Evaluation of antidiabetic potential, cardio, pancreatic, nephroprotective effect, and herb-herb-drug interaction of Madhukiran formulations in T2 diabetic rats by Vrushabh S. Kondalkar, Pranali P. Polshettiwar, Ganesh B. Choudhari, Anil T. Pawar, Vishnu P. Choudhari

“…Herb-herb interactions (HHI), and herb-drug interactions (HDI) along with antidiabetic, cardio, hepatic, pancreatic, and nephroprotective effects of Madhukiran Formulations (MFs) were studied on STZ-NA-induced T2D rats. …”
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Ex vivo delivery of recombinant IL-10 to human donor lungs by Jonathan C. Yeung, Terumoto Koike, Dirk Wagnetz, Tiago N. Machuca, Riccardo Bonato, Mingyao Liu, Stephen Juvet, Marcelo Cypel, Shaf Keshavjee

“…Because isolation of the donor lung on the ex vivo lung perfusion (EVLP) circuit removes it from the influence of renal and hepatic clearance mechanisms, a much-prolonged half-life of IL-10 is anticipated. …”
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Beneficial Effects of Apple Vinegar on Hyperglycemia and Hyperlipidemia in Hypercaloric-Fed Rats by Driss Ousaaid, Hassan Laaroussi, Meryem Bakour, Asmae ElGhouizi, Abderrazak Aboulghazi, Badiaa Lyoussi, Ilham ElArabi

“…The treatment during five weeks with D-glucose leads to increased plasma glucose, lipid profile, hepatic enzyme levels, urea, and creatinine. Simultaneous treatment with apple vinegar improves the parameters studied. …”
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Tangduqing Granules Attenuate Insulin Resistance and Abnormal Lipid Metabolism through the Coordinated Regulation of PPARγ and DGAT2 in Type 2 Diabetic Rats by Qinghua Zhang, Yingying Huang, Xiaojin Li, Hongyi Liu, Baichuan He, Bin Wang, Yuntao Ma, Xiang Zhou, Yaqin Liu, Shentao Wu

“…Besides, TDQ regulated hyperlipidemia symptoms, decreased serum lipid levels and liver TG, and reduced hepatic steatosis in a type 2 diabetic rat model. …”
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A “Catastrophic” Heparin-Induced Thrombocytopenia by D. Barcellona, M. Melis, G. Floris, A. Mameli, A. Muroni, G. Defazio, F. Marongiu

“…The thrombotic burden was very impressive involving the arterial and venous cerebral vessel and the venous pulmonary, hepatic, and inferior legs vascular beds. The patient was successfully treated with fondaparinux without recurrent thrombosis or bleeding. …”
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Targeting protein kinase C-α prolongs survival and restores liver function in sepsis: Evidence from preclinical models by Ling Xiong, Dustin Beyer, Na Liu, Tina Lehmann, Sophie Neugebauer, Sascha Schaeuble, Oliver Sommerfeld, Philipp Ernst, Carl-Magnus Svensson, Sandor Nietzsche, Sebastian Scholl, Tony Bruns, Nikolaus Gaßler, Markus H. Gräler, Marc Thilo Figge, Gianni Panagiotou, Michael Bauer, Adrian T. Press

“…Organ dysfunction includes hepatic involvement, weakening the immune system due to excretory liver failure, and metabolic dysfunction, increasing the death risk. …”
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Nile tilapia juveniles reared at cold suboptimal water temperatures do not benefit from dietary supplementation with cholesterol by Jorge Filipe Banze, Renata Oselame Nobrega, Bruna Mattioni, Bianca Leticia Richter, Katharinne Ingrid Moraes de Carvalho, Jacó Joaquim Mattos, Maria Risoleta Freire Marques, James Eugene Pettigrew, Débora Machado Fracalossi

