Associations between TGF-β1 Levels and Markers of Hemolysis, Inflammation, and Tissue Remodeling in Pediatric Sickle Cell Patients by Rayra P. Santiago, Magda O. S. Carvalho, Camylla V. B. Figueiredo, Luciana M. Fiuza, Rodrigo M. Oliveira, Sètondji C. M. A. Yahouédéhou, Valma M. L. Nascimento, Isa M. Lyra, Théo Araujo-Santos, Nívea F. Luz, Milena M. Aleluia, Caroline C. Guarda, Valéria M. Borges, Marilda S. Goncalves

“…A healthy control (HC) group of 59 individuals was also included. Hematological and biochemical analyses were carried out using electronic methods. …”
Get full text

Hubungan Rasio Leukosit Mean Platelet Volume dengan Skor GRACE sebagai Prediktor Prognosis pada Pasien Sindrom Koroner Akut by Theresia Ilyan, Herniah Asti Wulanjani, Edward Kurnia Setiawan Limijadi

“…Perhitungan rasio leukosit MPV dari hasil pemeriksaan hematologi pasien pertama kali saat rawat inap dan pengukuran skor GRACE dari rekam medis. …”
Get full text

Illuminating the impact of CD38-induced adenosine formation in B-cell lymphoma by Shams ElDoha Galal ElDin Zaiema, Heba Mohamed Saber Hafez, Diaa El-Din Moussa Sherif Abou El-Ela, Rawda Ahmed Alaaeldin Ahmed Mohamed Saad

“…This study examines the impact of heightened CD38 expression and extracellular ADO on various hematological and clinical parameters in patients with mature B-cell lymphoma, alongside their correlation with the soluble counterparts of the PD-1/PD-L1 axis. …”
Get full text

Characteristics and Cluster Analysis of 18,030 Sepsis Patients Who Were Admitted to Thailand’s Largest National Tertiary Referral Center during 2014–2020 to Identify Distinct Subty... by Phuwanat Sakornsakolpat, Surat Tongyoo, Chairat Permpikul

“…Cluster H1 had prominent hematologic abnormalities. Clusters H3 and H5 had younger ages and significant hepatic dysfunction. …”
Get full text

PARP inhibitors as therapy for small cell lung carcinoma: A systematic review and meta-analysis of clinical trials by Samuel Pratama, Lowilius Wiyono, Martien Silviandy Setiawan, Brigitta Cindy Lauren

“…The analysis showed increased Progression-Free Survival (PFS) (RR 0.92 (95 %CI 0.84–1.00; p=0.05)) and Objective Response Rate (ORR) (RR 1.27 (95 %CI 1.07–1.50; p=0.007)), no significant difference in Overall Survival (OS) (RR 1.03 (95 %CI 0.92–1.15; p=0.60)), and an increased risk for serious Treatment Emergent Adverse Events (TEAEs) (RR 1.13 (95 %CI 0.95–1.35; p=0.16)) in PARPi-receiving SCLC patients. Amongst the hematologic toxicities, sub-analysis showed that thrombocytopenia had the highest risk, followed by neutropenia, anemia, leukopenia, and lymphopenia. …”
Get full text

A Rare Case of Severe Facial Disfiguration Due to Extranodal NK/T-Cell Lymphoma by Deng H, Yang Q, Shi Z

“…Huiyi Deng,1,2 Qintai Yang,1,2 Zhaohui Shi1,2 1Department of Otolaryngology-Head and Neck Surgery, The Third Affiliated Hospital of Sun Yat-Sen University, Guangzhou, People’s Republic of China; 2Department of Allergy, The Third Affiliated Hospital of Sun Yat-Sen University, Guangzhou, People’s Republic of ChinaCorrespondence: Zhaohui Shi, Department of Otolaryngology-Head and Neck Surgery, Department of Allergy, The Third Affiliated Hospital of Sun Yat-Sen University, Guangzhou, People’s Republic of China, Email shizhh35@mail.sysu.edu.cnBackground: Extranodal NK/T-cell lymphoma, nasal type (ENKTCL-NT) is a rare, highly invasive Epstein-Barr virus associated hematological malignant tumor with an unfavorable prognosis. …”
Get full text

