Merck Open Global Health Library in vitro screening against Schistosoma mansoni identified two new substances with antischistosomal activities for further development by Monique Evelyn Ueberall, Martina Berchthold, Cécile Häberli, Sven Lindemann, Thomas Spangenberg, Jennifer Keiser, Christoph G. Grevelding

Get full text

A genomic strategy for precision medicine in rare diseases: integrating customized algorithms into clinical practice by Cristina Méndez-Vidal, Nereida Bravo-Gil, Javier Pérez-Florido, Irene Marcos-Luque, Raquel M. Fernández, José Luis Fernández-Rueda, María González-del Pozo, Marta Martín-Sánchez, Elena Fernández-Suárez, Marcela Mena, Rosario Carmona, Joaquín Dopazo, Salud Borrego, Guillermo Antiñolo

“…Here, we describe a personalized NGS-based strategy integrating precision medicine into a public healthcare system and its implementation in the routine diagnosis process during a five-year pilot program. …”
Get full text

Pairing regression and configurational analysis in health services research: modelling outcomes in an observational cohort using a split-sample design by Jason J Sico, Laura J Myers, Dawn M Bravata, Ying Zhang, Anthony J Perkins, Edward J Miech, Joanne Daggy

Get full text

Somatic comorbidities and health related uncertainty among Swedish adolescents with ADHD by Sara Lundqvist, Sara Lundqvist, Sara Röjås, Kourosh Bador, Maria Råstam, Nóra Kerekes, Nóra Kerekes

“…These findings highlight the importance of addressing both health literacy and access to healthcare. By focusing on this group, we cannot only improve their ability to understand and navigate the healthcare system but also strengthen their confidence in managing their own health.…”
Get full text

Association of burnout and working environment conditions in respiratory care professionals in Saudi Arabia: a cross-sectional study by Saad Al-Anazi, Saad Al-Anazi, Syed Shahid Habib, Thamir Al-khlaiwi, Abdulaziz Alhomaidi Alodhayani, Abdulmueen Alotaibi, Abdulmueen Alotaibi, Saja Aldulejan, Sufana Al Safadi, Fahad Saad Alshammari, Aqeelah Marar, Afaf Alrashdi, Alhanouf G. Almutairi, Mohammed Alshahrani

“…IntroductionBurnout is a pervasive issue in healthcare, and it impacts both the wellbeing of healthcare professionals and the quality of patient care. …”
Get full text

Accelerated aging as a mediator of the association between co-exposure to multiple air pollutants and risk of chronic kidney disease by Shuo Zhang, Yuxin Liu, Jike Qi, Yu Yan, Tongyu Gao, Xin Zhang, Dong Sun, Ting Wang, Ping Zeng

Get full text

Bringing lab to the field: Exploring innovations in point-of-care diagnostics for the rapid detection and management of tropical diseases in resource-limited settings by Abdullahi Tunde Aborode, Ridwan Olamilekan Adesola, Godfred Yawson Scott, Emele Arthur-Hayford, Oche Joseph Otorkpa, Somuah Daniel Kwaku, Emmanuel Ebuka Elebesunu, Eghaghe Osadebamwen Nibokun, Ibude Jane Aruorivwooghene, Adetolase A. Bakre, Oluwaseun Adeolu Ogundijo, Olamilekan Gabriel Banwo, Oluwatobiloba Ige, Ibrahim O. Adelakun, Isreal Ayobami Onifade, Segun E. Ogungbemi, Boluwatife T. Dosunmu, Oluwaseunayo Deborah Ayando, Nike Idowu, Grace A. Adegoye, Olusegun Oluwaseun Jimoh

“…The review focuses on rapid diagnostic tests, molecular diagnostic tools, and smartphone-based applications, analyzing their advantages, limitations, and potential impact on healthcare delivery. It also addresses the challenges and opportunities involved in deploying these technologies in resource-constrained environments. …”
Get full text

