Slowly digestible starch impairs growth performance of broiler chickens offered low-protein diet supplemental higher amino acid densities by inhibiting the utilization of intestina... by Caiwei Luo, Yao Yu, Gang Meng, Jianmin Yuan

“…Although the RDS diet resulted in growth performance similar to the corn starch diet, it reduced breast muscle mass by inhibiting protein synthesis and promoting degradation. Graphical Abstract…”
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AiGPro: a multi-tasks model for profiling of GPCRs for agonist and antagonist by Rahul Brahma, Sunghyun Moon, Jae-Min Shin, Kwang-Hwi Cho

“…This enhances prediction accuracy and accelerates virtual screening workflows, offering a valuable and innovative solution for advancing GPCR-targeted drug discovery. Graphical Abstract…”
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Technologies for Interoperable Internet of Medical Things Platforms to Manage Medical Emergencies in Home and Prehospital Care: Scoping Review by Mattias Seth, Hoor Jalo, Åsa Högstedt, Otto Medin, Bengt Arne Sjöqvist, Stefan Candefjord

“…The findings, including commonly used technologies and standards, are presented through narrative descriptions and graphical representations. ResultsThe primary technologies and standards reported for interoperable IoMT platforms in prehospital care and HBC included cloud computing (19/30, 63%), representational state transfer application programming interfaces (REST APIs; 17/30, 57%), Wi-Fi (17/30, 57%), gateways (15/30, 50%), and JSON (14/30, 47%). …”
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TGF-β induces cholesterol accumulation to regulate the secretion of tumor-derived extracellular vesicles by Dorival Mendes Rodrigues-Junior, Chrysoula Tsirigoti, Konstantina Psatha, Dimitris Kletsas, Michalis Aivaliotis, Carl-Henrik Heldin, Aristidis Moustakas

“…Conclusion Hence, we delineated a novel signaling cascade that leads to high rates of EV generation by cancer cells in response to TGF-β, with cholesterol being a key intermediate step in this mechanism. Graphical Abstract • TGF-β increases EV release by activating a MEK-ERK1/2-SREBP2-DHCR7 signaling and transcriptional pathway. • TGF-β-induced DHCR7 expression raises cholesterol abundance that promotes EV release. • EVs carry surface latent TGF-β and MMP9 that can activate TGF-β receptor signaling on the surface of recipient cells.…”
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Multimodal Imaging of Patients With Gliomas Confirms C-MET PET as a Complementary Marker to MRI for Noninvasive Tumor Grading and Intraindividual Follow-Up After Therapy by Kai R. Laukamp MD, Florian Lindemann PhD, Matthias Weckesser MD, Volker Hesselmann MD, Sandra Ligges PhD, Johannes Wölfer MD, Astrid Jeibmann MD, Bastian Zinnhardt PhD, Thomas Viel PhD, Michael Schäfers MD, Werner Paulus MD, Walter Stummer MD, Otmar Schober PhD, MD, Andreas H. Jacobs MD

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Voxelwise characterization of noise for a clinical photon-counting CT scanner with a model-based iterative reconstruction algorithm by Luigi Masturzo, Patrizio Barca, Luca De Masi, Daniela Marfisi, Antonio Traino, Filippo Cademartiri, Marco Giannelli

“…This is done without modifying noise histogram distribution shape, while limiting the low-frequency shift of noise power spectrum peak frequency. Graphical Abstract…”
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Bone marrow mesenchymal stem cell-derived extracellular vesicles alleviate diabetes-exacerbated atherosclerosis via AMPK/mTOR pathway-mediated autophagy-related macrophage polariza... by Libo Liu, Ziyu An, Huan Zhang, Xueqi Wan, Xin Zhao, Xueyao Yang, Jinfan Tian, Xiantao Song

“…BMSC-EVs thus hold promise as therapeutic agents for atherosclerosis. Graphical Abstract Extracellular vesicles derived from bone marrow mesenchymal stem cells may mitigate diabetes-aggravated atherosclerosis by regulating AMPK/mTOR-mediated autophagy-related macrophage polarization and inhibiting macrophage proliferation, migration, foam cell formation, and cholesterol transport.…”
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Surgical treatment experience of seven cases of Berry syndrome by Zhangke Guo, Zhimin Li, Feng Tong, Song Bai, Xiaofeng Li

