Effects of Intrathecal Bupivacaine with Adjuvants Midazolam versus Magnesium Sulphate in Tibia Fibula Surgeries: A Randomised Clinical Study by Tejash H Sharma, Jagrati Jain, Aanal Sha, Dushyant Chavda, Dinesh K Chauhan

“…The primary objective was to observe Heart Rate (HR), Blood Pressure (BP), Oxygen Saturation (SpO2) and Respiratory Rate (RR). …”
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RNA‐Binding Protein Hnrnpa1 Triggers Daughter Cardiomyocyte Formation by Promoting Cardiomyocyte Dedifferentiation and Cell Cycle Activity in a Post‐Transcriptional Manner by Chuling Li, Yijin Chen, Qiqi Chen, Haoxiang Huang, Michael Hesse, Yilin Zhou, Ming Jin, Yu Liu, Yifei Ruan, Xiang He, Guoquan Wei, Hao Zheng, Senlin Huang, Guojun Chen, Wangjun Liao, Yulin Liao, Yanmei Chen, Jianping Bin

“…By performing integrated bioinformatic analysis of snRNA‐seq data from neonatal and adult hearts, this study identified Hnrnpa1 as a potential RBP regulating CM DACCA. …”
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Global, regional, and national survey on burden and quality of care index (QCI) of nasopharyngeal cancer: A systematic analysis of the Global Burden of disease study 1990–2019 by Saba Ilkhani, Sahar Saeedi Moghaddam, Delaram Sakhaei, Mohammad-Mahdi Rashidi, Sina Azadnajafabad, Mohammadreza Azangou-Khyavy, Naser Ahmadi, Ozra Tabatabaei-Malazy, Mohammadreza Naderian, Erfan Ghasemi, Parnian Shobeiri, Sahar Mohammadi Fateh, Farzad Kompani, Bagher Larijani, Farshad Farzadfar

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Monitoring of Antimicrobial Susceptibility of Bacteria Isolated from Poultry Farms from 2014 to 2018 by Engy Ahmed Hamed, May Fathy Abdelaty, Hend Karam Sorour, Heba Roshdy, Mona Aly Abdelhalim AbdelRahman, Ola Magdy, Waleed Abdelfatah. Ibrahim, Ahmed Sayed, Hytham Mohamed, Mohammed Iraqi Youssef, Wafaa Mohamed Hassan, Heba Badr

“…A total of 657 different samples from internal organs (liver, heart, lung, and yolk) and paper-lining chick boxes were collected from native chicken farms which were submitted to the Reference Laboratory for Veterinary Quality Control on Poultry Production in the period from 2014 to 2018 for the detection of Salmonella, Escherichia coli (E. coli), and Staphylococcus. …”
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Clinical validation of an artificial intelligence algorithm for classifying tuberculosis and pulmonary findings in chest radiographs by Thiago Fellipe Ortiz de Camargo, Thiago Fellipe Ortiz de Camargo, Guilherme Alberto Sousa Ribeiro, Guilherme Alberto Sousa Ribeiro, Maria Carolina Bueno da Silva, Luan Oliveira da Silva, Pedro Paulo Teixeira e Silva Torres, Denise do Socorro Rodrigues da Silva, Mayler Olombrada Nunes de Santos, William Salibe Filho, Marcela Emer Egypto Rosa, Magdala de Araujo Novaes, Thiago Augusto Massarutto, Osvaldo Landi Junior, Elaine Yanata, Marcio Rodrigues da Cunha Reis, Gilberto Szarf, Pedro Vieira Santana Netto, Joselisa Peres Queiroz de Paiva

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Association of blood cadmium and physical activity with mortality: A prospective cohort study by Yilin Chen, Cien Zhen, Lin Zeng, Hongliang Feng, Jinyu Wang, Qi Yong H. Ai, Sizhi Ai, Jihui Zhang, Yannis Yan Liang, Huachen Xue, Yujing Zhou

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Delineation of the Genetic Architecture and Clinical Polymorphism of 3q29 Duplication Syndrome: A Review of the Literature and a Report of Two Novel Patients With Single‐Gene BDH1... by A. A. Kashevarova, M. E. Lopatkina, O. Yu. Vasilyeva, D. A. Fedotov, A. D. Lobanov, E. A. Fonova, I. Z. Zhalsanova, A. A. Zarubin, O. A. Salyukova, E. O. Belyaeva, V. V. Petrova, E. G. Ravzhaeva, A. A. Agafonova, A. D. Cheremnykh, N. B. Torkhova, S. L. Vovk, I. N. Lebedev

