Naringenin inhibits lipid accumulation by activating the AMPK pathway in vivo and vitro by Xiaoyu Cai, Songxue Wang, Huali Wang, Suwen Liu, Guishan Liu, Huibin Chen, Ji Kang, Hao Wang

“…Naringenin also alleviated hepatic steatosis and reduced the adipocyte size in the epididymis in high-fat-diet-induced SD rats. …”
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Real-Life Report on Chemoembolization Using DEBIRI for Liver Metastases from Colorectal Cancer by M. Stutz, A. Mamo, D. Valenti, A. Hausvater, T. Cabrera, P. Metrakos, P. Chaudhury, G. Steacy, E. Garoufalis, P. Kavan

“…Beads were delivered selectively into hepatic arteries. Primary endpoint was overall survival (OS), analyzed using the Kaplan-Meier method. …”
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Cystic Echinococcosis/Hydatid Cyst Coinfection with HIV: A Report from Shiraz, Iran by Yosef Sharifi, Seyed Mahmoud Sadjjadi, Hamed Nikoupour Dailami, Seyed Hamed Jafari, Mohammad Hossein Anbardar, Mohammad Bagher Khosravi

“…Ultrasound showed three large hepatic hydatid cysts with hundreds of daughter cysts. …”
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α₁-Acid Glycoprotein with Highly Fucosylated Glycans as a Potential Diagnostic Marker for Early Detection of Hepatobiliary and Pancreatic Cancers by Mizuki Endo, Shin Yazawa, Rie Sano, Takehiko Yokobori, Ken Shirabe, Hiroshi Saeki

“…<b>Methods</b>: The fAGP level was retrospectively measured in preoperative plasma samples from 213 patients with either hepatic, biliary tract, or pancreatic cancer and was analyzed together with levels of six existing tumor markers determined as reference standards. …”
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Integrative transcriptomic and metabolomic reveals squalene alleviating the inflammatory response and enhancing immunity of hybrid grouper (♀ Epinephelus fuscoguttatus × ♂ E. lance... by Xiaobo Yan, Simiao Pan, Xiangxiang Suo, Weibin Huang, Tao Li, Shuang Zhang, Yuanzhi Yang, Beiping Tan, Xiaohui Dong

“…Therefore, the present study was designed to use corn oil as the main lipid source to create a model of inflammation or low immunity and investigate the regulatory effect of squalene on the immunity of grouper, and to perform hepatic transcriptomic and metabolomic assays of grouper using omics technology, with the aim of providing basic data for the study of the mechanism of squalene. …”
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Starvation-induced metabolic rewiring affects mTORC1 composition in vivo by Edgar Kaade, Simone Mausbach, Nina Erps, Marc Sylvester, Farhad Shakeri, Ron D. Jachimowicz, Volkmar Gieselmann, Melanie Thelen

“…Deactivation of mTORC1 in vivo after short-term starvation causes a depletion of mTORC1 and the associated Ragulator complex in hepatic lysosomes, resulting in diminished phosphorylation of mTORC1 target proteins. …”
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High Plasma Glucagon Levels Correlate with Waist-to-Hip Ratio, Suprailiac Skinfold Thickness, and Deep Subcutaneous Abdominal and Intraperitoneal Adipose Tissue Depots in Nonobese... by Shajith Anoop, Anoop Misra, Surya Prakash Bhatt, Seema Gulati, Harsh Mahajan, Gokulraj Prabakaran

“…Plasma glucose and glucagon, serum insulin, hepatic transaminases, and lipid profile were measured. …”
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Zearalenone exacerbates lipid metabolism disorders by promoting liver lipid droplet formation and disrupting gut microbiota by Xiao Han, Bingxin Huangfu, Tongxiao Xu, Kunlun Huang, Xiaoyun He

“…Validation in combination with AML-12 cells revealed that ZEA promoted lipid synthesis and increased hepatic lipid droplet accumulation via the HNF1β/PPARγ and SREBP1c-HSD17B13/PLINs signal pathways. …”
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Effects of dietary curcumin supplementation on the liver health of juvenile channel catfish (Ictalurus punctatus) fed high-starch diet by Qisheng Lu, Yutong Zheng, Yu Wang, Yulong Liu, Jingyue Cao, Haokun Liu, Junyan Jin, Zhimin Zhang, Yunxia Yang, Xiaoming Zhu, Shouqi Xie, Dong Han

“…Dietary curcumin activated Keap1/Nrf2 to increase hepatic antioxidant capacity (T-AOC, SOD and GSH-PX) and inhibit apoptosis pathway (Bax, Bcl2, Caspase 3 and Caspase 9) (P < 0.05). …”
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Metastatic Renal Cell Carcinoma Presenting as Prolonged Pyrexia and Stauffer’s Syndrome: Can a Routine Ultrasound Scan Fail to Detect a Renal Cell Carcinoma? by C. L. Fonseka, A. G. T. A. Kariyawasam, S. A. G. L. Singhapura, C. M. de Silva, T. E. Kanakkahewa, I. G. T. M. Senarathna, C. K. Bodinayake

“…We report a patient who presented with unresolving fever with multiple pulmonary opacities with biochemical evidence of hepatic choleastasis and was later diagnosed to have metastatic RCC with Stauffer’s syndrome. …”
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Schistosoma japonicum Infection in Treg-Specific USP21 Knockout Mice by Youxiang Zhang, De-Hui Xiong, Yangyang Li, Guina Xu, Baoxin Zhang, Yang Liu, Shan Zhang, Qing Huang, Simin Chen, Fansheng Zeng, Jingyi Guo, Bin Li, Zhiqiang Qin, Zuping Zhang

