Sex-specific ultrasound imaging biomarkers of neurodegeneration in a mouse model by Mark B. Russell, Drew P. Locke, Haley M. Adams, Alexander R. Pelley, Rojan Saghian, Rojan Saghian, Alexandre S. Maekawa, Darcie Stapleton, Grace V. Mercer, John G. Sled, John G. Sled, John G. Sled, Lindsay S. Cahill, Lindsay S. Cahill

“…The highly reproducible progression of neurodegeneration in the decrepit (dcr) mouse allows investigation of early biomarkers and mechanisms of brain injury.MethodsUsing high-frequency ultrasound, the common carotid arteries of female and male dcr and control mice were imaged longitudinally at time points bracketing the disease progression (50, 75, and 125 days of age) (n = 6 mice/group/sex).ResultsOver the disease time course, the female dcr mice demonstrated increased carotid artery blood flow and pulse wave velocity while the male dcr mice had a decrease in heart rate and no change in carotid artery ultrasound parameters. …”
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Research progress and application prospects of flexible wearable sensor in spacesuit by Aiming Bu, Wanxin Zhang, Qian Ran, Dongyue Liu, Jialu Ma, Rongqing Wang, Kun Shang, Hongrui Yang, Zhiqiang Mei

“…It can realize the benefits of heart rate, breathing, sweat, action recognition and date acquisition, etc. …”
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Effects of ultrasound‑guided pericapsular nerve group block in combination with laryngeal mask airway on anesthesia, postoperative analgesia, and recovery of elderly patients with... by Rongen Qiu, Yunping Lan, Gang Liu, Ruifeng Zeng

“…Results: In comparison with the study group, heart rate (HR) and mean arterial pressure rose significantly in the control group at the time of skin incision, 20 minutes intraoperatively, and at the end of the surgery, and HR also increased when the patients entered a postanesthetic care unit (P <⁠0.05). …”
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Massive Blood Transfusion for Trauma Score to Predict Massive Blood Transfusion in Trauma by Osaree Akaraborworn, Boonying Siribumrungwong, Burapat Sangthong, Komet Thongkhao

“…Four factors were associated with MBT: a score of 3 for age ≥60 years; 2.5 for base excess ≤–10 mEq/L; 2 for lactate >4 mmol/L; and 1 for heart rate ≥105 /min. The AuROC was 0.85 (95% CI: 0.78–0.91). …”
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Association of cardiac troponin I level with in-hospital and late mortality in dialysis patients by Shahram Taheri, Golbarg Ghomi, Alireza Nematollahi, Sayed Mohsen Hosseini

“…This study was an observational study to evaluate correlation of first admitted cTnI level with early and late (during 6 months) hospitalization and mortality of ESRD patient admitted due to non-acute coronary and non-heart failure causes in ESRD patients. Materials and Methods: In this prospective observational study, 460 dialysis patients without overt CVD who were admitted at two university hospital were included and followed during 6 months. …”
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Machine learning-based interpretation of non-contrast feature tracking strain analysis and T1/T2 mapping for assessing myocardial viability by Amir GhaffariJolfayi, Alireza Salmanipour, Kiyan Heshmat-Ghahdarijani, MohammadHossein MozafaryBazargany, Amir Azimi, Pirouz Pirouzi, Ali Mohammadzadeh

“…Abstract Assessing myocardial viability is crucial for managing ischemic heart disease. While late gadolinium enhancement (LGE) cardiovascular magnetic resonance (CMR) is the gold standard for viability evaluation, it has limitations, including contraindications in patients with renal dysfunction and lengthy scan times. …”
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Potentials of Presepsin as a Novel Sepsis Biomarker in Critically Ill Adults: Correlation Analysis with the Current Diagnostic Markers by Mai S. Sater, Nourah Almansour, Zainab Hasan Abdulla Malalla, Salim Fredericks, Muhalab E. Ali, Hayder A. Giha

