Urinary tract infections in patients with decompensated liver cirrhosis, listed for liver transplantation by P. D. Bessonov, I. V. Borzunov, E. N. Bessonova

“…Frequency of urinary tract infections was higher in those with severe liver cirrhosis complications (in past history as well) such as hepatic encephalopathy, ascites, spontaneous bacterial peritonitis. …”
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Natural History of Metabolic Dysfunction-Associated Steatotic Liver Disease: From Metabolic Syndrome to Hepatocellular Carcinoma by Melchor Alpízar Salazar, Samantha Estefanía Olguín Reyes, Andrea Medina Estévez, Julieta Alejandra Saturno Lobos, Jesús Manuel De Aldecoa Castillo, Juan Carlos Carrera Aguas, Samary Alaniz Monreal, José Antonio Navarro Rodríguez, Dulce María Fernanda Alpízar Sánchez

“…Insulin resistance plays a central role in MASLD pathogenesis, exacerbated by high-fat diets and specific fatty acids, leading to hepatic steatosis. Lipotoxicity from saturated fatty acids further damages hepatocytes, triggering inflammation and fibrosis progression in MASH. …”
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Evaluation of High Fibers Okara and Soybean Bran as Functional Supplements for Mice with Experimentally Induced Type 2 Diabetes by Ismaiel Manal, Yang Hong, Cui Min

“…Soybean bran seemed more efficient than okara in alleviating hepatic cell histological changes. Results demonstrated the potential benefit of okara and soybean bran in glycemic control and reducing the risk of type 2 diabetes complications.…”
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Strawberry Polyphenol-Rich Fractions Can Mitigate Disorders in Gastrointestinal Tract and Liver Functions Caused by a High-Fructose Diet in Experimental Rats by Ewa Żary-Sikorska, Bartosz Fotschki, Monika Kosmala, Joanna Milala, Paulius Matusevicius, Aleksandra Rawicka, Jerzy Juśkiewicz

“…As a further consequence, diet supplementation with the EPA fraction caused more favorable changes in the levels of serum interleukin 6 and serum antioxidant capacity of water-soluble substances (ACW), in atherogenicity index lg((triglyceride/high-density lipoprotein cholesterol), hepatic oxidized glutathione as well as reduced to oxidized glutathione ratio). …”
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Mesenchymal Stem Cells Pretreated with HGF and FGF4 Can Reduce Liver Fibrosis in Mice by Sulaiman Shams, Sadia Mohsin, Ghazanfar Ali Nasir, Mohsin Khan, Shaheen N. Khan

“…Furthermore the cytokines pretreated MSCs also improved cell viability and enhanced hepatic and antiapoptotic markers in injured hepatocytes cocultured model as compared to untreated MSCs. …”
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Tuftelin 1 Facilitates Hepatocellular Carcinoma Progression through Regulation of Lipogenesis and Focal Adhesion Maturation by Lei Zhu, Kai X. Zhou, Ming Z. Ma, Lin L. Yao, Yan L. Zhang, Hui Li, Chang Du, Xiao M. Yang

“…Further, we found that TUFT1 can interact with CREB1, a transcription factor for hepatic lipid metabolism, and regulate its activity and the transcriptions of key enzymes for lipogenesis. …”
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METHODS OF EVALUATION OF THE FUNCTIONAL STATUS OF THE LIVER IN THE PLANNING OF ANATOMICAL RESECTIONS ABOUT PRIMARY AND METASTATIC TUMORS: CURRENT STATE OF THE PROBLEM, THEIR OWN EX... by D. V. Sidorov, N. A. Rubtsova, A. V. Leontyev, M. V. Lozhkin, L. O. Petrov, T. N. Lazutina, I. V. Pylova, P. A. Korolev, A. G. Isaeva

“…Methacetin breath test and 99mTc-technephyt hepatobiliary scintigraphy were performed prior to major resection in 53 high-risk patients, including 48 patients with hepatic metastases from colorectal cancer and 5 patients with hepatocellular carcinoma . …”
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Herbicide Widespread: The Effects of Pethoxamid on Nonalcoholic Fatty Liver Steatosis In Vitro by Anna Virginia Adriana Pirozzi, Antonietta Stellavato, Chiara Schiraldi, Mariateresa Giuliano

“…Based on our data, we can argue that NAFLD hepatic cells react to pethoxamid trying detoxifying strategies, ready to undergo cell death to avoid further degeneration. …”
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Normal tissue radioprotection by amifostine via Warburg-type effects by Michael I. Koukourakis, Alexandra Giatromanolaki, Christos E. Zois, Dimitra Kalamida, Stamatia Pouliliou, Ilias V. Karagounis, Tzu-Lan Yeh, Martine I. Abboud, Timothy D. W. Claridge, Christopher J. Schofield, Efthimios Sivridis, Costantinos Simopoulos, Savvas P. Tokmakidis, Adrian L. Harris

“…The effects of amifostine on human basal metabolism, mouse liver metabolism and on normal and tumor hepatic cells were studied. Indirect calorimetric canopy tests showed significant reductions in oxygen consumption and of carbon dioxide emission in cancer patients receiving amifostine. …”
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Liver GlucokinaseA456V Induces Potent Hypoglycemia without Dyslipidemia through a Paradoxical Induction of the Catalytic Subunit of Glucose-6-Phosphatase by Anna Vidal-Alabró, Alícia G. Gómez-Valadés, Andrés Méndez-Lucas, Jordi Llorens, Ramon Bartrons, Jordi Bermúdez, Jose C. Perales

