Physical health in young males and risk of chronic musculoskeletal, cardiovascular, and respiratory diseases by middle age: A population-based cohort study. by Aleksandra Turkiewicz, Karin Magnusson, Simon Timpka, Ali Kiadaliri, Andrea Dell'Isola, Martin Englund

“…We followed the participants through the Swedish National Patient Register for incidence of common musculoskeletal (osteoarthritis, back pain, shoulder lesions, joint pain, myalgia), cardiovascular (ischemic heart disease, atrial fibrillation), and respiratory diseases (asthma, chronic obstructive pulmonary disease, bronchitis). …”
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Association of Fontan Pathophysiology With Plasma Bile Acids by Ashish H. Shah, MD, MD-Research, Arun Surendran, MSc, Pedram Hassan-Tash, BSc, MD, C. Nolan Turnbull, BSc, Nicole Johnston, MSc, David Goodlett, BSc, PhD, Jun Han, PhD, Robin A. Ducas, MD, James W. Tam, MD, Eberhard Renner, MD, Todd A. Duhamel, PhD, Michel Aliani, MSc, PhD, Amir Ravandi, MD, PhD, Richard A. Krasuski, MD

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Pre-Hospital Point-of-Care Troponin: Is It Possible to Anticipate the Diagnosis? A Preliminary Report by Cristian Lazzari, Sara Montemerani, Cosimo Fabrizi, Cecilia Sacchi, Antoine Belperio, Marilena Fantacci, Giovanni Sbrana, Agostino Ognibene, Maurizio Zanobetti, Simone Nocentini

“…<b>Background</b>: Thanks to the evolution of laboratory medicine, point-of-care testing (POCT) for troponin levels in the blood (hs-cTn) has been greatly improved in order to quickly diagnose acute myocardial infarction (AMI) with an accuracy similar to standard laboratory tests. The rationale of the HEART POCT study is to propose the application of the 0/1 h European Society of Cardiology (ESC) algorithm in the pre-hospital setting using a POCT device (Atellica VTLi). …”
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The expression of MALAT1, plasma brain natriuretic peptide, and Tei index in sepsis-induced myocardial injury by Guangqing Huang, Wenzi Yang, Xu Zhao, Yong Bai, Xing Jiang, Jie Liu

“…However, significant differences were observed in heart rate, SOFA score, and APACHE II score between the two groups (P < 0.05). …”
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Integrative deep immune profiling of the elderly reveals systems-level signatures of aging, sex, smoking, and clinical traitsResearch in context by Lennart Riemann, Rodrigo Gutierrez, Ivan Odak, Joana Barros-Martins, Lennart M. Roesner, Ximena Leon Lara, Christine Falk, Thomas F. Schulz, Gesine Hansen, Thomas Werfel, Reinhold Förster, Berislav Bošnjak, Felix Jenniches, Norman Klopp, Till Robin Lesker, Martin Stangel

“…Additionally, we identified unique immune signatures associated with smoking, obesity, and diseases such as osteoporosis, heart failure, and gout. Interpretation: This study provides one of the most comprehensive immune profiles of elderly individuals, uncovering high-resolution immune changes associated with aging. …”
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Association of the Ratio of Triglycerides to High-Density Lipoprotein Cholesterol Levels with the Risk of Type 2 Diabetes: A Retrospective Cohort Study in Beijing by Hongzhou Liu, Shuangtong Yan, Gang Chen, Bing Li, Ling Zhao, Yajing Wang, Xiaodong Hu, Xiaomeng Jia, Jingtao Dou, Yiming Mu, Junping Wen, Zhaohui Lyu

“…After adjusting for age, sex, body mass index, smoking status, alcohol intake, low-density lipoprotein cholesterol level, strenuous activity, education level, family histories of T2DM and tumors, and the presence of hypertension, tumor, stroke, and coronary heart disease, we showed that TG/HDL-C was positively associated with the incidence of T2DM at the 4-year follow-up (OR=1.49, 95%CI=1.26–1.78). …”
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Effects of Eleclazine (GS6615) on the proarrhythmic electrophysiological changes induced by myocardial stretch by Francisco J. Chorro, Francisco J. Chorro, Francisco J. Chorro, Luis Such-Miquel, Luis Such-Miquel, Samuel Cuñat, Oscar Arias-Mutis, Oscar Arias-Mutis, Patricia Genovés, Patricia Genovés, Manuel Zarzoso, Manuel Zarzoso, Antonio Alberola, Antonio Alberola, Luis Such-Belenguer, Luis Such-Belenguer, Irene Del Canto, Irene Del Canto

