Anti-oxidative Effect of Complex Prescription Pien Tze Huang Gan Bao on Chemical Liver Injury by Jinming HUANG

“…Objective:To explore the hepatic protection of Pien Tze Huang Gan Bao (GB) on chemical liver injury.Methods:Sixty SD rats were randomly divided into control group, model group, silymarin group, and GB-low dose group, GB-middle dose group, GB-high dose group with ten rats per group. …”
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Exploring the Effects of Imidacloprid on Liver Health and the Microbiome in Rats: A Comprehensive Study by Alaa T. Qumsani

“…Histopathological examination showed that liver morphology changed significantly with the dose, including in terms of cellular disorganization and signs of stress, with an alteration in the hepatic architecture. Morphological changes were related to disturbances in the activity of liver enzymes, reflecting deteriorating liver function with increased imidacloprid exposure. …”
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Enhancement of Liver Targetability through Statistical Optimization and Surface Modification of Biodegradable Nanocapsules Loaded with Lamivudine by Srikar Grandhi, Moawia Al-Tabakha, Prameela Rani Avula

“…The results of in vivo pharmacokinetics from blood and liver tissues indicated that hepatic bioavailability of LMV was increased from 13.78 ± 3.48 μg/mL ∗ h for LMV solution to 32.94 ± 5.12 μg/mL ∗ h for the optimized LMV-ACNs and to 54.91 ± 6.68 μg/mL ∗ h for the surface-modified LMV-ACNs.…”
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HOXA-AS3 Promotes Proliferation and Migration of Hepatocellular Carcinoma Cells via the miR-455-5p/PD-L1 Axis by Cheng Zeng, Shaojun Ye, Yu Chen, Qu Zhang, Yan Luo, Liang Gai, Bo Luo

“…Hepatocellular carcinoma (HCC) is the most prevalent type of hepatic carcinoma. Long noncoding RNAs (lncRNAs) are considered crucial regulators of gene expression; however, their functions in HCC are not well understood. …”
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Efficacy of Contezolid in the Treatment of Catheter-Related Bloodstream Infections Caused by Methicillin-Resistant Staphylococcus aureus in a Patient with Hepatorenal Syndrome and... by Zhang X, Huang H, Wang J, Wei B

“…Xiucui Zhang,* Huili Huang,* Jianrong Wang, Bo Wei Department of Infectious Disease, Changzheng Hospital, Navy Medical University, Shanghai, People’s Republic of China*These authors contributed equally to this workCorrespondence: Bo Wei, Department of infectious disease, Changzheng Hospital, Navy Medical University, Shanghai, People’s Republic of China, Email weibi0816@163.comAbstract: The Hepatorenal Syndrome-Acute Kidney Injury (HRS-AKI) patients infected with methicillin-resistant Staphylococcus aureus (MRSA) urgently require safe and effective treatment options due to their compromised hepatic and renal functions, as well as thrombocytopenia resulting from hypersplenism. …”
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Anti-inflammatory potential of black cumin seed oil and its nanoemulsion formulation against lipopolysaccharide-induced liver injury in mice by Hesham Haffez, Rehab Hosni, Shady A. Swidan, Hatem K. Amin

“…Methods: LPS-induced acute liver injury mouse model was used to evaluate the effects of BCSO and its nanoemulsion formulation on liver function. Hepatic inflammatory markers including Toll-like receptor 4 (TLR4), interleukin(IL)-1β, heme-oxygenase 1, BAX, and BCL-2 were assessed using real-time PCR. …”
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The PPARα/γ Agonist, Tesaglitazar, Improves Insulin Mediated Switching of Tissue Glucose and Free Fatty Acid Utilization In Vivo in the Obese Zucker Rat by Kristina Wallenius, Ann Kjellstedt, Pia Thalén, Lars Löfgren, Nicholas D. Oakes

“…Whole body glucose disposal rate () and hepatic glucose output (HGO) were assessed under basal fasting and hyperinsulinemic isoglycemic clamp conditions using [3,3H]glucose. …”
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RETRACTED ARTICLE: Histological, ultrastructural, and biochemical study on the possible role of Panax ginseng in ameliorating liver injury induced by Lambda cyhalotherin by Manal Abdul-Hamid, Hanaa M. Mohamed, Sanaa M. Abd El-Twab, Karim Zaied

“…Conclusion Panax ginseng exhibited ameliorative effect against hepatic oxidative stress, apoptosis, histopathological, and ultrastructural changes induced by LCT.…”
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Mechanisms of liver fibrosis in metabolic syndrome by Wajahat Mehal

“…Both types of liver fibrosis have the transformation of the hepatic stellate cell (HSC) into a myofibroblast as a key step. …”
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Common variable immunodeficiency: An uncommon cause of bronchiectasis, granulomatous disease, chronic liver disease, and enteropathy – Case report and review of literature by Veena Shamsudeen, Arun Hegde, Uday Bhanu Kovilapu, Nisha Verma, Anurag Jain

