Differences in care delivery for children and adolescents with cancer in Europe – Results from the SIOPE OCEAN project by Maria Otth, Teresa de Rojas, Kerstin K. Rauwolf, Miguel Martins, Uta Dirksen, Delphine Heenen, Lejla Kameric, Pamela Kearns, Ruth Ladenstein, Cormac Owens, Caroline Queiroz, Richard Sullivan, Carmelo Rizzari, Gilles Vassal

“…Highly specialized treatment modalities and care structures are not available in every country. Public health insurances reimburse standard of care treatments in most countries (35/37); however, they do not cover all costs and additional funding is reported to be needed in up to one fifth of countries. …”
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Budget impact of maternal vaccination with RSVpreF to protect privately insured infants in Dubai against respiratory syncytial virus by Mostafa Zayed, Jean Joury, Mohamed Farghaly, Sara Al Dallal, Ramya Mahendiran, Amy W. Law, Diana Mendes, Erin Quinn, Emily Kutrieb, Ahuva Averin

“…Findings suggest that RSVpreF use among pregnant women would substantially reduce the clinical and economic burden of RSV-LRTI in infants, requiring an investment of just $0.19 PMPY by private health insurers.…”
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Implementation of an electronic medication management support system in hospitalised polypharmacy patients: study protocol of a stepped-wedge cluster-randomised controlled trial (T... by Peter Ihle, Katrin Christiane Reber, Juliane Köberlein-Neu, Ingo Meyer, Matthias Schilling, Daniel Grandt, Till Beckmann, Lara Düvel, Sara Söling, Simone Grandt, Wolfgang Greiner, Sarah Meyer, David Lampe, Adriana Poppe, Raphaele Bartels, Christoph Klaas, Adda Dumröse, Susanne Dolfen, Nathalie Sinnen, Carolin Polte, Olga Resch, Nicole Faulenbach, Hannah Britz, Beate Halex, Sofie May, Christof Shelian

“…The primary endpoint will be evaluated using hospital and outpatient claims data from participating statutory health insurances at the population level. There are multiple secondary endpoints with data linkage of primary and secondary data at study participant level. …”
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The influence of age, gender and pharmacogenetic profiles on the perspective on medicines in the German EMPAR study. by Veronica Atemnkeng Ntam, Tatjana Huebner, Michael Steffens, Christoph Roethlein, Britta Haenisch, Julia Stingl, Roland Linder, Catharina Scholl

“…<h4>Background</h4>Pharmacogenetic testing in routine care could provide benefits for patients, doctors and statutory health insurances. Therefore, the aim of the retrospective, observational study Einfluss metabolischer Profile auf die Arzneimitteltherapiesicherheit in der Routineversorgung (EMPAR) was to analyze the relationship between pharmacogenetic profiles, the risk of adverse drug reactions, and patients' perceptions of drug therapy in 10748 adult (≥18 years) participants in Germany.…”
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Costs and Outcomes of Clostridioides difficile Infections in Germany: A Retrospective Health Claims Data Analysis by Katharina Schley, Kirstin Heinrich, Jennifer C. Moïsi, Dennis Häckl, Dominik Obermüller, Gordon Brestrich, Christof von Eiff, Thomas Weinke

“…Methods A retrospective cohort study was conducted using a large, anonymized administrative health claims research database from Germany from which an age- and sex-representative sample of 4 million insured persons covered by approximately 60 statutory health insurances was extracted. Propensity score matching was conducted on age, sex, comorbidities, and antibiotic use to identify four matched controls (i.e., patients without CDI) for every eligible adult patient with CDI (i.e., case) in the study cohort. …”
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Exploring Opportunities and Challenges for the Spread, Scale-Up, and Sustainability of mHealth Apps for Self-Management of Patients With Type 2 Diabetes Mellitus in the Netherlands... by Catharina Margaretha van Leersum, Marloes Bults, Egbert Siebrand, Theodorus Johannes Josef Olthuis, Robin Enya Marije Bekhuis, Annemieke Ariënne Johanneke Konijnendijk, Marjolein Elisabeth Maria den Ouden

“…Essential strategies at the national level include guidelines for regulations, privacy, and security; the integration of mHealth into T2DM care guidelines; and sufficient reimbursement by health insurers.…”
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The role of guideline organizations in nationwide guideline implementation: a qualitative study by Andrea C. Thoonsen, Hanneke Merten, Toby T. Broeders, Anika Gans, Ilse van Beusekom, Diana M. J. Delnoij, Martine C. de Bruijne

“…Dutch guideline organizations, i.e. guideline developers, governmental agencies, health insurers and other national organizations, develop, authorize and/or support the use of guidelines in Dutch clinical practice. …”
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Business Venturing in Regulated Markets—Taxonomy and Archetypes of Digital Health Business Models in the European Union: Mixed Methods Descriptive and Exploratory Study by Sascha Noel Weimar, Rahel Sophie Martjan, Orestis Terzidis

“…ConclusionsThe findings highlight the critical elements constituting business models in the DHT domain, emphasizing the substantial impact of medical device regulations and revenue models, which often involve reimbursement from stakeholders such as health insurers. Three drivers contributing to DHT business model innovation were identified: direct targeting of patients and private individuals, use of artificial intelligence as an enabler, and development of DHT-specific reimbursement pathways. …”
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Challenging selective contracting: reforms for enhancing patient empowerment in healthcare by Gideon Leibner, Devorah Gold, Gabrielle Foreman, Shuli Brammli-Greenberg

