A novel USP4 inhibitor that suppresses colorectal cancer stemness by promoting β-catenin and Twist1 degradation by Fengtian Li, Yi Zhou, Xinyue Lin, Yaxin Zhang, Qingyong Hu, Enen Zhao, Huali Li, Xingyan Pan, Feng Shu, Kun Zhang, Chengmei Huang, Na Tang, Wenting Liao

“…Conclusions This study identifies U4-I05 as a USP4 inhibitor with significant therapeutic efficacy against CRC, offering a promising avenue for the development of new treatments targeting cancer stemness and chemotherapy resistance. Graphical abstract…”
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High, but variable prevalence of Sarcocystis cruzi infections in farm-raised American bison (Bison bison) beef destined for human consumption by Larissa S. de Araujo, Aditya Gupta, Marianne Dias Papadopoulos, Doaa Naguib, Jacquin Battle, Oliver Kwok, Asis Khan, Benjamin Rosenthal, Jitender P. Dubey

“…An unidentified species of Sarcocystis found in two bison samples needs further study. Graphical abstract…”
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Canadian Rhinology Working Group consensus statement: biologic therapies for chronic rhinosinusitis by Andrew Thamboo, S. Kilty, I. Witterick, Y. Chan, C. J. Chin, A. Janjua, A. Javer, J. Lee, E. Monterio, B. Rotenberg, J. Scott, K. Smith, D. D. Sommer, L. Sowerby, M. Tewfik, E. Wright, M. Desrosiers

“…As more biologics become available and additional trials are published we will provide updated versions of this white paper every few years. Graphical abstract…”
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BDH1 identified by transcriptome has a negative effect on lipid metabolism in mammary epithelial cells of dairy goats by Mengke Ni, Saige Zang, Yihan Wang, Xiaochen Qin, Min Tian, Tiantian Xiong, Chong Chen, Yue Zhang, Jun Luo, Cong Li

“…Furthermore, it may mitigate the inhibitory effect of R-BHBA on lipid metabolism in GMECs. Graphical Abstract BDH1 serves as a negative regulator of milk lipid synthesis in GMECs, and BDH1 counteracts the inhibitory effect of R-BHBA on lipid synthesis in mammary epithelial cells of dairy goats.…”
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A meta-analysis and systematic review of myocardial infarction-induced cardiomyocyte proliferation in adult mouse heart by Ya Liu, Lingyan Liu, Pengcheng Zhuang, Jiamin Zou, Xiaokang Chen, Hao Wu, Bingjun Lu, Wei Eric Wang

“…Very little overwhelming evidence shows that MI stimulates bona fide proliferation in the adult heart. Graphical Abstract…”
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Application of trichloroisocyanuric acid in controlling kiwifruit bacterial canker disease demonstrates its promising potential as an eco-friendly bactericide by Jianyou Gao, Jiewei Li, Cuixia Liu, Hongjuan Gong, Beibei Qi, Rongxiang Zhu, Liming Xia, Li Li, Shibiao Liu, Qiaosheng Jiang, Kaiyu Ye, Faming Wang

“…These findings position TCCA as a promising, environmentally friendly alternative to traditional toxic bactericides, offering a sustainable and effective solution for plant disease management with reduced ecological risks. Graphical Abstract…”
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Transcriptomic analysis of Rhipicephalus microplus hemocytes from female ticks infected with Babesia bovis or Babesia bigemina by Rubikah Vimonish, Janaina Capelli-Peixoto, Wendell Johnson, Lowell Kappmeyer, Perot Saelao, Naomi Taus, Chungwon Chung, Massaro Ueti

“…The findings of this study will enhance our understanding on how Babesia parasites survive in the hostile environment of ticks and perpetuate their transmission cycle, ultimately contributing to the spread of bovine babesiosis. Graphical Abstract…”
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Resourceful and economical designing of fermentation medium for lab and commercial strains of yeast from alternative feedstock: ‘transgenic oilcane’ by Shraddha Maitra, Bruce Dien, Kristen Eilts, Nurzhan Kuanyshev, Yoel R. Cortes-Pena, Yong-Su Jin, Jeremy S. Guest, Vijay Singh

“…The approach provides an economical solution to reduce the cost of fermentation at an industrial scale for second-generation drop-in fuel production. Graphical Abstract…”
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Failure to repair damaged NAD(P)H blocks de novo serine synthesis in human cells by Adhish S. Walvekar, Marc Warmoes, Dean Cheung, Tim Sikora, Najmesadat Seyedkatouli, Gemma Gomez-Giro, Sebastian Perrone, Lisa Dengler, François Unger, Bruno F. R. Santos, Floriane Gavotto, Xiangyi Dong, Julia Becker-Kettern, Yong-Jun Kwon, Christian Jäger, Jens C. Schwamborn, Nicole J. Van Bergen, John Christodoulou, Carole L. Linster

“…Conclusions Taken together, our study identifies a metabolic vulnerability in NAXD-deficient cells that can be targeted by small molecules such as NR or inosine, opening perspectives in the search for mechanism-based therapeutic interventions in PEBEL disorders. Graphical Abstract…”
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Bell’s palsy misdiagnosis: characteristics of occult tumors causing facial paralysis by Eun-Jae Chung, Damir Matic, Kevin Fung, S. Danielle MacNeil, Anthony C. Nichols, Ruba Kiwan, KengYeow Tay, John Yoo

