Recurrent Obscure Gastrointestinal Bleeding: Dilemmas and Success with Pharmacological Therapies. Case Series and Review by Majid Almadi, Peter M Ghali, Andre Constantin, Jacques Galipeau, Andrew Szilagyi

“…After multiple transfusions and several attempts at endoscopic management in some cases, long-acting octreotide was associated with decreased transfusion requirements and increased hemoglobin levels in all three cases, although other factors may have contributed in some. …”
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Upper Limb Deep Vein Thrombosis in Patient with Hemophilia A and Heterozygosity for Prothrombin G20210A: A Case Report and Review of the Literature by Fares Darawshy, Yosef Kalish, Issam Hendi, Ayman Abu Rmelieh, Tawfik Khoury

“…In the absence of external signs of bleeding or hematoma and normal hemoglobin level, we suspected an underlying DVT. Doppler ultrasonography of the right upper limb revealed thrombosis of the subclavian vein and this was confirmed by CT venography. …”
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HbSC Disease and Spontaneous Epidural Hematoma with Kernohan’s Notch Phenomena by Meera Yogarajah, Chidozie Charles Agu, Bhradeev Sivasambu, Mark A. Mittler

“…A 19-year-old African American male with hemoglobin SC disease (HbSC) presented with generalized body aches and was managed for acute painful crisis. …”
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Risk factors and early prediction of cardiorenal syndrome type 3 among acute kidney injury patients: a cohort study by Hui Lin, Xiaoyu Guo, Mengzhu Wang, Xiaole Su, Xi Qiao

“…Calibration and decision curve analyses upheld its accuracy and clinical utility.Conclusions We developed a nomogram predicting CRS type 3 in AKI patients, incorporating 6 risk factors: age, CVD history, MAP, hemoglobin, homocysteine, and AKI stage, enhancing early risk identification and patient management.…”
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Burden of Anemia among Human Immunodeficiency Virus-Positive Adults on Highly Active Antiretroviral Therapy at Hawassa University Compressive Specialized Hospital, Hawassa, Ethiopi... by Sisay Tesfaye, Melaku Hirigo, Dawit Jember, Mekdes Shifeta, Worku Ketema

“…Data on demographic characteristics, related factors of anemia, latest hemoglobin, CD4, and ART regimens were collected using a structured data abstraction format. …”
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Effects of dietary Chlorella ellipsoidea on growth performance, body composition, and hematology of stinging catfish, Heteropneustes fossilis by Alam Asraful, Bristy Fouzia Sultana, Amzad Hossain M., Rabiul Islam M., Fatema Umme Kaniz, Golam Rasul M.

“…The red blood cells, white blood cells, hemoglobin, hematocrit, and mean corpuscular hemoglobin levels of H. fossilis increased significantly (P < 0.05) when the fish were fed 5.0–10.0% dietary C. ellipsoidea compared with the control. …”
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Effects of yacon on carbohydrates and lipid metabolism, oxidative-nitrative stress markers changes in rats with experimental metabolic syndrome by Mariia Nagalievska, Khrystyna Vilkiv, Lidiya Mishchenko, Nataliia Sybirna

“…Results: The 14 days use of aqueous extract of yacon for the treatment of fructose-induced metabolic syndrome leads to a decrease of animals’ body weight (59.94 %), glucose concentration (10.33 %), glycosylated hemoglobin content (61.58 %), blood plasma triglycerides (50.35 %), cholesterol (24.46 %), low-density lipoproteins (21.56 %), as well as to increase in high-density lipoproteins concentration (29.29 %), paraoxonase activity (56.03 %). …”
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Cost-Benefit Analysis of Genetic Testing as a Prenatal Diagnostic Tool for Thalassemia: A Single-Center Study From Central Thailand by Malasai K, Jittikoon J, Udomsinprasert W, Talungchit P, Youngkong S, Sangroongruangsri S, Mahasirimongkol S, Chaikledkaew U