“…For the first time, we delineated and described the smallest minimal critical region, including the single BDH1 gene; in our patients, this region was associated with ASD, heart defects, biliary tract dysfunction, and obesity. …”
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Novel type 2 diabetes prediction score based on traditional risk factors and circulating metabolites: model derivation and validation in two large cohort studiesResearch in context by Ruijie Xie, Christian Herder, Sha Sha, Lei Peng, Hermann Brenner, Ben Schöttker

“…Additional funding was provided by the Welsh Assembly Government, British Heart Foundation, Cancer Research UK, and Diabetes UK, with support from the National Health Service (NHS). …”
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A comparative analysis of autograft choices of anterior cruciate ligament reconstruction and their effects on muscle strength and joint biomechanics by Wiem Issaoui, Wiem Issaoui, Ismail Dergaa, Ismail Dergaa, Ismail Dergaa, Hatem Ghouili, Abdelfatteh El Omri, Noomen Guelmami, Philippe Chomier, Mourad Ghrairi, Helmi Ben Saad, Helmi Ben Saad, Helmi Ben Saad, Wassim Moalla, Wassim Moalla

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Profil glucido-lipidique et risque cardiovasculaire chez les diabétiques de type 2 by Mourad Nachi, Ibtissem Kihel, Abdessamad Dali-Ali, Mouna Gourine, Fouzia Benrahal

“…The macrovascular disorders were observed on 30,9% of patients and microvascular ones on 66,8% of them (p = 0.0001).The logistic regression analysis showed that HbA1c was the most significant biological parameter (p=0,008).while for micro-vascular complications, high blood pressure was the only associated factor (p = 0.03). For ischemic heart disease, dyslipidemia and high blood pressure were the most associated factors. …”
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Association between major depressive disorder or depressive symptoms and the risk of vascular complications among patients with type 2 diabetes, and the mediating role of metabolic... by Guochen Li, Yongfu Yu, Chunqing Lin, Shichen Zheng, Hong Tu, Wanghong Xu

“…Cox proportional hazards models were performed to estimate the hazard ratios (HRs) and 95% confidence intervals (CIs) of MDD and depressive symptoms with the risks of incident heart failure (HF); total and individual atherosclerotic cardiovascular disease (ASCVD) including coronary artery disease (CAD), ischemic stroke (IS), and peripheral artery disease (PAD); total and individual microvascular complications of diabetic kidney disease (DKD), diabetic retinopathy (DR), and diabetic neuropathy (DN). …”
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Renal function and clinical outcomes in survivors of out-of-hospital cardiac arrest by Hao-Wei Lee, Ming-Jen Kuo, Pai-Feng Hsu, I-Hsin Lee, Chih-Yu Yang, Teh-Fu Hsu, Chorng-Kuang How, Yenn-Jiang Lin, Chin-Chou Huang

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Automated Quantification of Neuropad Improves Its Diagnostic Ability in Patients with Diabetic Neuropathy by Georgios Ponirakis, Hassan Fadavi, Ioannis N. Petropoulos, Shazli Azmi, Maryam Ferdousi, Mohammad A. Dabbah, Ahmad Kheyami, Uazman Alam, Omar Asghar, Andrew Marshall, Mitra Tavakoli, Ahmed Al-Ahmar, Saad Javed, Maria Jeziorska, Rayaz A. Malik

“…The diagnostic performance of Neuropad was compared between the categorical and continuous (image-analysis (Sudometrics)) outputs to diagnose diabetic peripheral neuropathy (DPN). 110 subjects with type 1 and 2 diabetes underwent assessment with Neuropad, Neuropathy Disability Score (NDS), peroneal motor nerve conduction velocity (PMNCV), sural nerve action potential (SNAP), Deep Breathing-Heart Rate Variability (DB-HRV), intraepidermal nerve fibre density (IENFD), and corneal confocal microscopy (CCM). 46/110 patients had DPN according to the Toronto consensus. …”
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Colon Epithelial MicroRNA Network in Fatty Liver by Paule V. Joseph, Sarah K. Abey, Dan Wang, Nicolaas H. Fourie, Natnael D. Kenea, Tatyana G. Vishnyakova, Jeffrey M. Robinson, Kristen R. Weaver, Christina M. Boulineaux, Hannah R. Davidson, LeeAnne B. Sherwin, Onyinyechi Ozoji, Ana F. Diallo, Paul A. Smyser, Amy P. Patterson, Wendy A. Henderson

