortality in the OM group was substantially lower than prior reports (23.4%). …”
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A soy glycinin derived octapeptide protects against MCD diet induced non-alcoholic fatty liver disease in mice by Peng Ma, Rongrong Huang, Yu Ou

“…In vivo, SGP8 lowered plasma alanine aminotransferase (ALT) and low density lipoprotein (LDL) content, normalized hepatic superoxide dismutase (SOD) and malondialdehyde (MDA) production, and reduced the severity of liver inflammation. …”
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Sm10.3, a member of the micro-exon gene 4 (MEG-4) family, induces erythrocyte agglutination in vitro and partially protects vaccinated mice against Schistosoma mansoni infection. by Vicente P Martins, Suellen B Morais, Carina S Pinheiro, Natan R G Assis, Barbara C P Figueiredo, Natasha D Ricci, Juliana Alves-Silva, Marcelo V Caliari, Sergio C Oliveira

“…The protective effect conferred by vaccination with rSm10.3 was demonstrated by 25.5-32% reduction in the worm burden, 32.9-43.6% reduction in the number of eggs per gram of hepatic tissue, a 23.8% reduction in the number of granulomas, an 11.8% reduction in the area of the granulomas and a 39.8% reduction in granuloma fibrosis.…”
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Ameliorated Impact of Fenugreek Seed Extract on Some Blood Cellular and Biochemical Parameters in Female Albino Rats Exposed to Lead Acetate by Rozhya Abduljalil Naser, Rabar Yousif Mameik, Nazar M. Shareef Mahmood, Kurdo Bapir Chato

“…It has a several diverse-organ toxicant effect in various healthy issues included diseases of the hepatic, renal, and other body systems. Fenugreek seeds (Trigonella foenum graecum L.) were used in curing medicine and as food supplement since ancient times. …”
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Effects of Dietary Resveratrol, Bile Acids, Allicin, Betaine, and Inositol on Recovering the Lipid Metabolism Disorder in the Liver of Rare Minnow Gobiocypris rarus Caused by Bisph... by Yingying Zhang, Yinan Jiang, Ziying Wang, Jiayu Wang, Mingzhen Zhu, Hui Yang

“…The liver morphology, hepatosomatic index (HSI), hepatic lipid deposition, TG level, and expression of lipid metabolism-related genes were analyzed after 5 weeks of feeding. …”
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Deaths during Sexual Activity by Agnė Okulevičiūtė, Sigitas Chmieliauskas, Sigitas Laima, Diana Vasiljevaitė, Jurgita Stasiūnienė

“…Concurrent findings included atherosclerotic changes in the heart, internal organ hyperemia and edema, hepatic steatosis, renal cyst, and a lack of ethyl alcohol in blood but 0.17 ‰ presence in urine according to toxicology analysis. …”
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The Effect of Puncture Sites of Portal Vein in TIPS with ePTFE-Covered Stents on Postoperative Long-Term Clinical Efficacy by Si-liang Chen, Peng Hu, Zhi-peng Lin, Jian-bo Zhao

“…The Kaplan-Meier analysis was performed to assess the effect of different puncture sites on primary patency, the incidence of hepatic encephalopathy (HE), and survival. Results. …”
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Investigating the Effect of 8 Weeks of Endurance Training on the Levels of Inflammatory Markers (IL-6/TNF-α) and Some Metabolic Parameters in Male Rats with Nonalcoholic Fatty Live... by Vahid Kazemizadeh, Amirabbas Monazzami, Fakhredin Saba, Andrew J McAinch

“…Results: The results of the present study showed that as a result of a high-fat diet with liquid fructose in HFD+HF group rats, non-alcoholic fatty liver disease (NAFLD) with complications such as a significant increase in the levels of IL-6 and TNF-α, Hepatic dysfunction, and metabolic parameters were disturbed (p<0.001). …”
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Association between Smoking and Liver Fibrosis among Patients with Nonalcoholic Fatty Liver Disease by Hongjie Ou, Yaojie Fu, Wei Liao, Caixia Zheng, Xiaolu Wu

“…We aimed at analyzing the role of smoking in hepatic fibrosis in patients with nonalcoholic fatty liver disease (NAFLD) and at exploring the related risk factors. …”
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The Effects of Different Insufflation Pressures on Liver Functions Assessed with LiMON on Patients Undergoing Laparoscopic Cholecystectomy by H. Barıs Eryılmaz, Dilek Memiş, Atakan Sezer, Mehmet Turan Inal

“…Laparoscopic cholecystectomy has been accepted as an alternative to laparotomy, but there is still controversy regarding the effects of pneumoperitoneum on splanchnic and hepatic perfusion. We assessed the effects of different insufflation pressures on liver functions by using indocyanine green elimination tests (ICG-PDR). …”
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Anti-Obesity Effects of Arum maculatum, Nasturtium officinale Plant Extracts and Exercise in High Fat Diet-Induced Obese Rats by Zana Hassan Ibrahim

“…Conclusions: Consumption of HFD for 8 weeks caused HFD-C rats obese, hyperglycemic and hyperlipidemic with hepatic cellular injury when compared to the NC rats. …”
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The Effect of Mesenchymal Stem Cell-Derived Exosomes and miR17-5p Inhibitor on Multicellular Liver Fibrosis Microtissues by Farnaz Sani, Mina Soufi Zomorrod, Negar Azarpira, Masoud Soleimani

“…Here, we aimed to develop a fibrotic liver microtissue composed of hepatocytes, hepatic stellate, and endothelial cells. In addition, the therapeutic effects of umbilical cord mesenchymal stem cell-derived exosomes (UC-MSC-EXO) and anti-miR17-5p as new antifibrotic drugs were investigated. …”
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Real-world safety of linaclotide in Chinese patients with irritable bowel syndrome with constipation: a multicenter, single-arm, prospective observational study by Yinglian Xiao, Xianmei Meng, Qingfeng Luo, Xiaohua Hou, Jie Jin, Xianfei Zhong, Wei Gong, Xiuling Li, Minhu Chen

“…Fifty-one (1.7%) and 70 patients (2.4%) interrupted and discontinued treatment due to AEs, respectively. One patient died of hepatic cancer, which was considered unrelated to linaclotide treatment. …”
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