A “Catastrophic” Heparin-Induced Thrombocytopenia by D. Barcellona, M. Melis, G. Floris, A. Mameli, A. Muroni, G. Defazio, F. Marongiu

“…The thrombotic burden was very impressive involving the arterial and venous cerebral vessel and the venous pulmonary, hepatic, and inferior legs vascular beds. The patient was successfully treated with fondaparinux without recurrent thrombosis or bleeding. …”
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Targeting protein kinase C-α prolongs survival and restores liver function in sepsis: Evidence from preclinical models by Ling Xiong, Dustin Beyer, Na Liu, Tina Lehmann, Sophie Neugebauer, Sascha Schaeuble, Oliver Sommerfeld, Philipp Ernst, Carl-Magnus Svensson, Sandor Nietzsche, Sebastian Scholl, Tony Bruns, Nikolaus Gaßler, Markus H. Gräler, Marc Thilo Figge, Gianni Panagiotou, Michael Bauer, Adrian T. Press

“…Organ dysfunction includes hepatic involvement, weakening the immune system due to excretory liver failure, and metabolic dysfunction, increasing the death risk. …”
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Nile tilapia juveniles reared at cold suboptimal water temperatures do not benefit from dietary supplementation with cholesterol by Jorge Filipe Banze, Renata Oselame Nobrega, Bruna Mattioni, Bianca Leticia Richter, Katharinne Ingrid Moraes de Carvalho, Jacó Joaquim Mattos, Maria Risoleta Freire Marques, James Eugene Pettigrew, Débora Machado Fracalossi

“…Increasing dietary cholesterol supplementation did not affect growth but affected lipid metabolism resulting in increased body and hepatic cholesterol deposition. Additionally, in plasma, we registered an increase in cholesterol and non-HDL lipoproteins but a decrease in the triacylglycerols. …”
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Multi-tissue network analysis reveals the effect of JNK inhibition on dietary sucrose-induced metabolic dysfunction in rats by Hong Yang, Cheng Zhang, Woonghee Kim, Mengnan Shi, Metin Kiliclioglu, Cemil Bayram, Ismail Bolar, Özlem Özdemir Tozlu, Cem Baba, Nursena Yuksel, Serkan Yildirim, Shazia Iqbal, Jihad Sebhaoui, Ahmet Hacımuftuoglu, Matthias Uhlen, Jan Boren, Hasan Turkez, Adil Mardinoglu

“…In this study, we challenged rats with sucrose-sweetened water and investigated the potential effects of JNK inhibition by employing network analysis based on the transcriptome profiling obtained from hepatic and extrahepatic tissues, including visceral white adipose tissue, skeletal muscle, and brain. …”
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Sodium alginate ameliorates health in freshwater fish through gut-liver axis modulation under high carbohydrate diets by Wenlu Zhu, Huilin Zhang, Haitao Pan, Hao Zeng, Wenjun Wang, Yunfeng Liu, Zirui Wang, Qiubai Zhou, Chuanqi Yu

“…Then our outcomes evinced that LA improves various health-related parameters, including reduction of hepatosomatic index (HSI), serum glucose, triglycerides, and aminotransferase levels, as well as the decrease in hepatic lipid droplets, glycogen, and collagen fiber content. …”
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Single-cell transcriptomic analysis reveals characteristic feature of macrophage reprogramming in liver Mallory-Denk bodies pathogenesis by Zixuan Fang, Bei Zhong, Yi Shi, Wanmei Zhou, Maoping Huang, Samuel W. French, Xiaoping Tang, Hui Liu

“…Mallory-Denk bodies (MDBs) are protein aggregates associated with hepatic inflammation, and MDBs pathogenesis could be induced in mice by feeding 3,5-diethoxycarbonyl-1,4-dihydrocollidine (DDC). …”
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The Cytotoxicity Assessment of Grapefruit Peel Essential Oil and Its Effect on Frying Stability of Sunflower Oil by Ghania Kaanin-Boudraa, Fatiha Brahmi, Linda Grimaud, Mohamed Lamine Freidja, Ourdia-Nouara Kernou, Daniel Henrion, Samir Hadjal, Khodir Madani, Lila Boulekbache-Makhlouf

“…Various EO concentrations (0.01-0.5 mg/ml) were added to cultured cells Human Umbilical Vein Endothelial Cells (HUVECs) and Human Stellar Hepatic Cell lines LX-2 (SCC064) and incubated for 24 and 48 h. …”
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SF1-specific deletion of the energy sensor AMPKγ2 induces obesity by Óscar Freire-Agulleiro, Ánxela Estévez-Salguero, Vitor Ferreira, Cassie Lynn Holleman, Julia García-Currás, Ismael González-García, Rubén Nogueiras, Manuel Tena-Sempere, Cristina García-Cáceres, Carlos Diéguez, Miguel López

“…Additionally, SF1-Cre AMPKγ2 mice exhibit hepatic lipid accumulation, but surprisingly maintain normal glucose homeostasis. …”
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Extrapolating Prognostic Factors of Primary Curative Resection to Postresection Recurrences Hepatocellular Carcinoma Treatable by Radiofrequency Ablation by Hui Ma, Zhongchen Li, Jia Yuan, Lan Zhang, Xiaoying Xie, Xin Yin, Rongxin Chen, Zhenggang Ren

“…After a median follow-up of 36 months, 54 patients died, and 128 patients had hepatic recurrence. On univariate analyses, patients whose primary tumors were less differentiated (p=0.032 and p=0.048) and required less time to recur (p=0.013 and p=0.001) after curative resection displayed poorer overall survival and higher recurrence rates following RFA. …”
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Impact of long-term cyanotoxin exposure on cattle: Biochemical, histological, and oxidative stress assessment by Mounira Bensalem, Amina Amrani, Hadjer Zaidi, Fateh Sedrati, Omar Laouar, Zhi Wang, Hichem Nasri