“…Abstract Background Health insurers and managed care organizations often limit patient choice to in-network care providers through selective contracting, involving procurement agreements with service providers or ownership of healthcare institutions. …”
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Implementing an enhanced recovery from surgery pathway to reduce hospital length of stay for primary hip or knee arthroplasty: a budget impact analysis by Melanie Lloyd, Zanfina Ademi, Ian A. Harris, Justine Naylor, Peter Lewis, Richard de Steiger, Rachelle Buchbinder, Anthony Wan, Ilana N. Ackerman

“…The model considered population-based future arthroplasty projections, published data on healthcare costs and resource utilisation, and aggregate health insurer claims data related to minor complexity elective hip or knee arthroplasty for osteoarthritis. …”
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High risk for life-threatening adverse events of fluoroquinolones in young adults: a large German population-based cohort study by Julia Wicherski, Jonas Peltner, Cornelia Becker, Katrin Schüssel, Gabriela Brückner, Andreas Schlotmann, Helmut Schröder, Winfried V. Kern, Britta Haenisch

“…Population-based longitudinal data from one of the largest German statutory health insurances were used. Episodes of newly dispensed fluoroquinolones (ciprofloxacin, levofloxacin, ofloxacin, moxifloxacin, norfloxacin, and enoxacin) were compared to other antibiotics (amoxicillin, amoxicillin clavulanic acid, azithromycin, cefuroxime, cephalexin, clindamycin, sulfamethoxazole-trimethoprim, and doxycycline). …”
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Prescription of guideline‐directed medical therapy in heart failure: impact on mortality and readmission by Martin Möckel, Samipa Pudasaini, Kristina Feldmann, Henning Thomas Baberg, Benny Levenson, Jürgen Malzahn, Thomas Mansky, Guido Michels, Christian Günster, Elke Jeschke

“…Methods and results We included anonymous data from all patients who were insured at Germany’s largest health insurer (Allgemeine Ortskrankenkasse [AOK]) and had a claims record for hospitalization (2019–2021) with the main diagnosis of HF. …”
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Short- and long-term survival after open versus endovascular repair of abdominal aortic aneurysm-Polish population analysis. by Bartosz Symonides, Andrzej Śliwczyński, Zbigniew Gałązka, Jarosław Pinkas, Zbigniew Gaciong

“…<h4>Design</h4>Retrospective survival analysis based on prospectively collected medical records of the national Polish public health insurer.<h4>Materials</h4>In the National Health Fund database we identified all patients who underwent elective open or endovascular treatment of AAA between January 1st 2011 and March 22nd 2016. …”
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Effects of an interprofessional care concept in nursing homes evaluated in the SaarPHIR project: A cluster-randomized controlled trial. by Lisa Tönnies, Viola Zimmer, Alexandra Piotrowski, Thorsten Lehr, Sonja Laag, Juliane Köberlein-Neu

“…The primary outcome, hospitalization, was assessed using claims data from six health insurers. Analyses were performed using generalized linear mixed models assuming both a Poisson and, for sensitivity analyses, a negative binomial distribution allowing for clustering at the nursing home level. …”
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Risk of admission to hospital with arterial or venous thromboembolism among patients diagnosed in the ambulatory setting with covid-19 compared with influenza: retrospective cohort... by Sean Hennessy, Rebecca A Hubbard, Vincent Lo Re, Claudia A Steiner, Yunping Zhou, Cheryl N McMahill-Walraven, Pamala A Pawloski, Laura Hou, Sarah K Dutcher, John G Connolly, Silvia Perez-Vilar, Terese A DeFor, Djeneba Audrey Djibo, Laura B Harrington, Maria E Kempner, Jennifer L Kuntz, Jolene Mosley, Andrew B Petrone, Allyson M Pishko, Meighan Rogers Driscoll, Noelle M Cocoros, Dean M Carbonari

“…Objective To measure the 90 day risk of arterial thromboembolism and venous thromboembolism among patients diagnosed with covid-19 in the ambulatory (ie, outpatient, emergency department, or institutional) setting during periods before and during covid-19 vaccine availability and compare results to patients with ambulatory diagnosed influenza.Design Retrospective cohort study.Setting Four integrated health systems and two national health insurers in the US Food and Drug Administration's Sentinel System.Participants Patients with ambulatory diagnosed covid-19 when vaccines were unavailable in the US (period 1, 1 April-30 November 2020; n=272 065) and when vaccines were available in the US (period 2, 1 December 2020-31 May 2021; n=342 103), and patients with ambulatory diagnosed influenza (1 October 2018-30 April 2019; n=118 618).Main outcome measures Arterial thromboembolism (hospital diagnosis of acute myocardial infarction or ischemic stroke) and venous thromboembolism (hospital diagnosis of acute deep venous thrombosis or pulmonary embolism) within 90 days after ambulatory covid-19 or influenza diagnosis. …”
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Identifying barriers and disparities in the healthcare of patients with alopecia areata: a mixed-methods analysis using claims data and qualitative interview data by Matthias Augustin, Christine Blome, Katharina Müller, Kristina Hagenström, Toni Maria Janke, Beke Hester, Theresa Klinger, Brigitte Stephan

“…Even though AA can be very burdensome to patients, the German social act has categorised AA as a ‘lifestyle disease’ and treatment is not covered by statutory health insurances (SHI). We aimed to characterise the healthcare situation of patients with AA in Germany, including potential inequalities, and to derive recommendations for action.Design This mixed-methods study combined: (1) semistructured qualitative interviews with patients and dermatologists, analysed through qualitative content analysis and (2) claims data analyses of a large nationwide German SHI from 2016 to 2020. …”
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