Downregulation of PGC-1α Prevents the Beneficial Effect of EET-Heme Oxygenase-1 on Mitochondrial Integrity and Associated Metabolic Function in Obese Mice by Shailendra P. Singh, Lars Bellner, Luca Vanella, Jian Cao, John R. Falck, Attallah Kappas, Nader G. Abraham

“…We postulate that EETs attenuate adiposity by stimulating mitochondrial function and induction of HO-1 via activation of PGC-1α in adipose and hepatic tissue. Methods. Cultured murine adipocytes and mice fed a high fat (HF) diet were used to assess the functional relationship among EETs, PGC-1α, HO-1, and mitochondrial signaling using an EET-agonist (EET-A) and PGC-1α-deficient cells and mice using lentiviral PGC-1α(sh). …”
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Local control and recurrence patterns after stereotactic irradiation delivered in more than 4 fractions for hepatocellular carcinomas and liver metastases: a retrospective study by Alizée Renan, Marie Bruand, Maria Jolnerovski, Aboubacar Diallo, Nicolas Demogeot

“…This study evaluated LC and recurrence patterns in patients administered hepatic SBRT in more than 4 fractions due to dosimetric constraints. …”
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Association between non-high-density lipoprotein cholesterol to high-density lipoprotein cholesterol ratio and telomere length: the NHANES 1999–2002 by Mingjie Liu, Chendong Wang, Bai Wei

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A real-world drug safety surveillance study from the FAERS database of hepatocellular carcinoma patients receiving pembrolizumab alone and plus lenvatinib by Huaxiang Wang, Junjun Li, Xiuling Zhu, Ruling Wang, Yunyan Wan

“…In both patient groups, the most frequently reported AEs were hepatic encephalopathy, blood bilirubin increased and diarrhea. …”
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Clinical and diagnostic study of ovine chronic progressive pneumonia (Maedi-Visna) in sheep of Basrah, Iraq by Kamal M. AlSaad, Ali J. Lafta, Mohand H. Lafta, Jihad A. Ahmed

“…Moreover, Early fiberoptic lesion refers to the stage of red hepatization of pneumonia besides many inflammatory cells, and erythrocyte infiltration in the alveolar spaces was also recognized. …”
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The Role of PPARs in Lung Fibrosis by Heather F. Lakatos, Thomas H. Thatcher, R. Matthew Kottmann, Tatiana M. Garcia, Richard P. Phipps, Patricia J. Sime

“…PPARα agonists, including the hypolidipemic fibrate drugs, inhibit the production of collagen by hepatic stellate cells and inhibit liver, kidney, and cardiac fibrosis in animal models. …”
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Therapeutic Decision Making in Hepatocellular Carcinoma According to Age and Child–Pugh Class: A Nationwide Cohort Analysis in South Korea by Sunmin Park, Chai Hong Rim, Young Kul Jung, Won Sup Yoon

“…After excluding distant and lymphatic metastases, the treatment preference for patients with a single lesion (excluding PVT (portal vein thrombosis), hepatic vessels, and bile duct invasion) and with PVT was evaluated in 7559 patients. …”
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Dietary Pyridoxine Requirements of Coho Salmon (Oncorhynchus kisutch) Post-Smolts by Hairui Yu, Xinyue Zhang, Ziyi Yuan, Leyong Yu, Youzhi Zhao, Lingyao Li

“…The gradient pyridoxine levels did not yield any statistically (P>0.05) significant impact on the whole-body composition including moisture, ash, crude lipid, and crude protein. The hepatic pyridoxine concentration, aspartate aminotransferase (AST), and alanine aminotransferase (ALT) activities increased significantly with dietary pyridoxine levels increasing from 0.32 to 4.08 mg/kg (P<0.05) and plateaued after that (P>0.05). …”
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Insulin resistance as a mediator in the association between nickel exposure and metabolic dysfunction-associated steatotic liver disease by Zhou Liu, Liang Zhang, Yanrui Wu, Zongbiao Tan, Guang Li, Zhenwen Li, Liying Zhan, Weiguo Dong

“…Methods The data utilized in this study was sourced from the National Health and Nutrition Examination Survey 2017–2020. Hepatic steatosis was evaluated utilizing controlled attenuation parameters (CAP), and nickel exposure level was reflected by urinary nickel concentration. …”
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Anatomical and three-dimensional study of the abdominal vascular system in female rabbit using dissections and ultrasound by Aya A. Sulaiman, Rabab A. Naser, Ramadan A. Ahmed

