Restorative Neurostimulation Therapy Compared to Optimal Medical Management: A Randomized Evaluation (RESTORE) for the Treatment of Chronic Mechanical Low Back Pain due to Multifid... by Frank Schwab, Nagy Mekhail, Kiran V. Patel, Meredith Langhorst, Robert D. Heros, Jonathan Gentile, Sherif Costandi, Gregory Moore, Christopher Gilmore, Smith Manion, Krishnan Chakravarthy, S. Craig Meyer, Justin V. Bundy, Jordan L. Tate, Rebecca Sanders, Sandeep Vaid, Oszkar Szentirmai, Johnathan Goree, Vikas V. Patel, Jeff Lehmen, Mehul J. Desai, Jason E. Pope, Anthony Giuffrida, Salim Hayek, Sohrab Singh Virk, Richard Paicius, William R. Klemme, Robert Levy, Christopher Gilligan, the RESTORE investigators

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Exploring the role of district clinical specialist teams in maternal health outcomes in a South African district: A mixed method study from 2012 to 2020 by J Basu, A Stewart, D Basu, J Wing, U Feucht

“…Such district-based clinical teams are a potential strategy to improve maternal health services within primary healthcare services. …”
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Influence of spine biomechanics and sagittal balance on the outcome of lumbar discectomy by José Poblete Carrizo, José Poblete Carrizo, Jesús Martínez, Julio González, Alejandra Mosteiro, Ramon Torné, Ramon Torné, Alberto Di Somma, Alberto Di Somma, José Ríos, Joaquim Enseñat, Joaquim Enseñat, Salvador Fuster, Salvador Fuster

“…Noteworthy, the radicular and lumbar pain and disability outcomes 12 and 24 months after surgery were significantly better in the group with normal sagittal balance (ODI 14.52 vs. 40.06 p < 0.001; radicular VAS 2.74 vs. 5.58 p < 0.001; lumbar VAS 3.61 vs. 4.06 p < 0.001).ConclusionLumbar degenerative disc disease represents a major burden for healthcare systems; thus, its management is determinant. …”
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Effectiveness of influenza vaccination in preventing confirmed influenza cases and hospitalizations in Northern Spain, 2023/24 season: A population-based test-negative case-control... by Iván Martínez-Baz, Ana Navascués, Camino Trobajo-Sanmartín, Francisco Pozo, Miguel Fernández-Huerta, Maddi Olazabal-Arruiz, Lucía Argente-Colas, Guillermo Ezpeleta, Aitziber Echeverria, Itziar Casado, Carmen Ezpeleta, Jesús Castilla

“…Methods: Two test-negative case-control studies analyzed patients who consulted primary healthcare or were hospitalized for respiratory symptoms and were tested for influenza by PCR in the 2023/24 season in Navarre, Spain. …”
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Association Between SHBG Levels and Hypertensive Disorders of Pregnancy: A Systematic Review and Meta‐Analysis by Ajay Malvi, Muhammed Shabil, Mahalaqua Nazli Khatib, Roopashree R, Mandeep Kaur, Manish Srivastava, Amit Barwal, G. V. Siva Prasad, Pranchal Rajput, Rukshar Syed, Kamal Kundra, Vinamra Mittal, Amit Kumar, Pancham Cajla, Ganesh Bushi, Rachana Mehta, Zaid Khan, Prakasini Satapathy, Shilpa Gaidhane, Renu Sah

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Demographic and clinical impact on preoperative BREAST-Q ePROM completion and baseline outcomes in women undergoing breast cancer surgery: a quantitative descriptive study at a Dan... by Karin Piil, Volker Jürgen Schmidt, Stine Thestrup Hansen, Lone Bak Hansen, Anna Mejldal, Julie Hougaard Prüsse, Lotte Gebhard Ørsted

