New model to predict survival in advanced pancreatic ductal adenocarcinoma patients by measuring GGT and LDH levels and monocyte count by Rocío del Campo-Pedrosa, Rocío del Campo-Pedrosa, Alfonso Martín-Carnicero, Ana González-Marcos, Alfredo Martínez

“…Cut-off points for hematological parameters were calculated and correlated with overall survival (OS) using Kaplan-Meier, log-rank test, robust Cox proportional hazards and logistic regressions.ResultsIn univariate analysis, individuals with low levels of GGT, LDH, ALP, leukocyte-, neutrophil- and monocyte counts showed significantly longer survival than patients with higher levels. …”
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Determinants of Deescalation Failure in Critically Ill Patients with Sepsis: A Prospective Cohort Study by Nawal Salahuddin, Lama Amer, Mini Joseph, Alya El Hazmi, Hassan Hawa, Khalid Maghrabi

“…On multivariate regression analysis, failure to deescalate was significantly predicted by hematologic malignancy OR 3.3 (95% CI 1.4–7.4) p<0.004, fungal sepsis OR 2.7 (95% CI 1.2–5.8) p=0.011, multidrug resistance OR 2.9 (95% CI 1.4–6.0) p=0.003, baseline serum procalcitonin OR 1.01 (95% CI 1.003–1.016) p=0.002, and SAPS II scores OR 1.01 (95% CI 1.004–1.02) p=0.006. …”
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Clinical Outcome Differences in Mucinous Versus Non-Mucinous Colonic Adenocarcinoma: A Comparative Study by Adrian Cote, Roxana Loriana Negrut, Hany Abdulateif Salem, Bogdan Feder, Mircea Gheorghe Pop, Adrian Marius Maghiar

“…No significant statistical differences were found regarding hematological parameters. However, MAC was associated with higher rates of local invasion and a predominant right-sided colonic location, necessitating more frequent right colectomies. …”
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Anti-VEGF therapy improves EGFR-vIII-CAR-T cell delivery and efficacy in syngeneic glioblastoma models in mice by Dai Fukumura, Rakesh K Jain, Jun Ren, Xinyue Dong, Zohreh Amoozgar, Somin Lee, Meenal Datta, Sylvie Roberge, Mark Duquette

“…Chimeric antigen receptor (CAR)-T cells have revolutionized the treatment of multiple types of hematological malignancies, but have shown limited efficacy in patients with glioblastoma (GBM) or other solid tumors. …”
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High and low dose radiotherapy combined with ICIs for MSS colorectal cancer patients with liver metastases: a phase I study (HaRyPOT) by Yuxuan Ding, Yong Feng, Yangfan Ye, Jiayi Shen, Chang Guo, Xia He, Liangjun Zhu, Lijun Wang

“…In exploratory endpoint analyses, tissue biopsies and paired hematologic samples from patients showed M2 macrophage reduction. …”
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Vitamin B12 and diabetic neuropathies by V.A. Serhiyenko, M.-Y. Markevych, V.B. Sehin, A.A. Serhiyenko

“…Vitamin B12 (cyanocobalamin, cobalamin) is an essential cofactor in two important biochemical pathways: methylmalonic acid metabolism and methionine synthesis from homocysteine. In addition to hematologic abnormalities (megaloblastic anemia or even pancytopenia), cobalamin deficiency can cause neurologic symptoms similar to diabetic neuropathy (DN). …”
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Immunophenotypic Characterization of Human Bone Marrow Mast Cells. A Flow Cytometric Study of Normal and Pathological Bone Marrow Samples by Luis Escribano, Alberto Orfao, Jesús Villarrubia, Beatriz Díaz-Agustín, Carlos Cerveró, Agustín Rios, José L. Velasco, Juana Ciudad, José L. Navarro, Jesús F. San Miguel

