Caregiver Global Impression Observations from EMBARK: A Phase 3 Study Evaluating Delandistrogene Moxeparvovec in Ambulatory Patients with Duchenne Muscular Dystrophy by Craig M. McDonald, Jacob S. Elkins, Sai Dharmarajan, Katherine Gooch, Teofil Ciobanu, Claire J. Lansdall, Alexander P. Murphy, Fiona McDougall, Eugenio M. Mercuri, Ivana Audhya, the EMBARK Study Group

Get full text

Prevalence of cardiovascular symptoms in post-acute COVID-19 syndrome: a meta-analysis by Li-wei Huang, Hua-min Li, Bei He, Xiao-bo Wang, Qi-zhi Zhang, Wen-xing Peng

“…Abstract Background Since its emergence in 2019, COVID-19 has continued to pose significant threats to both the physical and mental health of the global population, as well as to healthcare systems worldwide (Raman et al., Eur Heart J 43:1157–1172, 2022). …”
Get full text

Machine learning prediction models for mortality risk in sepsis-associated acute kidney injury: evaluating early versus late CRRT initiation by Chuanren Zhuang, Ruomeng Hu, Ke Li, Zhengshuang Liu, Songjie Bai, Sheng Zhang, Xuehuan Wen

“…SHAP analysis identified maximum lactate levels, age, and minimum SpO2 as the strongest predictors of mortality, while CRRT timing showed relatively lower impact on outcome prediction.ConclusionWhile later initiation of CRRT in S-AKI patients was associated with improved survival, this benefit comes with increased healthcare resource utilization. The clinical parameters, rather than CRRT timing, are the primary determinants of patient outcomes, suggesting the need for a more personalized approach to CRRT initiation based on overall illness severity.…”
Get full text

Delirium and Associated Length of Stay and Costs in Critically Ill Patients by Claudia Dziegielewski, Charlenn Skead, Toros Canturk, Colleen Webber, Shannon M. Fernando, Laura H. Thompson, Madison Foster, Vanja Ristovic, Peter G. Lawlor, Dipayan Chaudhuri, Chintan Dave, Brent Herritt, Shirley H. Bush, Salmaan Kanji, Peter Tanuseputro, Kednapa Thavorn, Erin Rosenberg, Kwadwo Kyeremanteng

“…This can provide insight into the required resources for the prevention of delirium, which may contribute to decreasing healthcare expenditure while optimizing the quality of care.…”
Get full text

Prediction model for unfavorable treatment outcome for complicated sever acute malnutrition (SAM) in under five children admitted in hospitals at Amhara Region by Almaw Genet Yeshiwas, Zelalem Alamrew Anteneh, Tilahun Degu Tsega, Ahmed Fentaw Ahmed, Chalachew Yenew

“…The models can have the potential to improve care and treatment outcomes in the clinical settings. Healthcare professionals prioritize the management of cSAM cases in children, particularly those presenting with baseline edema and co-morbidities such as pneumonia, anemia and diarrhea. …”
Get full text

Impact of acupuncture on mortality in patients with disabilities and newly diagnosed heart failure: a nationwide cohort study by Hyungsun Jun, Dasol Park, Jae-Uk Sul, Moon Joo Cheong, Haerim Kim, Inae Youn, Jungtae Leem, Jungtae Leem, Jungtae Leem

“…While several limitations exist, we highlight the potential role of acupuncture in managing cardiovascular diseases in this population and encourage further research to support healthcare policies.…”
Get full text

Fecal carriage of carbapenemase and AmpC-β-lactamase producers among extended spectrum β-Lactamase-producing E. coli and Klebsiella spp. isolates in patients attending hospitals by Zakaria Garba, Isidore J. O. Bonkoungou, Namwin Siourimè Somda, Magloire H. Natama, Georges Somé, Lassana Sangaré, Nicolas Barro, Halidou Tinto

