The association between TyG index and cardiovascular mortality is modified by antidiabetic or lipid-lowering agent: a prospective cohort study by Changchang Fang, Nanqin Peng, Jiang Cheng, Xiyu Zhang, Wenli Gu, Zicheng Zhu, Xiaoping Yin, Zhiwei Yan, Jing Zhang, Peng Yu, Xiao Liu

“…These findings suggest that future studies on the TyG index and its relationship with CVD and mortality should account for the modifying effects of these agents. Graphical abstract…”
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Is otologic surgery contributing to the opioid epidemic? by Valerie Dahm, Justin T. Lui, Rudolfs Liepins, Joseph M. Chen, Trung N. Le, Christoph Arnoldner, Vincent Y. W. Lin

“…Studies to evaluate pain after these operations as well as efficacy of analgesics following ear surgery are an important next step. Graphical abstract…”
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Comparison of ELISA and IFAT for Leishmania infantum by European and Middle Eastern diagnostic laboratories by Kurayi G. Mahachi, Marie Ozanne, Patrick Bourdeau, Juliana Sarquis, Eric Kontowicz, Laia Solano-Gallego, Luis Cardoso, Gaetano Oliva, Gad Baneth, Maria Grazia Pennisi, Angela M. Toepp, Guadalupe Miró, Margaret Carrel, Christine A. Petersen

“…Studies and interventional trials that use these tests will remain valid because of high diagnostic agreement between sites. Graphical Abstract…”
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Nicotinamide riboside supplementation ameliorates ovarian dysfunction in a PCOS mouse model by Zhenye Zhu, Min Lei, Ruizhi Guo, Yining Xu, Yanqing Zhao, Chenlu Wei, Qingling Yang, Yingpu Sun

“…These findings suggest that supplementing with NAD+ precursors could be a promising therapeutic strategy for addressing ovarian infertility associated with PCOS. Graphical Abstract Ovarian NAD+ levels decreased in DHEA-induced PCOS mice, accompanied by mitochondrial dysfunction in oocytes and ovarian stromal cells, resulting in reduced oocyte quantity and quality, decreased early embryonic development potential, and increased ovarian fibrosis. …”
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ACTION: Augmentation and computation toolbox for brain network analysis with functional MRI by Yuqi Fang, Junhao Zhang, Linmin Wang, Qianqian Wang, Mingxia Liu

“…The ACTION is a Python-based and cross-platform toolbox with graphical user-friendly interfaces. It enables automatic fMRI augmentation, covering blood-oxygen-level-dependent (BOLD) signal augmentation and brain network augmentation. …”
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Fluralaner systemic treatment of chickens results in mortality in Triatoma gerstaeckeri, vector of the agent of Chagas disease by Cassandra Durden, Yuexun Tian, Koyle Knape, Cory Klemashevich, Keri N. Norman, John B. Carey, Sarah A. Hamer, Gabriel L. Hamer

“…Conclusions Xenointoxication using fluralaner in poultry is a potential new tool for integrated vector control to reduce risk of Chagas disease. Graphical Abstract…”
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Application of photogrammetry and laser scanner on the Bronze Age structures of the Castillejos de Luna cist tomb necropolis (Pizarra, Spain) by Alejandro Muñoz-Muñoz, Diego Fernández-Sánchez, Eduardo Vijande-Vila, Serafín Becerra-Martín, Juan Jesús Cantillo-Duarte, Salvador Domínguez-Bella, Virgilio Martínez Enamorado, Francisca Rengel Castro, Pedro Cantalejo Duarte, María del Mar Espejo-Herrerías, José Suárez-Padilla, Juan Antonio Martín-Ruiz, José Ramos-Muñoz

“…The cist tombs necropolis at Castillejos de Luna, in Sierra de Gibralmora-Sierra del Hacho (Pizarra, Málaga, Spain) was known from the graphic documentation and the grave goods of two tombs. …”
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Mathematical modelling and optimization of cutting conditions in turning operation on MDN 350 steel with carbide inserts by Syed Adil, A. Krishnaiah, D. Srinivas Rao

“…The machining performance indicators of the first set are optimized using graphical method of contour plots. Artificial neural networks technique, which is well known for its versatility to model linear as well as non-linear data, is used to express the surface roughness as a function of tool geometrical variables. …”
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Pathologically altered articular cartilage attracts intense chondrocyte invasion into the extracellular matrix: in vitro pilot study by Victoria A. Shestakova, Ilya D. Klabukov, Ilya V. Kolobaev, Longfeng Rao, Dmitry A. Atiakshin, Michael A. Ignatyuk, Mikhail E. Krasheninnikov, Bagavdin G. Ahmedov, Sergey A. Ivanov, Peter V. Shegay, Andrey D. Kaprin, Denis S. Baranovskii

“…Conclusions Our preliminary results showed that human nasal chondrocytes are capable of infiltrating the pathologically altered extracellular matrix of articular cartilage damaged by arthritis, thereby promoting its repair to a physiologically relevant state. Graphical Abstract…”
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Selective arm-usage of pre-miR-1307 dysregulates angiogenesis and affects breast cancer aggressiveness by Oyku Ece Sumer, Korbinian Schelzig, Janine Jung, Xiaoya Li, Janina Moros, Luisa Schwarzmüller, Ezgi Sen, Sabine Karolus, Angelika Wörner, Verônica Rodrigues de Melo Costa, Nishanth Belugali Nataraj, Efstathios-Iason Vlachavas, Clarissa Gerhäuser, Karin Müller-Decker, Dominic Helm, Yosef Yarden, Birgitta Elisabeth Michels, Cindy Körner