“…The aim of this study was to investigate the electrophysiological modifications induced by eleclazine basally and during acute ventricular stretch.MethodsLeft ventricular stretch was induced at baseline and during perfusion with eleclazine in 26 Langendorff rabbit heart preparations. Programmed stimulation and high-resolution mapping techniques were applied using multiple epicardial electrodes.ResultsAt baseline, both the ventricular refractory period measured at a fixed cycle length (250 m) and its surrogate obtained during ventricular fibrillation (VF) decreased significantly during stretch (baseline 128 ± 15 vs. stretch 110 ± 14 m; n = 15; p &lt; 0.001, and baseline 52 ± 13 vs. stretch 44 ± 9 m; n = 11; p &lt; 0.05), while the VF dominant frequency (DF) increased significantly (DF baseline 13 ± 3 vs. stretch 17 ± 5Hz; n = 11; p &lt; 0.01). …”
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Coinfection of severe acute respiratory syndrome coronavirus 2 and polyomavirus in a patient with coronavirus disease 2019 detected by enrichment next-generation sequencing: a case... by Gunadi, Esensi Tarian Geometri, Pramana Adhityo, Ali Zainal Abidin, Marcellus, Dyah Ayu Puspitarani, Fadila Dyah Trie Utami, Kristy Iskandar, Hendra Wibawa, Mohamad Saifudin Hakim

“…Her vital signs were as follows: heart rate, 84 beats per minute; respiratory rate, 22 breaths per minute; temperature, 39 °C; and pulse oximetry, 96% on room air. …”
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Alleviation of liver fibrosis by inhibiting a non-canonical ATF4-regulated enhancer program in hepatic stellate cells by Li-Xian Yang, Chuangye Qi, Si Lu, Xiang-Shi Ye, Parnaz Merikhian, Du-Yu Zhang, Tao Yao, Jiang-Sha Zhao, Ying Wu, Yongshi Jia, Bo Shan, Jinghai Chen, Xiaozhou Mou, Jia You, Wenbo Li, Yu-Xiong Feng

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Effects of high-intensity interval and moderate-intensity continuous training on ambulatory blood pressure and cardiovascular outcomes in older adults with hypertension (HEXA Study... by Francisco Dalton-Alves, Maria Beatriz F Araújo, Bruno Erick B Lucena, Gabriel C Souto, Daniele Samara D Lopes, Maria Isabel S Lucena, Raíssa de Melo Silva, Ludmila L P Cabral, Yuri A Freire, Fabíola L Golveia, Telma Maria Araújo Lemos, Rodrigo A V Browne, Eduardo Caldas Costa

“…Secondary cardiovascular outcomes are resting blood pressure, cardiorespiratory fitness, pulse wave velocity, carotid intima-media thickness, heart rate variability and cardiac function/structure. …”
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The Role of Atrial Fibrillation and Oral Anticoagulation Status in Health‐Related Quality of Life 12 Months After Ischemic Stroke or TIA by Manuel C. Olma, Lena Steindorf‐Sabath, Serdar Tütüncü, Claudia Kunze, Cornelia Fiessler, Paulus Kirchhof, Joanna Dietzel, Johannes Schurig, Patrick Oschmann, Ludwig Niehaus, Christian Urbanek, Götz Thomalla, Darius G. Nabavi, Joachim Röther, Ulrich Laufs, Roland Veltkamp, Peter U. Heuschmann, Karl Georg Haeusler, Matthias Endres, for the MonDAFIS Investigators

“…AF symptom severity was assessed using the European Heart Rhythm Association classification and symptom severity score (EHRA score) categorizing patients with no/mild/severe/disabling AF‐related symptoms. …”
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Work performance, physiological and hemato-biochemical responses in working buffalo with different load weights by Visoky Paján-Jiménez, Fernando D. Pazmiño-Rodríguez, Patricia Roldán-Santiago, Cristian Larrondo-Cornejo, Anna Dutro-Aceves, Luis A. de la Cruz-Cruz

“…Physiological (respiratory rate, pulse, heart rate, and rectal temperature) and biochemical (glucose, lactate dehydrogenase, creatine kinase, and total protein) parameters, as well as blood cell count (white blood cell, neutrophils, lymphocytes, monocytes, eosinophils, and basophils), increased after work regardless of weight load (p<0.001). …”
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Strength Training Session Induces Important Changes on Physiological, Immunological, and Inflammatory Biomarkers by Ayla Karine Fortunato, Washington Martins Pontes, Débora Maria Soares De Souza, Jéssica Santos Ferreira Prazeres, Lucas Soares Marcucci-Barbosa, Júlia Miranda Mól Santos, Érica Leandro Marciano Veira, Eduardo Bearzoti, Kelerson Mauro De Castro Pinto, André Talvani, Albená Nunes Da Silva

