1H NMR-Based Metabolic Profiling of Urine from Mice Fed Lentinula edodes-Derived Polysaccharides by Xu Xiaofei, Yang Jiguo, Ning Zhengxiang, Zhang Xuewu

“…Using principal component analysis (PCA) and partial least squares-discriminate analysis (PLS-DA), 22 potential biomarkers were found to be mainly involved in some metabolic pathways: amino acid metabolism, energy metabolism, lipid metabolism, tricarboxylic acid (TCA) cycle, urea cycle and gut microbiota metabolism. Among them, the significantly altered metabolites include: elevated glutamate (75%) and creatine (64%); decreased proline (65%), betaine (58%), fucose (63%) and dimethylamine (59%). …”
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Exploring the Effects of Imidacloprid on Liver Health and the Microbiome in Rats: A Comprehensive Study by Alaa T. Qumsani

“…Overall, given these findings, it would seem that imidacloprid does indeed impose serious negative impacts on both liver function and gut microbiota composition and may have further impacts on health and ecological safety.…”
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The Mechanism of Metabolic Influences on the Endogenous GLP-1 by Oral Antidiabetic Medications in Type 2 Diabetes Mellitus by Thiquynhnga Nguyen, Min Gong, Song Wen, Xinlu Yuan, Chaoxun Wang, Jianlan Jin, Ligang Zhou

“…In this review, we discuss the metabolic relationships between oral antihyperglycemic drugs from the aspect of gut, microbiota, hormones, β cell function, central nervous system, and other cellular mechanisms.…”
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Lithocholic acid controls adaptive immune responses by inhibition of Th1 activation through the Vitamin D receptor. by Thijs W H Pols, Teresa Puchner, H Inci Korkmaz, Mariska Vos, Maarten R Soeters, Carlie J M de Vries

“…Many factors influence LCA levels, including bile acid-based drugs and gut microbiota. Our data may suggest that these factors also impact on adaptive immunity via a yet unrecognized LCA-Th cell axis.…”
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The trypanosomatid (Kinetoplastida: Trypanosomatidae) parasites in bees: A review on their environmental circulation, impacts and implications by Rossella Tiritelli, Giovanni Cilia, Tamara Gómez-Moracho

“…Biotic factors, including co-infections, gut microbiota, food contamination, and abiotic factors like environmental conditions, pesticides, and urbanization, play crucial roles in infection dynamics. …”
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Beta-Defensin-2 and Beta-Defensin-3 Reduce Intestinal Damage Caused by Salmonella typhimurium Modulating the Expression of Cytokines and Enhancing the Probiotic Activity of Enteroc... by Alessandra Fusco, Vittoria Savio, Marcella Cammarota, Alberto Alfano, Chiara Schiraldi, Giovanna Donnarumma

“…Based on the literature data, the purpose of this work was to create a line of intestinal epithelial cells able to stably express gene encoding human β-defensin-2 (hBD-2) and human β-defensin-3 (hBD-3), in order to test their role in S. typhimurium infections and their interaction with the bacteria of the gut microbiota.…”
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Sustainable Nutritional Strategies for Gut Health in Weaned Pigs: The Role of Reduced Dietary Crude Protein, Organic Acids and Butyrate Production by Kathryn Ruth Connolly, Torres Sweeney, John V. O’Doherty

“…These interventions selectively enhance butyrate-producing bacteria such as <i>Roseburia</i> and <i>Faecalibacterium prausnitzii</i>, further stabilising the gut microbiota. Integrating these strategies can enhance gut integrity, microbial resilience, and immune responses in weaned piglets. …”
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New Insights into the Mechanisms of Chinese Herbal Products on Diabetes: A Focus on the “Bacteria-Mucosal Immunity-Inflammation-Diabetes” Axis by Zezheng Gao, Qingwei Li, Xuemin Wu, Xuemin Zhao, Linhua Zhao, Xiaolin Tong

“…Here, we have proposed that many herbal monomers and formulae improve glucose homeostasis and diabetes through the BMID axis; B represents gut microbiota, M means mucosal immunity, I represents inflammation, and D represents diabetes. …”
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The Relationship among Physical Activity, Intestinal Flora, and Cardiovascular Disease by Qiuyu Yan, Wenhui Zhai, Chenghao Yang, Zihao Li, Longfei Mao, Mingyi Zhao, Xiushan Wu

“…PA benefits the metabolic changes that occur in the gut microbiota (GM). The major metabolites of the GM influence pathogenesis of CVDs through various pathways. …”
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Faecalibacterium prausnitzii: A Next-Generation Probiotic in Gut Disease Improvement by Xiaoya He, Shuyang Zhao, Yan Li