“…In this work, we analyzed the clinical data of 7 patients from January 2013 to July 2024 with Berry syndrome who underwent surgical treatment in our institution and showed one-stage surgical correction can achieved acceptable outcomes. Graphical Abstract…”
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The association between stress-induced hyperglycemia ratio and cardiovascular events as well as all-cause mortality in patients with chronic kidney disease and diabetic nephropathy by Boning Cao, Zhendong Guo, Dan-Ting Li, Le-Ying Zhao, Zhen Wang, Ya-Bin Gao, Yao-Xian Wang

“…SHR may serve as a critical biomarker for prognostic assessment in these populations, enabling clinicians to identify high-risk patients and tailor personalized treatment strategies that enhance patient quality of life and mitigate mortality risk. Graphical abstract…”
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A network analysis of depression and anxiety symptoms among Chinese elderly living alone: based on the 2017–2018 Chinese Longitudinal Healthy Longevity Survey (CLHLS) by Ze Chang, Yunfan Zhang, Xiao Liang, Yunmeng Chen, Chunyan Guo, Xiansu Chi, Liuding Wang, Xie Wang, Hong Chen, Zixuan Zhang, Longtao Liu, Lina Miao, Yunling Zhang

“…Depression and anxiety symptoms were assessed using the Center for Epidemiologic Studies Depression Scale-10 (CESD-10) and the Generalized Anxiety Disorder Scale-7 (GAD-7), respectively. A Gaussian Graphical Model (GGM) was employed to build the symptom network, and the Fruchterman-Reingold algorithm was used for visualization, with the thickness and color of the edges representing partial correlations between symptoms. …”
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Effects of converting cropland to grassland on greenhouse gas emissions from peat and organic-rich soils in temperate and boreal climates: a systematic review by Alena Holzknecht, Magnus Land, Jacynthe Dessureault-Rompré, Lars Elsgaard, Kristiina Lång, Örjan Berglund

“…CO2 emissions represent a major part of the climate impact of cultivated peat soils, so the data analyzed allow to draw the conclusion that a conversion from arable to grassland would not lead to large benefits in terms of GHG emissions, especially if root crops are not part of the arable crop rotation, or the grassland is fertilized. Graphical abstract…”
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Comparing the efficacy of 3D-printing-assisted surgery with traditional surgical treatment of fracture: an umbrella review by Lin Xiao, Peiyuan Tang, Shengwu Yang, Jingyue Su, Wenbo Ma, Han Tan, Ying Zhu, Wenfeng Xiao, Ting Wen, Yusheng Li, Shuguang Liu, Zhenhan Deng

“…The Measurement Tool to Assess Systematic Reviews (AMSTAR) 2 was used to rate the quality and reliability of the meta-analyses (MAs), and Grading of Recommendations Assessment, Development, and Evaluation (GRADE) was used to grade the outcomes. Furthermore, Graphical Representation of Overlap for Overviews (GROOVE) was employed to examine overlap, and the resulting evidence was categorized into four groups according to established criteria for evidence classification. …”
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Decreased attenuation difference between non-contrast and portal-venous phases of CT predicts the ultrasonography-unspecified adnexal torsion by Weili Xie, Zhongren Huang, Hongmei Kuang, Xiaoxing Li, Rixin Zhang, Wei Zeng, Cheng Jin, Junyuan Zhong, Jidong Peng, Weiling Cheng, Fuqing Zhou

“…Contrast-enhanced CT can be used as a second-line imaging approach after an equivocal ultrasonographic examination. Graphical Abstract…”
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Prevalence and drivers of malaria infection among asymptomatic and symptomatic community members in five regions with varying transmission intensity in mainland Tanzania by Gervas A. Chacha, Filbert Francis, Salehe S. Mandai, Misago D. Seth, Rashid A. Madebe, Daniel P. Challe, Daniel A. Petro, Dativa Pereus, Ramadhani Moshi, Rule Budodo, Angelina J. Kisambale, Ruth B. Mbwambo, Catherine Bakari, Sijenunu Aaron, Daniel Mbwambo, Stella Kajange, Samuel Lazaro, Ntuli Kapologwe, Celine I. Mandara, Deus S. Ishengoma