“…Increasing dietary cholesterol supplementation did not affect growth but affected lipid metabolism resulting in increased body and hepatic cholesterol deposition. Additionally, in plasma, we registered an increase in cholesterol and non-HDL lipoproteins but a decrease in the triacylglycerols. …”
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Multi-tissue network analysis reveals the effect of JNK inhibition on dietary sucrose-induced metabolic dysfunction in rats by Hong Yang, Cheng Zhang, Woonghee Kim, Mengnan Shi, Metin Kiliclioglu, Cemil Bayram, Ismail Bolar, Özlem Özdemir Tozlu, Cem Baba, Nursena Yuksel, Serkan Yildirim, Shazia Iqbal, Jihad Sebhaoui, Ahmet Hacımuftuoglu, Matthias Uhlen, Jan Boren, Hasan Turkez, Adil Mardinoglu

“…In this study, we challenged rats with sucrose-sweetened water and investigated the potential effects of JNK inhibition by employing network analysis based on the transcriptome profiling obtained from hepatic and extrahepatic tissues, including visceral white adipose tissue, skeletal muscle, and brain. …”
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Sodium alginate ameliorates health in freshwater fish through gut-liver axis modulation under high carbohydrate diets by Wenlu Zhu, Huilin Zhang, Haitao Pan, Hao Zeng, Wenjun Wang, Yunfeng Liu, Zirui Wang, Qiubai Zhou, Chuanqi Yu

“…Then our outcomes evinced that LA improves various health-related parameters, including reduction of hepatosomatic index (HSI), serum glucose, triglycerides, and aminotransferase levels, as well as the decrease in hepatic lipid droplets, glycogen, and collagen fiber content. …”
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Single-cell transcriptomic analysis reveals characteristic feature of macrophage reprogramming in liver Mallory-Denk bodies pathogenesis by Zixuan Fang, Bei Zhong, Yi Shi, Wanmei Zhou, Maoping Huang, Samuel W. French, Xiaoping Tang, Hui Liu

“…Mallory-Denk bodies (MDBs) are protein aggregates associated with hepatic inflammation, and MDBs pathogenesis could be induced in mice by feeding 3,5-diethoxycarbonyl-1,4-dihydrocollidine (DDC). …”
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3-Hydroxybutyrate alleviates septic liver injury by promoting macrophage polarization from M1 to M2 by Hu Jingjuan, Deng Fan, Sun Qishun, Min Yue, Feng Siyuan, Wu Ling, Chen Xiaofeng, Liu Kexuan

“…The survival rate, liver histopathological damage, serum levels of Alanine Transaminase(ALT) and Aspartate Aminotransferase(AST), and hepatic mRNA expression of inflammatory cytokines IL-1β and IL-6 were evaluated. …”
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The Cytotoxicity Assessment of Grapefruit Peel Essential Oil and Its Effect on Frying Stability of Sunflower Oil by Ghania Kaanin-Boudraa, Fatiha Brahmi, Linda Grimaud, Mohamed Lamine Freidja, Ourdia-Nouara Kernou, Daniel Henrion, Samir Hadjal, Khodir Madani, Lila Boulekbache-Makhlouf

“…Various EO concentrations (0.01-0.5 mg/ml) were added to cultured cells Human Umbilical Vein Endothelial Cells (HUVECs) and Human Stellar Hepatic Cell lines LX-2 (SCC064) and incubated for 24 and 48 h. …”
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SF1-specific deletion of the energy sensor AMPKγ2 induces obesity by Óscar Freire-Agulleiro, Ánxela Estévez-Salguero, Vitor Ferreira, Cassie Lynn Holleman, Julia García-Currás, Ismael González-García, Rubén Nogueiras, Manuel Tena-Sempere, Cristina García-Cáceres, Carlos Diéguez, Miguel López

