Trifluridine/tipiracil regimen in combination with bevacizumab for metastatic colorectal cancer in the third line: an expert opinion by Carmine Pinto, Sara Lonardi, Evaristo Maiello, Erika Martinelli, Michele Prisciandaro, Lisa Salvatore, Lisa Salvatore, Andrea Sartore-Bianchi, Andrea Sartore-Bianchi, Mario Scartozzi, Giuseppe Aprile, Chiara Cremolini, Alberto Sobrero

“…Of note, the efficacy is confirmed independently from KRAS mutational status and also for patients who had breaks in anti-vascular endothelial growth factor (anti-VEGF) therapy. Herein, we describe the current state of the art in the landscape of treatments after the second progression in mCRC. …”
Get full text

Adipose-Derived Stem Cells Alleviate Radiation-Induced Muscular Fibrosis by Suppressing the Expression of TGF-β1 by Wei Sun, Xinchu Ni, Suping Sun, Leiming Cai, Jingping Yu, Jian Wang, Bin Nie, Zhiqiang Sun, Xinye Ni, Xiufeng Cao

“…Significant decrease was noted in the integrated optimal density of the transforming growth factor β1 (TGF-β1) in the ASCs group compared with those of PBS group at 4 w, 8 w, and 26 w after irradiation. …”
Get full text

Plasma levels of immunosuppressive mediators during cardiopulmonary bypass by E. Borrelli, P. Giomarelli, A. Naldini, E. Luzzi, S. Silvestri, M. Gardinali, V. Bocci

“…The aim of this study was to evaluate plasma levels of two mediators with immunosuppressive properties, complement fraction C3a (C3a) and transforming growth factor-β1 (TGF-β1), during extracorporeal circulation. …”
Get full text

Comparative transcriptomic and metabolomics analysis of ovary in Nilaparvata lugens after trehalase inhibition by Yongkang Liu, Fan Yang, Sijing Wan, Xianzhong Wang, Liwen Guan, Yan Li, Caidi Xu, Binghua Xie, Shigui Wang, Xiao-Ling Tan, Bin Tang

“…The overlapping DEGs were implicated in various biological processes, including protein metabolism, fatty acid metabolism, AMPK signaling, mTOR signaling, insulin/insulin-like growth factor signaling (IIS), the tricarboxylic acid (TCA) cycle, oxidative phosphorylation, and the cellular process of meiosis in oocytes. …”
Get full text

Comparative Evaluation of Bone Repair with Four Different Bone Substitutes in Critical Size Defects by Gustavo Grossi-Oliveira, Leonardo P. Faverani, Bruno Coelho Mendes, Tárik Ocon Braga Polo, Gabriel Cury Batista Mendes, Valthierre Nunes de Lima, Paulo Domingos Ribeiro Júnior, Roberta Okamoto, Osvaldo Magro-Filho

“…Immunohistochemical analysis for Runt-related transcription factor 2 (Runx2), vascular endothelial growth factor (VEGF), and osteocalcin (OC) was performed. …”
Get full text

Toll-Like Receptor 4 in Bone Marrow-Derived Cells Contributes to the Progression of Diabetic Retinopathy by Hui Wang, Haojun Shi, Jing Zhang, Guoliang Wang, Jinxiang Zhang, Fagang Jiang, Qing Xiao

“…TLR4 mutation did not block the occurrence of high blood glucose after STZ injection compared with WT mice but did alleviate the progression of DR and alter the expression of the small vessel proliferation-related genes, vascular endothelial growth factor (VEGF), and hypoxia inducible factor-1α (HIF-1α). …”
Get full text

Synergistic Effects of Cabozantinib and EGFR-Specific CAR-NK-92 Cells in Renal Cell Carcinoma by Qing Zhang, Kang Tian, Jinjing Xu, Haixu Zhang, Liantao Li, Qiang Fu, Dafei Chai, Huizhong Li, Junnian Zheng

“…We developed an epidermal growth factor- (EGFR-) specific third-generation CAR. …”
Get full text