“…Facial reanimation surgery is a satisfactory option for these patients. Graphical abstract…”
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Avian influenza mRNA vaccine encoding hemagglutinin provides complete protection against divergent H5N1 viruses in specific-pathogen-free chickens by Zhaoyang Wang, Chongyu Tian, Jiahang Zhu, Shiqian Wang, Xiang Ao, Yanjuan He, Huixin Chen, Xiuying Liao, Deming Kong, Yongfei Zhou, Wanbo Tai, Ming Liao, Huiying Fan

“…Conclusions The vaccine developed in this study provides complete protection against divergent H5N1 AIV strains in chickens, offering a promising approach for the future development of mRNA vaccines against multivalent avian influenza subtypes. Graphical Abstract…”
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Development a glycosylated extracellular vesicle-derived miRNA Signature for early detection of esophageal squamous cell carcinoma by Jianlin Chen, Yue Zheng, Zhen Wang, Qi Gao, Kun Hao, Xiongfeng Chen, Nantian Ke, Xiang Lv, Jiamiao Weng, Yuhong Zhong, Zhixin Huang, Miao Fu, Lilan Zhao, Fan Lin, Hui Mi, Haijun Tang, Chundong Yu, Yi Huang

“…The unique glycosylated EVs-derived miRNAs-based signature shows the optimal potential as a biomarker for early detection of ESCC. Graphical Abstract…”
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Jianwei Xiaoshi oral liquid attenuates high-calorie diet-induced dyspepsia in immature rats via regulating the pancreatic secretion pathway and maintaining the homeostasis of intes... by Yan Zhang, Xiaolu Wei, Shan Jiang, Wenya Gao, Kun Wang, Hongjie Wang, Huijun Wang, Nan Si, Yanyan Zhou, Keke Luo, Mengxiao Wang, Yuyang Liu, Lihua Chen, Liqi Ni, Haiyu Zhao

“…Conclusion JWXS improved functional dyspepsia in immature rats via a mechanism involving the regulation of the secretion of 8 key proteins in the pancreatic secretion pathway and the amelioration of flora disorders. Graphical Abstract…”
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Targeting CXCL8 signaling sensitizes HNSCC to anlotinib by reducing tumor-associated macrophage-derived CLU by Xin Hu, Yikang Ji, Mi Zhang, Zhihui Li, Xinhua Pan, Zhen Zhang, Xu Wang

“…HNSCC-derived CXCL8 favors endogenous antioxidative processes and confers therapeutic resistance to nutrient-starvation therapies in HNSCC. Graphical Abstract…”
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A novel 2D nickel coordination polymer based on Trimesic acid with glyphosate coordination capabilities by João M. R. Gonçalves, Ademar Wong, Pedro H. O. Santiago, Guilherme Arroyos, Augusto H. Piva, Javier A. Ellena, Benedito S. Lima-Neto, Regina C. G. Frem

“…This coordination capability was demonstrated by Powder X-ray Diffraction (PXRD) and Infrared Spectroscopy (FTIR), along with electrochemical techniques such as Cyclic Voltammetry (CV) and Square Wave Voltammetry (SWV), thus confirming glyphosate coordination in Ni-BTC, with potential applications in detection and removal systems. Graphical Abstract…”
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User Experience of a Semi-Immersive Musical Serious Game to Stimulate Cognitive Functions in Hospitalized Older Patients: Questionnaire Study by Laurent Samson, Lena Carcreff, Frédéric Noublanche, Sophie Noublanche, Hélène Vermersch-Leiber, Cédric Annweiler

“…UX mean scores were computed and presented graphically. Verbal feedbacks were reported to support the quantitative results. …”
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A novel interpretable deep learning model for diagnosis in emergency department dyspnoea patients based on complete data from an entire health care system. by Ellen T Heyman, Awais Ashfaq, Ulf Ekelund, Mattias Ohlsson, Jonas Björk, Ardavan M Khoshnood, Markus Lingman

“…Each patient visit received their own unique attention plot, graphically displaying important clinical events for the diagnosis.…”
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Atherogenic index of plasma and coronary artery disease: a systematic review and meta-analysis of observational studies by Ramin Assempoor, Mohammad Shahabaddin Daneshvar, Aryan Taghvaei, Alireza Sattari Abroy, Amir Azimi, John R. Nelson, Kaveh Hosseini

“…However, more studies are needed to evaluate the predictive performance and determine the optimal cut-off for AIP in different populations. Graphical abstract…”
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Fractional-order PID feedback synthesis controller including some external influences on insulin and glucose monitoring by Kottakkaran Sooppy Nisar, Muhammad Farman, Khadija Jamil, Saba Jamil, Evren Hincal

“…Lastly, the results are obtained and visually shown using graphical representations, which provide empirical evidence in support of our theoretical findings. …”
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Computer-Aided Supporting Models of Customized Crack Propagation Sensors for Analysis and Prototyping by Paulina Kurnyta-Mazurek, Rafał Wrąbel, Artur Kurnyta

“…Another application is devoted to purely mechanical analysis. The graphical user interface (GUI) add-on based on the Abaqus 2018 software engine is prepared for advanced mechanical analysis simulations of sensor materials in selected loading scenarios. …”
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