“…USP21 may have potential for regulating hepatic fibrosis in patients with schistosomiasis.…”
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Prevention of Peritoneal Metastases from Colon Cancer in High-Risk Patients: Preliminary Results of Surgery plus Prophylactic HIPEC by Paolo Sammartino, Simone Sibio, Daniele Biacchi, Maurizio Cardi, Fabio Accarpio, Pietro Mingazzini, Maria Sofia Rosati, Tommaso Cornali, Angelo Di Giorgio

“…The 25 patients in the experimental group underwent hemicolectomy, omentectomy, bilateral adnexectomy, hepatic round ligament resection, and appendectomy, followed by HIPEC. …”
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Endothelial protease-activated receptor 4: impotent or important? by Rahul Rajala, Rahul Rajala, Rahul Rajala, Courtney T. Griffin, Courtney T. Griffin

“…A recent study from our lab identified low expressing but functional PAR4 in hepatic ECs in vivo. We also found that PAR4 likely has a higher signaling potency than PAR1. …”
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FFAR4 (GPR120) Signaling Is Not Required for Anti-Inflammatory and Insulin-Sensitizing Effects of Omega-3 Fatty Acids by Simone Isling Pærregaard, Marianne Agerholm, Annette Karen Serup, Tao Ma, Bente Kiens, Lise Madsen, Karsten Kristiansen, Benjamin Anderschou Holbech Jensen

“…We demonstrate that both KO and HET mice fed ω3-PUFAs were protected against obesity, hepatic triacylglycerol accumulation, and whole-body insulin resistance. …”
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Integrative analysis of single-cell and transcriptome sequencing with experimental validation reveals PKHD1L1 as a novel biomarker in lung adenocarcinoma by Xiangqian Zhang, Jie Wang, Hanyang Su, Xiaojin Liu

“…Abstract Polycystic kidney and hepatic disease 1-like protein 1 (PKHD1L1) is predicted to encode a large type I transmembrane protein involved in hearing transmission and mediating cellular immunity under physiological conditions. …”
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Clostridium Scindens Protects Against Vancomycin‐Induced Cholestasis and Liver Fibrosis by Activating Intestinal FXR‐FGF15/19 Signaling by Jintao Xiao, Yanliang Hou, Xingyang Luo, Yuhao Zhu, Wenhu Li, Bingbing Li, LinXiang Zhou, Xia Chen, Ying Guo, Xiaomei Zhang, Haiyue He, Xiaowei Liu

“…Mice treated with vancomycin exhibit increased hepatic collagen deposition and injury, due to the inhibition of intestinal FXR‐FGF15/19 axis and the elevation of bile acid levels. …”
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A perfusion-independent high-throughput method to isolate liver sinusoidal endothelial cells by Anna Babin-Ebell Gonçalves, Yifang Mao, Tinja Baljkas, Felix Wiedmann, Larissa Eis, Franziska Pilz, Manuel Winkler, Sina W. Kürschner-Zacharias, Marlene Hoffarth, Charlotta Funaya, Réza Shahidi, Cyrill Géraud, Chi-Chung Wu, Constanze Schmidt, Sergij Goerdt, Philipp-Sebastian Reiners-Koch, Mahak Singhal

“…Combining magnetic and fluorescence-activated cell sorting (FACS), LSECs from different zones of the hepatic sinusoid can now be isolated in high numbers in less than two hours for downstream applications including proteomics. …”
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Methodical approaches in experimental modelling of non-alcoholic fatty liver disease by N. V. Bivalkevich, Yu. K. Denisenko, T. P. Novgorodtseva

“…In the first the liver of laboratory animals is the main pathogenic target, metabolic disorders develop insignificantly (lines of animals with of Acetyl-CoA oxidase gene deletion, knockoutmice for methionine-adenosyl transferases-1А gene and animals with deleted specific hepatic phosphatase and tensin homologue gene). Genetic models of NAFLD developing on background of obesity and metabolicsyndrome represent the second category (animals, with leptin gene deletion – ob/ob, mice resistant to leptin action, – db/db and transgenic mice with excessive expression of styrene-regulating element of protein-1 isoform. …”
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Patient with Jaundice, Dyspnea and Hyperferritinemia after COVID-19 by V. R. Grechishnikova, P. E. Tkachenko, M. S. Zharkova, T. P. Nekrasova, V. T. Ivashkin

“…Laboratory tests revealed signs of hepatic insufficiency, markers of cholestasis and inflammation persisted in time. …”
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Repurposing of Drugs for Antibacterial Activities on Selected ESKAPE Bacteria Staphylococcus aureus and Pseudomonas aeruginosa by Bridget Kamurai, Molly Mombeshora, Stanley Mukanganyama

“…The drugs used in this study were amodiaquine an antimalarial drug, probenecid used to prevent gout, ibuprofen a painkiller, 2-amino-5-chlorobenzaxazole used as a tool for assessing hepatic cytochrome P450 activity in rodents, ellargic acid an antioxidant, quercetin an antioxidant and anti-inflammatory drug, N–N diacryloylpiperazine used to crosslink polyacrylamide gel in 2D-protein electrophoresis, epicatechin an antioxidant and antiviral drug, curcumin an anticancer drug, and quinine an antimalarial drug. …”
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