Comparison of CT-like MRI sequences for preoperative planning of cochlear implantation using super-high-resolution CT as a reference by Ulysse Puel, Achille Beysang, Gabriella Hossu, Michael Eliezer, Bouchra Assabah, Khalid Ambarki, Pedro Augusto Gondim Teixeira, Alain Blum, Cécile Parietti-Winkler, Romain Gillet

“…Round window depiction is not possible with CT-like MRI sequences. Graphical Abstract…”
Get full text

Periapical bone edema volume in 3D MRI is positively correlated with bone architecture changes by Alexander W. Marka, Monika Probst, Tobias Greve, Nicolas Lenhart, Niklas Graf, Florian Probst, Gustav Andreisek, Thomas Frauenfelder, Matthias Folwaczny, Egon Burian

“…MRI offers diagnostic advantages for early dental pathology detection. Graphical Abstract…”
Get full text

The miR-1269a/PCDHGA9/CXCR4/β-catenin pathway promotes colorectal cancer invasion and metastasis by Haitao Mei, Qingshan Luo, Junyong Weng, Jialing Hao, Jinfeng Cai, Runkai Zhou, Ce Bian, Yingzi Ye, Shengzheng Luo, Yugang Wen

“…The low level of PCDHGA9 activates the Wnt/β-catenin pathway by releasing its interaction with HOXA1, promoting the expression of CXCR4, and causing invasion, migration, and EMT in CRC. Graphical Abstract…”
Get full text

Molecular testing for cytologically suspicious and malignant (Bethesda V and VI) thyroid nodules to optimize the extent of surgical intervention: a retrospective chart review by Jessica Hier, Galit Avior, Marc Pusztaszeri, Joshua R. Krasner, Noura Alyouha, Veronique-Isabelle Forest, Michael P. Hier, Alex Mlynarek, Keith Richardson, Nader Sadeghi, Michael Tamilia, Richard J. Payne

“…Prospective studies with larger sample sizes are required to further investigate this finding. Graphical abstract…”
Get full text

Evaluating the potential of Kalanchoe pinnata, Piper amalago amalago, and other botanicals as economical insecticidal synergists against Anopheles gambiae by Sheena Francis, William Irvine, Lucy Mackenzie-Impoinvil, Lucrecia Vizcaino, Rodolphe Poupardin, Audrey Lenhart, Mark J. I. Paine, Rupika Delgoda

“…Novel synergists can help to overcome metabolic resistance to insecticides, which is increasingly reported in malaria vectors. Graphical Abstract…”
Get full text

Toward accurate prediction of carbon dioxide (CO2) compressibility factor using tree-based intelligent schemes (XGBoost and LightGBM) and equations of state by Behnam Amiri-Ramsheh, Aydin Larestani, Saeid Atashrouz, Elnaz Nasirzadeh, Meriem Essakhraoui, Ali Abedi, Mehdi Ostadhassan, Ahmad Mohaddespour, Abdolhossein Hemmati-Sarapardeh

“…Moreover, the results of the developed techniques were compared with those of Patel-Teja (PT) and Peng-Robinson (PR) equations of state (EoSs) applying various graphical and statistical error tests. The results demonstrated that the LightGBM intelligent technique has the highest accuracy with the lowest error value of 0.42 % and R2 of 0.999. …”
Get full text

Mfsd2a suppresses colorectal cancer progression and liver metastasis via the S100A14/STAT3 axis by Linfeng Sun, Xiangdong Li, Yuhao Xiao, Wenjie Yu, Xuyang Chen, Ziyi Wang, Nan Xia, Xuejiao Chen, Minhao Chen, Haoliang Zhu, Jie Li, Jie Wei, Sheng Han, Liyong Pu

“…Mfsd2a functions as a tumor suppressor in CRLM and could be a promising therapeutic target for treating CRC patients with liver metastasis. Graphical abstract…”
Get full text