“…However, completion rates for ePROMs varied by demographic factors such as age, marital status and access to healthcare. Younger, more educated, married patients with lower BMI who lived near major cities were more likely to report better pretreatment outcomes.…”
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DepRescribing inapprOpriate Proton Pump InhibiTors (DROPIT): study protocol of a cluster-randomised controlled trial in Swiss primary care by Stefan Neuner-Jehle, Katharina Tabea Jungo, Sven Streit, Sven Trelle, Nicolas Rodondi, Carole Elodie Aubert, Kristie Rebecca Weir, Enriqueta Vallejo-Yagüe, Samantha Chan, Marie Roumet, Pascal Juillerat, Sofia Carolina Zambrano Ramos, Jennifer Inauen, Angela Edith Schulthess-Lisibach, Renata Vidonscky Lüthold, Clémentine Tombez, Martina Zangger, Flurina Jenal, Yvonne Mattmann, Christof Bieri, Michaela Barbier

“…Nevertheless, PPIs are often overused leading to potential adverse effects and unnecessary healthcare costs. Deprescribing strategies have emerged to safely reduce or substitute inappropriate PPIs and optimise patient care in an evidence-based manner. …”
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Hospital attendance, malaria prevalence and self-medication with an antimalarial drug before and after the start of COVID-19 pandemic in a sentinel site for malaria surveillance in... by Denise Patricia Mawili-Mboumba, Fanny Bertrande Batchy Ognagosso, Noé Patrick M’Bondoukwé, Jacques Mari Ndong Ngomo, Bridy Chesly Moutombi Ditombi, Ahmed Adissa Agbanrin, Tatiana Nymane, Bedrich Pongui Ngondza, Reinne Moutongo Mouandza, Coella Joyce Mihindou, Dimitri Ardin Mabika Moussavou, Ornella Anaïse Mbang Nguema, Marielle Karine Bouyou-Akotet

“…Abstract Background The negative impact of COVID-19 pandemic on healthcare service utilization has been reported in several countries. …”
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Relationship between mucin gene polymorphisms and different types of gallbladder stones by Gongqing Ren, Yongmao Fan, Ruizi Zhong, Gang Zou, Xiaojun Huang, Yue Zhang

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Emerging burden of post-cancer therapy complications on unplanned hospitalisation and costs among Australian cancer patients: a retrospective cohort study over 14 years by Rashidul Alam Mahumud, Md. Shahjalal, Padam Kanta Dahal, Md. Parvez Mosharaf, Sabuj Kanti Mistry, Kamrun Nahar Koly, Sujana Haque Chowdhury, Andre M. N. Renzaho, Jeff Gow, Khorshed Alam, Olivia Wawryk

“…A retrospective cohort study was conducted among 8,633 cancer patients (1.03 million emergency hospital admissions) in Victoria, Australia from July 2006 to June 2020, from the Australian healthcare system perspective. Multivariate generalised linear regression models were employed to estimate the adjusted association between post-therapy complications and clinical characteristics with hospital LOS and associated hospitalisation medical costs. …”
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The novel manualized RELIEVE-group treatment for burdened relatives of cancer patients: a feasibility study by Jessica Neumann, Jessica Neumann, Jil Beckord, Jil Beckord, Helen Samira Hesse, Helen Samira Hesse, Carl Martin, Carl Martin, Carlotta Mons, Carlotta Mons, Diana Chur, Diana Chur, Jörg Hense, Jörg Hense, Mitra Tewes, Martin Teufel, Martin Teufel, Eva-Maria Skoda, Eva-Maria Skoda

“…No significant improvements were observed in self-efficacy, work and social security needs, and quality of life in the social relationships domain.DiscussionThe RELIEVE intervention demonstrated high feasibility and acceptance among emotionally affected relatives of cancer patients, addressing a gap in previous interventions that were often limited in scope and lacked standardised manuals.ConclusionThis feasibility study on treatment acceptance underlines the importance of measures that are tailored to the specific needs of cancer patients’ relatives, and of integrating them into the general healthcare system.…”
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Cohort profile: the Viral load Cohort North-East Lesotho (VICONEL) from 2016 to 2023 – cohort description, test volumes, predictors of viraemia and the road ahead by Tracy Glass, Frédérique Chammartin, Jochen Ehmer, Thomas Klimkait, Alain Amstutz, Josephine Muhairwe, Irene Ayakaka, Blaise Lukau, Jennifer Anne Brown, Lipontso Motaboli, Malebanye Lerotholi, Maurus Kohler, Kathrin Haenggi, Moliehi Mokete, Makobefo Gladys Chakela, Mpho Kao, Mathebe Kopo, Moleboheng Mokebe, Lorena Urda, Bienvenu Lengo Nsakala, Anna Klicpera, Nadine Tschumi, Niklaus Daniel Labhardt

