Characterization and ameliorative effects of Chenopodium murale hydroethanolic extract against diethylnitrosamine-induced hepato-renal damage and malfunction by Howida S. Abou- Seif, Osama M. Ahmed, Samah A. El-Newary, Marwa E. Shabana, Mahitab I. EL-Kassaby, Ghada M. Elqattan, Hussein G. Sawie

“…Also, lipid peroxidation and nitric oxide were elevated markedly. DEN lowered the hepatic and renal activities of endogenous antioxidants (CAT and SOD), reduced glutathione (GSH) level. …”
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Cardiac-Specific Gene Expression Facilitated by an Enhanced Myosin Light Chain Promoter by Wolfgang Boecker, Oliver Y. Bernecker, Joseph C. Wu, Xinsheng Zhu, Tomohiro Sawa, Luanda Grazette, Anthony Rosenzweig, Federica del Monte, Ulrich Schmidt, Roger J. Hajjar

“…Results: In vitro: By infecting hepatic versus cardiomyocyte cells, we found that the promoter specificity ratio (luc activity in cardiomyocytes per liver cells) was 20.4 versus 0.9 (Ad.4 × MLC 250 .Luc vs. …”
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Correlation of sarcopenia with progression of liver fibrosis in patients with metabolic dysfunction-associated steatotic liver disease: a study from two cohorts in China and the Un... by Fan Zhang, Longgen Liu, Wenjian Li

“…Liver controlled attenuation parameters (CAP) and liver stiffness measurements (LSM) were assessed by vibration-controlled transient elastography (VCTE) to evaluate the extent of hepatic steatosis and fibrosis. Sarcopenia was assessed by measuring appendicular skeletal muscle mass (ASM) and calculating ASMI. …”
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Two faces of the same coin non alcoholic fatty liver disease; with and without diabetes: Comparative clinico pathological analysis: A cross sectional observational study by Syed Mushfiq, Ghulam Nabi Yatoo, Bilal Ahmad Mir, Zubaida Rasool

“…Background and Aim: Non-alcohol fatty liver disease (NAFLD) is a metabolic disorder that represents the hepatic manifestation of systemic process, and is a strong risk factor for diabetes Meletus, whereas the presence of DM increases the severity of NAFLD/NASH and its progression. …”
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Golgi protein 73: charting new territories in diagnosing significant fibrosis in MASLD: a prospective cross-sectional study by Shan Hong, Ziyu Liu, Ping Li, Jing Zhang, Hongshan Wei

“…ObjectivesTo explore the correlation between serum Golgi protein 73 (GP73) levels and the degree of fibrosis in Metabolic dysfunction associated steatotic liver disease (MASLD); to establish a non-invasive diagnostic algorithm based on serum GP73 and liver elasticity.MethodsThis is a prospective cross-sectional study, including 228 patients diagnosed with MASLD from May 2018 to January 2024 at two tertiary hospitals. Clinical data and hepatic pathological features and the correlation between serum GP73 and liver fibrosis were assessed. …”
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Characteristics and Cluster Analysis of 18,030 Sepsis Patients Who Were Admitted to Thailand’s Largest National Tertiary Referral Center during 2014–2020 to Identify Distinct Subty... by Phuwanat Sakornsakolpat, Surat Tongyoo, Chairat Permpikul

“…Clusters H3 and H5 had younger ages and significant hepatic dysfunction. Cluster H5 had multiple organ dysfunctions, and a higher proportion of cluster H5 patients required vasopressor, mechanical ventilation, and renal replacement therapy. …”
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A comprehensive review of remimazolam for sedation by Nazir Noor, Rhorer Legendre, Alexandra Cloutet, Ahish Chitneni, Giustino Varrassi, Alan D. Kaye

“…The drug's ester moiety makes it a substrate for non-specific tissue esterase enzymes, meaning its metabolism and elimination are not impaired in patients with hepatic and/or renal disease. Its addictive potential closely resembles that of its parent compound, midazolam. …”
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Genome-wide association study of the fatty liver index in the Taiwanese population reveals shared and population-specific genetic risk factors across ethnicities by Pei Pei Lau, Chun-Yu Wei, Min-Rou Lin, Wan-Hsuan Chou, Yu-Jui Yvonne Wan, Wei-Chiao Chang

“…Pathway analysis of GWAS significant genes revealed that lipid metabolism and the peroxisome proliferator-activated receptor (PPAR) signaling pathway are causes of hepatic fat accumulation. Conclusion This study identified six independent NAFLD-associated variants in GCKR, LPL, TRIB1AL, and FTO and emphasized ZPR1 and FTO as shared risk genes for FLI-defined FLD in both Taiwanese and European populations. …”
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Association between Serum Uric Acid to HDL-Cholesterol Ratio and Nonalcoholic Fatty Liver Disease in Lean Chinese Adults by Ya-Nan Zhang, Qin-Qiu Wang, Yi-Shu Chen, Chao Shen, Cheng-Fu Xu

“…NAFLD was diagnosed based on hepatic ultrasound examination, with exclusion of other etiologies. …”
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Improvement of surgical treatment of an acute biliary pancreatitis at elderly and senile patients by V. I. Midlenko, A. L. Charyshkin, O. V. Midlenko, I. I. Midlenko, V. Yu. Shchegolev

