ERYTHROCYTE SEDEMENTATION RATE:A USEFUL TOOL IN DIAGNOSTIC APPROACH by Muhammad Usman

“…Although it doesn’t enjoy the status of being called a diagnostic test,even then it is in continuous use as a good indicator in conditions like infections and inflammations; for screening and prognosis of certain diseases and also for monitoring the course of an existing disease.It is a good indicator to estimate the quantitative change in plasma that may occur in a lot of clinical conditions ranging from simple to much serious disorders such as inflammation, infection, pregnancy, obesity and even malignancies. In certain hematological conditions such as polycythaemia, sickle cell anaemia, leukemia, hypoproteinaemia as well as few other conditions like hyper viscosity, congestive heart failure etc. …”
Get full text

A Critical Review of Shonitasthapana Varga Dravyas on Rakta Dhatu by Naveen V, MS Veena Mullur

“…The judicious use of these dravyas after ascertaining their qualities and pharmacological activities offer a wide scope for utility of these drugs in various hematological disorders.…”
Get full text

A Case Report of a Patient with Soaring Clozapine Levels after Developing a Urinary Tract Infection by Adesh Kumar Agrawal, Soumitra Das, Lorenzo Abednego B. Adre, Nakka Raghuma, Sharanya Kaushik, Adarsha Adhikari

“…It can induce dose-dependent adverse effects such as increased susceptibility to infections and hematological irregularities. In this case report, we present a 37-year-old woman with schizoaffective disorder who experienced clozapine side effects following a moderate urinary tract infection (UTI). …”
Get full text

A Novel Mutation in the Adult-Onset Alexander’s Disease GFAP Gene by Dhillon B. Zaver, Nathan T. Douthit

“…A full neurologic and hematologic workup yielded very little results, until a thorough literature search of her presenting complaints and radiologic findings pointed to adult-onset Alexander’s Disease. …”
Get full text

Vertigo as the First Sign of Chronic Myeloid Leukemia: A Case Report and Literature Review by Rubén Martín-Hernández, Diego Hernando Macías-Rodríguez, Víctor Martín-Sánchez, Cristina Cordero-Civantos, Santiago Santa Cruz-Ruiz, Ángel Batuecas-Caletrio

“…In this case we detail the importance of taking hematological disorders into consideration in the differential diagnosis of patients with otoneurological symptoms, and we also review the etiopathogenic mechanisms, symptoms, diagnosis, and therapeutic options for chronic myeloid leukemia with sudden hearing loss and vertigo.…”
Get full text

Human Herpesviridae Methods of Natural Killer Cell Evasion by Carl I. Odom, David C. Gaston, James M. Markert, Kevin A. Cassady

“…Human herpesviruses cause diseases of considerable morbidity and mortality, ranging from encephalitis to hematologic malignancies. As evidence emerges about the role of innate immunity and natural killer (NK) cells in the control of herpesvirus infection, evidence of viral methods of innate immune evasion grows as well. …”
Get full text

CAR-T cell therapy: developments, challenges and expanded applications from cancer to autoimmunity by Yaojie Kong, Jingyao Li, Xueyao Zhao, Yanwei Wu, Liang Chen

“…Chimeric Antigen Receptor (CAR)-T cell therapy has rapidly emerged as a groundbreaking approach in cancer treatment, particularly for hematologic malignancies. However, the application of CAR-T cell therapy in solid tumors remains challenging. …”
Get full text

The probable progression of Epstein-Barr virus (EBV) to chronic active EBV/reactivation weakens the immune response and stimulates Cryptococcus neoformans infection, which invariab... by Gargee Mishra, Gaurav Sarnaik, Joydeep Samanta, Archana Keche, Sanjay Singh Negi

“…This report highlights the need for clinical suspicion of EBV in unexplained cases of neurological manifestation, the hematological disorder of pancytopenia, a lower CD4 count, and multiorgan involvement such as pleural effusion, coarse liver echotexture, and splenomegaly.…”
Get full text

Spontaneous Massive Splenic Infarction in the Setting of Renal Transplant and Septic Shock: A Case Report and Review of the Literature by Christine L. Bokman, Maroun Sfeir, Veer Chahwala, Enrique Ginzburg

“…Causes of MSI include hematological disorders, coagulopathies, infection, and embolization, and, rarely, MSI is spontaneous. …”
Get full text

Effects of Long-Term Dietary Administration of Kale ( Brassica oleracea L. var. acephala DC) Leaves on the Antioxidant Status and Blood Biochemical Markers in Rats by Katarzyna Papierska, Ewa Ignatowicz, Jadwiga Jodynis-Liebert, Małgorzata Kujawska, Róża Biegańska-Marecik

“…The standard blood biochemical and hematological markers, antioxidant enzyme activities, level of lipid peroxidation, reduced glutathione content, and damage to DNA in the liver were measured. …”
Get full text

Rationale and design of APOLLO: a personalized rehAbilitation PrOgram in aLLOgeneic bone marrow transplantation by Edith Pituskin, Stephen Foulkes, Rachel J. Skow, Thomas McMurtry, Calvin Kruger, Janet E. Bates, Daena Lamoureux, Joseph Brandwein, Elena Lieuw, Cynthia Wu, Nancy Zhu, Peng Wang, Daniel Sawler, Minakshi Taparia, Marlene Hamilton, Tiffany Comfort-Riddle, Tara Meyer, Gabor T. Gyenes, Ian Paterson, Carla M. Prado, Mark J. Haykowsky, Justin G. Greiner, Margaret L. McNeely, Puneeta Tandon, Richard B. Thompson