Vitamin C exerts anti-cadmium induced fracture functions/targets: bioinformatic and biostructural findings by Rong Li, Songzuo Yu, Xiao Liang, Yu Li, Keng Po Lai

“…Nine core targets were characterized, including tumor protein p53, epidermal growth factor receptor, proto-oncogene c, mitogen-activated protein kinase-1 (MAPK1), MAPK3, signal transducer and activator of transcription-3, MAPK14, prostaglandin-endoperoxide synthase 2, and estrogen receptor alpha. …”
Get full text

Unhealthy Phenotype as Indicated by Salivary Biomarkers: Glucose, Insulin, VEGF-A, and IL-12p70 in Obese Kuwaiti Adolescents by Mor-Li Hartman, J. Max Goodson, Ping Shi, Jorel Vargas, Tina Yaskell, Danielle Stephens, Maryann Cugini, Hatice Hasturk, Roula Barake, Osama Alsmadi, Sabiha Al-Mutawa, Jitendra Ariga, Pramod Soparkar, Jawad Behbehani, Kazem Behbehani, Francine Welty

“…Elevated salivary glucose and insulin occurring together was associated with elevated vascular endothelial growth factor and reduced salivary interleukin-12. Conclusion. …”
Get full text

Endocrinopathies after Allogeneic and Autologous Transplantation of Hematopoietic Stem Cells by Francesco Orio, Giovanna Muscogiuri, Stefano Palomba, Bianca Serio, Mariarosaria Sessa, Valentina Giudice, Idalucia Ferrara, Libuse Tauchmanovà, Annamaria Colao, Carmine Selleri

“…Dysfunctions of the hypothalamus-pituitary-growth hormone/insulin growth factor-I axis, hypothalamus-pituitary-thyroid axis, and hypothalamus-pituitary-adrenal axis were documented as later complicances, occurring in about 10, 30, and 40–50% of transplanted patients, respectively. …”
Get full text

IGF-1R Inhibition Suppresses Cell Proliferation and Increases Radiosensitivity in Nasopharyngeal Carcinoma Cells by Zhe Wang, Guangyan Liu, Jiwei Mao, Min Xie, Ming Zhao, Xuefen Guo, Shanshan Liang, Heming Li, Xuefeng Li, Ruoyu Wang

“…Although ionizing radiation (IR) has provided considerable improvements in nasopharyngeal carcinoma (NPC) treatment, radioresistance is still a major threat for some subsets of patients. The insulin-like growth factor-1 receptor (IGF-1R) signaling pathway is tightly regulated and plays critical roles in mediating cell proliferation, growth, and survival. …”
Get full text

Effects of Activating Mutations on EGFR Cellular Protein Turnover and Amino Acid Recycling Determined Using SILAC Mass Spectrometry by Michael J. Greig, Sherry Niessen, Scott L. Weinrich, Jun Li Feng, Manli Shi, Ted O. Johnson

“…Utilizing SILAC MS, we measured the cellular turnover rates of an important non-small cell lung cancer target, epidermal growth factor receptor (EGFR). Wild-type (WT) EGFR, EGFR with a single activating mutant (Del 746–750 or L858R), and the drug-resistant double mutant (L858R/T790M) EGFR were analyzed. …”
Get full text

Interfacial cfDNA Enrichment and Amplification with On‐Chip Thermoplasmonics for Highly Sensitive Cancerous Liquid Biopsy by Danhua Wang, Linlin Liu, Wenjing Chi, Zhenping Liu, Jiayun Wu, Yirou Liang, Fei He, Ruixiang Zhang, Pengxin Huang, Yunbo Li, Guangyu Qiu

“…Typical cfDNA biomarkers, including epidermal growth factor receptor (EGFR), tumor protein 53 (TP53), phosphatase and tensin homologue deleted on chromosome 10 (PTEN), and cyclin‐dependent kinase inhibitor (CDKN2A), are quantified with detection limits down to femtomolar‐level. …”
Get full text