Development of a multi-laboratory integrated predictive model for silicosis utilizing machine learning: a retrospective case-control study by Guo-kang Sun, Yun-hui Xiang, Lu Wang, Pin-pin Xiang, Zi-xin Wang, Jing Zhang, Ling Wu

“…Logistic regression analysis and receiver operating characteristic (ROC) curves were used to construct a multiple biomarker-based model for the diagnosis of silicosis, which was applied to both the training and the testing datasets.ResultsThe training cohort revealed significant statistical differences (P < 0.05) in multiple hematologic parameters between silicosis patients and healthy individuals. …”
Get full text

Synchronous Occurrence of Splenic Pleomorphic Mantle Cell Lymphoma and Esophageal Adenocarcinoma with Overexpression of BCL1 Protein by Dominik Dabrowski, Roberto F. Silva, Michael Constantinescu, Rodney E. Shackelford, Nestor Dela Cruz, Eric X. Wei

“…We have reviewed previous reports of synchronic mantle cell lymphoma and other solid tumors or hematological malignancies in the literature.…”
Get full text

Epidemiology and Resistance Profiles of Bacteria Isolated From Blood Samples in Septic Patients at Emergency Department Admission: A 6-Year Single Centre Retrospective Analysis Fro... by Valeria Cento, Sara Carloni, Riccardo Sarti, Linda Bussini, Zian Asif, Paola Morelli, Francesco De Fazio, Federica Maria Tordato, Maddalena Casana, Debora Mondatore, Antonio Desai, Elena Generali, Nicola Pugliese, Elena Costantini, Massimo Vanoni, Maurizio Cecconi, Stefano Aliberti, Giorgio Da Rin, Erminia Casari, Michele Bartoletti, Antonio Voza

“…Carbapenem-resistant Enterobacterales were rare (2.1%-2.8%), predominantly involving Klebsiella pneumoniae. Onco-hematological patients had a lower multidrug-resistance prevalence (9.5% vs. 21.1%, P < 0.001). …”
Get full text

Discovery and development of ANV419, an IL-2/anti-IL-2 antibody fusion protein with potent CD8+ T and natural killer cell-stimulating capacity for cancer immunotherapy by Patrizia Murer, Barbara Brannetti, Jean-Michel Rondeau, Laetitia Petersen, Nicole Egli, Simone Popp, Catherine Regnier, Kirsten Richter, Andreas Katopodis, Christoph Huber

“…These data support the clinical development of ANV419 in solid tumors and hematological malignancies as monotherapy and in combination with checkpoint inhibitors or agents that induce antibody-dependent cellular cytotoxicity. …”
Get full text

Specialty palliative care use among cancer patients: A population-based study. by J Brian Cassel, Donna McClish, David Buxton, Leanne Yanni, Seth Roberts, Nevena Skoro, Peter May, Egidio Del Fabbro, Danielle Noreika

“…Characteristics associated with using SPC use included being in an socio-economic status quintile other than the lowest; being younger; being Black; having a solid (versus hematological) cancer; having a shorter survival with cancer; dying in the latter two years of the study; being from an area of low or complete rurality; having a hospital admission in the final 60 days prior to initiation of PC or death; having more days in hospital; and living within 15 miles of a hospital offering SPC.…”
Get full text

Evaluation of Leea rubra Leaf Extract for Oxidative Damage Protection and Antitumor and Antimicrobial Potential by Nibedita Das, Sanowar Hossain, Jaytirmoy Barmon, Shahnaj Parvin, Mahadi Hasan, Masuma Akter, Ekramul Islam

“…Antitumor activity was assessed by evaluating the percentage inhibition of cell growth, morphological changes of Ehrlich’s ascites carcinoma (EAC) cells, and hematological parameters. Antimicrobial activity was determined by the disc diffusion method against different resistant microorganisms. …”
Get full text

Escherichia coli in septic arthritis: prevalence and antibiotics susceptibility patterns by Masroora Ali Khan, Muhammad Kamran Taj, Zahid Khan, Imran Taj, Muhammad Naeem, Saima Azam

“…Joint aspirates (2ml) and blood (5ml) were analyzed for microbial and hematological examination. Results: There were 5.45% samples positive, and 94.5% negative for E. coli. …”
Get full text