“…Concentrations of five plasma markers (IL-6, IL-8, TREM1, uPAR, and presepsin) were compared with 13 well-established measures of SSI in critically ill patients. These measures were heart rate (HR), white blood count (WBC), C-reactive protein (CRP), procalcitonin (PCT), lactate plasma concentrations, and measures of hemostasis status (platelets count (PLT), fibrinogen, prothrombin time (PT), activated partial thromboplastin time (APTT), international normalization ratio (INR) and D-dimer). …”
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Endoplasmic reticulum protein TXNDC5 modulates thyroid eye disease TGF-β1-induced myofibroblast transdifferentiation by Albert Y Wu, Hsun-I Chiu, Shi-Bei Wu, Chieh-Chih Tsai

“…Endoplasmic reticulum (ER) stress may play a role in TED pathogenesis since it has been linked to liver, kidney, heart and lung fibrotic remodelling. We would evaluate the role of thioredoxin domain containing 5 (TXNDC5), a fibroblast-enriched ER protein, in TGF-β1-induced myofibroblast transdifferentiation from TED orbital fibroblasts.Methods Orbital fibroblasts from patients with TED were treated with TGF-β1 to investigate ER stress-relative gene expression especially for TXNDC5. …”
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Comprehensive Analysis of Metabolic Changes in Mice Exposed to Corilagin Based on GC-MS Analysis by Xu B, Wang C, Zhu X, Zhu L, Han G, Cui C

“…Using MetaboAnalyst 5.0 and the KEGG database was used to depict the 12 key metabolic pathways.Results: Compared with the control group, the Corilagin induced 20, 9, 11, 7, 16, 19, 14, 15, and 16 differential metabolites in the intestine, lung, kidney, stomach, heart, liver, hippocampus, cerebral cortex, and serum, respectively. …”
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Diabetes Increases Risk of Cardiovascular Events in Patients Receiving Permanent Pacemaker: A Propensity Score-Matched Cohort Study by Huang-Chung Chen, Wen-Hao Liu, Chien-Hao Tseng, Yung-Lung Chen, Wei-Chieh Lee, Yen-Nan Fang, Shaur-Zheng Chong, Mien-Cheng Chen

“…The primary outcome was cardiovascular events including heart failure (HF) hospitalization and acute myocardial infarction (AMI). …”
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Sepsis-induced cardiogenic shock: controversies and evidence gaps in diagnosis and management by Ryota Sato, Daisuke Hasegawa, Stephanie Guo, Abdulelah E. Nuqali, Jesus E. Pino Moreno

“…However, sepsis can also cause reversible myocardial dysfunction, particularly in the elderly with pre-existing heart conditions. The Surviving Sepsis Campaign Guidelines recommend using dobutamine with norepinephrine or epinephrine alone for patients with septic shock with cardiac dysfunction and persistent hypoperfusion despite adequate fluid resuscitation and stable blood pressure. …”
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Evaluation of e-Lung automated quantitative computed tomography biomarkers in idiopathic pulmonary fibrosis by Peter M. George, Christian Rennison-Jones, Giacomo Benvenuti, Aliki Sifostratoudaki, Finja A. Ottink, Wassim Bou-Zeid, Roberta E. Ledda, Roqia F. Abul Kadir, Bushra Johari, Claire Fernandez, George W.J. Harston, Olivier Joly, Stephen Gerry, Anand Devaraj

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The value of growth differentiation factor 15 as a biomarker for peripheral artery disease in diabetes patients by Wan-Chi Chuang, Chih-Hsun Chu, Cai-Sin Yao, Mei-Chih Wei, I-Lun Hsieh, Chia-Mei Liao

