Targeting AURKA with multifunctional nanoparticles in CRPC therapy by Bin Deng, Binghu Ke, Qixing Tian, Yukui Gao, Qiliang Zhai, Wenqiang Zhang

“…These findings suggest that CM-AMS@AD NPs offer a promising triple-combination therapy for CRPC, integrating photothermal, chemotherapy, and immunotherapy, with significant potential for future clinical applications. Graphical Abstract…”
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Development of cinnamon essential oil-loaded Pickering emulsions stabilized by chitosan/gelatin nanoparticles with enhanced antibacterial and antibiofilm actives by Zhilang Xu, Xinxin Wang, Huaqian Liang, Xinying Li, Derong Li, Changdao Mu, Liming Ge, Defu Li

“…Hence, CEO-delivered CGP emulsion could serve as a potential strategy against biofilm infections and bacterial resistance. Graphical abstract…”
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Convenient estimation of oxytetracycline and polymyxin B by a novel high-performance liquid chromatography method: development and validation by Tanu Chaudhary, Balak Das Kurmi, Dilpreet Singh

“…Conclusions: Linear CC were obtained with a correlation coefficient (R2 > 0.99) with acceptable results of accuracy and precision. Graphical abstract.Ultraviolet visible and HPLC method development…”
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Sol–gel synthesis of silicon oxide (SiO2) nanoparticles: exploring gas sensing and photocatalytic applications by Laxmi D. Sonawane, Abhinay S. Mandawade, Anil B. Gite, Sarika D. Shinde, Ganesh E. Patil, Latesh K. Nikam, Vishal H. Goswami, Ramesh B. Bhise, Pradip B. Sarawade, Mahendra S. Shinde

“…The response time was 18 S, with a quick recovery time of approximately 22 S. Graphical Abstract…”
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AxiWorm: a new tool using YOLOv5 to test antiparasitic drugs against Trichinella spiralis by Javier Sánchez-Montejo, Miguel Marín, María Alejandra Villamizar-Monsalve, María del Carmen Vieira, Belén Vicente, Rafael Peláez, Julio López-Abán, Antonio Muro

“…Conclusion YOLOv5 is capable of accurately counting and distinguishing between healthy and affected L1s, thus improving the performance of the assessment of meat inspection and potential new drugs. Graphical Abstract…”
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Orthoweb: a software package for evolutionary analysis of gene networks by R. A. Ivanov, A. M. Mukhin, F. V. Kazantsev, Z. S. Mustafin, D. A. Afonnikov, Y. G. Matushkin, S. A. Lashin

“…The software offers advanced visualization tools, such as gene network mapping and graphical representations of phylostratigraphic index distributions of network elements, ensur­ing intuitive interpretation of complex evolutionary relationships. …”
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Premature Mortality from Colorectal Cancer by Ronaldo Valdés Villafranca, Suleidy Pérez García, Ángel Ernesto Ramos Cordero, Suniel Pérez García, Rubén Valdés Villafranca, Elvis Hernández

“…Exploratory data analysis was performed through graphical and mathematical methods of descriptive statistics. …”
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Design, synthesis and biological evaluation of buthutin derivatives as cardioprotective agents by Yuan Liu, Fa-Qi Wang, Xin-Hao Hua, Shu-Han Yang, Li-Ning Wang, Yun-Sheng Xu, Chen-Yue Shao, Xiang-Bo Gou, Yu-Ming Liu

“…This research would open new avenues for developing amide-guanidine-based cardioprotective agents. Graphical Abstract…”
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Effects of sodium alginate and calcium on quality attributes of Shepherd’s purse under ultrasound impregnation during blanching processing by Qihui Wu, Zhongyuan Zhang, Yihong Bao, Dajing Li, Xin Wen, Lei Feng, Meimei Nie, Zhuqing Dai, Yayuan Xu

“…Overall, the treatment of ultrasound assisted impregnation has been found to be bio-protective for leaf vegetables when exposed to heat. Graphical Abstract…”
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Advancing precision medicine in esophageal squamous cell carcinoma using patient-derived organoids by Suya Shen, Bing Liu, Wenyan Guan, Ziyao Liu, Yuqing Han, Yingzhe Hu, Yiqiang Chen, Siyuan Liu, Jian He, Zhiwen Li, Weifeng Tang, Pengju Zhang, Wei Ren, Yudong Qiu, Hongping Zheng, Jingjing Li

“…The findings demonstrate that this framework offers robust predictive value in clinical settings, enhances precision therapeutics, and advances drug discovery for esophageal cancer. Graphical Abstract…”
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An antibacterial, antioxidant and hemostatic hydrogel accelerates infectious wound healing by Ziyi Zhou, Dengjun Zhang, Xuchao Ning, Linbo Jin, Yijing Lin, Chen Liang, Xin Wen, Tianhao Huang, Junli Zhou, Yiming Zhang

“…In summary, the HA@TA-Okra system exhibits comprehensive properties such as antibacterial, antioxidant and hemostatic properties, which has a potential application in the field of tissue repair medicine. Graphical Abstract…”
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Environmental innovations as factor of development of petrochemical industry in Russia by A. I. Shinkevich, S. S. Kudryavtseva, Yu. N. Khakimullin, M. I. Farakhov