‘Striving to achieve control’. Registered nurses’ experiences of palliative care quality during the COVID-19 pandemic – a qualitative study by Tuva Sandsdalen, Ann Karin Helgesen, Vigdis Abrahamsen Grøndahl, Carina Bååth, Maria Larsson, Christina Melin Johansson, Cecilia Olsson, Maria Tillfors, Jane Österlind, Reidun Hov, Marie Dahlen Granrud

“…Both specialist and community healthcare services cared for patients that faced life-threatening illness and who were influenced by the restrictions of the COVID-19 pandemic. …”
Get full text

Prevalence and Determinants of Home Delivery among Women with Easy Access to Health Facilities in Sub-Saharan African Countries: A Multi-level Mixed Effect Analysis by Berhan Tekeba, Alebachew Ferede Zegeye, Deresse Abebe Gebrehana, Tadesse Tarik Tamir

“…After adjusting for confounders, being above 35 years, being a rural resident, being from the poorest and lowest wealth quintile, and living in rural regions all increase the likelihood of home birth among women in sub-Saharan Africa who have easy access to healthcare. Women with higher education, women who have optimal antenatal care (ANC) visits, women involved in healthcare decisions in households, and households with health insurance coverage reduce the odds of home delivery among women who have easy access to health facilities in sub-Saharan Africa. …”
Get full text

Altered functional network topology properties to detect anxiety and depression caused by Crohn’s disease and disease severity by Jiaxing Yang, Kechen Yue, Jingwen Sun, Changjie Pan, Xintong Wu, Yongjun Cheng, Xiaomeng Wu, Haifeng Shi

Get full text

Relationship between kidney function and healthy life expectancy: A historical cohort study by Hisayuki Ogura, Tadashi Toyama, Hikaru Samuta, Kohei Hirako, Tomoya Itatani, Shiori Nakagawa, Megumi Oshima, Shinji Kitajima, Akinori Hara, Norihiko Sakai, Miho Shimizu, Tomoyuki Takura, Takashi Wada, Yasunori Iwata

“…Abstract Background The impact of chronic kidney disease (CKD) on healthy life expectancy and healthcare costs requires research. This study examined associations between CKD and healthy life expectancy, and its economic burden. …”
Get full text

Challenges and support factors in managing type 2 diabetes among pregnant women in Thailand: A convergent mixed-methods study by Ratchanok Phonyiam, Chiao-Hsin Teng, Catherine Sullivan, Aunchalee Palmquist, Eric Hodges, Yamnia Cortés, Marianne Baernholdt

“…We identified six main themes: 1) challenges at the individual level in managing diabetes, 2) support factors at the individual level for diabetes management, 3) challenges at the interpersonal level in controlling diet, 4) interpersonal support factors for managing diabetes, 5) challenges at the societal level in accessing healthcare, and 6) societal support factors for healthcare access. …”
Get full text

The pattern and burden of non-communicable diseases in armed conflict-exposed populations in Northeastern Nigeria by Roland I. Stephen, Jennifer A. Tyndall, Jamiu S. Olumoh, Malachy I. Okeke, Jacob A. Dunga, Tonde G. Elijah, Dillys M. Bello, Oyelola A. Adegboye, Jimmy A. Reyes

“…As this region undergoes recovery, understanding the prevalence of NCDs, such as hypertension, diabetes, depression, and obesity, and the associated behavioral coping mechanisms, is crucial for developing tailored healthcare solutions. Therefore, this study aimed to assess the impact of conflict on the prevalence of NCDs in conflict-exposed areas in Northeastern Nigeria compared with non-conflict regions. …”
Get full text

Cost Savings in Chronic Pain Patients Initiating Peripheral Nerve Stimulation (PNS) with a 60-Day PNS Treatment by David M. Dickerson, Hemant Kalia, Kevin E. Vorenkamp, Konstantin V. Slavin, Jonathan M. Hagedorn, Candace Gunnarsson, Eric L. Keuffel, Andrew J. Epstein, Mark Stultz, Nathan D. Crosby

