Leveraging computational approaches in identifying novel HER-2 + breast cancer potential therapeutics: integrating virtual screening and molecular dynamics simulation by Olawale Quadri Bolaji, Temitope Isaac Adelusi, Taiwo Ooreoluwa Ojo, Ibrahim Damilare Boyenle, Abdul-Quddus Kehinde Oyedele, Taiwo Temitope Ogunjobi, Adegboye Oyewole Oyaronbi, Sukurat Oluwatoyin Ayoola, Abdeen Tunde Ogunlana

“…While immensely promising, further optimization and pre-clinical investigation are imperative to validate this compound as a viable alternative to existing therapies for HER-2 positive breast cancer. Graphical abstract…”
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Predicting deamidation and isomerization sites in therapeutic antibodies using structure-based in silico approaches by David Hoffmann, Joschka Bauer, Markus Kossner, Andrew Henry, Anne R. Karow-Zwick, Giuseppe Licari

“…The resulting model has been implemented as a plugin named “Forecasting Reactivity of Isomerization and Deamidation in Antibodies” in MOE software, completed with a user-friendly graphical interface to facilitate its use.…”
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Human migrations, anthropogenic changes, and insect-borne diseases in Latin America by André B. B. Wilke, Priscilla Farina, Marco Ajelli, Angelo Canale, Filipe Dantas-Torres, Domenico Otranto, Giovanni Benelli

“…Key measures include scaling vaccine coverage, especially for dengue and yellow fever; developing vaccines and treatments for neglected diseases; improving housing and sanitation; strengthening vector surveillance and control; fostering community engagement; enhancing data-driven interventions. Graphical Abstract…”
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Protective effect of quercetin loaded on bifunctional periodic mesoporous organosilica against damage induced by irradiation on the male reproductive system by S. F. Mirtaheri, S. N. Mousavi, Z. Abdi, E. Hosseini, M. S. Seyed Dorraji, F. Kabiri Esfahani, M. Gholami

“…The novel synthesized PMO containing Quer reduced the side effects of irradiation on the male reproductive system. Graphical Abstract…”
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Physics-Based Self-Supervised Grasp Pose Detection by Jon Ander Ruiz, Ander Iriondo, Elena Lazkano, Ander Ansuategi, Iñaki Maurtua

“…The system is optimized to run on CPU in headless-parallelized mode, with the option of running in a graphical interface or headless and storing videos of the process. …”
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Nanocomplex hyaluronic acid/ganciclovir@ZIF-8 for ganciclovir efficient delivery and targeted anti-KSHV treatment by Fangling Li, Chengjing Liu, Wenyi Gu, Qianhe Xu, Dongmei Li, Dongdong Cao, Zhiyong Liu

“…The results open a gate for the targeted anti-KSHV treatment. Graphical Abstract…”
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Glucocorticoid receptor (NR3C1) genetic polymorphisms and the outcomes of sudden sensorineural hearing loss by Chen-Yu Chien, Shu-Yu Tai, Kuan-Hui Li, Hua-Ling Yang, Ling-Feng Wang, Kuen-Yao Ho, Ning-Chia Chang

“…Conclusion These results suggest that NR3C1 genetic polymorphisms may influence the outcomes of SSNHL. Graphical Abstract…”
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The use of nano-structured cellulose to improve plywood: A review by L.C. Lirya Silva, F.O. Lima, S.N. Monteiro, A.R.G. Azevedo, A.L. Christoforo, B.S. Ferreira, D. Goveia, C.I. de Campos

“…The Virtual Operating System (VOS) Viewer was used to develop a graphical mapping. The main authors were selected for an in-depth analysis of their results. …”
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Effectiveness of breathing exercises on urinary symptoms, muscle activity, and strength in women with multiple sclerosis and urinary incontinence—a study protocol for a randomized... by Atieh Nazem, Shabnam ShahAli, Mehdi Dadgoo, Holakoo Mohsenifar, Ismail Ebrahimi Takamjani, Laleh Abadi Marand

“…Trial registration The trial was registered in the Iranian Registry of Clinical Trials with code IRCT20180916041051N3 and was approved on 23 May 2024. Graphical Abstract…”
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Standardization, validation, and comparative evaluation of a convenient surrogate recombinant vesicular stomatitis virus plaque reduction test for quantification of Hantaan orthoha... by Jing Wei, Hui Zhang, Jiawei Pei, Qiqi Yang, Yuan Wang, Xiaolei Jin, He Liu, Liang Zhang, Hongwei Ma, Linfeng Cheng, Yangchao Dong, Yingfeng Lei, Yinlan Bai, Zhikai Xu, Pengbo Yu, Fanglin Zhang, Wei Ye

“…Our results suggest that rVSV-HTNV-GP based PRNT is a reliable lower-biosafety level surrogate for HTNV NAbs evaluation, which is easy to perform with higher sensitivity. Graphical abstract…”
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Application and progress of non-invasive imaging in predicting lung invasive non-mucinous adenocarcinoma under the new IASLC grading guidelines by Jinbao Feng, Xiaonan Shao, Jianxiong Gao, Xinyu Ge, Yan Sun, Yunmei Shi, Yuetao Wang, Rong Niu