“…As of December 2023, it encompasses all viral load testing from 24 healthcare facilities in two districts of Lesotho.Findings to date From January 2016 to December 2023, 137 660 viral load test results were available for 29 380 participants. …”
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Tuberculosis and drug resistance in a region of Southern Italy among native and foreign-born populations: A twelve-year province-based study by Salvatore Rotundo, Salvatore Nisticò, Helen Linda Morrone, Luigia Gallo, Saveria Dodaro, Carmelo Papola, Pasquale Minchella, Giovanni Matera, Francesca Greco, Luigi Principe, Lorenzo Antonio Surace, Francesco Lucia, Francesca Serapide, Alessandro Russo, Carlo Torti, Enrico Maria Trecarichi

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Prognostic signature of multimorbidity, geriatric syndromes and resources cluster in older in- and outpatients: a pooled secondary analysis with a 6-month follow-up by Thomas Benzing, Jill Stegemann, Anna Maria Affeldt, Luisa Mück, Anne Ferring, Laura Gerhards, Lena Pickert, Annika Bausch, Philipp Antczak, M Cristina Polidori

“…The present analysis aimed to identify clusters of comorbidities, GS and GR, and to measure their multidimensional prognostic signature in older patients admitted to different healthcare settings.Design Pooled secondary analysis of three longitudinal interventional studies with the 3- and 6-month follow-up data collection on mortality and rehospitalisation.Setting Inpatients in an internal medicine ward (n=495), inpatients in an ageing medicine ward (n=123) and outpatients from a general practice (n=105).Participants A total of 734 patients with multimorbidity who aged over 60 years were recruited between August 2016 and July 2020 (mean age 77.8 years, SD 6.2 and 43% female).Outcome measures Comprehensive Geriatric Assessment (CGA), including Cumulative Illness Rating Scale (CIRS), 17 GS and 10 GR, and the CGA-based Multidimensional Prognostic Index (MPI) as a measure of multidimensional prognosis and frailty were assessed. …”
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Migrant Health Country Profile tool (MHCP-t) for transforming health data collection and surveillance in the Middle East and North African (MENA) region: tool development protocol... by Farah Seedat, Bouchra Assarag, Kolitha Wickramage, Sally Hargreaves, Ana Requena-Mendez, Dominik Zenner, Anna Deal, Stella Evangelidou, Oumnia Bouaddi, Moudrick Abdellatifi, Hassan Edries, Eman Elafef, Taha Maatoug, Anissa Ouahchi, Sara Arias, Adel Abdelkhalek, Ibrahim Ahmed Bani, Kenza Hassouni, Mahmoud Hilali, Mohamed Khalis, Wejdene Mansour, Ali Mtiraoui, Hassan Chrifi, Mohamed Douagi, Abdedayem Khelifi

“…To address this problem, we aim to design and pilot test the Migrant Health Country Profile tool (MHCP-t) which can collate country-level data collection around migration health data, policies and healthcare provision.Methods and analysis The MHCP-t development is a stepwise process that will integrate a process evaluation model with active involvement and engagement of multilevel stakeholders. …”
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Effectiveness of tacrolimus therapy in refractory ulcerative colitis compared to infliximab with propensity score matching by Takeo Yoshihara, Takahiro Amano, Shinichiro Shinzaki, Yuri Tsujii, Akiko Asakura, Taku Tashiro, Mizuki Tani, Yuriko Otake-Kasamoto, Takuya Yamada, Yuko Sakakibara, Naoto Osugi, Shuji Ishii, Satoshi Egawa, Manabu Araki, Yuki Arimoto, Masanori Nakahara, Yoko Murayama, Ichizo Kobayashi, Kazuo Kinoshita, Hiroyuki Ogawa, Satoshi Hiyama, Narihiro Shibukawa, Masato Komori, Yorihide Okuda, Takashi Kizu, Tetsuhisa Kitamura, Minoru Kato, Yoshiki Tsujii, Takahiro Inoue, Hideki Iijima, Yoshito Hayashi, Tetsuo Takehara