“…The results showed that the mean hepatic artery diameter for 1-1.5 kg was 0.25&plusmn;0.04 cm while for 1.5-2 kg it was 0.37&plusmn;0.07, and the mean renal artery diameter for 1-1.5 kg was 0.20&plusmn;0.03 cm while for 1.5-2 kg it was 0.25&plusmn;0.04. …”
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Insights into the toxic impact of long-term exposure to diethyl phthalate on commercially important species Catla (Labeo catla) by Satabdi Ganguly, Basanta Kumar Das, Anupam Adhikari, Subir Kumar Nag

“…This led to an increase in circulating sex steroids E2 (41.62%) and 11 KT (24.59%) and eventually triggered hepatic Vtg production (23.90%) in a dose-dependent manner. …”
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Влияние курсового приема L-орнитин- L-аспартата на фиброз и стеатоз печени у больных ассоциированной с нарушениями метаболизма жировой болезнью печени (неалкогольной жировой болезн... by Е. V. Garanina

“…MAFLD-hyperammonaemic patients also had the significantly higher male ratio, type 2 diabetes and severer hepatic steatosis rates vs. hyperammonaemia-negative MAFLD individuals. …”
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Differences in Clinical and Imaging Features between Asymptomatic and Symptomatic COVID-19 Patients by Xi Ma, Zhi-Yan Lu, Yan-Juan Qu, Li-Hong Xing, Yu Zhang, Yi-Bo Lu, Li Dong, Hong-Jun Li, Li Li, Xiao-Ping Yin, Chuan-Jun Xu

“…The bulk of asymptomatic carriers who developed symptoms and most of the COVID-19 patients were older than 18 years of age with a decreased lymphocyte count, abnormal hepatic and renal function, and increased D-dimer and C-reactive protein. …”
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Comparative Study on the Effects of Four Plant Protein Sources on the Liver and Intestinal Health of Largemouth Bass, Micropterus salmoides by Shibin Yao, Wenjian Li, Chunfang Cai, Chengrui Wang, Jia Kang, Honglin Hu, Ping Wu, Xiamin Cao, Yuantu Ye

“…Morphology and histology showed reduced liver size, hepatic steatosis, and fibrosis in fish fed diets containing PPS. …”
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Effect of Liraglutide on Serum TSH Levels in Patients with NAFLD and its Underlying Mechanisms by JiaoJiao Ye, Jing Xu, WenJie Wen, Bin Huang

“…In conclusion, liraglutide improves hepatic thyroid hormone resistance in T2DM with NAFLD, and restoration of impaired TRβ expression in NAFLD is a potential mechanism involved in the process of liraglutide therapy.…”
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Pathological effects of pregabalin toxicity in rats by Roaa Salih Mahdi, Nawras Najah, Sura Salman Ejam

“…Hemorrhages, congestion of portal region blood vessels, and central veins and hepatic sinusoids were some of the most notable pathological abnormalities seen in the livers of those using PGB. …”
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Antioxidative and hepatoprotective activities of a novel polysaccharide (LSAP) from Lepista sordida mycelia by Yingyin Xu, Yuanhui Li, Yuxiao Lu, Xiaobin Feng, Guoting Tian, Qinghong Liu

“…Administration of LSAP in mice prior to CCl4 significantly prevented the CCl4-induced elevation in serum alanine aminotransferase, aspartate aminotransferase, and hepatic malondialdehyde. Mice treated with LSAP demonstrated to increase activities in superoxide dismutase (SOD) and glutathione peroxidase (GSH-Px) in the liver. …”
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The role of inflammasomes in hepatocellular carcinoma: Mechanisms and therapeutic insights by Valentina Arrè, Roberto Negro, Gianluigi Giannelli

“…The tumor microenvironment is crucial for the progression of HCC, as immune cells, tumor-associated fibroblasts and hepatic stellate cells interact to promote chronic inflammation and tumor spread. …”
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Discussion on the Mechanism of Gandoufumu Decoction Attenuates Liver Damage of Wilson’s Disease by Inhibiting Autophagy through the PI3K/Akt/mTOR Pathway Based on Network Pharmacol... by Lulu Tang, Chenling Zhao, Jing Zhang, Ting Dong, Huaizhen Chen, Taohua Wei, Jiuxiang Wang, Wenming Yang

“…GDFMD effectively attenuated serum liver enzymes, oxidative stress, autophagy, and degree of hepatic histopathological impairment and reduced serum copper content. …”
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Investigation of the histopathological effects of increasing amounts of peppermint oil (mentha piperita) added to quail (coturnix coturnix japonica) feed as a growth promoter on li... by Mustafa Ünal Boyraz, Muhammet Bahaeddin Dörtbudak, Besime Daş, Akın Yiğin, Mehmet Şevki Çadırcı, Aydın Daş

“…A small amount of inter lobuler interstitium and consequently the triple structure (trias hepatica) expected to coexist in the hepatic lobes, contrary to what is known, was scattered. …”
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