“…The underlying mechanisms might inspire new therapeutic strategies aimed at shifting the balance towards tumor-suppressive miRNA species. Graphical Abstract…”
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MicroRNA-21 as a biomarker in terminal stage oral squamous cell carcinoma (OSCC) in the South Indian population by Chevuru Sai Shreya Reddy, Ashikha Shirin Usman P.P, Dhanraj M. Ganapathy, Ameya K.P., Durairaj Sekar

“…Level of expression of genes in both cancer cells and normal cells are also analysed using graphical method. Result: miR-21 secondary structure is predicted by applying mature sequence of miRNA. …”
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Surgical margins of the oral cavity: is 5 mm really necessary? by James Fowler, Yael Campanile, Andrew Warner, Francisco Laxague, Naif Fnais, Kevin Fung, Adrian Mendez, Danielle MacNeil, John Yoo, David Palma, Anthony Nichols

“…These findings require validation through multi-institutional collaborative efforts. Graphical abstract…”
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Ceria nanoparticles ameliorate renal fibrosis by modulating the balance between oxidative phosphorylation and aerobic glycolysis by Mengling Wang, Feng Zeng, Fengling Ning, Yinhang Wang, Shilin Zhou, Jiaqi He, Cong Li, Cong Wang, Xiaolin Sun, Dongliang Zhang, Jisheng Xiao, Ping Hu, Svetlana Reilly, Hong Xin, Xudong Xu, Xuemei Zhang

“…This may provide another therapeutic option for renal fibrosis. Graphical Abstract…”
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Combination of rapamycin and adipose-derived mesenchymal stromal cells enhances therapeutic potential for osteoarthritis by Damien Veret, Gautier Tejedor, Esther Perez, Alison Chomette, Maylis Farno, Rosanna Ferreira-Lopez, Louis Dagneaux, Yves-Marie Pers, Christian Jorgsensen, Claire Gondeau, Jean-Marc Brondello

“…Conclusions Our findings suggest that the rapamycin and AD-MSC combination enhances the therapeutic efficacy of these cells in senescence-driven degenerative diseases such as OA, notably by improving their anti-fibrotic and anti-inflammatory properties. Graphical abstract…”
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Hepatoprotective potential of Chrysin in a rat model of isoniazid- and rifampicin-induced hepatic injury: suppression of matrix metalloproteinase and transforming growth factor β by Deepa Mandlik, Akhilesh Tokey, Rohit Lokhande, Yash Dagadu, Heena Choudhary, Satish Mandlik

“…Conclusions It is concluded that the CHY protects against INH + RFM-induced oxidative liver injury in rats. Graphical abstract…”
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Structural characterization and immunomodulatory activity of polysaccharides from the flowers of Imperata cylindrica Beauv.var. major (Nees) C.E.Hubb by Honglin He, Haijun Huang, Yunheng Yang, Yi Liu, Ailing Liang, Yao Lei, Chenghuai Tang, Ling Yao, Zhiwei Chen

“…Conclusions These findings provide useful evidence that support the development and potential clinical application of polysaccharides derived from the flowers of Imperata cylindrica. Graphical Abstract…”
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Mural cell dysfunction contributes to diastolic heart failure by promoting endothelial dysfunction and vessel remodelling by Mandy O. J. Grootaert, Alessandra Pasut, Jana Raman, Steven J. Simmonds, Bram Callewaert, Ümare Col, Mieke Dewerchin, Peter Carmeliet, Stephane Heymans, Elizabeth A. V. Jones

“…Conclusion Mural cell dysfunction contributes to HFpEF by inducing coronary vessel remodelling, at least in part by reducing EC proliferation and inducing EC inflammation through TNFα-dependent paracrine signalling. Graphic abstract…”
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Exploring the potential of gemcitabine-metal–organic frameworks in combating pancreatic cancer under ketogenic conditions by Samira Nekoufar, Marjan Ghorbani, Sahar Safaei, Gholamreza Alinezhadi Khosroushahi, Farzad Izak Shirian, Behzad Baradaran, Masoumeh Tavakoli-Yaraki

“…Conclusion The use of metal–organic framework to encapsulate gemcitabine yielded notable pro-apoptotic effects in MIA-PaCa-2 cells with which ketogenic conditions had a synergistic effect that can hold promise for improving therapeutic options. Graphical Abstract…”
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Association between triglyceride-glucose-body mass index and risk of aortic stenosis progression in patients with non-severe aortic stenosis: a retrospective cohort study by Zhen Guo, Zhenyu Xiong, Lixiang He, Shaozhao Zhang, Xinghao Xu, Guanzhong Chen, Mengjie Xie, Wenjing Zhang, Ziwen Hui, Jiaying Li, Xinxue Liao, Xiaodong Zhuang

“…TyG-BMI index, as an effective alternative indicator of IR, can identify people at high risk of AS progression at an early stage of the disease, thereby improving the prognosis and reducing the socio-economic burden. Graphical abstract…”
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A smartphone application to objectively monitor music listening habits in adolescents by Danique E. Paping, Jantien L. Vroegop, Simone P. C. Koenraads, Carlijn M.P. le Clercq, André Goedegebure, Robert J. Baatenburg de Jong, Marc P. van der Schroeff

“…We consider a smartphone application to monitor listening habits of added value in future research investigating the possible damaging effects of PLDs on hearing acuity. Graphical abstract…”
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