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Development and validation of predictive models of early immune effector cell–associated hematotoxicity
Published 2025-02-01“…Therefore, we performed comprehensive univariate analyses to identify factors associated with severe (grade 3-4) early ICAHT (eICAHT) in 691 patients who received commercial or investigational CAR T-cell therapy for hematologic malignancies. In univariate logistic regression, preinfusion factors associated with severe eICAHT included disease type (acute lymphoblastic leukemia), prelymphodepletion (pre-LD) blood counts including absolute neutrophil count (ANC), lactate dehydrogenase (LDH), and inflammatory (C-reactive protein [CRP], ferritin, and interleukin-6 [IL-6]) and coagulopathy biomarkers (D-dimer). …”
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Interferon gamma‐mediated prevention of tumor progression in a mouse model of multiple myeloma
Published 2024-12-01Get full text
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Role of B-Cell Lymphoma/Leukemia 11A in Normal and Malignant Hematopoiesis
Published 2025-01-01“…The dysregulation of BCL11A disrupts downstream molecular pathways, contributing to the development of several hematological malignancies, particularly leukemias. This review provides a comprehensive overview of the role of BCL11A in normal and malignant hematopoiesis, details the hematological disorders associated with its dysregulation and explores the current therapeutic strategies targeting this transcription factor.…”
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CD9 in acute myeloid leukemia: Prognostic role and usefulness to target leukemic stem cells
Published 2019-03-01Get full text
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