Hyperglycemia and Correlated High Levels of Inflammation Have a Positive Relationship with the Severity of Coronavirus Disease 2019 by Wen Zhang, Chuanwei Li, Yu Xu, Binfeng He, Mingdong Hu, Guoqiang Cao, Li Li, Shuang Wu, Xia Wang, Chun Zhang, Jianping Zhao, Jungang Xie, Zihui Xu, Qi Li, Guansong Wang

“…There was no association between severity of COVID-19 and known diabetes adjusted for age, sex, body mass index (BMI), known hypertension, and coronary heart disease. The leucocyte count, NLR, and C-reactive protein (CRP) level increased with increasing BG level. …”
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Prognostication in emergency room patients: comparing ultrasensitive and contemporary quantification of cardiac troponin levels below the 99th percentile by Anna Carrasquer, Anna Carrasquer, Anna Carrasquer, Germán Cediel, Germán Cediel, Germán Cediel, Alma Gómez-Sanz, Alma Gómez-Sanz, Óscar M. Peiró, Óscar M. Peiró, Óscar M. Peiró, Isabel Fort-Gallifa, Isabel Fort-Gallifa, Isabel Fort-Gallifa, Alfredo Bardaji, Alfredo Bardaji, Alfredo Bardaji, Jose Luis Ferreiro, Jose Luis Ferreiro, Jose Luis Ferreiro

“…Their cumulative incidence of the composite cardiovascular event (death, readmission for myocardial infarction, and readmission for heart failure) was 25.9% over the 4-year follow-up. …”
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MicroRNA-132, Delivered by Mesenchymal Stem Cell-Derived Exosomes, Promote Angiogenesis in Myocardial Infarction by Teng Ma, Yueqiu Chen, Yihuan Chen, Qingyou Meng, Jiacheng Sun, Lianbo Shao, Yunsheng Yu, Haoyue Huang, Yanqiu Hu, Ziying Yang, Junjie Yang, Zhenya Shen

“…In addition, transplantation of miR-132 exosomes in the ischemic hearts of mice markedly enhanced the neovascularization in the peri-infarct zone and preserved heart functions. …”
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What all physicians should know about women’s health: a Delphi study by Susanna Price, Eva Gerdts, Julien Mazières, Alexandra Kautzky-Willer, Fedde Scheele, Chiara Benedetto, Kerry Wilbur, Gertraud Stadler, Marieke Wermer, Jeanine Roeters van Lennep, Merel H de Heer-Koster, Vesna Bjegović-Mikanović, Indre Banaitytė-Baleišienė, Mary Perdiou, Alyson McGregor, Connie Newman, Simona Stankevičiūtė, Iris E Sommer, Florence Thibaut, Karine van 't Land

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Epidemiology and impact of device-specific infections on patients receiving left ventricular assist devices by Amit Iyengar, MD MSE, Jason Feinman, MD, Joyce Jiang, BS, Cindy Song, BA, Spencer Kim, BA, Alvin Mathew, MD, Sophia Golec, MD, Aarti Rao, MD, Ankitha Radakrishnan, MD, Michaela Asher, MPhil, David Rekhtman, BS, John DePaolo, MD PhD, Noah Moss, MD, Shinobu Itagaki, MD, Anelechi Anyanwu, MD, Joyce Wald, DO, Marisa Cevasco, MD MPH, Aditya Parikh, MD

“…Methods: Retrospective analysis was performed of adult patients receiving HeartMate 3 implants at the University of Pennsylvania and Mount Sinai Health Systems from January 1, 2015 to March 31, 2021, with follow-up until March 31, 2022. …”
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Provocation of brachial plexus and systemic symptoms during the elevated arm stress test in individuals with myalgic encephalomyelitis/chronic fatigue syndrome or idiopathic chroni... by Charles C. Edwards, Julia M. Byrnes, Camille A. Broussard, Alba M. Azola, Meghan E. Swope, Colleen L. Marden, Renee L. Swope, Ying Wei Lum, Richard L. Violand, Peter C. Rowe

“…The test was considered abnormal for systemic symptoms if the participant experienced overall fatigue, cognitive fogginess, lightheadedness, racing heart, diaphoresis, dyspnea, overall warmth, or nausea. …”
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Identification of Clusters in a Population With Obesity Using Machine Learning: Secondary Analysis of The Maastricht Study by Maik JM Beuken, Melanie Kleynen, Susy Braun, Kees Van Berkel, Carla van der Kallen, Annemarie Koster, Hans Bosma, Tos TJM Berendschot, Alfons JHM Houben, Nicole Dukers-Muijrers, Joop P van den Bergh, Abraham A Kroon, Iris M Kanera