Exosomal mir-126-3p derived from endothelial cells induces ion channel dysfunction by targeting RGS3 signaling in cardiomyocytes: a novel mechanism in Takotsubo cardiomyopathy by Xuehui Fan, Guoqiang Yang, Yinuo Wang, Haojie Shi, Katja Nitschke, Katherine Sattler, Mohammad Abumayyaleh, Lukas Cyganek, Philipp Nuhn, Thomas Worst, Bin Liao, Gergana Dobreva, Daniel Duerschmied, Xiaobo Zhou, Ibrahim El-Battrawy, Ibrahim Akin

“…These findings provide new perspectives on the pathogenesis of TTC and suggest potential therapeutic targets for treatment. Graphical Abstract…”
Get full text

Target trial emulation to evaluate the effect of immune-related adverse events on outcomes in metastatic urothelial cancer by Renate Pichler, Josef Fritz, Sarah Maier, Melanie R. Hassler, Johanna Krauter, David D`Andrea, Ekaterina Laukhtina, Kilian Gust, Keiichiro Mori, Karl H. Tully, Dora Niedersuess-Beke, Lea Korber, Jasmin Alija Spiegelberg, Thomas Bauernhofer, José D. Subiela, Roman Mayr, Andreas Kronbichler, Marco Moschini, Jeremy Teoh, Benjamin Pradere, Shahrokh F. Shariat, Hanno Ulmer, Laura S. Mertens, European Association of Urology–Young Academic Urologists (EAU-YAU): Urothelial Carcinoma Working Group

“…These findings demonstrate that TTE is a suitable formal framework to avoid immortal time bias in studies with time-dependent non-interventional exposures. Graphical abstract…”
Get full text

Green sanctuaries: residential green and garden space and the natural environment mitigate mental disorders risk of diabetic patients by Erxu Xue, Jianhui Zhao, Jingyu Ye, Jingjie Wu, Dandan Chen, Jing Shao, Xue Li, Zhihong Ye

“…This highlights the potential for local governments to enhance the sustainability of such interventions, grounded in public health and urban planning, through strategic planning initiatives. Graphical Abstract…”
Get full text

Optimization and characterization studies of poultry waste valorization for peptone production using a newly Egyptian Bacillus subtilis strain by Hajar Saeed, Anthony Ragaey, Ziad Samy, Viola Ashraf, Aly ElMostafa, Norhan Ahmad, Enjy Bebawy, Nour ElHoda M. Sorour, Salwa M. El-Sayed, Ashraf Bakry, Naglaa Ebeed, Hesham Elhariry, Thanaa El-Noby, Samah H. Abu-Hussien

“…This study successfully valorized poultry waste by developing a sustainable and cost-effective alternative to commercial peptones, contributing to waste valorization and sustainable biotechnological processes. Graphical abstract…”
Get full text

Enhanced therapeutic effects of hypoxia-preconditioned mesenchymal stromal cell-derived extracellular vesicles in renal ischemic injury by Fei Yuan, Jie Liu, Liang Zhong, Pengtao Liu, Ting Li, Kexin Yang, Wei Gao, Guangyuan Zhang, Jie Sun, Xiangyu Zou

“…Our findings highlight that hypoxia-pretreated MSC-EVs represent a novel and promising therapeutic strategy for renal IRI. Graphical Abstract…”
Get full text

Frequency and accuracy of intraoperative bone margin sampling for T4a cancers of the head and neck at the QEII Health Sciences Centre: a retrospective chart review by Anna-Claire Lamport, Colin A. MacKay, Martin J. Bullock, S. Mark Taylor, Jonathan R. Trites, Martin Corsten, Matthew H. Rigby

“…This will provide baseline data for comparison of the standardized intraoperative bone margin sampling protocol implemented at the QEII Health Sciences Centre. Graphical Abstract…”
Get full text

