Targeted inhibition of the PTEN/PI3K/AKT pathway by YSV induces cell cycle arrest and apoptosis in oral squamous cell carcinoma by Lin Qiu, Qian Gao, Yiheng Liao, Xinxin Li, Cuiying Li

“…The combination of YSV and PI3K inhibitors, such as LY294002, exhibited enhanced anti-tumor activity, suggesting potential therapeutic strategies for OSCC treatment. Graphical abstract…”
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Quantifying the benefits of incorporating biochar in green roof substrates: field study on the highrise rooftop in temperate climate setting by Marek Petreje, Michal Sněhota, Václav Šípek, Tereza Hnátková, Jan Punčochář, Stanislav Buchtelík, Michael Hardman, Lukáš Trakal

“…The study provides evidence for the potential of wood-based biochar as a sustainable and effective addition to green roof substrates, contributing to the development of more resilient and sustainable urban environments. Graphical Abstract…”
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Online tools to predict individualised survival for primary oesophageal cancer patients with and without pathological complete response after neoadjuvant therapy followed by oesoph... by Jie Zhang, Xiang Chen, Dong Dong, Lijie Tan, Yajie Zhang, Hecheng Li, Yuqin Cao, Binhao Huang, Han Tang, Tianzheng Shen, Xijia Feng, Jiahao Zhang, Liqiang Shi, Chengqiang Li, Heng Jiao

“…Two distinct multivariable Cox models of overall survival (OS) were constructed for pCR and non-pCR patients, respectively, and were presented using web-based dynamic nomograms (graphical representation of predicted OS based on the clinical characteristics that a patient could input into the website). …”
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Ritonavir loaded solid lipid nanoparticles for oral drug delivery and bioavailability enhancement by Ananda Kumar Chettupalli, Sarad Pawar Naik Bukke, Shaik Abdul Rahaman, Aziz Unnisa, Madhumitha Adepu, Marati Kavitha, Molakpogu Ravindra Babu, Bayapa Reddy Narapureddy, Hope Onohuean

“…The results of the present study can become a promising platform for the enhancement of oral bioavailability by novel nano carriers. Graphical abstract…”
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Proteinuria and the risk of Incident atrial fibrillation according to glycemic stages: a nationwide population-based cohort study by Muhan Yeo, So-Ryoung Lee, Eue-Keun Choi, JungMin Choi, Kyung-Yeon Lee, Soonil Kwon, Hyo-Jeong Ahn, Bong-Seong Kim, Kyung-Do Han, Seil Oh, Gregory Y. H. Lip

“…Tailoring clinical strategies to proteinuria level could potentially mitigate this risk, improving patient outcomes. Graphical abstract…”
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Incorporation of kiwifruit peel improved the property of carboxymethyl cellulose-gum Arabic active film and its effects on the quality of beef sausages by Evans Frimpong Boateng, Ziyi Yang, Jian Zhang, Lei Zhou, Lujuan Xing, Wangang Zhang

“…CG-KPE treatments showed antimicrobial effectiveness and lesser TBARS values than CG-CT treatments during storage. Graphical Abstract…”
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Advancing soil-structure interaction (SSI): a comprehensive review of current practices, challenges, and future directions by Imtiyaz Akbar Najar, Raudhah Ahmadi, Akeem Gbenga Amuda, Raghad Mourad, Neveen El Bendary, Idawati Ismail, Nabilah Abu Bakar, Shanshan Tang

“…This review bridges the gap between theoretical advancements and practical applications of soil-structure interaction (SSI) by synthesizing current knowledge, identifying critical research gaps, and proposing innovative solutions to enhance structural resilience, sustainability, and seismic safety. Graphical Abstract…”
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Nano-delivery platform with strong protection and efficient delivery: preparation of self-assembled RNA pesticide with dual RNAi targets against Apolygus lucorum by Heng Qiao, Qinhong Jiang, Jing Zhao, Liubin Xiao, Keyan Zhu-Salzman, Dejin Xu, Guangchun Xu, Jie Shen, Aiguo Gu, Dejun Hao, Shuo Yan, Yongan Tan

“…Conclusions Our study comprehensively demonstrated the advantages of SPc-based dsRNA delivery platform, and developed a self-assembled RNA pesticide with dual RNAi targets, which provided a reference for the design of novel RNA pesticides. Graphical abstract…”
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β-Hydroxybutyrate-induced mitochondrial DNA (mtDNA) release mediated innate inflammatory response in bovine mammary epithelial cells by inhibiting autophagy by Yihui Huo, Taiyu Shen, Tianyin Feng, Moli Li, Wanli Zhao, Juan J. Loor, Ben Aernouts, Androniki Psifidi, Chuang Xu

“…Conversely, autophagy activation has been shown to alleviate this process by promoting cytoplasmic mtDNA degradation. Graphical Abstract…”
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Prognostic stratification of patients with AJCC 2018 pN1 disease in stage III oral squamous cell carcinoma by Ming-Hsien Tsai, Hui-Ching Chuang, Yu-Tsai Lin, Tai-Lin Huang, Fu-Min Fang, Hui Lu, Chih-Yen Chien