“…The goal of the present paper was to define the immunophenotype of bone marrow mast cells (BMMC) from healthy controls and patients with hematologic malignancies (HM) based on the use of multiple stainings with monoclonal antibodies analyzed by flow cytometry. …”
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Phase I Trial of Upamostat Combined With Gemcitabine in Locally Unresectable or Metastatic Pancreatic Cancer: Safety and Preliminary Efficacy Assessment by Xiuping Lai, Di Cheng, Huixin Xu, Jingshu Wang, Xiaozhi Lv, Herui Yao, Liuning Li, Junyan Wu, Suiwen Ye, Zhihua Li

“…Pharmacokinetic analysis revealed a dose‐related increase in LH011 and its metabolite WX‐UK1 exposure from 100 to 400 mg but not in the 600 mg group. Hematological toxicity, mainly attributable to gemcitabine, was the predominant grade 3 or 4 adverse event, with additional occurrences of loss of appetite, rash, and interstitial lung disease. …”
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Alloreactivity of Allogeneic Mesenchymal Stem/Stromal Cells and Other Cellular Therapies: A Concise Review by Kiran Shah, Nirali Shah, Fatameh Ghassemi, Carolyn Ly, Teena George, Carla Lutz, Huseyin Sumer

“…The area has been further strengthened with the approval of Chimeric Antigen Receptor added on T cells (CAR-T) therapies by the regulatory authorities USA’s Food and Drugs Administration (FDA), European Medical Agency (EMA), the Australian Therapeutic Goods Administration (TGA), and in many countries in 2017 to treat hematological cancers. Another milestone was achieved when allogeneic Mesenchymal Stem Cell- (MSC-) based therapy was approved by the EMA to treat Chrohn’s disease in 2018. …”
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The influence of sex on sleep characteristics in the adult and older adult population: findings from the EPISONO sleep study by Mayra dos Santos Silva, Priscila Farias Tempaku, Priscila Farias Tempaku, Monica Levy Andersen, Monica Levy Andersen, Sergio Tufik, Sergio Tufik, Dalva Poyares, Dalva Poyares

“…They also underwent full-night polysomnography (PSG) and peripheral blood collection for biochemical and hematological measurements. In both editions (2007 and 2015), physical and anthropometric assessments were also assessed. …”
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Si-Wu-Tang improves liver fibrosis by restoring liver sinusoidal endothelial cell functionality and reducing communication with hepatic stellate cells by Le Wang, Jiaorong Qu, Jianan Li, Xiaoyong Xue, Lingling Qin, Yufei Li, Yuanfeng Dou, Xiaohong Mu, Xiaojiaoyang Li

“…Si-Wu-Tang (SWT), a traditional Chinese herbal remedy, has been extensively studied for its effectiveness in treating hematological, gynecological and hepatic diseases. Materials and methods The component of SWT were identified by ultra-high-performance liquid chromatography (UHPLC). …”
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MLL-AF4 upregulates 5-lipoxygenase expression in t(4;11) leukemia cells via the ALOX5 core promoter by Marius Hyprath, Maximilian Molitor, Ilona Schweighöfer, Rolf Marschalek, Dieter Steinhilber

“…As key enzyme in leukotriene biosynthesis, 5-LO plays a central role in inflammatory diseases, but the 5-LO pathway has also been linked to development of certain hematological and solid tumor malignancies. Of note, previous studies have shown that the leukemogenic fusion protein MLL-AF4 strongly increases ALOX5 gene promoter activity. …”
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Positive association between chronic hepatitis B virus infection and anemia in pregnancy in Southern China by Renliang Huang, Zhe Lu, Xinze Li, Duo Zhou, Jing Xu, Dan Lin, Yunxue Fu, Yan Liang, Xuexia Li, Frank Petersen, Qiaomiao Zhou, Xinhua Yu

“…Further analysis unveiled distinctive hematological alterations among cases with chronic hepatitis B virus infection, characterized by diminished erythrocyte size and reduced levels of corpuscular hemoglobin. …”
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Effect of Praziquantel on Preventing Delayed Infection of <i>Schistosoma japonicum</i> in Buffaloes and Goats by Xiang Gui, Bing Shao, Haoran Zhong, Rongxue Lv, Hao Li, Ke Lu, Yang Hong, Zhiqiang Fu, Zhenjie Lu, Mengge Xu, Yamei Jin, Jinming Liu