“…Results: Exposed cattle exhibited significant elevations in liver enzymes and oxidative stress markers, indicating hepatic inflammation and redox imbalance. Histological analysis revealed macrovacuolar steatosis, fibrosis, and bile duct dilatation. …”
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From gut to liver: Exploring the crosstalk between gut-liver axis and oxidative stress in metabolic dysfunction-associated steatotic liver disease by Mi Zhou, Jianyu Lv, Xinli Chen, Yujie Shi, Guanqun Chao, Shuo Zhang

“…As our comprehension of MASLD deepens, it has become evident that this condition extends beyond the liver, embodying a complex, multi-systemic disease with hepatic manifestations that mirror the broader metabolic landscape. …”
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NMR metabolic profiling of the liver following administrationof alcohol andthemushroom Ganoderma lucidum in rats by M. S. Krestina, O. B. Shevelev, I. V. Koptyug, L. A. Gerlinskaya, S. E. Peltek, A. E. Akulov

“…Binuclear hepatocytes indicate proliferative activity, and the concentration of the metabolites participating in the formation of new hepatic cells decreases. Thus, the study of liver tissues by 1H NMR spectroscopy allows for detection of early changes in metabolite concentra­tions following chronic consumption of alcohol at insignificant doses. …”
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Effects of dietary supplementation with novel organic rare earths on growth performance, gut and liver health, gut microbiota in golden pompano by Ming Li, Hui Liang, Rui Xia, Jian Zhang, Jie Chen, Wenhao Zhou, Qianwen Ding, Yalin Yang, Zhen Zhang, Yuanyuan Yao, Chao Ran, Zhigang Zhou

“…Meanwhile, dietary supplementation of novel organic rare earths alleviated liver inflammation by decreasing the expression of hepatic pro-inflammatory cytokines and elevating that of anti-inflammatory cytokines. …”
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Relationship between Serum Cytokeratin-18, Control Attenuation Parameter, NAFLD Fibrosis Score, and Liver Steatosis in Nonalcoholic Fatty Liver Disease by Sumitro Kosasih, Wong Zhi Qin, Rafiz Abdul Rani, Nazefah Abd Hamid, Ngiu Chai Soon, Shamsul Azhar Shah, Yazmin Yaakob, Raja Affendi Raja Ali

“…Both the fragmented CK-18 level and the CAP, but not NAFLD Fibrosis Score, were well correlated with hepatic steatosis grade as assessed by US.…”
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A soy glycinin derived octapeptide protects against MCD diet induced non-alcoholic fatty liver disease in mice by Peng Ma, Rongrong Huang, Yu Ou

“…In vivo, SGP8 lowered plasma alanine aminotransferase (ALT) and low density lipoprotein (LDL) content, normalized hepatic superoxide dismutase (SOD) and malondialdehyde (MDA) production, and reduced the severity of liver inflammation. …”
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The impact of a humanized bile acid composition on atherosclerosis development in hypercholesterolaemic Cyp2c70 knockout mice by Tess Yntema, Tim R. Eijgenraam, Niels J. Kloosterhuis, Rick Havinga, Mirjam H. Koster, Milaine V. Hovingh, Jan Freark de Boer, Debby P. Y. Koonen, Folkert Kuipers

“…Cyp2c70 −/− mice showed reduced hepatic total cholesterol and triglycerides (p < 0.05) combined with lower plasma total cholesterol (p < 0.05) and triglycerides (p = 0.05) due to lower VLDL levels. …”
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Ameliorated Impact of Fenugreek Seed Extract on Some Blood Cellular and Biochemical Parameters in Female Albino Rats Exposed to Lead Acetate by Rozhya Abduljalil Naser, Rabar Yousif Mameik, Nazar M. Shareef Mahmood, Kurdo Bapir Chato

“…It has a several diverse-organ toxicant effect in various healthy issues included diseases of the hepatic, renal, and other body systems. Fenugreek seeds (Trigonella foenum graecum L.) were used in curing medicine and as food supplement since ancient times. …”
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Effects of Dietary Resveratrol, Bile Acids, Allicin, Betaine, and Inositol on Recovering the Lipid Metabolism Disorder in the Liver of Rare Minnow Gobiocypris rarus Caused by Bisph... by Yingying Zhang, Yinan Jiang, Ziying Wang, Jiayu Wang, Mingzhen Zhu, Hui Yang

“…The liver morphology, hepatosomatic index (HSI), hepatic lipid deposition, TG level, and expression of lipid metabolism-related genes were analyzed after 5 weeks of feeding. …”
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Deaths during Sexual Activity by Agnė Okulevičiūtė, Sigitas Chmieliauskas, Sigitas Laima, Diana Vasiljevaitė, Jurgita Stasiūnienė

“…Concurrent findings included atherosclerotic changes in the heart, internal organ hyperemia and edema, hepatic steatosis, renal cyst, and a lack of ethyl alcohol in blood but 0.17 ‰ presence in urine according to toxicology analysis. …”
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The Effect of Puncture Sites of Portal Vein in TIPS with ePTFE-Covered Stents on Postoperative Long-Term Clinical Efficacy by Si-liang Chen, Peng Hu, Zhi-peng Lin, Jian-bo Zhao

“…The Kaplan-Meier analysis was performed to assess the effect of different puncture sites on primary patency, the incidence of hepatic encephalopathy (HE), and survival. Results. …”
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