“…The carbapenemase producers were detected at tertiary and secondary hospitals, mainly in hospitalized patients and females, whereas AmpC-β-lactamase producers were detected at all levels of healthcare, predominantly in non-hospitalized patients, male, and under 15 years of age. …”
Get full text

Femoral Head Pathology in Subcapital Hip Fractures: Clinical Value and Cost-Effectiveness in a 230-Patient Case Series by Nissim Ohana, Omer Marom, David Segal, Refael Behrbalk, Yuval Ben-Sira, Alex Tavdi, Ezequiel Palmanovich, Eyal Yaacobi

“…<b>Background/Objectives:</b> Osteoporotic fractures, particularly subcapital hip fractures (SCF), pose a significant healthcare and economic burden. The routine pathological examination of resected femoral heads in such cases is common practice, aimed at identifying malignancies that may have contributed to bone fragility. …”
Get full text

The Impact of Endometriosis on Mental Health - A Literature Review of Depression and Anxiety Symptoms by Julia Woźniak, Sabina Kadłubek, Magdalena Mąka, Natalia Kapturska, Szymon Kalinowski, Kinga Cymerys, Piotr Kardaszewski, Jakub Kamiński, Dominik Sikora, Ewa Góralczyk

“…Women with endometriosis experience social stigmatization manifested not only from society members but also from healthcare professionals. The approach to the medical treatment by patients was discovered to be of consequence. …”
Get full text

The experience of bodily image for patients with left ventricular assist device by Irena Milaniak, Emilia Witkowska, Marta Cebula, Paulina Tomsia, Grzegorz Wasilewski, Izabela Górkiewicz-Kot, Sylwia Wiśniowska-Śmiałek, Michał Kaleta, Karol Wierzbicki, Karol Wierzbicki

“…The presence of anxiety and depressive symptoms and complications after LVAD significantly predicted low body image concerns.DiscussionHealthcare professionals should be aware of challenges regarding body image faced by LVAD-implanted patients and address related factors, especially anxiety and depression.…”
Get full text

Impact of COVID-19 restrictions on behavioural and psychological symptoms in home-dwelling people with dementia: a prospective cohort study (PAN.DEM) by Maarja Vislapuu, Mala Naik, Bettina S Husebø, Marie H Gedde, Ipsit V Vahia, Janne Mannseth, Line I Berge

“…NPI-12 total score worsened in 57 (55%) of people with dementia and was associated with postponed or averted contacts with healthcare professionals (logistic regression, OR 3.96, 95% CI 1.05 to 14.95). …”
Get full text

A multi-stakeholder collaborative approach to awareness, education and support needed in the haemophilia gene therapy patient journey – a report on insights from a European patient... by O’Mahony Brian, Fletcher Simon, Baarslag Manuel, Khair Kate, Breederveld Daan, Jansen Nathalie, Pembroke Luke, Pinachyan Karen, Sivasubramaniyam Sujan

“…Participants agreed that informed shared decision-making was essential for gene therapy, but most felt the choice to have gene therapy would be limited by healthcare budgets and access arrangements. They identified key education needed by PwH to enable true informed decision-making, best delivered through a collaborative approach by patient organisations and HCPs. …”
Get full text

Methyl 3-Bromo-4,5-dihydroxybenzoate Attenuates Inflammatory Bowel Disease by Regulating TLR/NF-κB Pathways by Jing Huang, Lei Li, Liyan Xu, Lixin Feng, Yuxin Wang, Attila Gabor SIK, Meng Jin, Rongchun Wang, Kechun Liu, Xiaobin Li

“…Inflammatory bowel disease (IBD) is characterized by uncontrolled, chronic relapsing inflammation in the gastrointestinal tract and has become a global healthcare problem. Here, we aimed to illustrate the anti-inflammatory activity and the underlying mechanism of methyl 3-bromo-4,5-dihydroxybenzoate (MBD), a compound derived from marine organisms, especially in IBD, using a zebrafish model. …”
Get full text