“…The identified vulnerable groups and hotspots should be targeted with specific interventions to reduce the disease burden and support the ongoing malaria elimination efforts in Tanzania. Graphical Abstract…”
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Enhancing deep learning methods for brain metastasis detection through cross-technique annotations on SPACE MRI by Tassilo Wald, Benjamin Hamm, Julius C. Holzschuh, Rami El Shafie, Andreas Kudak, Balint Kovacs, Irada Pflüger, Bastian von Nettelbladt, Constantin Ulrich, Michael Anton Baumgartner, Philipp Vollmuth, Jürgen Debus, Klaus H. Maier-Hein, Thomas Welzel

“…Further validation in prospective studies is needed. Graphical Abstract…”
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Insights into the biology and insecticide susceptibility of the secondary malaria vector Anopheles parensis in an area with long-term use of insecticide-treated nets in northwester... by Salum Abdallah Mapua, Ismail Hassan Nambunga, Joel Ouma Odero, Gustav Mkandawile, John Paliga Masalu, Najat Feruz Kahamba, Emmanuel Elirehema Hape, Nancy Stephen Matowo, Frederic Tripet, Fredros Oketch Okumu

“…These findings provide a foundation for future research and may inform control strategies targeting residual malaria transmission involving An. parensis. Graphical Abstract…”
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Thoracolumbar fascia ultrasound shear strain differs between low back pain and asymptomatic individuals: expanding the evidence by Norio Tomita, Marie-Hélène Roy-Cardinal, Boris Chayer, Stacey Daher, Ameer Attiya, Aline Boulanger, Nathaly Gaudreault, Guy Cloutier, Nathalie J. Bureau

“…A brief standardized massage therapy technique did not influence elastography parameters. Graphical Abstract…”
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Specifically blocking αvβ8-mediated TGF-β signaling to reverse immunosuppression by modulating macrophage polarization by Cuicui Guo, Hui Sun, Yulei Du, Xiaodong Dai, Yu Pang, Zhen Han, Xinhui Xiong, Shaowei Li, Junhua Zhang, Qingbing Zheng, Xun Gui

“…These results support further clinical evaluation of αvβ8 antibodies. Graphical abstract…”
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Effect of Rifaximin and a Multi-Strain Probiotic on the Intestinal Microbiome and Cardiovascular Risk Indicators in Patients with Coronary Heart Disease by E. A. Kashukh, E. A. Poluektova, A. V. Kudryavtseva, G. S. Krasnov, V. I. Kazey, P. D. Sobolev, P. V. Gremyakova, V. T. Ivashkin

“…To study the composition of fecal microflora, 16S sequencing was used followed by a graphical representation of the results. The results were analysed using the IBM SPSS 22.0 statistical data processing software.Results. …”
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Preparation of future teachers for innovative activities in pedagogical and technological educational environment by N. I. Naumkin, N. N. Shekshaeva, V. F. Kupryashkin, E. V. Zabrodina

“…The environment includes conceptually-targeted, infrastructural, content-based, psychological-didactic, methodological-technological and relaxation-diagnostic components, its features are the following: 1) focus on innovative training of technology teachers as directly related to the material objects of the innovative economy of the country; 2) universality in the form of the possibility of using it to solve other educational tasks; 3) graphical visualisation of the environment model with an indication of the hierarchy and interrelation of components, its scale, combinatoricity and functional sufficiency; 4) compliance of the environment with all the requirements of regulatory documents on educational activities at the university; 5) possibility of full-scale implementation of modern approaches to learning (innovative, personalised, environmental, project, etc.); 6) possibility of constant monitoring and control of the implementation of the environment within its relaxation and diagnostic component; 7) use of modern educational technologies, including digital; 8) possibility of obtaining specialised knowledge and studying other disciplines within the framework of using network learning; 9) innovativeness of the environment, determined by the novelty of the approach to teaching the teachers innovation technology and its effectiveness.To teach innovation activity in this environment, a model of a methodological system for the formation of competence in innovation activity among future technology teachers has been created, combining conceptually-targeted, meaningful, instrumental-activity and reflexive-evaluative components. …”
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