Machine learning identifies the association between second primary malignancies and postoperative radiotherapy in young-onset breast cancer patients. by Yulin Lai, Peiyuan Huang

“…YWBC patients receiving PORT had significantly greater risks of second primary solid malignancies (SPSMs, RR = 1.61), including breast cancer (RR = 1.89), lung cancer (RR = 2.12) and thyroid cancer (RR = 1.48), but not second primary hematologic malignancies (RR = 1.32; 0.94-1.88). SPSMs were more common in YWBC individuals who were black, had a lower median household income and had fewer lymph nodes examined. …”
Get full text

Shared Medical and Environmental Risk Factors in Dry Eye Syndrome, Sjogren’s Syndrome, and B-Cell Non-Hodgkin Lymphoma: A Case-Control Study by Hadas Ben-Eli, Doron J. Aframian, Eldad Ben-Chetrit, Dror Mevorach, Geffen Kleinstern, Ora Paltiel, Abraham Solomon

“…NHL patients were more likely to report first-degree relatives with hematologic cancer, while having first-degree relatives with an autoimmune disease (AID) was associated with SS (OR=5.25; 95% CI: 2.59-10.63) and DES (OR=3.55; 95% CI: 1.83-6.91) compared to controls. …”
Get full text

Pulmonary aspergillosis in US Veterans with COVID-19: a nationwide, retrospective cohort study by Kaitlin Swinnerton, Nathanael R. Fillmore, Ikwo Oboho, Janet Grubber, Mary Brophy, Nhan V Do, Paul A Monach, Westyn Branch-Elliman

“…Selected clinical characteristics included age >70, receipt of immune-compromising drugs, hematologic malignancy, chronic respiratory disease, vaccination status, and vaccine era. …”
Get full text

Postoperative fever following surgery for oral cancer: Incidence, risk factors, and the formulation of a machine learning-based predictive model by Yanling Zhang, Kun Long, Zhaojian Gong, Ruping Dai, Shuiting Zhang

“…The analysis encompassed 34 parameters, incorporating demographic and clinical characteristics, biochemical and hematological assay results, surgical-related data, hospitalization costs and stay in hospital. …”
Get full text

Early- and Late-Onset Preeclampsia: A Comprehensive Cohort Study of Laboratory and Clinical Findings according to the New ISHHP Criteria by Anna Wójtowicz, Małgorzata Zembala-Szczerba, Dorota Babczyk, Monika Kołodziejczyk-Pietruszka, Olga Lewaczyńska, Hubert Huras

“…In addition, the EOP group had more frequent occurrence of severe cardiorespiratory (p<0.0001) and hematological (p=0.0127) complications, adverse fetoplacental conditions (p<0.0001), and severe fetoplacental complications (p=0.0003). …”
Get full text

WT1 Peptide Cancer Vaccine for Patients with Hematopoietic Malignancies and Solid Cancers by Yoshihiro Oka, Akihiro Tsuboi, Olga A. Elisseeva, Hiroko Nakajima, Fumihiro Fujiki, Manabu Kawakami, Toshiaki Shirakata, Sumiyuki Nishida, Naoki Hosen, Yusuke Oji, Ichiro Kawase, Haruo Sugiyama

“…In contrast, reduction of WT1 peptide dose may be needed for the treatment of patients with hematological stem cell diseases, because rapid and strong destruction of malignant cell-sustained hematopoiesis before recovery of normal hematopoiesis may lead to pancytopenia in these patients.…”
Get full text

HDAC10 and its implications in Sézary syndrome pathogenesis by Monika Pieniawska, Karolina Rassek, Bogumiła Skwara, Magdalena Żurawek, Iwona Ziółkowska-Suchanek, Lydia Visser, Monique Lodewijk, Małgorzata Sokołowska-Wojdyło, Małgorzata Sokołowska-Wojdyło, Berenika Olszewska, Roman J. Nowicki, Roman J. Nowicki, Tomasz Stein, Aleksandra Dańczak-Pazdrowska, Adriana Polańska, Marta Szymoniak-Lipska, Natalia Rozwadowska, Katarzyna Iżykowska

“…Cutaneous T-cell lymphomas (CTCL) are a group of rare hematological malignancies characterized by infiltration of malignant T-cells into the skin. …”
Get full text