Pseudoprogression in CAR-T cell therapy for solid tumor: Case report by Xuan Zhao, Xuan Zhao, Yanfen Liu, Yanfen Liu, Guohui Qin, Guohui Qin, Yan Ge, Qinglong Li, Xinfeng Chen, Xinfeng Chen, Ximei Tian, Yong Yu, Jiangtao Ren, Yi Zhang, Yi Zhang, Yi Zhang, Yi Zhang, Yi Zhang

“…We reported the pseudoprogression in an elderly patient with advanced gastric cancer after chimeric antigen receptor (CAR)-T cell therapy. The hepatic metastases enlarged 1 month after CAR-T cell infusion and then shrunk the next month as seen through computed tomography scanning. …”
Get full text

A Rare Cause of Acute Kidney Injury in a Female Patient with Breast Cancer Presenting as Renal Colic by Roxana Jurubita, Bogdan Obrisca, Gener Ismail

“…We present here a rare case of renal infarction that occurred in the setting of a hypercoagulable state, in a female patient with a history of breast cancer and documented hepatic metastases.…”
Get full text

Retroperitoneal Leiomyosarcoma Presenting as Lower Gastrointestinal Bleeding: A Case Report and Review of the Literature by Dominic G. Ventura, Shyam J. Thakkar, Katie Farah

“…CT scan showed a 26 × 20 × 13 cm heterogeneous retroperitoneal mass and multiple hypodense hepatic lesions. Liver biopsy revealed leiomyosarcoma. …”
Get full text

An Unexpected Interaction between Sofosbuvir/Ledipasvir and Atorvastatin and Colchicine Causing Rhabdomyolysis in a Patient with Impaired Renal Function by Shyam Patel, Jennifer Andres, Kamran Qureshi

“…Hepatitis C virus (HCV) infection affects roughly 170 million people worldwide. …”
Get full text

Secondary Hemochromatosis due to Chronic Oral Iron Supplementation by Ronald Lands, Emmanuel Isang

“…Diabetes mellitus and hepatic cirrhosis due to pancreas and liver damage are just two examples of diseases that result from iron overload. …”
Get full text

Vancomycin-Induced DRESS Syndrome: An Important Concern in Orthopedic Surgery by Emma Littlehales, Odhrán Murray, Robert Dunsmuir

“…The criteria for diagnosis of DRESS, including the RegiSCAR scoring system and commonly affected systems (renal, cardiac, and hepatic), are detailed, and we also discuss evidence for steroid treatment and considerations important in the use of this.…”
Get full text

Modern treatment methods of patients with liver metastases of colorectal cancer by Ye. N. Grebenkin, V. D. Chhikvadze, U. S. Stanoyevich, Ye. I. Dekhissi

“…Efficacy of liver resection, radio-frequency ablation (RFA), systemic and intra-arterial hepatic chemotherapy (IAHC) was studied.Results. The five-years general survival rate at liver resection was 33,3%, relapse-free – 22,2%, at RFA – 16,2 and 13,5% respectively. …”
Get full text

Isolated Gastrointestinal Metastasis of Breast Carcinoma: A Case Report by M. A. Titi, A. Anabtawi, A. D. Newland

“…She had breast carcinoma treated 7 years previously with normal follow-up since. Colonoscopy showed hepatic flexure thickening that was confirmed to be breast metastasis. …”
Get full text

Nonfatal Hyperammonemic Encephalopathy as a Late Complication of Roux-en-Y Gastric Bypass by Juan D. Salcedo, Jordan S. Goldstein, Jose M. Quinonez, Maria Antonietta Mosetti

“…Hyperammonemic encephalopathy in the absence of known hepatic dysfunction presents a diagnostic dilemma. …”
Get full text

Bacillus cereus Typhlitis in a Patient with Acute Myelogenous Leukemia: A Case Report and Review of the Literature by James D. Denham, Sowmya Nanjappa, John N. Greene

“…Individual case reports and case series exist in the literature describing various clinical manifestations of B. cereus in the neutropenic patient including bacteremia/septicemia, pneumonia, meningitis/encephalitis, hepatic abscesses, and gastritis. In this report, we describe a case of typhlitis caused by B. cereus in a 74-year-old female with recently diagnosed acute myelogenous leukemia (AML), and we summarize the available English language literature to draw tentative conclusions regarding the clinical manifestations of this organism.…”
Get full text

Nonalcoholic Fatty Liver Disease: A Clinical Approach and Review by Maitreyi Raman, Johane Allard