Co-isolation of human donor eye cells and development of oncogene-mutated melanocytes to study uveal melanoma by Yunxi Chen, Eva Jin, Mohamed Abdouh, Éric Bonneil, Daniel Alexander Jimenez Cruz, Thupten Tsering, Qianqian Zhou, Aurélie Fuentes-Rodriguez, Alexandra Bartolomucci, Alicia Goyeneche, Solange Landreville, Miguel N. Burnier, Julia V. Burnier

“…The co-isolated RPE cells could benefit research on other ocular pathologies, such as age-related macular degeneration. Graphical Abstract Created with https://www.biorender.com/ .…”
Get full text

Metabolomics, network pharmacology, and microbiome analyses uncover the mechanisms of the Chinese herbal formula for the improvement of meat quality in spent hens by Zhihua Li, Md. Abul Kalam Azad, Chengwen Meng, Xiangfeng Kong, Jue Gui, Wenchao Lin, Yadong Cui, Wei Lan, Qinghua He

“…Conclusions Our results suggest that CHF supplementation improved the quality and nutritional value of meat, which will provide a theoretical basis for the utilization of CHF as a feed additive in spent hens’ diets. Graphical Abstract…”
Get full text

Inducible engineering precursor metabolic flux for synthesizing hyaluronic acid of customized molecular weight in Streptococcus zooepidemicus by Rui Zhao, Jun Li, Yingtian Li, Xujuan Pei, Jingyi Di, Zhoujie Xie, Hao Liu, Weixia Gao

“…The HA MW of strain SE3 can be accurately manipulated by adjusting sucrose concentration, establishing a novel strategy for customized HA fermentation. Graphical Abstract…”
Get full text

Specimen oriented intraoperative margin assessment in oral cavity and oropharyngeal squamous cell carcinoma by P. Horwich, C. MacKay, M. Bullock, S. M. Taylor, R. Hart, J. Trites, L. Geldenhuys, B. Williams, M. H. Rigby

“…This change in protocol leads to decreased patient morbidity by avoiding therapy escalation attributable only to positive margins, and avoids the economic costs of these treatments. Graphical abstract…”
Get full text

Predictive factors of fibrotic interstitial lung abnormality on high-resolution computed tomography scans: a prospective observational study by Kazuya Ichikado, Hidenori Ichiyasu, Kazuhiro Iyonaga, Kodai Kawamura, Yuko Yasuda, Keisuke Anan, Hiroko Okabayashi, Kimitaka Akaike, Noritaka Higashi, Takeshi Johkoh, Kiminori Fujimoto, Tetsuo Saito, Jun Morinaga, Minoru Yoshida, Katsuhiko Mitsuzaki, Takuro Sakagami

“…Clinical laboratory evaluations are expressed as medians and interquartile ranges for each evaluation time point, and boxplots were created for graphical representation. The percentages of abnormal clinical laboratory results were compared between the groups using chi-square or Fisher’s exact tests. …”
Get full text

Risk of hemorrhagic fever with renal syndrome associated with meteorological factors in diverse epidemic regions: a nationwide longitudinal study in China by Nan Chang, Wenzhong Huang, Yanlin Niu, Zhihu Xu, Yuan Gao, Tingting Ye, Zihao Wang, Xiaohui Wei, Yuming Guo, Qiyong Liu

“…These findings provide novel scientific evidence for the formulation and implementation of region-specific HFRS prevention policies. Graphical Abstract…”
Get full text

Differentiation status determines the effects of IFNγ on the expression of PD-L1 and immunomodulatory genes in melanoma by Teitur Sævarsson, Adrián López García de Lomana, Ólafur Sánchez, Veerle van Esch, Gunnar Bjarni Ragnarsson, Siggeir Fannar Brynjólfsson, Eiríkur Steingrímsson, Berglind Ósk Einarsdóttir

“…These results imply that modulating melanoma differentiation may help shape IFNγ responsiveness. Graphical Abstract…”
Get full text