“…Kwandao Malasai,1,2 Jiraphun Jittikoon,3 Wanvisa Udomsinprasert,3 Pattarawalai Talungchit,4,5 Sitaporn Youngkong,5,6 Sermsiri Sangroongruangsri,6 Surakameth Mahasirimongkol,7 Usa Chaikledkaew5,6 1Social, Economic and Administrative Pharmacy (SEAP) Graduate Program, Faculty of Pharmacy, Mahidol University, Bangkok, Thailand; 2Social Pharmacy Research Unit, Faculty of Pharmacy, Mahasarakham University, Maha Sarakham, Thailand; 3Department of Biochemistry, Faculty of Pharmacy, Mahidol University, Bangkok, Thailand; 4Department of Obstetrics and Gynecology, Faculty of Medicine Siriraj Hospital, Mahidol University, Bangkok, Thailand; 5Mahidol University Health Technology Assessment (MUHTA) Graduate Program, Mahidol University, Bangkok, Thailand; 6Social and Administrative Pharmacy Division, Department of Pharmacy, Faculty of Pharmacy, Mahidol University, Bangkok, Thailand; 7Information and Communication Technology Center, Office of the Permanent Secretary, Ministry of Public Health, Nonthaburi, ThailandCorrespondence: Usa Chaikledkaew, Social and Administrative Pharmacy Division, Department of Pharmacy, Faculty of Pharmacy, Mahidol University, 447 Sri-Ayudhaya Road, Rachathewi, Phayathai, Bangkok, 10400, Thailand, Email usa.chi@mahidol.ac.thPurpose: This study aimed to evaluate the costs and benefits of genetic testing, specifically mutation analysis and prenatal diagnostic testing, for the confirmation of thalassemia in at-risk pregnancies in Thailand, providing crucial insights to inform public health policy decision-making.Patients and Methods: We analyzed the costs and benefits of following standard screening guidelines, which included a sequence of tests such as mean corpuscular volume (MCV)/mean corpuscular hemoglobin (MCH) with dichlorophenol indophenol precipitation (DCIP), hemoglobin (Hb) typing, genetic testing, and amniocentesis. …”
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Co-administration of Hibiscus sabdariffa linn and Daflon-500® mitigates weight loss, hyperglycemia, hematological and oxidative changes in male rats with type-2 diabetes by Aishat Omobolanle Olatunji, Root Oluwapelumi Alegbe, Suleiman Folorunsho Ambali, Muftau Shittu, Ganiu Jimoh Akorede, Abdulfatai Aremu, Afisu Basiru, Jamila Abdulhamid Atata, Kolawole Yusuf Suleiman, Charles Amoto Shuaibu

“…Significantly higher packed cell volume, hemoglobin levels, red blood cell counts, lymphocytes, and mean corpuscular hemoglobin were observed in groups 5–7. …”
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Association of biochemical indicators with multimorbidity in 19,624 older adult individuals with chronic diseases: a study from Jindong District, Jinhua City, China by Qihuan Yao, Guozhong Chen

“…Multiple biochemical indicators were significantly associated with multimorbidity, particularly lipid parameters (low HDL-C and elevated TG), glucose parameters (elevated FBG and positive U-GLU), liver function (elevated ALT), and hemoglobin levels. These findings provide important evidence for research on factors associated with multimorbidity in the older adult population.…”
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Effect of Multimodal App-Based Interventions on Glycemic Control in Patients With Type 2 Diabetes: Systematic Review and Meta-Analysis by Emma Bodner, Lena Roth, Kathleen Wiencke, Christian Bischoff, Peter EH Schwarz

“…The outcome of interest was a reduction in glycated hemoglobin (hemoglobin A1c [HbA1c]; long-term blood glucose measurements). …”
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The clinical implication of CD45RA+ naïve T cells and CD45RO+ memory T cells in advanced pancreatic cancer: a proxy for tumor biology and outcome prediction by Junjie Hang, Junjie Huang, Siyuan Zhou, Lixia Wu, Yingwei Zhu, Lina Zhu, Hanyu Zhou, Kequn Xu, Hua Jiang, Xuguang Yang