“…Abstract Background Hematopoietic stem cell transplantation (HSCT) is a common therapy for many hematologic malignancies. While advances in transplant practice have improved cancer-specific outcomes, multiple and debilitating long term physical and psychologic effects remain. …”
Get full text

Epidemiological and clinical characteristics of hospitalized pediatric patients with Mycoplasma pneumoniae pneumonia before and after the COVID-19 pandemic in China: a retrospectiv... by Yuqian Zhang, Chenglei Su, Yang Zhang, Shuo Ding, Xianliang Yan, Jianguo Zhang, Zhimin Tao

“…After the COVID-19 pandemic, the increased incidence of IAV/IBV co-infection may contribute to the differences in clinical symptoms and hematological profiles, while the adding usage of corticosteroids might treat more effectively.…”
Get full text

The Effect of Diacerein on Type 2 Diabetic Mellitus: A Systematic Review and Meta-Analysis of Randomized Controlled Trials with Trial Sequential Analysis by Shizhe Guo, Xianshan Guo, Hongya Zhang, Xuan’e Zhang, Zhen Li

“…Secondary outcomes were glycosylated hemoglobin A1c (HbA1c), body mass index (BMI), lipid profiles, hematological indexes including hematocrit and platelet count, and systematic inflammatory level expressed as a C-reactive protein (CRP) level. …”
Get full text

Experimental infection of wild boars (Sus scrofa) with Rickettsia rickettsii and evaluation of the transmission potential to Amblyomma sculptum ticks by Lucianne Cardoso Neves, Lina de Campos Binder, Warley Vieira de Freitas Paula, Nicolas Jalowitzki de Lima, Ennya Rafaella Neves Cardoso, Rayane Almeida Santos, Raphaela Bueno Mendes Bittencourt, Gracielle Teles Pádua, Gabriel Cândido dos Santos, Mariana Avelar Tavares, Maria Carolina de Azevedo Serpa, Adriano Pinter, Artur Luiz de Almeida Felicio, Marcelo B. Labruna, Felipe da Silva Krawczak

“…Results The wild boars showed no clinical or hematological alterations, and bacteremia was not detected by qPCR or inoculation of wild boar blood into guinea pigs. …”
Get full text

Hematopoietic cell transplantation soon after first relapse in acute myeloid leukemia – the PROS by Edward Copelan, Robert P. Gale

Get full text

Recent Advances in Our Understanding of HLA-G Biology: Lessons from a Wide Spectrum of Human Diseases by Fabio Morandi, Roberta Rizzo, Enrico Fainardi, Nathalie Rouas-Freiss, Vito Pistoia

“…However, HLA-G can be expressed de novo at high levels in several pathological conditions, including solid and hematological tumors and during microbial or viral infections, leading to the impairment of the immune response against tumor cells or pathogens, respectively. …”
Get full text

An Overview of the Safety, Efficiency, and Signal Pathways of Stem Cell Therapy for Systemic Lupus Erythematosus by Qian Yang, Yiping Liu, Guangyong Chen, Wancong Zhang, Shijie Tang, Tianbiao Zhou

“…Mesenchymal stem cells (MSCs) are considered a good source for autoimmune disease and hematological disease therapy. This review will summarize the efficacy, safety, and mechanisms of MSC therapy for SLE. …”
Get full text

Current developments in personalized treatment strategies for elderly acute myelogenous leukemia patients by Xueting Hou, Jizhang Bao

“…Acute myelogenous leukemia(AML) is a life-threatening hematologic malignancy that predominantly affects the elderly.Currently, chemotherapy and hematopoietic stem cell transplantation are the primary treatment modalities for AML, though their clinical application is limited in older patients.Recent years have seen the development of novel molecular targeted therapies, such as isocitrate dehydrogenase 1/2 (IDH1/2) and Feline macrophage stimulator-like tyrosine kinase 3 (FLT3) inhibitors, as well as individualized approaches like chimeric antigen receptor T-cell (CAR-T) therapy.However, due to patient heterogeneity and drug resistance, treatment outcomes for elderly AML remain unsatisfactory, underscoring the need for more precise and safer individualized treatment strategies.The combination of chemotherapy with novel targeted or immunotherapies shows promise as a future treatment direction.This research reviews the latest advances in the treatment of elderly AML, with a focus on achieving more individualized and safer therapeutic approaches.…”
Get full text

Obstructive shock secondary to an unusual cause: primary cardiac lymphoma by Gregoire Ottavy, Laurent Camous, Claire Fieschi, Lucas Della Torre, Jean-David Pommier

“…Conclusion When a cardiac mass is associated with extracardiac symptoms indicative of a hematological malignancy, the preferred treatment is chemotherapy, and cardiac surgery should be avoided.…”
Get full text

Lung transplantation for pulmonary chronic graft-versus-host disease: a missed opportunity? by Andrea Zajacova, MD, Hélène Schoemans, MD, PhD, Mark Greer, MD, MRCP, Hildegard Greinix, MD, Peter Jaksch, MD, Osnat Shtraichman, MD, Rayid Abdulqawi, MD, PhD, Are M. Holm, MD, PhD, Robin Vos, MD, PhD, Saskia Bos, MD, PhD

“…This review addresses common concerns regarding referral and listing of PcGvHD patients for LuTx (such as risk of relapse of hematological malignancy, infectious complications and rejection) and survival outcomes of this specific cohort of patients. …”
Get full text