“…Thus, for reshaping ecological balance, a growing body of the literatures have proposed numerous strategies to modulate the structure of the gut microbiota, which provide more revelation for amelioration of these inflammation or infection-related diseases. …”
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Interaction studies unveil potential binding sites on bovine serum albumin for gut metabolite trimethylamine n-oxide (TMAO) by Awadhesh Kumar Verma, Payal Gulati, GBVS Lakshmi, Anand Mohan, Neeta Raj Sharma, Pratima R. Solanki, Anil Kumar

“…Abstract Trimethylamine-N-oxide (TMAO) is gut microbiota-derived metabolite, plays a critical role in human health and diseases such as metabolic, cardiovascular, colorectal cancer and, neurological disorders. …”
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Digging deeper into necrotizing enterocolitis: bridging clinical, microbial, and molecular perspectives by Deshuang Zhang, Dongke Xie, Yi Qu, Dezhi Mu, Shaopu Wang

“…We further critically examine dysbiotic alterations within the gut microbiota, with a particular focus on imbalances in bacterial and viral communities, which may contribute to the onset of NEC. …”
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Gut Microbiome Profiles in Colorectal Cancer Patients in Iraq by Fatima J. Kadhim, Zahid S. Aziz, Khalid S. Ibrahim

“…This study aims to investigate the differences in gut microbiota between CRC patients and healthy individuals in Iraq, using 16S rRNA metagenomic sequencing on Illumina NovaSeq (PE250-Seq). …”
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Nonpharmacological Modulation of Chronic Inflammation in Parkinson’s Disease: Role of Diet Interventions by Stefania Kalampokini, Anouck Becker, Klaus Fassbender, Epameinondas Lyros, Marcus M. Unger

“…Food-based therapies may favorably modulate gut microbiota composition and enhance the intestinal epithelial integrity or decrease the proinflammatory response by direct effects on immune cells. …”
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2′-Fucosyllactose as a prebiotic modulates the probiotic responses of Bifidobacterium bifidum by Jingfang Du, Hong Yang

“…These observations provide a useful guideline for developing synbiotic supplements to intervene the infant gut microbiota.…”
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Development of a risk prediction nomogram model of pyrotinib-induced severe diarrhea by Qingqing Chen, Guoding Huang, Yaowen Xia, Hongmei Zhao, Yu zheng, Yiyi Liao

“…Results History of adverse reactions (ADRs), initial dose of pyrotinib, combination with capecitabine, thrombocytopenia, aspartate transaminase (AST), and use of probiotics or other drugs that regulate the gut microbiota were identified as independent influencing factors for pyrotinib-induced severe diarrhea (all P < 0.05). …”
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Intrathecal Immunoglobulin A Synthesis in Multiple Sclerosis: From Biological Aspects to Clinical Relevance by Dariia Kliushnikova, Ferdinand Otto, Georg Pilz, Peter Wipfler, Andrea Harrer

“…A connection between intrathecal IgA synthesis and the gut–brain axis in MS was further corroborated by the discovery of gut microbiota-specific IgA+ B cells in human CNS during relapse. …”
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A comprehensive metabolome profiling of Terminalia chebula, Terminalia bellerica, and Phyllanthus emblica to explore the medicinal potential of Triphala by Santhosh N. Hegde, Lavanya Devi K, Mahima Choudhary, Nandita Menon, Gurmeet Singh

“…Pathway enrichment analysis highlighted dominant phenylpropanoid biosynthesis pathways across all extracts, while a comprehensive polyphenol classification identified 71 polyphenols, with significant interactions predicted between polyphenols and gut microbiota. Additionally, five common polyphenols showed potential human targets related to antioxidant activity. …”
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Diversity and Species Composition of Midgut Symbiotic Bacteria in Culex quinquefasciatus Mosquitoes in Gampaha District, Sri Lanka by Randi Hathnagoda, Pinidi Gunathilake, Thilini Buddhinee, Pabasara Welgama, Hasini Gunarathna, Harshani Perera, Koshila Ranasinghe

“…The present study focuses on the importance of understanding mosquito gut microbiota for implementing innovative vector control strategies, thereby mitigating disease transmission. …”
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Evaluation of Faecal Microbiota Following Probiotics in Infants of Mothers with Gestational Diabetes Mellitus Trial: Protocol for Double-Blind Placebo-Controlled Randomized Trial by Gayatri Athalye-Jape, Chandra Prakash Rath, Harshad Panchal, Archita Mishra, Dorothy Graham, Sanjay Patole

“…The current evidence indicates that GDM, especially in conjunction with maternal overweight, can alter the composition of infants’ gut microbiota, potentially increasing the risk of inflammatory diseases, metabolic disorders, and neurodevelopmental issues later in life. …”
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