“…Additionally, SF1-Cre AMPKγ2 mice exhibit hepatic lipid accumulation, but surprisingly maintain normal glucose homeostasis. …”
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Extrapolating Prognostic Factors of Primary Curative Resection to Postresection Recurrences Hepatocellular Carcinoma Treatable by Radiofrequency Ablation by Hui Ma, Zhongchen Li, Jia Yuan, Lan Zhang, Xiaoying Xie, Xin Yin, Rongxin Chen, Zhenggang Ren

“…After a median follow-up of 36 months, 54 patients died, and 128 patients had hepatic recurrence. On univariate analyses, patients whose primary tumors were less differentiated (p=0.032 and p=0.048) and required less time to recur (p=0.013 and p=0.001) after curative resection displayed poorer overall survival and higher recurrence rates following RFA. …”
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Impact of long-term cyanotoxin exposure on cattle: Biochemical, histological, and oxidative stress assessment by Mounira Bensalem, Amina Amrani, Hadjer Zaidi, Fateh Sedrati, Omar Laouar, Zhi Wang, Hichem Nasri

“…Results: Exposed cattle exhibited significant elevations in liver enzymes and oxidative stress markers, indicating hepatic inflammation and redox imbalance. Histological analysis revealed macrovacuolar steatosis, fibrosis, and bile duct dilatation. …”
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Targeting immune cellular populations and transcription factors: unraveling the therapeutic potential of JQF for NAFLD by Lijuan Zhou, Jingyi Zhao, Kaile Ma, Rui Hao, Chensi Yao, Xiaowen Gou, Chuanxi Tian, Li Wan, Min Li, Xiaolin Tong

“…Single-cell RNA sequencing and spatial transcriptomics furthered our understanding of NAFLD pathophysiology and JQF’s treatment mechanisms.ResultsOur findings initially revealed significant improvements in JQF on hepatic steatosis, inflammation, fibrosis and glucose tolerance in NAFLD mice. …”
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From gut to liver: Exploring the crosstalk between gut-liver axis and oxidative stress in metabolic dysfunction-associated steatotic liver disease by Mi Zhou, Jianyu Lv, Xinli Chen, Yujie Shi, Guanqun Chao, Shuo Zhang

“…As our comprehension of MASLD deepens, it has become evident that this condition extends beyond the liver, embodying a complex, multi-systemic disease with hepatic manifestations that mirror the broader metabolic landscape. …”
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NMR metabolic profiling of the liver following administrationof alcohol andthemushroom Ganoderma lucidum in rats by M. S. Krestina, O. B. Shevelev, I. V. Koptyug, L. A. Gerlinskaya, S. E. Peltek, A. E. Akulov

“…Binuclear hepatocytes indicate proliferative activity, and the concentration of the metabolites participating in the formation of new hepatic cells decreases. Thus, the study of liver tissues by 1H NMR spectroscopy allows for detection of early changes in metabolite concentra­tions following chronic consumption of alcohol at insignificant doses. …”
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Effects of dietary supplementation with novel organic rare earths on growth performance, gut and liver health, gut microbiota in golden pompano by Ming Li, Hui Liang, Rui Xia, Jian Zhang, Jie Chen, Wenhao Zhou, Qianwen Ding, Yalin Yang, Zhen Zhang, Yuanyuan Yao, Chao Ran, Zhigang Zhou

“…Meanwhile, dietary supplementation of novel organic rare earths alleviated liver inflammation by decreasing the expression of hepatic pro-inflammatory cytokines and elevating that of anti-inflammatory cytokines. …”
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Complement 3a receptor 1 on macrophages and Kupffer cells is not required for the pathogenesis of metabolic dysfunction-associated steatotic liver disease by Edwin A Homan, Ankit Gilani, Alfonso Rubio-Navarro, Maya A Johnson, Odin M Schaepkens, Eric Cortada, Renan Pereira de Lima, Lisa Stoll, James C Lo

“…Overall, C3aR1-MφKO and C3aR1-KpKO mice have similar body weight gain without significant alterations in glucose homeostasis, hepatic steatosis and fibrosis, compared to controls on a MASLD-inducing diet. …”
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