“…To estimate various variants of surgical treatment of acute biliary pancreatitis at patients of over 60 years old, to develop a method of cholecystectomy at the large Hartmann pouch adherent to biliary tracts, to decrease such complications, as bleeding, bile leakage, damage (intersection) of common bile or common hepatic duct.Material and methods. Patients separated into 3 groups in relation to operative access. …”
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The Gut Microbiota-Related Antihyperglycemic Effect of Metformin by Izabela Szymczak-Pajor, Józef Drzewoski, Małgorzata Kozłowska, Jan Krekora, Agnieszka Śliwińska

“…The drug primarily inhibits hepatic gluconeogenesis and increases the sensitivity of target cells (hepatocytes, adipocytes and myocytes) to insulin; however, increasing evidence suggests that it may also influence the gut. …”
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The Long Noncoding RNA LOXL1-AS1 Promotes the Proliferation, Migration, and Invasion in Hepatocellular Carcinoma by Jiang Liu, Chengtong Zhai, Degan Liu, Jianhua Liu

“…In the present study, we observed that the expression level of LOXL1-AS1 in hepatocellular carcinoma tissue was significantly higher than that in adjacent nontumor tissues, and its expression in three hepatic carcinoma cell lines was obviously higher than that in a normal cell line. …”
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Supplemental technologies of liver ultrasound investigation at the 1-st type tyrosinemia in pediatrics by G. M. Dvoryakovskaya, S. A. Ivleva, I. V. Dvoryakovsky, S. I. Polyakova

“…To carry out objective estimation of liver parenchyma state in children with the 1-st type hereditary tyrosinemia (НТ-1) by ultrasound method with quantitative estimation of hepatic parenchyma pattern.Material and methods. Overall 14 children with the 1-st type tyrosinemia aged 3 months to 14 years (6 — with acute and subacute forms and 8 — with chronic form) were studied. …”
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Immunohistochemistry for (Pro)renin Receptor in Humans by Satoshi Morimoto, Noriko Morishima, Daisuke Watanabe, Yoichiro Kato, Noriyuki Shibata, Atsuhiro Ichihara

“…It was observed in thyroid follicular epithelial cells, hepatic cells, pancreatic duct epithelial cells, zona glomerulosa and zona reticularis of the cortex and medulla of the adrenal gland, proximal and distal tubules and collecting ducts of the kidney, cardiomyocytes, and skeletal muscle cells. …”
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Results of a Randomized, Open-Label, Clinical Trial Investigating the Effects of Supplementation with Heracleum persicum Extract as an Adjunctive Therapy for Dyslipidemia by Yunes Panahi, Bahram Pishgoo, Fatemeh Beiraghdar, Zahra Mohammadi Araghi, Amirhossein Sahebkar, Ehsan Abolhasani

“…Weight, body mass index (BMI), lipid profile, and biomarkers of hepatic and renal injury were determined at baseline and at the end of the trial. …”
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CCN3: lactational bone booster by Nathan Xu, Kyle Yang, Mengjie Wang

“…Using a comprehensive set of parabiosis coupled with in vivo µCT, bone transplant studies, cell culturing and differentiation assays, mouse genetic models, pharmacologic interventions, hepatic viral transduction, and sequencing analysis, a recent study discovered that cellular communication network factor 3 (CCN3), derived from ARHERα/Kiss1 neurons, functions as an osteogenic hormone to sustain bone formation and progeny survival during lactation. …”
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Effects of Low or High Dosages of Dietary Sodium Butyrate on the Growth and Health of the Liver and Intestine of Largemouth Bass, Micropterus salmoides by Yiyang Ge, Shibin Yao, Ye Shi, Chunfang Cai, Chengrui Wang, Ping Wu, Xiamin Cao, Yuantu Ye

“…The size of hepatocytes was enlarged, and the intracellular lipid droplets and the degree of hepatic fibrosis were increased in the SB20 group compared to the CON group. …”
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Association between Monocyte to High-Density Lipoprotein Cholesterol Ratio and Nonalcoholic Fatty Liver Disease: A Cross-Sectional Study by Hangkai Huang, Qinqiu Wang, Xiaoying Shi, Yishu Chen, Chao Shen, Juanwen Zhang, Chengfu Xu

“…We performed the anthropometric and laboratory measurements and diagnosed NAFLD by hepatic ultrasonography without evidence of other etiologies of chronic liver disease. …”
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Visceral Adipose Tissue Inflammation and Vascular Complications in a Rat Model with Severe Dyslipidemia: Sex Differences and PAI-1 Tissue Involvement by Irena Markova, Martina Hüttl, Natalie Gayova, Denisa Miklankova, Kristyna Cerna, Martina Kavanova, Petra Skaroupkova, Sona Cacanyiova, Hana Malinska

“…Using male and female hereditary hypertriglyceridemic (HHTg) rats—a nonobese prediabetic model featuring dyslipidemia, hepatic steatosis, and insulin resistance—we found that HHTg females exhibited more pronounced hypertriglyceridemia than males, while HHTg males had higher non-fasting glucose levels. …”
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Augmented Reality-Assisted Pancreaticoduodenectomy with Superior Mesenteric Vein Resection and Reconstruction by Rui Tang, Wei Yang, Yucheng Hou, Lihan Yu, Guangdong Wu, Xuan Tong, Jun Yan, Qian Lu

“…Intraoperative AR applications displayed virtual images of the pancreas, SMV, bile duct, common hepatic artery (CHA), and superior mesenteric artery (SMA). …”
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