“…Methods applied: general scientific methods are used — system analysis, causeand-effect relationships, description and generalization; as well as special methods — graphical analysis, component analysis, factor analysis, descriptive statistics. …”
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The Vanishing Volcanic Geoheritage of a Key Scoria Cone and its Significance in Volcanic Hazard Resilience of the Active Monogenetic Volcanic Field near Al Madinah, Kingdom of Saud... by Karoly Nemeth, Mohammed Moufti, Mahmoud Ashor, Abdulrahman Sowaigh, Turki Hablil, Khalid Abdulhafez, Turki Sehli

“…This location shows graphically the need for geoconservation to preserve such sites that are potentially the only, or best locations to show the potential eruptive styles and scenarios of future eruptions if they occur in similar environments.…”
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Enhanced brightness and photostability of dye-sensitized Nd-doped rare earth nanocomposite for in vivo NIR-IIb vascular and orthotopic tumor imaging by Syue-Liang Lin, Shih-Po Su, Yuan-Zhen Yang, Cheng-Yu Chiang, Hsin-Yu Chi, Cheng Allen Chang, Tse-Ying Liu, Huihua Kenny Chiang

“…This innovation holds promise for future biomedical imaging technologies, particularly in areas requiring high-resolution and long-duration monitoring. Graphical Abstract…”
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Size effect-based improved antioxidant activity of selenium nanoparticles regulating Anti-PI3K-mTOR and Ras-MEK pathways for treating spinal cord injury to avoid hormone shock-indu... by Peixin Liu, Xiaodong Liu, Zihao Wu, Kui Shen, Zhaofeng Li, Xiaowei Li, Qifeng Wu, Leung Chan, Zhong Zhang, Yutong Wu, Liwen Liu, Tianfeng Chen, Yi Qin

“…These findings suggest that LNT-UsSeNPs are promising candidates for further development in nanomedicine for the effective treatment of SCI. Graphical abstract…”
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Molecular dependencies and genomic consequences of a global DNA damage tolerance defect by Daniel de Groot, Aldo Spanjaard, Ronak Shah, Maaike Kreft, Ben Morris, Cor Lieftink, Joyce J. I. Catsman, Shirley Ormel, Matilda Ayidah, Bas Pilzecker, Olimpia Alessandra Buoninfante, Paul C. M. van den Berk, Roderick L. Beijersbergen, Heinz Jacobs

“…The unique characteristics of type 3 deletions implicate the existence of a novel deletion pathway in mice and humans that is counteracted by DDT. Graphical Abstract…”
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A ROS-responsive hydrogel encapsulated with matrix metalloproteinase-13 siRNA nanocarriers to attenuate osteoarthritis progression by Qiuyang Wang, Kai Feng, Guangsheng Wan, Wei Liao, Jing Jin, Peng Wang, Xiaolian Sun, Weijun Wang, Qing Jiang

“…This study reveals that si-Fe-HPP, with its ROS-responsive and RNAi abilities, can significantly protect chondrocytes and attenuate OA progression, providing novel insights and directions for the development of therapeutic materials for OA treatment. Graphical Abstract…”
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18F-FDG-PET/CT can be used to predict distant metastasis in hypopharyngeal squamous cell carcinoma by Shinsuke Suzuki, Satoshi Toyoma, Tomoe Abe, Tentaro Endo, Teppei Kouga, Yohei Kaswasaki, Takechiyo Yamada

“…Conclusions SUVmax determined via pretreatment FDG-PET/CT is useful for predicting distant metastasis, distant metastasis-free survival, and overall survival in patients with HPSCC. Graphical Abstract…”
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Rapid isothermal molecular tests to discriminate between Leishmania braziliensis and Leishmania infantum infections in dogs by Rafaela Lira Nogueira de Luna, Kamila Gaudêncio da Silva Sales, Lucas Lisboa Nunes Bonifácio, Luciana Aguiar Figueredo, Thomas R. Shelite, Fábio dos Santos Nogueira, Domenico Otranto, Filipe Dantas-Torres

“…Conclusions The RPA-LF assays developed here may be promising diagnostic tools for point-of-care diagnosis of L. infantum and L. braziliensis infection in dogs, particularly in remote rural areas lacking laboratory infrastructure. Graphical Abstract…”
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The SIRT5-JIP4 interaction promotes osteoclastogenesis by modulating RANKL-induced signaling transduction by Kecheng Zhu, Chunxiang Sheng, Linlin Zhang, Yuying Yang, Xiaojing Chen, Tao Jiang, Jiaxi Song, Deng Zhang, Xiao Wang, Hongyan Zhao, Lihao Sun, Libin Zhou, Bei Tao, Jianmin Liu

“…Taken together, the results of this study reveal that the SIRT5-JIP4 axis is a novel positive regulator that finely regulates RANKL-induced osteoclast differentiation and suggest that targeting this axis is a therapeutic strategy for preventing osteoporotic bone loss. Graphical Abstract…”
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