“… BackgroundModern lifestyle risk factors, like physical inactivity and poor nutrition, contribute to rising rates of obesity and chronic diseases like type 2 diabetes and heart disease. Particularly personalized interventions have been shown to be effective for long-term behavior change. …”
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Cardiovascular disease risk in cancer survivors: a population-based cohort study from the UK Biobank, and meta-analysis of cohort studies by Hong Li, Yazhou He, Zubing Mei, Hong Wu, Yang Shen, Ziqiang Wang, Jichun Zhao, Chuan Xu, Yanhong Zhou, Chi Shu, Botao Yu, Xiran Wang, Changtao Li, Yiqiang Liu

“…Evidence appraisal identified one convincing association between hematologic/lymphatic malignancies and ischaemic heart disease, along with 29 highly suggestive associations.Conclusions Our study provided comprehensive estimates of CVD incidence in cancer survivors and identified a significantly elevated CVD risk among patients with cancer, regardless of chemotherapy or radiotherapy. …”
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Association of Estimated Glomerular Filtration Rate (eGFR) and High-Sensitivity C-Reactive Protein (Hs-CRP) with the Risk of New-Onset Atrial Fibrillation in Patients with Diabetes by Liu Y, Liu H, Sun D, Zheng Y, Tse G, Chen K, Qiu J, Wu S, Liu T

“…We employed multivariable Cox regression analysis to evaluate the relationships between eGFR, hs-CRP, and new-onset AF, adjusting for confounders including smoking status, alcohol consumption, blood pressure, fasting blood glucose (FBG), heart rate, lipid levels, body mass index (BMI), and medication usage. …”
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Electrocardiographic signs of cardiac ischemia at rest and during exercise in patients with COPD traveling to 3,100 m: data from a randomized trial of acetazolamide by Marla Christen, Marla Christen, Aline Buergin, Aline Buergin, Maamed Mademilov, Maamed Mademilov, Laura Mayer, Laura Mayer, Simon R. Schneider, Simon R. Schneider, Mona Lichtblau, Mona Lichtblau, Talant M. Sooronbaev, Talant M. Sooronbaev, Silvia Ulrich, Silvia Ulrich, Konrad E. Bloch, Konrad E. Bloch, Michael Furian, Michael Furian

“…IntroductionIn patients with chronic obstructive pulmonary disease (COPD), oxygen delivery to the heart may be impaired during travel at altitude. …”
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Outcome and complications in postcardiotomy cardiogenic shock treated with extracorporeal life support – a systematic review and meta-analysis by Romana Maria Kienlein, Ralf Felix Trauzeddel, Nilufar Akbari, Leonello Avalli, Fausto Biancari, Carlotta Sorini Dini, Sabina Guenther, Christian Hagl, Matthias Heringlake, Jochen Kruppa, Timo Mäkikallio, Raphael Martins, Marc Pineton de Chambrun, Ardawan Julian Rastan, Antonio Rubino, Floris van den Brink, Michael Nordine, Sascha Treskatsch

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Morphological Characteristics, Mitochondrial Genome, and Evolutionary Insights Into a New Sea Squirt From the Beibu Gulf by Yichuan Zhang, Yuting Qin, Yueying Wu, Liping Liu, Wenguang Zhang, Ling Ding, Xiangpei Ya, Zhiting Wen, Kuaili Feng, Hong Wang, Yujun Wang

“…Firstly, YZ‐2024 can be preliminarily distinguished by the following morphological features: (1) smooth surface of the tunica, without protuberances; (2) except for the attachment site, the tunica is orange‐red; (3) absence of neural ganglia, and the tunica does not contract abruptly when disturbed; (4) the heart is oval‐shaped. Most importantly, the mitochondrial genome characteristics of YZ‐2024 effectively and accurately distinguish it from other congeneric species, with a mitochondrial genome size of 14,520 bp (GenBank No. …”
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CD94-driven in vitro expansion of highly functional adaptive NKG2C+ NKG2A- CD57+ NK cells from CMV+ healthy donors by Chiara Giordano, Simona Carlomagno, Simona Carlomagno, Michela Falco, Claudia Cantoni, Claudia Cantoni, Massimo Vitale, Ignazio Caruana, Johannes Dirks, Alberto Serio, Letizia Muccio, Giulia Bartalucci, Alessandra Bo, Franco Locatelli, Franco Locatelli, Cristina Bottino, Cristina Bottino, Simona Sivori, Simona Sivori, Mariella Della Chiesa, Mariella Della Chiesa

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COVID-19 and children with congenital anomalies: a European survey of parents’ experiences of healthcare services by Ingeborg Barisic, Carlos Matias Dias, Amanda Neville, Anna Pierini, Anke Rissmann, Joan K Morris, Judith Rankin, Ester Garne, Anna Latos-Bielenska, Elena Marcus, Anna Jamry-Dziurla, Ljubica Odak, Clara Cavero- Carbonell, Elly Den Hond, Lucas Genard, Ana João Santos, L Renée Lutke, Christina Neergaard Pedersen, Annika Niemann, Lucía Páramo-Rodríguez