“…Abstract Introduction This study evaluates the financial impact on healthcare payers when chronic pain patients initiate peripheral nerve stimulation (PNS) with a 60-day percutaneous PNS (60-Day PNS) treatment versus a conventional brief PNS trial (PNS-BT) with possible follow-on of a permanently implanted PNS system (PNS-PI). …”
Get full text

Simulation of Image-Guided Microwave Ablation Therapy Using a Digital Twin Computational Model by Frankangel Servin, Jarrod A. Collins, Jon S. Heiselman, Katherine C. Frederick-Dyer, Virginia B. Planz, Sunil K. Geevarghese, Daniel B. Brown, William R. Jarnagin, Michael I. Miga

“…Emerging computational tools such as healthcare digital twin modeling are enabling the creation of patient-specific surgical planning, including microwave ablation to treat primary and secondary liver cancers. …”
Get full text

Pharmacist-led DE-eSCALation of opioids post-surgical dischargE (DESCALE) – A multi-centre, non-randomised, feasibility study protocol [version 2; peer review: 1 approved, 2 approv... by Ellie Santer, Julie H Hedayioglu, Vanessa J Short, Sabina Hulbert, Emma L Veale, Melanie Rees-Roberts, Johanna Theron

“…Qualitative interviews with participants and associated healthcare professionals will explore acceptability and implementation of the intervention. …”
Get full text

Age modulates, religious coping mediates: the role of attitude to self in cancer patients’ quality of life by Maria-Chidi C. Onyedibe, Runcie C.W. Chidebe, Runcie C.W. Chidebe, Runcie C.W. Chidebe, Barbara L. Andersen, Uzoamaka F. Ugwoke, Lawrence Ejike Ugwu, Lawrence Ejike Ugwu

“…This is particularly evident in low and middle-income countries (LMICs) where healthcare disparities exacerbate distress. Cognitive vulnerabilities, including negative generalization, self-criticism, and high standards, may influence HRQoL through their effects on coping mechanisms. …”
Get full text

Monitoring and evaluation in disaster management courses: a scoping review by George Teo Voicescu, Hamdi Lamine, Andra Elena Loșonți, Eugenia Maria Lupan-Mureșan, Sonia Luka, José García Ulerio, Luca Ragazzoni, Francesco Della Corte, Marta Caviglia

“…Results Fifty-seven articles met the inclusion and exclusion criteria, described DM training targeting healthcare and non-healthcare professionals and employed diverse teaching methods and topics. …”
Get full text

Can electronic monitoring with a digital smart spacer support personalised medication adherence and inhaler technique education in patients with asthma?: Protocol of the randomised... by Job F. M. van Boven, Boudewijn H.J. Dierick, Maria Achterbosch, Sandra Been-Buck, Titia Klemmeier, Susanne J. van de Hei, Paul Hagedoorn, Huib A.M. Kerstjens, Janwillem W.H. Kocks

“…At t=1, usability and satisfaction will be analysed using the System Usability Scale and interviews with patients and healthcare providers. Primary outcome is the overall feasibility of a definitive trial assessed by patient recruitment speed, participation and drop-out rate. …”
Get full text

Artificial Intelligence in Cardiac Surgery: Transforming Outcomes and Shaping the Future by Vasileios Leivaditis, Eleftherios Beltsios, Athanasios Papatriantafyllou, Konstantinos Grapatsas, Francesk Mulita, Nikolaos Kontodimopoulos, Nikolaos G. Baikoussis, Levan Tchabashvili, Konstantinos Tasios, Ioannis Maroulis, Manfred Dahm, Efstratios Koletsis

“…<b>Background:</b> Artificial intelligence (AI) has emerged as a transformative technology in healthcare, with its integration into cardiac surgery offering significant advancements in precision, efficiency, and patient outcomes. …”
Get full text