“…Down-staging and reclassifying pT1N1 subgroup patients with oral cancer may be considered in tumor staging. Graphical Abstract…”
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Information system on microbial collections as a part of bioresource collections portal for Russia’s FASO organizations: a working protocol by F. V. Kazantsev, A. A. Smirnova, A. S. Rozanov, Yu. E. Uvarova, D. A. Afonnikov, S. E. Peltek, S. A. Lashin

“…In this paper, we describe the principles of working with the portal. The portal’s graphical interface allows users, both registered and unregistered, to receive the following information about collections of microorganisms: a list of collections represented in the database, contact details of the organization and information about the curator of the collection, summary statistics for each collection, as well as information on storage units. …”
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hnRNPU-mediated pathogenic alternative splicing drives gastric cancer progression by Guoguo Jin, Yanming Song, Shaobo Fang, Mingyang Yan, Zhaojie Yang, Yang Shao, Kexin Zhao, Meng Liu, Zhenwei Wang, Zhiping Guo, Zigang Dong

“…Targeting the FTO/hnRNPU axis may interfere with abnormal AS events and provide a potential diagnostic and therapeutic strategy for GC. Graphical Abstract Schematic model for the findings of this work: Aberrant hnRNPU in GC binds FTO. …”
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Microvascular decompression: a contemporary update by Inibehe Ime Okon, Sidharth Sunil Menon, Mahmoud Osama, Maidan Aiman, Luis F. Fabrini Paleare, Don Lucero-Prisno Eliseo, Muhammad Danish Shafqat, Chizowa Okwuchukwu Ezeaku, Márcio Yuri Ferreira, Youssef Razouqi, Marianna Kapsetaki, Jovy Dia Remolino Saniel, Naneta M. Panit, Asad Gul Rao, Umer Iqbal, Daniel David Otobo, Ibraheem M. Alkhawaldeh, Felipe Salvagni Pereira, Imad Akbar, Omar Kasimieh, Bipin Chaurasia

“…However, further research is necessary to standardize surgical protocols and address disparities in healthcare systems globally. Graphical Abstract…”
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Functionalization of sawdust biochar using Mg-Fe-LDH and sodium dodecyl sulfonate enhanced its stability and immobilization capacity for Cd and Pb in contaminated water and soil by Xin Pan, Shaoping Kuang, Xiao Wang, Habib Ullah, Zepeng Rao, Esmat F. Ali, Qumber Abbas, Sang Soo Lee, Sabry M. Shaheen

“…These results indicate that MSB could be used for remediation of Cd and Pb contaminated soil and water. Graphical Abstract…”
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Strontium nitrate-dopped zinc oxide-loaded alginate gels with gentamicin for improved wound healing by Suhair Hikmat, Ola Tarawneh, Lama Hamadneh, Rania Hamed, Ala A. Alhusban, Mohammad Hailat, Hadeel Abu Mahfouz, Sawsan Shraim, Alghadeer Al-Shammari, Aya Aljariri, Rafa Abu Rayya, Lana Hamdan

“…The study also found significant overexpression of MIP α and MIP β in tissues and downregulation of CCL2, IL8, and TGF β, explaining wound healing with minimal scar formation. Graphical Abstract…”
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Exploring the role of splicing in TP53 variant pathogenicity through predictions and minigene assays by Cristina Fortuno, Inés Llinares-Burguet, Daffodil M. Canson, Miguel de la Hoya, Elena Bueno-Martínez, Lara Sanoguera-Miralles, Sonsoles Caldes, Paul A. James, Eladio A. Velasco-Sampedro, Amanda B. Spurdle

“…Conclusions In conclusion, this study enhances the integration of splicing predictions and provides splicing assay data for exonic variants to support TP53 germline classification. Graphical abstract…”
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COVID-19–sensitive tumour response: 2-year assessment of the SARS-CoV-2 humoral response in cancer patients in oncology hospital in Poland by Piotr Kosiorek, Bożena Mikołuć, Samuel Stróż, Anna Hryniewicz, Dorota E. Kazberuk, Robert Milewski, Anna Grzeszczuk, Magdalena J. Borkowska, Anna Stasiak‐Barmuta

“…The above observation applies to patients with breast, lung, colon, kidney, and testicular cancer, although the response varies significantly depending on the type of cancer. Graphical abstract…”
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Efficient recovery of rare metal lanthanum from water by MOF-modified biochar: DFT calculation and dynamic adsorption by Qilan Huang, Qianru Zhang, Shuwen Zhao, Chuchen Zhang, Huixin Guan, Jianqiao Liu

“…Ligand exchange and La–O–Fe formation dominated in lanthanide ion removal. Graphical Abstract…”
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Insight into the current practice of ototoxicity monitoring during cisplatin therapy by N. M. Santucci, B. Garber, R. Ivory, M. A. Kuhn, M. Stephen, D. Aizenberg

“…Improved education and collaboration between otolaryngology, audiology, and medical oncology is needed to develop and promote an effective ototoxicity-monitoring program. Graphical abstract…”
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First detection of Culex tritaeniorhynchus in Western Australia using molecular diagnostics and morphological identification by Kimberly L. Evasco, Craig Brockway, Tamara Falkingham, Margaret Hall, Nerida G. Wilson, Abbey Potter

“…Although the role that Cx. tritaeniorhynchus may play in JEV transmission into the future is not yet understood, it presents a potential risk to public health in the region. Graphical abstract…”
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