“…CD4+ naïve/memory ratio showed close correlations with hemoglobin, red blood cell (RBC), absolute neutrophil count (ANC) and platelet while CD8+ naïve/memory ratio was correlated with hemoglobin, RBC and CEA. …”
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Cobalamin Malabsorption due to a Dysfunctional Intrinsic Factor by Jeanne Drouin, Nadia Mikhael

“…A family study showed normal cobalamin absorption for all tested subjects, as well as two α-hemoglobin gene deletions in the father and a single α-gene deletion in the patient. …”
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THERAPEUTIC GENE EDITING FOR HEMOGLOBINOPATHIES by Ugo Testa, Giuseppe Leone, Maria Domenica Cappellini

“…Initial studies of gene therapy for hemoglobinopathies involved the use of lentiviral vectors to add functional copies of the gene encoding b-globin in defective CD34 cells; more recently, gene editing techniques have been used involving either CRISPR-Cas9, transcription activation-like effector protein nuclease, zinc finger nuclease, and base editing to either induce fetal hemoglobin production at therapeutic levels or to genetically repair the underlying molecular defect causing the disease. …”
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The Role of Heme and Reactive Oxygen Species in Proliferation and Survival of Trypanosoma cruzi by Marcia Cristina Paes, Daniela Cosentino-Gomes, Cíntia Fernandes de Souza, Natália Pereira de Almeida Nogueira, José Roberto Meyer-Fernandes

“…Trypanosoma cruzi, the protozoan responsible for Chagas disease, has a complex life cycle comprehending two distinct hosts and a series of morphological and functional transformations. Hemoglobin degradation inside the insect vector releases high amounts of heme, and this molecule is known to exert a number of physiological functions. …”
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The Fluorescent Detection of Alkaline Phosphatase Based on Iron Nanoclusters and a Manganese Dioxide Nanosheet by Liang Zhao, Xinyue Liu, Xinwen Zhang, Siyu Liu, Jiazhen Wu

“…Herein, we synthesized hemoglobin-coated iron nanoclusters (Hb−Fe NCs) with a significant fluorescence emission peak at 615 nm and investigated the inner-filter effect of fluorescence induced by a manganese dioxide nanosheet (MnO₂ NS). …”
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Anti-diabetic and anti-hyperlipidemic effects of sea cucumber (Cucumaria frondosa) gonad hydrolysates in type II diabetic rats by Tingting Wang, Lin Zheng, Shuguang Wang, Mouming Zhao, Xiaoling Liu

“…Results showed that SCGH significantly reduced water intake, fasting blood glucose level and glycated hemoglobin level. Moreover, the oral glucose tolerance, insulin resistance and plasma lipid level in diabetic rats were also alleviated. …”
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The effect of Moringa oleifera leaf extract in feed as an immunostimulant for Aeromonas hydrophilla bacterial infections by Imelda Arisa Iko, Faradila Maisa, Mellisa Siska

“…In conclusion, doses of 100-150 mg kg-1 of Moringa leaf extract produced the best results, including reduced clinical symptoms, survival rates (70-83.33%), leukocyte count (173-223 x 103 cells mm-3), hematocrit (27-28%), and hemoglobin levels (6.6-7 g dL-1), indicating its potential as an effective immunostimulant for tilapia.…”
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Massive Fetomaternal Hemorrhage Caused by an Intraplacental Choriocarcinoma: A Case Report by Anna-Karina Aaris Henningsen, Lisa Leth Maroun, Hanne Havsteen, Jens Svare

“…A fetomaternal hemorrhage resulted in a hemoglobin concentration in the infant of only 2,1 g/dL. …”
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Laparoscopic Splenectomy for Hairy Cell Leukemia in Pregnancy by Beni Adegoke Adeniji, Moses Fallas, Marc Incerpi, Solomon Hamburg, Robert Katz, Dotun Ogunyemi

“…We present a successful case of laparoscopic splenectomy for a massively enlarged spleen at 25 weeks of gestation for hairy cell leukemia in pregnancy in a woman with initial hemoglobin of 4.3 gm/dl and platelet count of 18,000/mm3. …”
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