Drug Repositioning for Gynecologic Tumors: A New Therapeutic Strategy for Cancer by Kouji Banno, Miho Iida, Megumi Yanokura, Haruko Irie, Kenta Masuda, Yusuke Kobayashi, Eiichiro Tominaga, Daisuke Aoki

“…Metformin, an antidiabetic drug, is effective for endometrial cancer through inhibition of the PI3K-Akt-mTOR pathway by activating LKB1-AMPK and reduction of insulin and insulin-like growth factor-1 due to AMPK activation. COX-2 inhibitors for cervical cancer may also be examples of drug repositioning. …”
Get full text

Involvement of the TGF-β pathway in epithelialmesenchymal transition promoted by the pulmonary microenvironment in Mycoplasma pneumoniae pneumonia by Fan Lu, Wang Huixia, Xu Nuo, Guo Yun, Li Ling

“…Transcriptome sequencing revealed significant upregulation of pathways including transforming growth factor beta (TGF-β), tumor protein 53 (P53), protein kinase Hippo, Ras-proximate-1 or Ras-related protein 1 (Rap1), and members of class O forkhead box proteins (FoxO) in cells exposed to bronchoalveolar lavage fluid (BALF) from MPP patients with atelectasis. …”
Get full text

Thrombospondin and VEGF-R: Is There a Correlation in Inflammatory Bowel Disease? by Jaroslaw Wejman, Michal Pyzlak, Dariusz Szukiewicz, Dorota Jarosz, Wieslaw Tarnowski, Grzegorz Szewczyk

“…The purpose of our study was to evaluate the relationship between vascular density and expression of thrombospondin-1 (TSP-1) and vascular endothelial growth factor receptor 1 (VEGFR-1) in full-thickness tissue fragments of intestinal wall taken from patients after colectomy, comparing those with IBD to non-IBD control group. …”
Get full text

Similarity of Fibroglandular Breast Tissue Content Measured from Magnetic Resonance and Mammographic Images and by a Mathematical Algorithm by Fatima Nayeem, Hyunsu Ju, Donald G. Brunder, Manubai Nagamani, Karl E. Anderson, Tuenchit Khamapirad, Lee-Jane W. Lu

“…We also found that the number of completed pregnancies, C-reactive protein, aspartate aminotransferase, and progesterone were more strongly associated with amounts of glandular tissue than adipose tissue, while fat body mass, alanine aminotransferase, and insulin like growth factor-II appear to be more associated with the amount of breast adipose tissue. …”
Get full text

Evidence That ADAM17 Mediates the Protective Action of CGRP against Angiotensin II-Induced Inflammation in Vascular Smooth Muscle Cells by Si-yu Zeng, Li Yang, Chen-liang Hong, Hui-qin Lu, Qiu-jiang Yan, Yan Chen, Xu-ping Qin

“…Small interference RNA (siRNA) and inhibitors of CGRP, epidermal growth factor receptor (EGFR), and extracellular signal-regulated kinase 1/2 (ERK1/2) were adopted to investigate their effect on Ang II-induced inflammation in VSMCs. …”
Get full text

Establishment of a Model of Microencapsulated SGC7901 Human Gastric Carcinoma Cells Cocultured with Tumor-Associated Macrophages by Jin-Ming Zhu, Xiu-Lian Quan, Shi-Chao Han, Xue-Jun Fan, He-Ming Li, Shan-Shan Liang, Xi Chen, Ruo-Yu Wang, Xue-Ning Ji

“…Immunocytochemistry confirmed that Proliferating Cell Nuclear Antigen (PCNA) and Vascular Endothelial Growth Factor (VEGF) were expressed in microencapsulated SGC7901 cells on days 7 and 14. …”
Get full text

Fenofibrate Inhibited the Differentiation of T Helper 17 Cells In Vitro by Zhou Zhou, Weiliang Sun, Ying Liang, Yanxiang Gao, Wei Kong, Youfei Guan, Juan Feng, Xian Wang

“…Our results showed that fenofibrate inhibited transforming growth factor-β (TGF-β) and IL-6-induced differentiation of Th17 cells in vitro. …”
Get full text