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Technology acceptance and use among nursing staff in Latin American hospitals: A mixed methods study by Juan Manuel Aranda, María Elisa Moreno-Fergusson, William Javier Guerrero, Beatriz Sanchez Herrera, María Alejandra Galiano, Maryory Guevara, Ingrid Xiomara Bustos, Francisca Muñóz

“…Background: Digital health technologies can improve health outcomes and the efficiency of healthcare delivery when used appropriately. Nevertheless, the human-computer interaction is a concern in compassionate patient care and nurses' professional well-being. …”
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Critical review of multimorbidity outcome measures suitable for low-income and middle-income country settings: perspectives from the Global Alliance for Chronic Diseases (GACD) res... by Najma Siddiqi, Meena Daivadanam, J Jaime Miranda, Trishul Siddharthan, John R Hurst, Rajesh Vedanthan, Gary Parker, Gina Agarwal, Shabbar Jaffar, Naomi Levitt, Niels H Chavannes, Pallab K Maulik, Patricio Lopez-Jaramillo, Kamran Siddiqi, Muralidhar M Kulkarni, Gillian Sandra Gould, Job F M van Boven, Kirsten Bobrow, M O Owolabi, Joan B Soriano, Erick Wan-Chun Huang, Shahirose Sadrudin Premji, Lijing Yan, Ricardo Araya, F Xavier Gómez-Olivé, Bruce J Kirenga, Rianne M J J van der Kleij, Laura Loli-Dano, Shane Norris, Josefien van Olmen, Antigona C Trofor

“…We, therefore, aimed to summarise and critically review outcome measures suitable for studies investigating mitigation of multimorbidity in LMIC settings.Setting LMIC.Participants People with multimorbidity.Outcome measures Identification of all outcome measures.Results We present a critical review of outcome measures across eight domains: mortality, quality of life, function, health economics, healthcare access and utilisation, treatment burden, measures of ‘Healthy Living’ and self-efficacy and social functioning.Conclusions Studies in multimorbidity are necessarily diverse and thus different outcome measures will be appropriate for different study designs. …”
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A pan-immune panorama of bacterial pneumonia revealed by a large-scale single-cell transcriptome atlas by Kun Xiao, Yan Cao, Zhihai Han, Yuxiang Zhang, Laurence Don Wai Luu, Liang Chen, Peng Yan, Wei Chen, Jiaxing Wang, Ying Liang, Xin Shi, Xiuli Wang, Fan Wang, Ye Hu, Zhengjun Wen, Yong Chen, Yuwei Yang, Haotian Yu, Lixin Xie, Yi Wang

“…Abstract Bacterial pneumonia is a significant public health burden, contributing to substantial morbidity, mortality, and healthcare costs. Current therapeutic strategies beyond antibiotics and adjuvant therapies are limited, highlighting the need for a deeper understanding of the disease pathogenesis. …”
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Knowledge, Attitude, and Practice (KAP) Survey toward Skin Cancer among Ecuadorian Population by Victor H. Pinos-León, César Sandoval, Franklin Cabrera, Esmeraldas Terán, Ana Garnica, Ana Kellendonk, Mery Alvear, Carla Rosero, Lorena Vaca, Jorge Bonifaz, Anita Buestán, Claudia Armas, Raquel Trujillo, Patricio Freire, Tamara León, Giselle Erazo, Liliana García, Marcela Alzate, Vicente Toapanta, Myriam Ortega, Daniela Caicedo, Alicia Pereira, Lenin Gómez-Barreno, Juan S. Izquierdo-Condoy, Merry Charlie, Esteban Ortiz-Prado, Katherine Simbaña-Rivera

“…For this reason, the prevention and health promotion programs at a national level from primary healthcare centers are recommended. Due to the limitation of the representativeness of the sample, the use of more studies among Ecuadorian residents of the low socioeconomic level and replication in different provinces of Ecuador is justified.…”
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