“…The primary abnormality or ‘first hit’ in patients with NAFLD is insulin resistance leading to hepatic steatosis. The second hit involves multiple proinflammatory cytokines resulting in non-alcoholic steatohepatitis. …”
Get full text

Growth Hormone and Reproduction: A Review of Endocrine and Autocrine/Paracrine Interactions by Kerry L. Hull, Steve Harvey

“…The somatotropic axis, consisting of growth hormone (GH), hepatic insulin-like growth factor I (IGF-I), and assorted releasing factors, regulates growth and body composition. …”
Get full text

Synthesis and Evaluation of Some New Isoquine Analogues for Antimalarial Activity by Chandra Nath Saha, Sanjib Bhattacharya, Dipak Chetia

“…Amodiaquine is a 4-aminoquinoline antimalarial that can cause adverse side effects including hepatic and haematological toxicity. The drug toxicity involves the formation of an electrophilic metabolite, amodiaquine quinoneimine (AQQI), which binds to cellular macromolecules leading to hepatotoxicity and agranulocytosis. …”
Get full text

Targeting the Hepcidin-Ferroportin Axis in the Diagnosis and Treatment of Anemias by Elizabeta Nemeth

“…The hepatic peptide hormone hepcidin regulates dietary iron absorption, plasma iron concentrations, and tissue iron distribution. …”
Get full text

Hilar Tumours by Guido Costamagna, Andrea Tringali, Lucio Petruzziello, Cristiano Spada

“…Even though jaundice can be relieved if only 30% of the liver is drained, the presence of undrained bile ducts may result in pruritus and a continued risk of cholangitis and hepatic abscess. The biliary anatomy is defined by cholangiography, which today can be performed by magnetic resonance; the stricture is dilated, and plastic or metallic stents are endoscopically inserted over a guidewire. …”
Get full text

Protective effect of brain and muscle arnt-like protein-1 against ethanol-induced ferroptosis by activating Nrf2 in mice liver and HepG2 cells by Yanan Zhao, Ranran Zhang, Ziheng Chen, Ziyi Wang, Shuang Guan, Jing Lu

“…Collectively, our results unveiled that the protective action of BMAL1 during alcohol challenge depends on its ability to activate Nrf2-ARE antiferroptosis pathway and targeting hepatic BMAL1 to dampen hepatic ferroptosis signaling may have therapeutic potential for ALD.…”
Get full text

Abdominal visceral and subcutaneous adipose tissue and associations with cardiometabolic risk in Inuit, Africans and Europeans: a cross-sectional study by Gregers Stig Andersen, Mette Aadahl, Niels Grarup, Torsten Lauritzen, Bendix Carstensen, Pernille Falberg Rønn, Marit Eika Jørgensen, Dirk Lund Christensen

“…Measurements included abdominal fat distribution assessed by ultrasound, oral glucose tolerance test, hepatic insulin resistance, blood pressure and lipids. …”
Get full text

Hepatoprotective Effects of a Novel Trihoney against Nonalcoholic Fatty Liver Disease: A Comparative Study with Atorvastatin by Hamad Abdulsalam Hamad Alfarisi, Muhammad Bin Ibrahim, Zenab B. Hamad Mohamed, Nuraniza Azahari, Asmah Hanim Bt. Hamdan, Che Anuar Che Mohamad

“…Trihoney and atorvastatin showed marked (p<0.001) reduction of hepatic lipid peroxidation. Trihoney showed histological protection against progression of NAFLD to nonalcoholic steatohepatitis (NASH). …”
Get full text

Calcium hydroxide nanoparticles induce cell death, genomic instability, oxidative stress and apoptotic gene dysregulation on human HepG2 cells by Hanan R. H. Mohamed, Esraa H. Ibrahim, Shahd E. E. Shaheen, Nesma O. E. Hussein, Ayman Diab, Gehan Safwat

“…Further studies are required to explore the biological and toxicological properties and therapeutic potential of Ca(OH)2NPs in hepatic cancer treatment.…”
Get full text

Effect of soluble dietary fiber extracted from Lentinula edodes (Berk.) Pegler on lipid metabolism and liver protection in mice on high-fat diet by Kangxiao Guo, Kangxiao Guo, Jing Liu, Zihan Yao, Zhoujin Tan, Tao Yang

“…After 4 weeks, we assessed general state, organ conditions, liver status, blood parameters, expression of hepatic lipid metabolism genes, mRNA levels of key hepatic lipid metabolism genes. …”
Get full text