“…Objective To survey parents and carers of children with a congenital anomaly across Europe about their experiences of healthcare services and support during the COVID-19 pandemic.Design Cross-sectional study.Setting Online survey in 10 European countries, open from 8 March 2021 to 14 July 2021.Population 1070 parents and carers of children aged 0–10 years with a cleft lip, spina bifida, congenital heart defect (CHD) requiring surgery and/or Down syndrome.Main outcome measures Parental views about: the provision of care for their child (cancellation/postponement of appointments, virtual appointments, access to medication), the impact of disruptions to healthcare on their child’s health and well-being, and satisfaction with support from medical sources, organisations and close relationships.Results Disruptions to healthcare appointments were significantly higher (p<0.001) in the UK and Poland, with approximately two-thirds of participants reporting ‘cancelled or postponed’ tests (67/101; 256/389) and procedures compared with approximately 20% in Germany (13/74) and Belgium/Netherlands (11/55). …”
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Vitamin K-Dependent Proteins as Predictors of Valvular Calcifications and Mortality in Hemodialysis Patients by Marcel Palamar, Iulia Dana Grosu, Adalbert Schiller, Ligia Petrica, Madalina Bodea, Alexandru Sircuta, Elisabeta Gruescu, Oana Daniela Matei, Maria Daniela Tanasescu, Ionut Golet, Flaviu Bob

“…However, other cardiovascular markers, such as coronary heart disease and ejection fraction < 50%, did not have a statistically significant impact on mortality in our patients. …”
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PET/CT-derived coronary calcium score may predict cardiac complications in anthracycline-treated patients with lymphoma by Genevieve Douglas, Zoe Loh, Evonne S.Y. Shum, Sze-Ting Lee, Niamh Waters, Garry Hamilton, Geoffrey Chong, Alexandra C. Murphy, Eliza A. Hawkes

“…We reviewed medical records to identify pre-existing cardiac conditions, CVR, and posttreatment cardiac events, including coronary events, heart failure (HF), and arrhythmias. Logistic and Cox regression models were used to assess associations between CVR, CACS categories (CACS = 0, CACS 1-400, CACS >400), and new cardiac events. …”
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Risk factors associated with degenerative glenohumeral osteoarthritis by Ravi Prakash, Nitin B Jain, Ziyi Chen, Folefac D Atem, Michael S Khazzam, Rashmi Pathak, Daniel Tai, Ursa BezanPetric, Estefanie Garduno Rapp

“…Univariate, least absolute shrinkage and selection operator and multivariate analyses identified risk factors, including age, body mass index (BMI), sex, work-related shoulder problems, shoulder disability, dislocation, previous trauma, surgery, smoking, hypertension, diabetes, depression, heart disease, OA, night pain and overall sleep quality.Results A total of 1827 cases and 1556 controls were identified for GH OA. …”
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Anticholinergic burden and behavioral and psychological symptoms in older patients with cognitive impairment by Sabrina Pistorio, Gianluca Scotto di Tella, Vittoria Canzanella, Raffaella Merenda, Gianluigi Cuomo, Paola Iacotucci, Vincenzo Carnovale, Leonardo Bencivenga, Maria Vargas, Annalaura Manes, Mauro Cataldi, Giuseppe Rengo, Giuseppe Rengo, Michela Zanetti, Grazia Daniela Femminella, Grazia Daniela Femminella

“…No statistically significant differences were found between the two groups in terms of demographics (age, sex) and anamnestic variables (education, marital status, family history of dementia, hypertension, diabetes, smoking, dyslipidemia, atrial fibrillation, coronary heart disease and use of alcohol). Significantly higher NPI scores were found in patients with ACB ≥ 3 (mean scores 47.3 ± 34.8 versus 25.5 ± 24.6, p &lt; 0.001). …”
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Tuberculosis and drug resistance in a region of Southern Italy among native and foreign-born populations: A twelve-year province-based study by Salvatore Rotundo, Salvatore Nisticò, Helen Linda Morrone, Luigia Gallo, Saveria Dodaro, Carmelo Papola, Pasquale Minchella, Giovanni Matera, Francesca Greco, Luigi Principe, Lorenzo Antonio Surace, Francesco Lucia, Francesca Serapide, Alessandro Russo, Carlo Torti, Enrico Maria Trecarichi

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Prognostic signature of multimorbidity, geriatric syndromes and resources cluster in older in- and outpatients: a pooled secondary analysis with a 6-month follow-up by Thomas Benzing, Jill Stegemann, Anna Maria Affeldt, Luisa Mück, Anne Ferring, Laura Gerhards, Lena Pickert, Annika Bausch, Philipp Antczak, M Cristina Polidori

“…Additionally, two clusters were identified pertaining to the CIRS, encompassing sensory-vegetative and heart-kidney morbidity. Patients within the iatrogenic cluster exhibited significantly higher MPI and readmissions during follow-up compared with those outside this cluster (p&lt;0.001). …”
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