“…This study aimed to evaluate the efficacy of PZQ in preventing <i>S. japonicum</i> infection in buffaloes and goats via assessing worm burden, worm size, hematological changes, and immune modulation. In the present study, buffaloes and goats were pretreated with PZQ at various doses (7–25 mg/kg body weight), followed by infection with <i>S. japonicum</i> cercariae. …”
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The molecular receptor NKBB enhances the persistence and anti-hepatocellular carcinoma activity of GPC3 CAR-T cells by Minghao Sui, Tiantian Liu, Xuanli Song, Ji Li, Han Ding, Yuqian Liu, Xinyu Wang, Huimin Liu, Yuchan Xue, Jianni Qi, Miao Zhang, Songbo Zhao, Qiang Zhu

“…Chimeric antigen receptor (CAR) T cells have encouraging results in the treatment of hematological malignancies. However, CAR-T therapy still faces numerous challenges against solid tumors, such as hepatocellular carcinoma (HCC), owing to heterogeneous antigen expression in tumor cells, limited persistence of CAR-T cells, etc. …”
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Novel metabolic prognostic score for predicting survival in patients with cancer by Jinyu Shi, Chenan Liu, Xin Zheng, Yue Chen, Heyang Zhang, Tong Liu, Qi Zhang, Li Deng, Hanping Shi

“…Finally, nomogram prognostic models and corresponding calculators were constructed and evaluated using the areas under the receiver operating characteristic curves (AUC), decision curve analysis (DCA), and calibration curves. Five of the 19 hematological indexes, including hemoglobin, neutrophils, direct bilirubin, albumin, and globulin, were selected as the evaluation indicators of metabolic disorder burden and independent risk factors for prognosis in cancer patients. …”
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Cobalamin and Folic Acid Status in Relation to the Etiopathogenesis of Pancytopenia in Adults at a Tertiary Care Centre in North India by M. Premkumar, N. Gupta, T. Singh, T. Velpandian

“…We investigated the clinical, etiological and hematological profile including bone marrow morphology of patients with pancytopenia in relation to their vitamin B12 and folic acid status at a tertiary care referral hospital in north India. …”
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A Case of Undiagnosed HIV Infection in a 57-Year-Old Woman with Multiple Myeloma: Consequences on Chemotherapy Efficiency and Safety by I. Poizot-Martin, S. Brégigeon, C. Tamalet, R. Bouabdallah, O. Zaegel-Faucher, V. Obry-Roguet, A. Ivanova, C.E. Cano, C. Solas

“…A 57-year-old woman diagnosed with multiple myeloma underwent a first round of chemotherapy by bortezomib/lenalidomide and then with bortezomib/liposomal-doxorubicine/dexamethasone, with partial remission, poor hematological tolerance, and multiple episodes of pneumococcal infection. …”
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Effect of Gum Arabic (Acacia senegal) on Growth Performance, Carcass Quality and Health of Clarias gariepinus Juveniles by Augustine Eyiwunmi Falaye, Abel Abah, Shakiru Okanlawon Sule

“…Carcass quality revealed dietary levels were superior to control with GA10 significantly different (p < 0.05) amongst treatments in protein and fat content. Hematological profile showed variations; erythrocyte indices compared to control, while plasma chemistry of aspartate aminotransferase, alkaline phosphatase, and alanine aminotransferase showed no difference (p > 0.05). …”
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Myocarditis in malaria—current evidence and future directions: a literature review by Gbolahan Olatunji, Emmanuel Kokori, Ikponmwosa Jude Ogieuhi, Olumide Akinmoju, Oluwatobi Omoworare, Doyin Olatunji, David Timilehin Isarinade, God-dowell O. Odukudu, Israel Charles Abraham, Samuel Owolabi, Jamil Nasrallah, Emmanuel Egbunu, Babafemi Oluwadarasimi Jaiyeoba, Ismaila Ajayi Yusuf, Olawale Olanisa, Nicholas Aderinto

“…Despite its primarily recognized impact on the hematological system, recent studies shed light on severe cardiac complications, particularly myocarditis, associated with Plasmodium infections. …”
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