“…The single session of strength training elevated the heart rate (HR), rating of perceived exertion (RPE), visual analog scale (VAS), and lactate blood level in UTG and TG. …”
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What are the barriers to the diagnosis and management of chronic respiratory disease in sub-Saharan Africa? A qualitative study with healthcare workers, national and regional polic... by Angela Obasi, Rachel Tolhurst, Kingsley Rex Chikaphupha, Miriam Taegtmeyer, Kevin Mortimer, Louis Niessen, Maia Lesosky, Jahangir Khan, William Worodria, Jamie Rylance, Lindsay Zurba, Imelda Bates, Stellah G Mpagama, Elizabeth Henry Shayo, Rose Oronje, Emmanuel Addo-Yobo, Brian Allwood, Hastings Banda, Amsalu Binegdie, Adegoke Falade, Bertrand Mbatchou, Beatrice Mutayoba, Nyanda Elias Ntinginya, Heather Zar, Eliya Zulu, Helen Meme, Uzochukwu Egere, Asma Elsony, Martha Chinouya, S Bertel Squire, Stephen Mulupi, Irene Ayakaka, Nicole Kozak, Elhafiz Abdalla, Rashid Osman

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Serious Bacterial Infections and Hepatitis C Virus Among People Who Inject Drugs: A Syndemic or Intertwined Epidemics? by Thomas J. Stopka, Robin M. Nance, L. Sarah Mixson, Hunter Spencer, Judith I. Tsui, Judith M. Leahy, Mai T. Pho, Jean DeJace, Judith Feinberg, April M. Young, Wei-Teng Yang, Amelia Baltes, Eric Romo, Randall T. Brown, Kerry Nolte, William C. Miller, William A. Zule, Wiley D. Jenkins, Joseph A. Delaney, Peter D. Friedmann

“…Limited research has examined the possible synergistic interrelationships between serious bacterial infections (SBIs) of the heart (i.e., endocarditis), bone, spine, brain, or joints (e.g., osteomylelitis) and hepatitis C virus (HCV) infections. …”
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Noel Hernández Rodríguez, scalpel in hand plastic surgeon by Tatiana Hernández González, Yaneisy Valdés Gutierrez, Yurisbel Tomás Solenzal Alvarez

“…He was a simple, modest, hardworking, persevering man, which allowed him throughout his life to assume seriously the assigned responsibilities, both in his professional life as well as in the heart of the family, in these aspects he always was an example for the new generations. …”
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Reims antique, acquis et perspectives by Magalie Cavé, Philippe Rollet, Régis Bontrond

“…The results of the last thirty years of excavations, as well as the research programs currently underway, allow us to reconstruct the major evolutionary phases of Reims/Durocortorum (Marne), including the overarching structure of the urban fabric, both in the historical heart of the city and in the outlying districts, which have provided the most recent and major archaeological advances. …”
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Aides à la navigation, pratique de la navigation et construction des paysages maritimes en Atlantique du Nord-Est : quelques éléments de réflexion by Pascal Arnaud

“…As is the case in other regions, the study of the Atlantic maritime cultural landscape takes us to the heart of the diversity of its markers, its users and their ships. …”
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Dynamic EIT technology for real-time non-invasive monitoring of acute pulmonary embolism: a porcine model experiment by Junyao Li, Mingxu Zhu, Yitong Guo, Weichen Li, Qing He, Yu Wang, Yuxuan Liu, Benyuan Liu, Yang Liu, Weice Wang, Zhenyu Ji, Xuetao Shi

“…Abstract Background Acute pulmonary embolism represents the third most prevalent cardiovascular pathology, following coronary heart disease and hypertension. Its untreated mortality rate is as high as 20–30%, which represents a significant threat to patient survival. …”
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Joint effects of temperature and humidity with PM2.5 on COPD by Huan Minh Tran, Feng-Jen Tsai, Yuan-Hung Wang, Kang-Yun Lee, Jer-Hwa Chang, Chi-Li Chung, Chien-Hua Tseng, Chien-Ling Su, Yuan-Chien Lin, Tzu-Tao Chen, Kuan-Yuan Chen, Shu-Chuan Ho, Feng-Ming Yang, Sheng-Ming Wu, Kian Fan Chung, Kin-Fai Ho, Kai-Jen Chuang, Hsiao-Chi Chuang

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