“…Several GK mutations affect GKRP binding, resulting in permanent activation of the enzyme. We hypothesize that hepatic overexpression of a mutated form of GK, GKA456V, described in a patient with persistent hyperinsulinemic hypoglycemia of infancy (PHHI) and could provide a model to study the consequences of GK-GKRP deregulation in vivo. …”
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Development of Bifunctional Three-Dimensional Cysts from Chemically Induced Liver Progenitors by Yu Huang, Yusuke Sakai, Takanobu Hara, Takeshi Katsuda, Takahiro Ochiya, Tomohiko Adachi, Masaaki Hidaka, Wei-Li Gu, Susumu Eguchi

“…These cell types gradually diverged into specialized mature cells, as demonstrated by the expression of mature biliary markers (Cftr, Ae2, and Aqp1) and hepatic markers (Alb and Mrp2). The 3D cysts also expressed functional multidrug resistance protein 1 (Mdr1), as indicated by epithelial efflux of rhodamine. …”
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Dimethyl fumarate effects on paraquat-induced hepatotoxicity in mice via anti-oxidative, anti-inflammatory, and anti-apoptotic activities by Maryam Kavianinia, Hadi Kalantar, Maryam Salehcheh, Layasadat Khorsandi, Saeedeh Shariati, Shokooh Mohtadi, Mohammad Javad Khodayar

“…Furthermore, PQ decreased hepatic total thiol and activity levels of catalase, superoxide dismutase, and glutathione peroxidase. …”
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High-starchy carbohydrate diet aggravates NAFLD by increasing fatty acids influx mediated by NOX2 by Yuqi Gao, Rui Hua, Kezheng Peng, Yuemiao Yin, Chenye Zeng, Yannan Guo, Yida Wang, Liyuan Li, Xue Li, Ying Qiu, Zhao Wang

“…Moreover, the large amounts of ROS produced by NOX2 further exacerbated insulin resistance and increased lipolysis in perirenal white adipose tissue (periWAT), thereby providing fatty acids for hepatic lipid synthesis. In addition, the interaction between AMPKα1 and p47phox was the pathway that mediated the high expression of NOX2 induced by a HCD. …”
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Extensive Use of Interventional Therapies Improves Survival in Unresectable or Recurrent Intrahepatic Cholangiocarcinoma by Ricarda Seidensticker, Max Seidensticker, Kathleen Doegen, Konrad Mohnike, Kerstin Schütte, Patrick Stübs, Erika Kettner, Maciej Pech, Holger Amthauer, Jens Ricke

“…Patients with unresectable ICC may benefit from hepatic tumor control provided by local or locoregional therapies. …”
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«SAVING» A TWO-STAGE LIVER RESECTION BY THE ALPPS TYPE by D. V. Sidorov, M. V. Lozhkin, L. O. Petrov, A. G. Isaeva

“…It has been proved that the reduction of liver and FLR functional reserves of less than 20% at normal and 40% in the case of compromised liver parenchyma, the implementation of surgical interventions is associated with a high risk of hepatic insufficiency. One of the promising ways to overcome this obstacle is to perform various modifications of ALPPS liver resections.In the present work, we present a clinical case of performing a two-stage liver resection according to the type of ALPPS in a patient with metastatic colorectal liver cancer who had previously undergone PVL with unrealized vicar hypertrophy. …”
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Exploring the molecular mechanisms of tirzepatide in alleviating metabolic dysfunction-associated fatty liver in mice through integration of metabolomics, lipidomics, and proteomic... by Jinliang Liang, Huanyi Liu, Guo Lv, Xiaotong Chen, Zhaoshou Yang, Kunhua Hu, Hongyan Sun

“…The results demonstrated that tirzepatide significantly reduced serum levels of alanine transaminase (ALT) and aspartate transaminase (AST), as well as hepatic triglycerides (TG) and total cholesterol (TC), indicating its efficacy in treating MAFLD. …”
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Dexamethasone potentiates the insulin-induced Srebp-1c expression in primary rat hepatocytes by Yan Zhang, Xiangming Fang, Fen Shuang, Guoxun Chen

“…Dex and insulin mutually affect each other’s ability to regulate the expression levels of hepatic genes involved in glucose and fatty acid metabolism. …”
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Febuxostat Attenuates Renal Damage besides Exerting Hypouricemic Effect in Streptozotocin-Induced Diabetic Rats by Jianmin Ran, Gang Xu, Huixuan Ma, Hailing Xu, Yan Liu, Rongshao Tan, Ping Zhu, Jun Song, Gancheng Lao

“…However, UCr and urinary urea nitrogen (UUN) levels remained unchanged, while SCr and BUN levels decreased by >30% in these rats. Although hepatic gene expression, content, and activity of XO increased significantly in diabetic rats, febuxostat only slightly decreased its content. …”
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Supplementation with Branched-Chain Amino Acids Induces Unexpected Deleterious Effects on Astrocyte Survival and Intracellular Metabolism with or without Hyperammonemia: A Prelimin... by Ting Wang, Kazuyuki Suzuki, Toshimi Chiba, Keisuke Kakisaka, Yasuhiro Takikawa

“…Ammonia is a key component in the pathogenesis of hepatic encephalopathy. Branched-chain amino acids (BCAA) have been reported to improve the symptoms of HE induced by hyperammonemia; however, we recently reported that ammonia increases intracellular levels of BCAA and exerts toxic effects on astrocytes. …”
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Melanoma in pregnancy: multidisciplinary treatment management and outcome by Francesca Romana Grippaudo, Giulia Ruggeri, Paola De Simone, Monia Di Prete, Guglielmo Tellan, Elena Rita Govoni, Emilia Migliano

“…Two patients developed metastases, with one fatality from hepatic metastases. The overall survival rate at 5-year follow-up was 86%, and 72% for advanced stages and disease-free patients. …”
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