“…Nearly 20%–25% of cases develop autoimmune complications such as autoimmune hemolytic anemia and immune thrombocytopenia. Hepatic involvement can occur in the form of abnormal biochemistry, nodular degenerative hyperplasia, and cirrhosis of liver. …”
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Role of the Surgical Method in Development of Postoperative Cholangiocarcinoma in Todani Type IV Bile Duct Cysts by Hong-tian Xia, Tao Yang, Bin Liang, Jian-ping Zeng, Jia-hong Dong

“…Radical resection of both intra- and extrahepatic cysts combined with hepatic resection and Roux-en-Y hepaticojejunostomy is associated with a reduced risk of subsequent cancer development. …”
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Metabolic and hematological disruptions induced by Diphenyl Diselenide in male wistar rats by Joseph A. Olagunju, Gabriel O. Ajayi, Babatunde A. Murtala, Adejuwan A. Adeneye

“…The resultant increased gluconeogenesis and hepatic glycogen storage could be a detoxification mechanism whereby excess lactate due to increased glycolysis is converted to a non-toxic and neutral glucose to maintain pH balance in order to preserve the animals against DPDS toxicity.…”
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Role of High-Density Lipoprotein Cholesterol (HDL-C) as a Clinical Predictor of Decompensation in Patients with Chronic Liver Disease (CLD) by Harshavardhan Rao B, Priya Nair, Anoop K. Koshy, S. Krishnapriya, C. R. Greeshma, Rama P. Venu

“…Each patient was carefully followed up for development of decompensation events such as new-onset/worsening ascites, hepatic encephalopathy, or variceal bleed during follow-up. …”
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Manganese Neurotoxicity as a Complication of Chronic Total Parenteral Nutrition by Alisha Khan, Jonathan Hingre, Amit S. Dhamoon

“…Our objective in presenting this case is to highlight manganese neurotoxicity as a rare complication of TPN in a patient without known hepatic dysfunction and to emphasize the importance of routinely monitoring patients for the possible adverse effects of chronic TPN. …”
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Protective Effects of Garlic and Cinnamon Oils on Hepatocellular Carcinoma in Albino Rats by Salah M. Aly, Hamdy A. Fetaih, Abeer A. I. Hassanin, Mosleh M. Abomughaid, Aliaa A. Ismail

“…The HCC-induced group showed a significant decrease in the body mass and a significant elevation in the liver weight, alpha-fetoprotein (AFP), liver enzymes, hepatic malondialdehyde (MDA), and p53 protein expression levels as well as genetic mutations in intron 5 of p53 gene in the form of Single-Nucleotide Polymorphisms (SNPs) and insertions. …”
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Carvacrol alleviates acrylamide-induced hepatotoxicity in rats: an experimental insights by Aysegul Bulut, Goktug Senturk, Durmus Hatipoglu, Mehmet Burak Ates

“…<p> <b>Results:</b> In microscopic examination, it was determined that AA causes hydropic/vacuolar degeneration, fatty changes, necrosis/apoptosis, bile duct proliferation, hepatic cord dissociation, congestion, megalocytosis and mononuclear cell infiltration. …”
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Lipid Horizons: Recent Advances and Future Prospects in LBDDS for Oral Administration of Antihypertensive Agents by null Preeti, Sharda Sambhakar, Rohit Malik, Saurabh Bhatia, Ahmed Al Harrasi, Renu Saharan, Geeta Aggarwal, Suresh Kumar, Renu Sehrawat, Chanchal Rani

“…LBDDSs overcome the shortcomings that are associated with antihypertensive agents because around fifty percent of the antihypertensive agents experience a few drawbacks including short half-life because of hepatic first-pass metabolism, poor aqueous solubility, low permeation rate, and undesirable side effects. …”
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Macrofilaricidal Activity, Acute and Biochemical Effects of Three Lichen Species Found on Mount Cameroon by Thierry Roland Kang, Jerome Nyhalah Dinga, Ayuk Elizabeth Orock, Elvis Monya, Moses Njutain Ngemenya

“…These two most active extracts had no significant effect on liver enzymes, alanine aminotransferase, and aspartate (P values < 0.05), but a high AST : ALT ratio (2.59) for Pammet indicates likely reversible adverse hepatic toxicity. The high macrofilaricidal activity and selectivity of P. tinctorum suggest it is a potential source of new macrofilaricides which should be further investigated to identify its bioactive constituents.…”
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Diabetes-Resistant NOR Mice Are More Severely Affected by Streptozotocin Compared to the Diabetes-Prone NOD Mice: Correlations with Liver and Kidney GLUT2 Expressions by S. Kahraman, C. Aydin, G. O. Elpek, E. Dirice, A. D. Sanlioglu

“…We also detected GLUT2 expression profiles in NOD and NOR hepatic and renal tissues by western blot analysis and observed considerably higher GLUT2 expression levels in liver and kidney tissues of NOR mice. …”
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The Effect of Endotoxin-Induced Inflammation on the Activity of the Somatotropic Axis in Sheep by Maciej Wójcik, Dorota Anna Zieba, Joanna Bochenek, Agata Krawczyńska, Marcin Barszcz, Alina Gajewska, Hanna Antushevich, Andrzej Przemysław Herman

“…It can suppress growth and hepatic metabolism to spare energy expenditure.…”
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