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Prevalence and factors associated with burnout syndrome in resident physicians: A cross-sectional study in Italy by Luca DI GIAMPAOLO, Andrea ROSSETTI, Teresa GALANTI, Simone DE SIO, Luca COPPETA, Hector NIETO, Hiroo WADA, Niu QUIAO, Younes RAMI, Hicham KHABBACHE, Driss AIT ALI, Amelia RIZZO, Kavita BATRA, Murat YILDIRIM, Mahmood BAHRAMIZADEH, Francesco CHIRICO

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Bisphenol S exposure interrupted human embryonic stem cell derived cardiomyocytes differentiation through ER-NF-κB/ERK signaling pathway by Yongru Zhou, Lin Tian, Liang Wang, Wenjing Wu, Baofang Liang, Wei Xiong, Lishi Zhang, Xiaomeng Li, Jinyao Chen

“…However, exposure to BPS throughout the differentiation stage may disrupt the immune response and cell differentiation, which in turn interrupts heart function. The benchmark dose lower confidence limit (BMDL) of the relative expression of cTnT mRNA exposed by BPS during DP3 was the lowest among all the BMDLs of a good fit, with BMDL5 of 1.96 × 10−2 µg/mL, which is lower than the current reported exposure levels of BPS in maternal serum (0.03–0.07 ng/mL) and maternal umbilical cord serum (0.03–0.12 ng/mL).…”
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Genetic factors shaping the plasma lipidome and the relations to cardiometabolic risk in children and adolescentsResearch in context by Yun Huang, Sara Elizabeth Stinson, Malte Thodberg, Louise Aas Holm, Roman Thielemann, Karolina Sulek, Morten Asp Vonsild Lund, Cilius Esmann Fonvig, Min Kim, Kajetan Trost, Helene Bæk Juel, Trine Nielsen, Peter Rossing, Maja Thiele, Aleksander Krag, Cristina Legido-Quigley, Jens-Christian Holm, Torben Hansen

“…Funding: Novo Nordisk Foundation, The Innovation Fund Denmark, The Danish Heart Foundation, EU Horizon, and LundbeckFonden.…”
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Advancing early detection of organ damage and cardiovascular risk prevention: the Suzhou cardiometabolic health study protocol - exploring the role of oral microbiome and metabolic... by Mengmeng Zhu, Mengmeng Zhu, Yiwen Li, Wenting Wang, Longkun Liu, Wenwu Liu, Jiayu Yu, Qian Xu, Jing Cui, Yanfei Liu, Keji Chen, Yue Liu, Yue Liu

“…Subjects will be followed up every 2 years, with the primary outcome being the first occurrence of coronary heart disease and stroke, and the secondary outcome being subclinical target organ damage.DiscussionThis study focuses on cardiovascular 1.5-level prevention strategy, combining metabolic factors with tongue coating microbiota characteristics, aiming to optimize the risk assessment system for subclinical target organ damage. …”
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Analysis of clinical characteristics and risk factors for patients with heat stroke in western China in 2022: a multicenter retrospective study by Xin Zheng, Yuchun Gao, Qinli Xie, Qiulan Chen, Chuan Guo, Qionglan Dong, Jin Tang, Jun Luo, Ying Ge, Jian He, Xiaolin Hou, Guanghong Zhou, Yuan Chen, Haiquan Cao, Jiujia Xiao, An Lan, Qiu Chen, Yonghong Zeng, Jing Huang, Huaicong Long

“…HS patients with high blood cell counts, impaired coagulation, liver and kidney diseases, and those with a specific type of CHS may face a poor prognosis. In patients with heart failure, APACHE II, Lac, and Scr were independent risk factors for a poor prognosis.…”
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Diastolic Cardiac Function Improvement by Liraglutide Is Mainly Body Weight Reduction Dependent but Independently Contributes to B-Type Natriuretic Peptide Reduction in Patients wi... by Kunimasa Yagi, Teruhiko Imamura, Hayato Tada, Daisuke Chujo, Jianhui Liu, Yuuki Shima, Azusa Ohbatake, Yukiko Miyamoto, Satoko Okazaki, Naoko Ito, Kaoru Nakano, Masataka Shikata, Asako Enkaku, Akiko Takikawa, Hisae Honoki, Shiho Fujisaka, Hideki Origasa, Kazuyuki Tobe

“…Patients with type 2 diabetes and left ventricular ejection fraction LVEF≥40% without heart failure symptoms were enrolled, and daily injection with liraglutide (0.9 mg) was introduced. …”
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