Development of Novel Nomograms to Predict 5- and 7-Year Biochemical-Recurrence-Free Survival in High-Risk Prostate Cancer Patients After Carbon-Ion Radiotherapy and Androgen Depriv... by Takanobu Utsumi, Hiroyoshi Suzuki, Masaru Wakatsuki, Kana Kobayashi, Atsushi Okato, Mio Nakajima, Shuri Aoki, Taisuke Sumiya, Tomohiko Ichikawa, Koichiro Akakura, Hiroshi Tsuji, Shigeru Yamada, Hitoshi Ishikawa

Get full text

Burden of Antimicrobial Resistance in Adult Hospitalized Patients With Cancer: A Multicenter Analysis by Vikas Gupta, Michael J. Satlin, Kalvin Yu, Yehoda M. Martei, Lillian Sung, Lars F. Westblade, Scott C. Howard, ChinEn Ai, Diane C. Flayhart

“…Methods This retrospective, cross‐sectional evaluation of AMR assessed hospitalized adult patients in 168 United States (US) healthcare facilities between April 2018 and December 2022. …”
Get full text

Latent profile and determinants of self-management behaviors among older adult patients with chronic diseases: a cross-sectional study by Yu Jiao Shao, Xiao Cui Duan, Xue Jun Xu, Hong Yan Guo, Ze Yu Zhang, Shuang Zhao, Fu Zhi Wang, Yong Xia Chen, Qin Chen, Shi Qing Zhang, Xiu Mu Yang

“…Multivariate logistic regression revealed that residence, aCCI, number of digital devices used, perceived usefulness of digital health information, digital health literacy, social support, chronic disease management self-efficacy, and psychological status were significant factors affecting self-management profiles (all p &lt; 0.05).ConclusionSelf-management behaviors in older adult patients with chronic diseases were generally low, with substantial heterogeneity across profiles. Healthcare providers should tailor interventions based on the characteristics of each group to enhance self-management in digital health contexts.…”
Get full text

Achilles Tendon Rupture In Recreational Athletes - Hobby-Ending Incident or Easily Treatable Injury? Current Insight Into Risk Factors, Treatment Options and Recovery Strategies by Jakub Kędzia, Joanna Duda, Kinga Racisz, Paweł Racisz, Alicja Obcowska, Aleksandra Walendzik, Łukasz Sencerek

“…It will also highlight prevalent risk factors, aiding in injury prevention for patients and healthcare professionals. Materials and methods: This literature review summarizes data from PubMed, Google Scholar, and other scientific sources on ATR. …”
Get full text

Public insight into knee osteoarthritis: a cross-sectional study from the West Bank, Palestine by Haya Jebreen Mohammed Warasna, Bashar Yaser Hasan Awad, Mohamad A. Banat, Mohammad Yaser Hasan Awad, Ahmed Farid Gadelmawla, Jameel Suliman, Tarek A. Owais, Ahmad J. Warasna

“…The use of informal sources highlights the importance of specific educational programs by healthcare providers.…”
Get full text

A Review of Human Studies Assessing the Efficacy of Cannabidiol for Anxiety Disorders by Kuba Borys Romańczuk, Katarzyna Kamińska-Omasta, Bartosz Omasta, Olga Krupa, Paulina Dorota Pietrukaniec, Zofia Martyna Wójcik, Kinga Furtak, Szymon Przemysław Stolarczyk, Magdalena Agata Czerska, Daria Rybak

Get full text

Impacts of National Reimbursement Drug Price Negotiation on drug accessibility, utilization, and cost in China: a systematic review by Zheng Zhu, Jiawei Zhang, Zhihu Xu, Quan Wang, Yu Qi, Li Yang

“…The published studies indicated the implementation of the NRDPN policy decreased drug prices, ranging from 24 to 72%, which increased the affordability of success-negotiated drugs (refer to those medications that have undergone a successful price negotiation process between pharmaceutical companies and healthcare authorities) and decreased out-of-pocket expenditures. …”
Get full text