“…It is feasible to apply non-invasive imaging methods to predict the new IASLC grading system. Graphical Abstract…”
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Multimodal lung cancer theranostics via manganese phosphate/quercetin particle by Chong Qiu, Fei Xia, Qingchao Tu, Huan Tang, Yinan Liu, Hongda Liu, Chen Wang, HaiLu Yao, Linying Zhong, Yuanfeng Fu, Pengbo Guo, Weiqi Chen, Xinyu Zhou, Li Zou, Licheng Gan, Jiawei Yan, Yichong Hou, Junzhe Zhang, Huanhuan Pang, Yuqing Meng, Qiaoli Shi, Guang Han, Xijun Wang, Jigang Wang

“…In vitro and in vivo experiments demonstrated that AHA@MnP/QCT NPs enabled non-invasive imaging and tumor treatment, which presented a one-stone-for-two-birds strategy for combining tumor diagnosis and treatment, with broad potential for clinical application in non-small cell lung cancer therapy. Graphical Abstract…”
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Fate and long-lasting therapeutic effects of mesenchymal stromal/stem-like cells: mechanistic insights by Akram Hoseinzadeh, Seyed-Alireza Esmaeili, Reza Sahebi, Anahita Madani Melak, Mahmoud Mahmoudi, Maliheh Hasannia, Rasoul Baharlou

“…Therefore, the long-term reconstructive process of MSCs may potentially be mediated by MSC apoptosis and subsequent phagocyte-mediated efferocytosis. Graphical Abstract…”
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Numerical Approximations and Fractional Calculus: Extending Boole’s Rule with Riemann–LiouvilleFractional Integral Inequalities by Abdul Mateen, Wali Haider, Asia Shehzadi, Hüseyin Budak, Bandar Bin-Mohsin

“…Numerical examples, computational analysis, applications to quadrature formulas and graphical illustrations substantiate the efficacy of the proposed inequalities in improving the accuracy of integral approximations, particularly within the context of fractional calculus. …”
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Analysis of water based Casson hybrid nanofluid (NiZnFe2O4+MnZnFe2O4) flow over an electromagnetic actuator with Cattaneo–Christov heat-mass flux: A modified Buongiorno model by S. Baskaran, R. Sowrirajan, S. Divya, S. Eswaramoorthi, K. Loganathan

“…The implication of key parameters on both direction velocities, temperature, nanofluid concentration, skin friction coefficients, local Nusselt number, and Sherwood number are displayed graphically. Our investigation revealed that fluid velocities are suppressed by increasing the values of Forchheimer number. …”
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Metabolomic and transcriptomic analyses revealed potential mechanisms of Anchusa italica Retz. in alleviating cerebral ischemia–reperfusion injury via Wnt/β-catenin pathway modulat... by Wenta Tan, Shuo Fu, Yufei Wang, Bojun Hu, Guiquan Ding, Li Zhang, Wen Zhang, Guanhua Du, Junke Song

“…By restoring the balance of mitochondrial function and energy metabolism, AIRE might offer a potentially therapeutic strategy for addressing CIRI. Graphical Abstract…”
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Role of drug-induced sleep endoscopy in evaluation of positional vs non-positional OSA by Ming-Chin Lan, Stanley Yung-Chuan Liu, Ming-Ying Lan, Yun-Chen Huang, Tung-Tsun Huang, Yen-Bin Hsu

“…Therefore, further treatment modalities should address the distinct anatomical trait between positional and non-positional OSA. Graphical abstract…”
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A national study of choanal atresia in tertiary care centers in Canada – part II: clinical management by Josee Paradis, Agnieszka Dzioba, Hamdy El-Hakim, Paul Hong, Frederick K. Kozak, Lily H. P. Nguyen, Demitri Perera, Evan Jon Propst, Jennifer M. Siu, Monika Wojtera, Murad Husein, National Choanal Atresia Study Working Group

“…The optimal surgical approach, age at surgical repair, use of stents, surgical adjuncts, and need for planned second look warrant further investigation. Graphical abstract…”
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MetaboLINK is a novel algorithm for unveiling cell-specific metabolic pathways in longitudinal datasets by Jared Lichtarge, Gerarda Cappuccio, Gerarda Cappuccio, Soumya Pati, Soumya Pati, Alfred Kwabena Dei-Ampeh, Alfred Kwabena Dei-Ampeh, Senghong Sing, Senghong Sing, Senghong Sing, LiHua Ma, Zhandong Liu, Zhandong Liu, Mirjana Maletic-Savatic, Mirjana Maletic-Savatic, Mirjana Maletic-Savatic

“…As biological datasets, particularly metabolomics, become larger and more complex, innovative strategies are essential for deciphering the intricate molecular and cellular networks.MethodsWe introduce a pioneering analytical approach that combines Principal Component Analysis (PCA) with Graphical Lasso (GLASSO). This method is designed to reduce the dimensionality of large datasets while preserving significant variance. …”
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Platycodon grandiflorum-derived extracellular vesicles suppress triple-negative breast cancer growth by reversing the immunosuppressive tumor microenvironment and modulating the gu... by Min Yang, Jia Guo, Jinxian Li, Shuyue Wang, Yuan Sun, Ying Liu, Yinghua Peng

“…In conclusion, these findings highlight PGEVs as a promising natural, biocompatible and efficient nanotherapeutic candidate for treating TNBC. Graphical Abstract…”
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