Plasma Membrane Transporters in Modern Liver Pharmacology by Jose J. G. Marin

“…Both detoxification and pharmacological processes occurring in the liver require the uptake of the drug by hepatic cells and, in some cases, the elimination into bile. …”
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Imaging the Abdominal Manifestations of Cystic Fibrosis by C. D. Gillespie, M. K. O’Reilly, G. N. Allen, S. McDermott, V. O. Chan, C. A. Ridge

“…We review their presentation and expected imaging findings, with a focus on the challenges facing diagnosis of the hepatic manifestations of the disease. An increased familiarity with these abdominal manifestations will facilitate timely diagnosis and management, which is paramount to further improving outcomes for patients with cystic fibrosis.…”
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Single-cell morphological tracking of cell states to identify small-molecule modulators of liver differentiation by Rebecca E. Graham, Runshi Zheng, Jesko Wagner, Asier Unciti-Broceta, David C. Hay, Stuart J. Forbes, Victoria L. Gadd, Neil O. Carragher

“…This work has identified small-molecule Src family kinase inhibitors that promote the differentiation of HepaRG cells toward a hepatocyte-like lineage as well as primary human hepatic progenitor cells toward a hepatocyte-like phenotype in vitro. …”
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Neonatal Abdominal Hemangiomatosis: Propranolol beyond Infantile Hemangioma by Siu Ying Angel Nip, Kam Lun Hon, Wing Kwan Alex Leung, Alexander K. C. Leung, Paul C. L. Choi

“…Visceral hemangioma often involves the liver and manifests as a life-threatening disorder. Hepatic hemangiomas may be associated with high output cardiac failure, coagulopathy, and hepatomegaly which generally develop between 1 and 16 weeks of age. …”
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Severe Lactic Acidosis in a Patient with B-Cell Lymphoma: A Case Report and Review of the Literature by Farn Huei Chan, Daniel Carl, Laurel J. Lyckholm

“…The pathogenesis of malignancy-induced lactic acidosis is not well understood; however associated factors include increased glycolysis, increased lactate production by cancer cells, and decreased hepatic clearance of lactate. When it occurs, lactic acidosis is a poor prognostic sign in these patients. …”
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Synchronous Occurrence of Primary Breast Carcinoma and Primary Colon Adenocarcinoma by Gurkan Yetkin, Fevzi Celayir, Ismail Ethem Akgun, Ramazan Ucak

“…Colonoscopy was performed, and a hepatic flexure tumor was detected. Histopathological examination of biopsy revealed adenocarcinoma. …”
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Primitive Neuroectodermal Tumor of the Liver: A Case Report by Eduardo Cambruzzi, Enilde Eloena Guerra, Hamilton Cardoso Hilgert, Herbert Jorge Schmitz, Vinícius Lopes Silva, Daniel Marini Milani, Ricardo Pedrini Cruz, Raul Pruinelli

“…The clinical evaluation revealed a solid mass in the right hepatic lobe. On the gross examination of the resected liver specimen, the right lobe of the liver was replaced by a yellow-red solid mass measuring 21 cm in its largest dimension. …”
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Inhibitory Effects of Pretreatment with Radon on Acute Alcohol-Induced Hepatopathy in Mice by Teruaki Toyota, Takahiro Kataoka, Yuichi Nishiyama, Takehito Taguchi, Kiyonori Yamaoka

“…Furthermore, pretreatment with radon inhibited the depression of hepatic functions and antioxidative functions. These findings suggested that radon inhalation activated antioxidative functions in the liver and inhibited acute alcohol-induced hepatopathy in mice.…”
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Preventive role of Pastinaca sativa in mitigating metabolic dysfunction-associated steatotic liver disease via modulation of metabolic endotoxemia by Ji-Eun Park, Hye-Bin Lee, Yu Ra Lee, Guijae Yoo, Hee-Kyoung Son, Sang Yoon Choi, Miri Park, Ho-Young Park

“…Mice fed a high-fat diet with 50 or 100 mg/kg PRE for eight weeks showed reduced fat accumulation, improved serum metabolic profiles, and decreased liver injury markers. PRE also lowered hepatic lipogenic protein levels induced by the high-fat diet. …”
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Mediastinal extension of amoebic liver abscess: A case report on the rare thoracic complication of Entamoeba histolytica by Gautam Jesrani, Jaspreet Kaur, Samiksha Gupta, Yuvraj Singh Cheema, Prashant Ahlawat

“…However, postintercostal drainage, her chest X-ray demonstrated a right mediastinal shadow, which was confirmed as an intrathoracic extension of the hepatic liver abscess on computed tomography. An ultrasound-guided pigtail catheter was manipulated and placed at the site of thoracic communication. …”
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Pharmacokinetics study of a supersaturatable self-microemulsifying drug delivery system for ellagic acid by UHPLC-Q-TOF-MS by Wang Jinglong, Fan Liqun, Zhang Lihua, Zheng Dandan, Wang Yingzi, Sun Xiao, Ji Yonghui