“…Increased age (p = 0.025 OR:1.02; 95% CI [0.13–0.87]), family history (p = 0.001 OR:1.37; 95%CI: [0.37–5.05]), heart failure (p = 0.002 OR:4.96; 95%CI: [1.76–13.97]), sodium-glucose linked transporter 2 (SGLT 2) inhibitor use (p = 0.026), estimated glomerular filtration rate (eGFR) (p = < 0.001), and uric acid (p = < 0.001) was also positively associated with high GDF15 levels. …”
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Selenium-enriched and ordinary green tea extracts prevent high blood pressure and alter gut microbiota composition of hypertensive rats caused by high-salt diet by Meirong Wu, Xiaobin Wu, Jiangxiong Zhu, Fanglan Li, Xinlin Wei, Yuanfeng Wang

“…Our results showed that GT and Se-GT supplementations significantly prevented the increase of blood pressure (BP), activated the phosphoinosmde-3-kinase/protein kinase B (PI3K/Akt) signaling pathway, and regulated the gene expression related to BP, as well as improved the tissue damage like heart, liver, and kidneys. Besides, the key parameters associated with oxidative stress, inflammation and endothelial dysfunction were also altered by GT and Se-GT treatments. …”
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PPARs: Nuclear Receptors Controlled by, and Controlling, Nutrient Handling through Nuclear and Cytosolic Signaling by Maria Moreno, Assunta Lombardi, Elena Silvestri, Rosalba Senese, Federica Cioffi, Fernando Goglia, Antonia Lanni, Pieter de Lange

“…., liver, skeletal muscle, heart, and white adipose tissue). We address the structure and function of the PPARs, and their interaction with other nuclear receptors, including PPAR cross-talk. …”
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Fractional exhaled nitric oxide in a respiratory healthy general population through the lifespan by Christina Bal, Caspar Schiffers, Marie-Kathrin Breyer, Sylvia Hartl, Alvar Agusti, Ahmad Karimi, Wolfgang Pohl, Marco Idzko, Robab Breyer-Kohansal

“…The normal FeNO values over lifespan in a respiratory healthy population and the factors related to them remain unclear.Materials and Methods We determined FeNO levels in 2,251 respiratory healthy, non-atopic, and non-smoking participants from the Lung, hEart, sociAl, boDy (LEAD) cohort, a general population, observational cohort study of participants aged 6–82 years in Austria.Results The median FeNO value in the total study population was 13.0 [interquartile range: 9.0, 20.0] ppb, increases with age, and, except in young participants (<18 years: 9.0 [7.0, 12.0], ≥18 years: 15.0 [11.0, 22.0]), it was significantly lower in females versus males. …”
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RED-Net: A Neural Network for 3D Thyroid Segmentation in Chest CT Using Residual and Dilated Convolutions for Measuring Thyroid Volume by Min-Ji Kim, Jin-A Kim, Naae Kim, Yul Hwangbo, Hyun Jeong Jeon, Dong-Hwa Lee, Ji Eun Oh

“…Unlike the lungs or the heart, the thyroid gland is not a primary target in chest computed tomography (CT) scans and is relatively small; hence, it is difficult for radiologists to always clinically delineate it in chest CT to incidentally detect a goiter. …”
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Impact of physician’s sex/gender on processes of care, and clinical outcomes in cardiac operative care: a systematic review by Louise Y Sun, Sylvain Boet, Amy Johnston, Katina Zheng, Mimi Deng, Fadi Mansour, Hussein Said, Cole Etherington

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Ferroptosis genes and ST-segment elevation myocardial infarction outcomes: A predictive signature by Xing-jie Wang, Lei Huang, Min Hou, Jie Guo, Xi-ming Li

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Adapting self-measured blood pressure monitoring to reduce health disparities (ASPIRE): a pilot hybrid effectiveness‑implementation study protocol by Rasha Khatib, Nicole Glowacki, Iridian Guzman, Maureen Shields, Joseph Chase, Melanie Gordon

“…Despite advances in blood pressure management, significant racial and ethnic disparities persist, resulting in higher risks of stroke, heart disease, and mortality among non-White populations. …”
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