“…The drug was found to be absorbed rapidly in vivo, and the plasma concentration-time curve showed double peaks, indicating that ellagic acid were reabsorbed by entero-hepatic circulation after oral administration. Compared with ellagic acid suspension, the apparent clearance of ellagic acid-loaded S-SMEDDS and SMEDDS reduced significantly, and the AUC0~t of them were 4.7 and 5.8-fold increase, respectively. …”
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Structure and Functions of Human Serum Albumin in Normal Conditions and in Patients with Liver Cirrhosis by A. A. Turkina, M. V. Mayevskaya, M. S. Zharkova, V. T. Ivashkin

“…Further investigation of albumin conformation and albumin functions in patients with hepatic insufficiency can serve as an additional criterion for assessing the severity of cirrhosis and predictor of complications may become an additional criterion to new clinical applications and treatment strategies of liver failure.…”
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Increased Porphyrins in Primary Liver Cancer Mainly Reflect a Parallel Liver Disease by Jerzy Kaczynski, Göran Hansson, Sven Wallerstedt

“…Hepatic porphyries have been associated with an increased risk of primary liver cancer (PLC), which on the other hand may cause an increased porphyrin production. …”
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The Role of Organelle Stresses in Diabetes Mellitus and Obesity: Implication for Treatment by Yi-Cheng Chang, Siow-Wey Hee, Meng-Lun Hsieh, Yung-Ming Jeng, Lee-Ming Chuang

“…Autophagy is required for clearance of hepatic lipid clearance, alleviation of pancreatic beta-cell stress, and white adipocyte differentiation. …”
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LC-MS/MS assisted pharmacokinetic and tissue distribution study of ropivacaine and 3-OH-ropivacaine on rats after plane block anesthesia by Mihaela Butiulca, Mihaela Butiulca, Lenard Farczadi, Silvia Imre, Silvia Imre, Camil Eugen Vari, Laurian Vlase, Bogdan Cordos, Leonard Azamfirei, Leonard Azamfirei, Alexandra Elena Lazar, Alexandra Elena Lazar

“…The results showed a tissue affinity of the anesthetics, a clearance of ropivacaine mainly by hepatic metabolism, and the final, mainly renal excretion of the hydroxylated metabolite. …”
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Malignant Spinal Cord Compression Syndrome as an Initial Presentation of Testicular Cancer by Carlos Eduardo Salazar-Mejía, Edio Llerena-Hernández, David Hernández-Barajas, Oscar Vidal-Gutiérrez, Adriana González-Gutiérrez, Rolando Jacob Martínez-Granados, Blanca Otilia Wimer-Castillo

“…Imaging studies showed an infiltrative lesion in the left testicle, pulmonary and hepatic metastatic disease, and a large retroperitoneal ganglionar conglomerate that infiltrated the spinal cord through the intervertebral foramina of the vertebra level T11 with displacement of the L1 vertebral body. …”
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Differential Impacts of Soybean and Fish Oils on Hepatocyte Lipid Droplet Accumulation and Endoplasmic Reticulum Stress in Primary Rabbit Hepatocytes by Xueping Zhu, Zhihui Xiao, Yumin Xu, Xingli Zhao, Ping Cheng, Ningxun Cui, Mingling Cui, Jie Li, Xiaoli Zhu

“…While these deleterious events induce hepatocyte injury, FOLE at high doses cause only minor ER and mitochondrial damage, which has no effect on hepatic function. SOLE also significantly upregulated glucose-regulated protein 94 mRNA and protein expression. …”
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Ameliorative Potential of Tamarindus indica on High Fat Diet Induced Nonalcoholic Fatty Liver Disease in Rats by Suja Rani Sasidharan, Joshua Allan Joseph, Senthilkumar Anandakumar, Vijayabalaji Venkatesan, Chandrasekharan Nair Ariyattu Madhavan, Amit Agarwal

“…Treatment with ETS at all tested dose levels significantly attenuated the pathological alterations associated with HFD induced NAFLD viz. hepatomegaly, elevated hepatic lipid and lipid peroxides, serum alanine aminotransferase, and free fatty acid levels as well as micro-/macrohepatic steatosis. …”
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Research Progress on Zearalenone Biodegradation and Its Detoxification Mechanism by LI Kailong, LIU Kunlun, XIN Ying, YANG Chenxian, WANG Zikun

“…Zearalenone (ZEN) has been detected at high rates in moldy corn, wheat, and other grains, and exposure to ZEN pollution can induce reproductive, hepatic, and renal toxicity. Due to its widespread contamination and severe hazards, ZEN has become a major hidden danger to food safety. …”
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Juvenile Hemochromatosis due to a Homozygous Variant in the HJV Gene by María-Belén Moreno-Risco, Manuel Méndez, María-Isabel Moreno-Carralero, Ana-María López-Moreno, José-Manuel Vagace-Valero, María-José Morán-Jiménez

“…We report a child with hepatic iron overload and family history of hemochromatosis. …”
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